Chunk #22 — Results — Studies in Cocaine Addicts, Alcoholics and Controls — Genes encoding GABAA receptor associated proteins

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GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.

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From Table 2 and Figure 3A it can be seen that, relative to alcoholics and controls, cocaine addicts showed significant or trend down-regulation of GPHN (p = 0.02), NSF (p<0.001) (Figure S2), ZDHHC3 (p = 0.056) and UBQLN1 (p = 0.062). Alcoholics had increased expression of GABARAP relative to cocaine addicts (p = 0.021).