Neurogenesis and Alzheimer's disease: at the crossroads.

paper Cited Public

Authors: Lazarov, Orly; Marr, Robert A
Year: 2010
Journal: Experimental neurology
PMID: 19699201
DOI: 10.1016/j.expneurol.2009.08.009
PMCID: PMC2864344

#	Section	Preview
0	Introduction	Alzheimer's disease (AD) is characterized by a progressive memory loss and cognitive decline [For…
1	Introduction	of the aspartyl protease γ-secretase complex that cleaves numerous membrane proteins…
2	Introduction	ectodomain shedding is carried out by the aspartyl protease β-site APP cleaving enzyme I [(BACE1;…
3	Introduction	The hallmarks of AD are neurofibrillary tangles, intraneuronal lesions composed of aggregated…
4	Introduction	Abnormally phosphorylated tau protein is found in the neuropil of the CA1-subiculum region, followed…
5	Introduction	While most of the self-renewal capacity characterizing its embryonic development ceases, the adult…
6	Introduction	rats, amounting to 0.1% of the population of the entire DG, with a survival rate of about 50%…
7	Introduction	long term potentiation more rapidly (van Praag et al., 2002). While the precise physiological…
8	Introduction	Increasing evidence suggests that new neurons play a role in certain forms of brain function…
9	Introduction	stimulus-specific manner, and contribute to strengthening of memory circuits related to the stimulus…
10	Introduction	underlie, at least in part, the progressive loss of memory and compromised ability to learn and…
11	Converging Pathways Implicated in Neurogenesis and AD Pathology — The neurogenic niche (key pathways)	The neurogenic niche is thought to be a specialized microenvironment within the adult brain, which…
12	Converging Pathways Implicated in Neurogenesis and AD Pathology — The neurogenic niche (key pathways)	et al., 2004; Doetsch, 2003a; Doetsch, 2003b; Lim and Alvarez-Buylla, 1999; Song et al., 2002a). In…
13	Converging Pathways Implicated in Neurogenesis and AD Pathology — The neurogenic niche (key pathways)	The neurogenic niche is comprised of soluble, membrane-tethered and extracellular matrix signaling…
14	Converging Pathways Implicated in Neurogenesis and AD Pathology — The neurogenic niche (key pathways)	Of particular interest, the Wnt family (Lie et al., 2005; Sato et al., 2004), β-catenin (Chenn and…
15	Converging Pathways Implicated in Neurogenesis and AD Pathology — The neurogenic niche (key pathways)	self-renewal of neural stem cells. Noteworthy are the findings that β-catenin promotes neural…
16	Converging Pathways Implicated in Neurogenesis and AD Pathology — The neurogenic niche (key pathways)	EGF is a critical growth factor regulating neural progenitor cell proliferation in the SVZ [Figure…
17	Converging Pathways Implicated in Neurogenesis and AD Pathology — The neurogenic niche (key pathways)	In the SVZ, the neuregulin receptor, ErbB4, is primarily expressed by immature neuroblasts but is…
18	Converging Pathways Implicated in Neurogenesis and AD Pathology — Alpha secretases in neurogenesis and AD	Members of the disintegrin-metalloproteinases (ADAMs) family and ADAM10 and ADAM17 (TACE) in…
19	Converging Pathways Implicated in Neurogenesis and AD Pathology — Alpha secretases in neurogenesis and AD	Both ADAM10 and 17 are implicated in development-regulated notch signaling by ectodomain shedding of…

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In this knowledge base

Title	Year	PMID
Stress-response pathways are altered in the hippocampus of chronic alcoholics.	2013	23981442

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Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders.	Loprinzi PD	—	2020	→
GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice.	Liu F et al.	—	2020	→
Harnessing neurogenesis in the adult brain-A role in type 2 diabetes mellitus and Alzheimer's disease.	Lazarov O et al.	—	2020	→
HGF Mediates Clinical-Grade Human Umbilical Cord-Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence-Accelerated Mouse Model of Alzheimer's Disease.	Jia Y et al.	—	2020	→
Impaired adult neurogenesis is an early event in Alzheimer's disease neurodegeneration, mediated by intracellular Aβ oligomers.	Scopa C et al.	—	2020	→
Intermittent hypoxia improves cognition and reduces anxiety-related behavior in APP/PS1 mice.	Meng SX et al.	—	2020	→
