Conceptualization of eCB signaling within the forebrain as being overlaid upon parallel but interactive cortico-striato-pallidal loops, with each node in the circuit subject to the same functional modulation across cortical subdomains (motor and limbic; see Fig. 2), could allow for a more integrated understanding of the role of eCB signaling on behavioral output. This conceptualization yields testable hypotheses that could drive future research into the role of eCB signaling in the modulation of forebrain function from both a systems and computational perspective.
