We included only the genotyped individuals of European descent, as verified by ancestry analysis using genome-wide SNP data.30,31 We selected a set of 3,535 “unrelated” adults (1,421 males and 2,114 females; from 18 to 91 years old, with mean of 45) and 724 “unrelated” 16-year-old adolescents (354 males and 370 females), for a combined dataset of 4,259 “unrelated” individuals according to the pedigree information.