Mesenchymal Stem Cells Therapy Improved the Streptozotocin-Induced Behavioral and Hippocampal Impairment in Rats.	Zappa Villar MF et al.	—	2020	→
Microvascular Dysfunction Is Associated With Worse Cognitive Performance: The Maastricht Study.	Rensma SP et al.	—	2020	→
Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies.	Gatto RG	—	2020	→
Neuroinflammation and Neurogenesis in Alzheimer's Disease and Potential Therapeutic Approaches.	Sung PS et al.	—	2020	→
Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer's Disease.	Wang X et al.	—	2020	→
Scabronine G Methyl Ester Improves Memory-Related Behavior and Enhances Hippocampal Cell Proliferation and Long-Term Potentiation via the BDNF-CREB Pathway in Olfactory Bulbectomized Mice.	Nakagawasai O et al.	—	2020	→
Sugarcane (<i>Saccharum officinarum</i> L.) Top Extract Ameliorates Cognitive Decline in Senescence Model SAMP8 Mice: Modulation of Neural Development and Energy Metabolism.	Iwata K et al.	—	2020	→
The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis.	Jeon SG et al.	—	2020	→
Volumetric MRI demonstrates atrophy of the olfactory cortex in AD.	Al-Otaibi M et al.	—	2020	→
Absence of the neurogenesis-dependent nuclear receptor TLX induces inflammation in the hippocampus.	Kozareva DA et al.	—	2019	→
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.	Terreros-Roncal J et al.	—	2019	→
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.	Yousef H et al.	—	2019	→
Alzheimer's Disease and Its Potential Alternative Therapeutics.	Kisby B et al.	—	2019	→
Amyloid β Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics.	Ribeiro MF et al.	—	2019	→
Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells.	Martín-Maestro P et al.	—	2019	→
Cadmium Exposure Impairs Adult Hippocampal Neurogenesis.	Wang H et al.	—	2019	→
Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?	Mohajeri M et al.	—	2019	→
Cholinesterase inhibitory isoquinoline alkaloids from Corydalis mucronifera.	Zhang J et al.	—	2019	→
Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model.	Houben S et al.	—	2019	→
Neurodegeneration and Neuro-Regeneration-Alzheimer's Disease and Stem Cell Therapy.	Vasic V et al.	—	2019	→
Nutrients in the Prevention of Alzheimer's Disease.	Cremonini AL et al.	—	2019	→
The Cognitive Control of Eating and Body Weight: It's More Than What You "Think".	Davidson TL et al.	—	2019	→
The leukotriene signaling pathway: a druggable target in Alzheimer's disease.	Michael J et al.	—	2019	→
The Social Component of Environmental Enrichment Is a Pro-neurogenic Stimulus in Adult c57BL6 Female Mice.	Moreno-Jiménez EP et al.	—	2019	→
The α7 nicotinic acetylcholine receptors regulate hippocampal adult-neurogenesis in a sexually dimorphic fashion.	Otto SL et al.	—	2019	→
Trehalose as glucose surrogate in proliferation and cellular mobility of adult neural progenitor cells derived from mouse hippocampus.	Bertl A et al.	—	2019	→
Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.	Bartolome F et al.	—	2018	→
Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.	Jiang XY et al.	—	2018	→
Environmental enrichment reverses Aβ pathology during pregnancy in a mouse model of Alzheimer's disease.	Ziegler-Waldkirch S et al.	—	2018	→
GABA<sub>A</sub> receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.	Kwakowsky A et al.	—	2018	→
Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice.	Appel JR et al.	—	2018	→
Memorcise and Alzheimer's disease.	Loprinzi PD et al.	—	2018	→
Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis.	Catavero C et al.	—	2018	→
Neural stem cells and adult brain fatty acid metabolism: Lessons from the 3xTg model of Alzheimer's disease.	Hamilton LK et al.	—	2018	→
Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology.	Díaz-Moreno M et al.	—	2018	→
Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches.	Corrêa-Velloso JC et al.	—	2018	→
sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca<sup>2+</sup> homeostasis and CREB1-signaling.	Hesse R et al.	—	2018	→
The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.	Pankratova S et al.	—	2018	→
Topographic Markers Drive Proteinopathies to Selection of Target Brain Areas at Onset in Neurodegenerative Dementias.	Abbate C	—	2018	→
