Detailed GEE results of the alcohol response analyses for HD and LD and among the three AUD subgroups within HD are summarized in Table 2. In brief, at both phases, relative to LD, HD exhibited higher sensitivity to alcohol stimulating and rewarding effects (Fig 2A–2C). HD also had lower sensitivity to sedation (Fig 3A) and cortisol response versus LD (Fig 3B). For the HD subgroups, there was a subgroup x phase interaction for stimulation such that the high AUD subgroup persisted with heightened stimulation at re-examination and the intermediate group persisted at intermediate levels, but the low AUD subgroup showed a reduction in stimulation over time. For alcohol reward, there were main effects of AUD subgroup: relative to the low AUD subgroup, the high and intermediate AUD subgroups had persistently higher alcohol liking and wanting over time than the low AUD subgroup. The relationships of stimulation, liking and wanting were positive for the high and intermediate AUD subgroups, suggesting that stimulation is pleasurable; these correlations were not significant in the low AUD subgroup (Supplemental Results). The AUD subgroups did not
