A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder.
paper
Cited
Public
- Authors
- King, Andrea C; Hasin, Deborah; O'Connor, Sean J; McNamara, Patrick J; Cao, Dingcai
- Year
- 2016
- Journal
- Biological psychiatry
- PMID
- 26117308
- DOI
- 10.1016/j.biopsych.2015.05.007
- PMCID
- PMC4644521
BACKGROUND: The main neurobiological theories of the development of addiction, including tolerance, sensitization, incentive-sensitization, and allostasis, have not been tested in longitudinal human alcohol response research. To address this issue, we conducted the first controlled prospective investigation of subjective and neuroendocrine responses to alcohol measured over a 5-year interval in at-risk young adult heavy drinkers (HD) and light drinker control subjects. METHODS: Participants were 156 individuals, 86 heavy drinkers and 70 light drinkers, undergoing an initial oral alcohol challenge testing (.8 g/kg alcohol vs. placebo) and an identical re-examination testing 5 to 6 years later. Alcohol use disorder (AUD) symptoms and drinking behaviors were assessed in the interim follow-up period. RESULTS: At re-examination, HD continued to exhibit higher sensitivity on alcohol's stimulating and rewarding effects with lower sensitivity to sedative effects and cortisol reactivity, relative to light drinkers. In HD with high AUD symptom trajectories over follow-up, heightened alcohol stimulation and reward persisted at re-examination. HD with low AUD symptoms showed reduced alcohol stimulation over time and lower reward throughout compared with the HD with high and intermediate AUD symptoms. CONCLUSIONS: Results support the early stage phase of the allostasis model, with persistently heightened reward sensitivity and stimulation in heavy drinkers exhibiting AUD progression in early mid-adulthood. While there are multiple pathways to development of a disorder as complex as AUD, maintenance of alcohol stimulatory and rewarding effects may play an important role in the continuation and progression of alcohol addiction.
BrAC curve data as mean (SEM) for light and heavy drinkers at initial and re-examination testing.
Figure 2AβC. Alcohol stimulation, liking and wanting at initial and re-examination phases.Data are shown for light (n=70) and heavy drinker groups (n=86), as well the heavy drinker AUD trajectory subgroups, including low AUD (n=26), intermediate AUD (n=51), and high AUD (n=9). Fig 2A is the net change score (alcohol session peak BrAC minus baseline change score minus the same change score for the placebo session) for the BAES stimulation; three outliers (<3 SD below mean) were removed in this analysis. Fig 2B and 2C are the DEQ like and want more change scores (alcohol session minus placebo session), respectively. GEE results are depicted for group and group x phase effects, see Table 2 for post-estimation testing results.
Figure 3AβB. Alcohol sedation and cortisol response at initial and re-examination phases.Data are shown for light (n=70) and heavy drinker groups (n=86), as well the heavy drinker AUD trajectory subgroups, including low AUD (n=26), intermediate AUD (n=51), and high AUD (n=9). Fig 3A is the net change score (alcohol session peak BrAC minus baseline change score minus the same change score for the placebo session) for the BAES sedation and Fig 3B is the net change score (alcohol session 180 minutes minus baseline change score minus the same change score for the placebo session) for salivary cortisol levels; three outliers (two > 3 SD above mean, one <3 SD below mean) were removed in this analysis. GEE results are depicted for group effects.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Are you feeling what I'm feeling? Momentary interactions between personal and perceived peer subjective response predict craving and continued drinking in young adults. | King SE et al. | β | 2025 | β |
| Aversion-resistant alcohol seeking in the human laboratory. | Garrison ACS et al. | β | 2025 | β |
| Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder. | Meredith LR et al. | β | 2025 | β |
| Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse. | Milivojevic V et al. | β | 2025 | β |
| Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner. | Pearl AJ et al. | β | 2025 | β |
