Chunk #73 — Methods — Derivation of summary-PrediXcan formula

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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

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The goal of summary-PrediXcan is to infer the results of PrediXcan using only GWAS summary statistics. Individual level data are not needed for this algorithm. We will introduce some notations for the derivation of the analytic expressions of S-PrediXcan.