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Chunk #64 — Online Methods (Limit 3,000 words, at end of manuscript, currently 2,064) — Coexpression of SCZ genes throughout development

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
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We investigate spatiotemporal expression of our associated genes using publicly available developmental transcriptome data, obtained from the BRAINSPAN consortium53. We partitioned these data into biologically relevant spatio-temporal data sets95, corresponding to four general brain regions; the frontal cortex, temporal and parietal regions, sensory-motor regions, and subcortical regions (Figure 3a96), and eight developmental time-points (four pre-natal, four post-natal)95.