| Modeling escalation of drug intake to identify molecular targets for treating substance use disorders: A slippery slope upward. | Bardo MT et al. | β | 2025 | β |
| Pace of alcohol drinking during in natural-environment drinking is associated with heightened alcohol-related reward and negative consequences in risky drinkers. | Atkinson EA et al. | β | 2025 | β |
| Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats. | Windram M et al. | β | 2025 | β |
| Semaglutide, Tirzepatide, and Retatrutide Attenuate the Interoceptive Effects of Alcohol in Male and Female Rats | Windram M et al. | β | 2025 | β |
| Understanding the associations between eHealth activities and support for alcohol restrictions among drinkers-the roles of alcohol-related health risk awareness and self-efficacy. | Wang ZC et al. | β | 2025 | β |
| Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence. | Ramirez LA et al. | β | 2024 | β |
| Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol? | Reed C et al. | β | 2024 | β |
| Exploratory analysis of blood alcohol concentration-related technology use and drinking outcomes among young adults. | Wilson SE et al. | β | 2024 | β |
| Metadehumanization, fundamental needs and coping strategies: A comparison of drinkers at low versus high risk of alcohol use disorder. | Fontesse S et al. | β | 2024 | β |
| The key role of specific DSM-5 diagnostic criteria in the early development of alcohol use disorder: Findings from the RADAR prospective cohort study. | Slade T et al. | β | 2024 | β |
| A preliminary investigation of salivary Ξ±-amylase as a novel biomarker of subjective response to alcohol: A brief report. | King SE et al. | β | 2023 | β |
| Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study. | Ray LA et al. | β | 2023 | β |
| Assessing real-time positive subjective effects of alcohol using high-resolution ecological momentary assessment in risky versus light drinkers. | Fridberg DJ et al. | β | 2023 | β |
| Drinking context, alcohol use, and subjective responses during binge drinking episodes measured by high-resolution ecological momentary assessment (HR-EMA). | Fischer AM et al. | β | 2023 | β |
| Incremental Predictive Validity of the Dualistic Model of Passion for Cannabis Use Among College Undergraduate Students With and Without a Cannabis Use Disorder. | Davis AK et al. | β | 2023 | β |
| Subjective effects of simultaneous alcohol and cannabis versus alcohol-only use: A qualitative analysis. | Waddell JT et al. | β | 2023 | β |
| Translational models of addiction phenotypes to advance addiction pharmacotherapy. | Ray LA et al. | β | 2023 | β |
| Acute alcohol rewarding effects as a risk factor for hangover frequency. | Chavarria J et al. | β | 2022 | β |
| Bidirectional influence of heroin and cocaine escalation in persons with dual opioid and cocaine dependence diagnoses. | Butelman ER et al. | β | 2022 | β |
| Haven't lost the positive feeling: a dose-response, oral alcohol challenge study in drinkers with alcohol use disorder. | King AC et al. | β | 2022 | β |
| Hazardous drinking and alcohol use disorders. | MacKillop J et al. | β | 2022 | β |
| Momentary subjective responses to alcohol as predictors of continuing to drink during daily-life drinking episodes. | Wycoff AM et al. | β | 2022 | β |
| Reward sensitivity and hazardous alcohol consumption in women: The parallel mediation effect of self-control and impulsivity traits. | MartΓn-PΓ©rez C et al. | β | 2022 | β |
| The prospective interactive effects of alcohol expectancies and subjective response on future drinking behavior. | Waddell JT et al. | β | 2022 | β |
| Alcohol subjective responses in heavy drinkers: Measuring acute effects in the natural environment versus the controlled laboratory setting. | Fridberg DJ et al. | β | 2021 | β |
| A meta-regression of methodological features that predict the effects of medications on the subjective response to alcohol. | Green R et al. | β | 2021 | β |
| Association between polymorphism in gene related to the dopamine circuit and motivations for drinking in patients with alcohol use disorder. | CΓ©spedes IC et al. | β | 2021 | β |
| Clinical Neuroscience of Addiction: What Clinical Psychologists Need to Know and Why. | Ray LA et al. | β | 2021 | β |
| Compensatory neuroadaptation to binge drinking: Human evidence for allostasis. | Correas A et al. | β | 2021 | β |
