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Chunk #11 — RESULTS — Alcohol Intake during Alcohol Drinking Induction

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Varenicline Reduces Alcohol Intake During Repeated Cycles of Alcohol Reaccess Following Deprivation in Alcohol-Preferring (P) Rats.
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When given an 8-hour free-choice between two alcohol solutions (15% v/v and 30% v/v) and water for 17 days, rats of the P line attained an average daily alcohol intake of 4.2 g alcohol/kg BW (Fig. 1). When access to alcohol was reduced to 4 hours a day for 11 days, P rats consumed approximately 3.0 g alcohol/kg BW daily and when access to alcohol was further reduced to 2 hours a day for 27 days prior to initiation of alcohol deprivation, P rats consumed an average of 2.0 g alcohol/kg BW per day. These levels of alcohol consumption agree well with our prior findings in P rats under similar scheduled alcohol access conditions (Froehlich et al., 2013a, b, 2015, 2016).