ectodomain shedding is carried out by the aspartyl protease β-site APP cleaving enzyme I [(BACE1; also known as memapsin and Asp2) (Hussain et al., 1999; Sinha et al., 1999; Vassar et al., 1999; Lin et al., 2000; Yan et al., 1999; Hong et al., 2000). Followed by γ-secretase cleavage, this RIP pathways yields the production of the beta –amyloid peptide (Aβ) and other APP metabolites involved in the progression of AD.