Tramadol ameliorates behavioural, biochemical, mitochondrial and histological alterations in ICV-STZ-induced sporadic dementia of Alzheimer's type in rats.	Dhull DK et al.	—	2018	→
Weak power frequency magnetic fields induce microtubule cytoskeleton reorganization depending on the epidermal growth factor receptor and the calcium related signaling.	Wu X et al.	—	2018	→
All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer's mouse model.	Takamura R et al.	—	2017	→
Anti-aggregant tau mutant promotes neurogenesis.	Joseph M et al.	—	2017	→
Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition.	Hollands C et al.	—	2017	→
Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice.	Engstrom AK et al.	—	2017	→
Increased adult neurogenesis associated with reactive astrocytosis occurs prior to neuron loss in a mouse model of neurodegenerative disease.	Liu TT et al.	—	2017	→
Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.	Bao H et al.	—	2017	→
NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice.	Zhang W et al.	—	2017	→
The role of cognitive activity in cognition protection: from Bedside to Bench.	Li BY et al.	—	2017	→
Abca7 deletion does not affect adult neurogenesis in the mouse.	Li H et al.	—	2016	→
Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms.	Hollands C et al.	—	2016	→
Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease.	Unger MS et al.	—	2016	→
Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8).	Griñan-Ferré C et al.	—	2016	→
Gastrodin Protects Neural Progenitor Cells Against Amyloid β (1-42)-Induced Neurotoxicity and Improves Hippocampal Neurogenesis in Amyloid β (1-42)-Injected Mice.	Li M et al.	—	2016	→
Hippocampal neurogenesis: Learning to remember.	Lazarov O et al.	—	2016	→
Lentiviral-Mediated Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Ameliorates LPS-Induced Cognitive Impairment in Mice.	Wang W et al.	—	2016	→
Linking adult hippocampal neurogenesis with human physiology and disease.	Bowers M et al.	—	2016	→
MeHg Suppressed Neuronal Potency of Hippocampal NSCs Contributing to the Puberal Spatial Memory Deficits.	Tian J et al.	—	2016	→
Neurogenesis, Neurodegeneration, Interneuron Vulnerability, and Amyloid-β in the Olfactory Bulb of APP/PS1 Mouse Model of Alzheimer's Disease.	De la Rosa-Prieto C et al.	—	2016	→
Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?	Ryan SM et al.	—	2016	→
Preserved neurogenesis in non-demented individuals with AD neuropathology.	Briley D et al.	—	2016	→
Retroviral induction of GSK-3β expression blocks the stimulatory action of physical exercise on the maturation of newborn neurons.	Llorens-Martín M et al.	—	2016	→
Role of Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Treating Neurodegenerative Diseases.	Srinageshwar B et al.	—	2016	→
Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.	Ghosal K et al.	—	2016	→
The ATM- and ATR-related SCD domain is over-represented in proteins involved in nervous system development.	Cara L et al.	—	2016	→
The role of neurogenesis during development and in the adult brain.	Jin X	—	2016	→
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors.	Di Martino RM et al.	—	2016	→
1,25-dyhydroxyvitamin D3 attenuates L-DOPA-induced neurotoxicity in neural stem cells.	Jang W et al.	—	2015	→
Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease.	Hamilton LK et al.	—	2015	→
Adult neurogenesis in neurodegenerative diseases.	Winner B et al.	—	2015	→
Alzheimer's disease: distinct stages in neurogenic decline?	Adamowicz DH et al.	—	2015	→
Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.	Rao SK et al.	—	2015	→
Human tau expression reduces adult neurogenesis in a mouse model of tauopathy.	Komuro Y et al.	—	2015	→
Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells.	Guadagno J et al.	—	2015	→
Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs.	Lilja AM et al.	—	2015	→
New neurons for injured brains? The emergence of new genetic model organisms to study brain regeneration.	Fernández-Hernández I et al.	—	2015	→
Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer's disease.	Ghoneim FM et al.	—	2015	→
Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers.	Costa V et al.	—	2015	→
Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease.	Briyal S et al.	—	2015	→
Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration.	Sankowski R et al.	—	2015	→
