The associations with heavy smoking for the SNPs in the CHRNB3-CHRNA6 gene region or in the CHRNA4 and CHRNB2 genes are shown in Table 5. Two SNPs (rs7012713, in the CHRNB3 gene, and rs7828365, located 5' to the CHRNA6 gene) were significantly associated with heavy smoking [for rs7012713, per allele OR=1.42 (1.05, 1.94), p=0.023, for rs7828365, per allele OR=0.84 (0.72, 0.99), p=0.039]. However, these associations were no longer statistically significant after correction for multiple comparisons. No other statistically significant associations were found for these four genes.
