With regard to alcohol intake during the first 5 days of alcohol reaccess, there was a significant effect of treatment F (3, 42) = 9.8, p<0.001, day F (4, 168) = 3.3, p<0.05, and a treatment X day interaction F (12, 168) = 1.8, p<0.05 (Fig. 2). Dunnett’s multiple comparisons against a single mean (VEH) revealed that VAR, in doses of 1.0, and 2.0 mg/kg BW, each reduced alcohol intake (p<0.01, and p<0.001, respectively), and that the lowest dose of VAR (0.5 mg/kg BW) showed a strong trend toward a reduction in alcohol intake (p=0.054) (Fig. 2). Dunnett’s multiple comparisons for each dose against a single mean (VEH) within day, revealed that the lowest dose of VAR (0.5 mg/kg BW), reduced alcohol intake only on day 2 of treatment (p<0.05). A higher dose of VAR, 1.0 mg/kg BW, reduced alcohol intake on days 2–5 of treatment (days 2 and 4; p<0.001; days 3 and 5, p<0.01), and the highest dose of VAR (2.0 mg/kg BW), reduced alcohol intake on days 2–5 of treatment (day 2, p<0.001; days 3, 4, and 5, p<0.01).
