Participants were recruited via local media and internet advertisements and word-of-mouth referrals. Initial inclusion criteria were: age 21–35 years, weight 110–210 pounds, good general health, not pregnant or lactating, no current or past major medical or Axis I psychiatric disorders including alcohol and substance dependence (other than nicotine), and no current use of any centrally-acting medications. The medical screening by the study nurse included a brief physical assessment, health history, vital signs, a blood draw to confirm normal liver enzyme levels (<2 SD of normal range), and a urine toxicology screen (cocaine, opiates, benzodiazepines, amphetamines, barbiturates, and PCP) and pregnancy test for women. A trained research assistant conducted the alcohol Quantity-Frequency Interview (QFI)(35) and the alcohol disorders module from the Structured Clinical Interview for DSM-IV (SCID), non-patient version (36). The participant also completed demographic measures, a two-generational biological family history (FH) tree for alcohol use disorders and the FH Research Diagnostic Criteria for drinking consequences(37), an alcohol Timeline Follow-back for past month drinking(38), the Alcohol Use Disorders Identification Test (AUDIT (39)), and the Drinker Inventory of Consequences (Dr-InC2R (40). Heavy
