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Chunk #72 — Methods — Association enrichment

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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.
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We display the enrichment for selected phenotypes in Supplementary Fig. 5, measured as mean(Z2). For visualization purposes, we selected 25 phenotypes from different categories such as anthropometric traits, cardiometabolic traits, autoimmune diseases, and psychiatric conditions (please see figure caption for the list of selected phenotypes). The simple mean of Z2 for all gene-tissue pairs in a phenotype was taken.