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Chunk #30 — Results — GWAS findings

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Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15.
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Using the FASTSNP program, we analyzed the potential functions of these nine SNPs. According to the analyses, four of the SNPs are located at potential transcription factor (TF) binding sites. For the SNP rs4956302, a polymorphic change of T→C may establish a binding site for the TF, Lyf-1. For the SNP, rs17354547, a polymorphic change of A→C may delete binding sites for the TFs, CdxA and YY1. For the SNP, rs17354568, a polymorphic change of A→C may create a binding site for the TF, Ik-2. For the SNP, rs6838494, a polymorphic change of C→A may create a binding site for TFs, CdxA and Nkx-2 but delete the binding site for Oct-1.