CAD was initiated between 11am and 12pm. Subjects consumed 1 placebo drink followed by 3 active alcohol drinks administered at 45-min intervals to progressively increase breath alcohol content (BAC) (0.03–0.1%) over 2 hrs. A terminal BAC of 0.1% was selected based on our experience in previous studies (Turkkan et al., 1988, Uhart et al., 2013), and to target BAC reached during binge/heavy drinking. Doses for each subject were determined using a Computerized Blood Alcohol Calculator (Fisher et al., 1987) which adjusts for age, height, weight, gender differences in body water, and time spent drinking, to target similar BAC in males and females. The Johns Hopkins Investigational Drug Services prepared each 120 mL drink by mixing the appropriate mL of 95% ethanol (Spectrum Chemicals) in calorie-free Cherry Kool-Aid using a w/v metric. A placebo drink was utilized in order to account for expectation of alcohol effects that are independent of pharmacological effects of alcohol. Subjects were blind to the drink contents and were told “During the session you will receive alcohol drinks or placebo drinks. Drinks may contain different amounts of