| Effects of alcohol sensitivity on alcohol-induced blackouts and passing out: An examination of the alcohol sensitivity questionnaire among underage drinkers. | Davis CN et al. | β | 2021 | β |
| Impact of sex, strain, and age on blood ethanol concentration and behavioral signs of intoxication during ethanol vapor exposure. | Glover EJ et al. | β | 2021 | β |
| Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol. | Weafer J et al. | β | 2021 | β |
| Subjective alcohol responses in high- and low-risk adolescents: results from the Dresden Longitudinal Study on Alcohol Use in Young Adults. | Chavarria J et al. | β | 2021 | β |
| Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder. | King A et al. | β | 2021 | β |
| The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews. | Boness CL et al. | β | 2021 | β |
| The future of translational research on alcohol use disorder. | Ray LA et al. | β | 2021 | β |
| Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. | Parker CC et al. | β | 2020 | β |
| An Exploratory Factor Analysis of the Stimulant, Sedative, and Affective Responses to Alcohol. | Grodin EN et al. | β | 2020 | β |
| Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Quetiapine Fumarate XR in Lowering Alcohol Intake in Alcohol Use Disorder Patients. | Vatsalya V et al. | β | 2020 | β |
| Mechanisms of Alcohol Addiction: Bridging Human and Animal Studies. | Kramer J et al. | β | 2020 | β |
| Poor inhibitory control is associated with greater stimulation and less sedation following alcohol. | Weafer J et al. | β | 2020 | β |
| Stability of acute responses to drugs in humans across repeated testing: Findings with alcohol and amphetamine. | Murray CH et al. | β | 2020 | β |
| The Feasibility, Tolerability, and Safety of Administering a Very High Alcohol Dose to Drinkers with Alcohol Use Disorder. | Vena A et al. | β | 2020 | β |
| The Role of Stress, Trauma, and Negative Affect in Alcohol Misuse and Alcohol Use Disorder in Women. | Guinle MIB et al. | β | 2020 | β |
| Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of Ξ²-arrestin2. | Luessen DJ et al. | β | 2019 | β |
| Alcohol use disorders. | Carvalho AF et al. | β | 2019 | β |
| A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors. | Bocarsly ME et al. | β | 2019 | β |
| Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures. | Plawecki MH et al. | β | 2019 | β |
| Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty in disordered gambling behavior. | Hellberg SN et al. | β | 2019 | β |
| Cue-Elicited Anxiety and Alcohol Craving as Indicators of the Validity of ALCO-VR Software: A Virtual Reality Study. | GhiΕ£Δ A et al. | β | 2019 | β |
| Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol? | Berey BL et al. | β | 2019 | β |
| Drug-induced stress responses and addiction risk and relapse. | Wemm SE et al. | β | 2019 | β |
| Effects of oxytocin on stress reactivity and craving in veterans with co-occurring PTSD and alcohol use disorder. | Flanagan JC et al. | β | 2019 | β |
| Evidence for incentive salience sensitization as a pathway to alcohol use disorder. | CofresΓ RU et al. | β | 2019 | β |
| Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses. | Martins JS et al. | β | 2019 | β |
| Interneuronal Ξ΄-GABA<sub>A</sub> receptors regulate binge drinking and are necessary for the behavioral effects of early withdrawal. | MelΓ³n LC et al. | β | 2019 | β |
| Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta-analysis. | Ray LA et al. | β | 2019 | β |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | β | 2019 | β |
| Preliminary Evidence That Real World Sleep Timing and Duration are Associated With Laboratory-Assessed Alcohol Response. | Hasler BP et al. | β | 2019 | β |
| Real-Time Mobile Monitoring of Drinking Episodes in Young Adult Heavy Drinkers: Development and Comparative Survey Study. | Fridberg DJ et al. | β | 2019 | β |
| Relationships between generalized impulsivity and subjective stimulant and sedative responses following alcohol administration. | Berey BL et al. | β | 2019 | β |
| The Interplay Between Subjective Response to Alcohol, Craving, and Alcohol Self-Administration in the Human Laboratory. | Green R et al. | β | 2019 | β |
| The role of alcohol response phenotypes in the risk for alcohol use disorder. | King AC et al. | β | 2019 | β |
