(~0.8) demonstrating that the same genetic signals can explain variance in schizophrenia liability in different case-control samples collected; given that these samples were collected independently with genotyping conducted at different laboratories, it is difficult to envision artefacts that could generate such high correlations. Hence, we conclude that the PGC-SCZ estimate of h2 represents the lower bound of variance in liability that would be explained by common SNPs in a large phenotypically and genetically homogeneous sample with no genotyping artefacts.
