We also assessed the association of the risk and protective SNPs with lung cancer directly while controlling for smoking phenotype. No association was observed for the protective SNPs and lung cancer risk [for rs3743078, CG OR=0.89 (95% CI: 0.55, 1.44), GG OR=1.31 (95% CI: 0.51, 3.36)]. However, the homozygous variant genotype of the risk SNPs was significantly associated with an increased risk of lung cancer [for rs16969968, GA OR=0.67 (95% CI: 0.41, 1.10), AA OR=1.80 (95% CI: 1.02, 3.20)].
