The p50 homodimer DNA binding activity (Table 2; Student's t-test with unequal variances; T1,14.9 = 2.41, P = 0.029), and the constitutively active and total NF-κB DNA-binding activity (Student's t-test with unequal variances; active, T1,14.3 = 2.31, P = 0.037; total, Mann-Whitney U test: Z1,22 = 2.58, P = 0.01, respectively), were lower in the PFC of alcoholics compared to controls. No significant differences between alcoholics and controls in the DNA binding activity of p50 homodimer and constitutively active NF-κB were found in the MC although a trend (Student's t-test; T1;22 = 2.02, P = 0.055) for decrease of the total NF-κB DNA binding activity was observed in alcoholics (Table S2).
