eCB modulation of local GABAergic transmission and afferent glutamatergic inputs. Within the CeAL, which exhibits homology to the striatum, eCBs modulate glutamatergic inputs to this region, while eCB signaling modulates GABAergic transmission from the CeAL to the CeAM (which shows homology to the globus pallidus). From these anatomical and physiological similarities arise several testable hypotheses. First, the functional role of eCB signaling, from an information processing perspective, is likely to be similar across homologous structures (i.e. PFC, sensory cortex, and BLA; striatum and CeAL; globus pallidus and CeAM). Second, the net modulation of circuit output is a function of the combined modulation at each step of the cortico-striato-pallidal circuit. Third, regulatory mechanisms that govern adaptations of eCB signaling may be similar across anatomical domains (i.e. cortex and BLA, striatum and CeAL).