| Time for a Drink? A Mathematical Model of Non-human Primate Alcohol Consumption. | Moore S et al. | β | 2019 | β |
| A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism. | Schuckit MA et al. | β | 2018 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| CBI-20: Psychometric Properties for the Coping Behaviors Inventory for Alcohol Abuse in Brazil. | Constant HMRM et al. | β | 2018 | β |
| Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability. | Milivojevic V et al. | β | 2018 | β |
| Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm. | Bujarski S et al. | β | 2018 | β |
| Drunk decisions: Alcohol shifts choice from habitual towards goal-directed control in adolescent intermediate-risk drinkers. | Obst E et al. | β | 2018 | β |
| GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use. | Mallard TT et al. | β | 2018 | β |
| Several behavioral traits relevant for alcoholism are controlled by Ι£2 subunit containing GABA<sub>A</sub> receptors on dopamine neurons in mice. | Stojakovic A et al. | β | 2018 | β |
| Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes. | Ramchandani VA et al. | β | 2018 | β |
| Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. | Weafer J et al. | β | 2018 | β |
| Alcohol-induced performance impairment: a 5-year re-examination study in heavy and light drinkers. | Brumback T et al. | β | 2017 | β |
| Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders. | Blaine SK et al. | β | 2017 | β |
| A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel. | Schuckit MA et al. | β | 2017 | β |
| A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence. | Hendershot CS et al. | β | 2017 | β |
| A Review of Developmental Considerations in Human Laboratory Alcohol Research. | Hendershot CS et al. | β | 2017 | β |
| Association of Anticipated and Laboratory-Derived Alcohol Stimulation, Sedation, and Reward. | Fridberg DJ et al. | β | 2017 | β |
| Craving and acute effects of alcohol in youths' daily lives: Associations with alcohol use disorder severity. | Treloar H et al. | β | 2017 | β |
| From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process. | Deutsch AR et al. | β | 2017 | β |
| Impulsivity Moderates Subjective Responses to Alcohol in Alcohol-Dependent Individuals. | Westman JG et al. | β | 2017 | β |
| Mediation of effects of the level of response to alcohol and impulsivity 15 years later in 36-year-old men: Implications for prevention efforts. | Schuckit MA et al. | β | 2017 | β |
| Relationships of Impulsivity and Subjective Response to Alcohol Use and Related Problems. | Berey BL et al. | β | 2017 | β |
| Subjective alcohol responses in a cross-sectional, field-based study of adolescents and young adults: Effects of age, drinking level, and dependence/consequences. | Treloar H et al. | β | 2017 | β |
| The neural correlates of priming emotion and reward systems for conflict processing in alcoholics. | Schulte T et al. | β | 2017 | β |
| The Subjective Response to Nitrous Oxide is a Potential Pharmaco-Endophenotype for Alcohol Use Disorder: A Preliminary Study with Heavy Drinkers. | Walsh K et al. | β | 2017 | β |
| Alcohol Effects on Stress Pathways: Impact on Craving and Relapse Risk. | Blaine SK et al. | β | 2016 | β |
| Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. | Boyd SJ et al. | β | 2016 | β |
| Effect of Alcohol on Encoding and Consolidation of Memory for Alcohol-Related Images. | Weafer J et al. | β | 2016 | β |
| Individual differences in subjective alcohol responses and alcohol-related disinhibition. | Quinn PD et al. | β | 2016 | β |
| Persisting Differences in the Sensitivity to the Effects of Alcohol: What We Know and Where to Go From Here. | Pedersen SL | β | 2016 | β |
| Subjective Response to Alcohol as a Research Domain Criterion. | Ray LA et al. | β | 2016 | β |
| [The rewarding alcohol effects are not diminished even in high intake]. | Weinland C | β | 2016 | β |
| Integrating alcohol response feedback in a brief intervention for young adult heavy drinkers who smoke: A pilot study. | Fridberg DJ et al. | β | 2015 | β |
| Oral operant ethanol self-administration in the absence of explicit cues, food restriction, water restriction and ethanol fading in C57BL/6J mice. | Stafford AM et al. | β | 2015 | β |