The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease.	Phillips C et al.	—	2015	→
The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.	Imai Y et al.	—	2015	→
The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro.	Collins SJ et al.	—	2015	→
Transcranial magnetic stimulation and aging: Effects on spatial learning and memory after sleep deprivation in Octodon degus.	Estrada C et al.	—	2015	→
Uncomfortable bedfellows: Whole brain radiation therapy and neurocognition in animal and human studies.	Dutta V	—	2015	→
Venlafaxine reverses decreased proliferation in the subventricular zone in a rat model of early life stress.	Martisova E et al.	—	2015	→
Young systemic factors as a medicine for age-related neurodegenerative diseases.	Katsimpardi L et al.	—	2015	→
Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice.	Yan Y et al.	—	2014	→
Age-dependent neuron loss is associated with impaired adult neurogenesis in forebrain neuron-specific Dicer conditional knockout mice.	Cheng S et al.	—	2014	→
Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise.	Irwin RW et al.	—	2014	→
Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic.	Aso E et al.	—	2014	→
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.	Sproul AA et al.	—	2014	→
Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.	Fitzsimons CP et al.	—	2014	→
Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders.	Irwin RW et al.	—	2014	→
Galantamine promotes adult hippocampal neurogenesis via M₁ muscarinic and α7 nicotinic receptors in mice.	Kita Y et al.	—	2014	→
Human cognitive function and the obesogenic environment.	Martin AA et al.	—	2014	→
Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice.	Jansen D et al.	—	2014	→
Mitochondrial toxic effects of Aβ through mitofusins in the early pathogenesis of Alzheimer's disease.	Wu Z et al.	—	2014	→
Modulation of neurogenesis by targeting epigenetic enzymes using small molecules: an overview.	Swaminathan A et al.	—	2014	→
New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.	Medina M et al.	—	2014	→
NF-κB mediated regulation of adult hippocampal neurogenesis: relevance to mood disorders and antidepressant activity.	Bortolotto V et al.	—	2014	→
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.	Wilkins HM et al.	—	2014	→
Pathogenic microbes, the microbiome, and Alzheimer's disease (AD).	Hill JM et al.	—	2014	→
Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels.	Wesnes KA et al.	—	2014	→
Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice.	Kanemoto S et al.	—	2014	→
Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse.	Kim SH et al.	—	2014	→
T cells promote the regeneration of neural precursor cells in the hippocampus of Alzheimer's disease mice.	Liu J et al.	—	2014	→
The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons.	Wang B et al.	—	2014	→
A longitudinal study of cognition, proton MR spectroscopy and synaptic and neuronal pathology in aging wild-type and AβPPswe-PS1dE9 mice.	Jansen D et al.	—	2013	→
Aβ increases neural stem cell activity in senescence-accelerated SAMP8 mice.	Díaz-Moreno M et al.	—	2013	→
Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype.	Lane RM et al.	—	2013	→
Developmental patterns of DR6 in normal human hippocampus and in Down syndrome.	Iyer A et al.	—	2013	→
Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice.	Jansen D et al.	—	2013	→
Identification of BACE1 inhibitors from Panax ginseng saponins-An Insilco approach.	Karpagam V et al.	—	2013	→
Intrahippocampal injection of Aβ1-42 inhibits neurogenesis and down-regulates IFN-γ and NF-κB expression in hippocampus of adult mouse brain.	Zheng M et al.	—	2013	→
Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases.	Maki T et al.	—	2013	→
Modeling Alzheimer's disease with non-transgenic rat models.	Lecanu L et al.	—	2013	→
Modifications of hippocampal circuits and early disruption of adult neurogenesis in the tg2576 mouse model of Alzheimer's disease.	Krezymon A et al.	—	2013	→
Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery.	Baldassarro VA et al.	—	2013	→
Neuropathological approaches to cerebral aging and neuroplasticity.	Jellinger KA et al.	—	2013	→
Of mice and men: neurogenesis, cognition and Alzheimer's disease.	Lazarov O et al.	—	2013	→
proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro.	Guo J et al.	—	2013	→
Stress-response pathways are altered in the hippocampus of chronic alcoholics.	McClintick JN et al.	—	2013	→
The function of BMP4 during neurogenesis in the adult hippocampus in Alzheimer's disease.	Xu H et al.	—	2013	→
Tissue resident stem cells: till death do us part.	Raveh-Amit H et al.	—	2013	→
3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit.	Russo I et al.	—	2012	→
All in the Family: How the APPs Regulate Neurogenesis.	Lazarov O et al.	—	2012	→
An overview of notch signaling in adult tissue renewal and maintenance.	Sato C et al.	—	2012	→
Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease.	Jaszberenyi M et al.	—	2012	→
Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model.	Kamphuis W et al.	—	2012	→
Differential role of cyclooxygenase isozymes on neuronal density in hippocampus CA1 region of intracerebroventricular streptozotocin treated rat brain.	Dhull DK et al.	—	2012	→
Hedgehog signalling as an antagonist of ageing and its associated diseases.	Dashti M et al.	—	2012	→
How close is the stem cell cure to the Alzheimer's disease: Future and beyond?	Tang J	—	2012	→
Ion channels in postnatal neurogenesis: potential targets for brain repair.	Swayne LA et al.	—	2012	→
Neural stem cells in the diabetic brain.	Bachor TP et al.	—	2012	→
Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology.	Perry EK et al.	—	2012	→
Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism.	Leal MC et al.	—	2012	→
Numb and Alzheimer's disease: the current picture.	Ntelios D et al.	—	2012	→
Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation.	Wicki-Stordeur LE et al.	—	2012	→
Significance of the cell adhesion molecules and sialic acid in neurodegeneration.	Wielgat P et al.	—	2012	→
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease.	Pimentel-Coelho PM et al.	—	2012	→
The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.	Tanveer R et al.	—	2012	→
The influence of exercise on brain aging and dementia.	Lautenschlager NT et al.	—	2012	→
Therapeutic application of neural stem cells and adult neurogenesis for neurodegenerative disorders: regeneration and beyond.	Latchney SE et al.	—	2012	→
The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update.	Bales KR	—	2012	→
α2δ ligands act as positive modulators of adult hippocampal neurogenesis and prevent depression-like behavior induced by chronic restraint stress.	Valente MM et al.	—	2012	→
2-(Cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one, a novel compound with neuroprotective and neurotrophic effects in vitro.	Elbrønd-Bek H et al.	—	2011	→
Adult hippocampal neurogenesis and its role in Alzheimer's disease.	Mu Y et al.	—	2011	→
Anatomical connectivity mapping: a new tool to assess brain disconnection in Alzheimer's disease.	Bozzali M et al.	—	2011	→
Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.	Esposito G et al.	—	2011	→
Elevated levels of BMP6 impair neurogenesis in Alzheimer's disease.	Choi SH et al.	—	2011	→
Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats.	Liu L et al.	—	2011	→
Neurodegenerative disease and adult neurogenesis.	Winner B et al.	—	2011	→
Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.	Irwin RW et al.	—	2011	→
Presenilin-1 regulates neural progenitor cell differentiation in the adult brain.	Gadadhar A et al.	—	2011	→
Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.	van Tijn P et al.	—	2011	→
Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APP(Sw,Ind) transgenic mice.	Valero J et al.	—	2011	→
The interesting interplay between interneurons and adult hippocampal neurogenesis.	Masiulis I et al.	—	2011	→
The role of phytochemicals in the treatment and prevention of dementia.	Howes MJ et al.	—	2011	→
Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide.	Shruster A et al.	—	2011	→
APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation.	Ghosal K et al.	—	2010	→
Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice.	Hu YS et al.	—	2010	→
Degeneration and repair in central nervous system disease.	Lo EH	—	2010	→
Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.	Kim YH et al.	—	2010	→
Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice.	Cuccurazzu B et al.	—	2010	→
Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice.	Demars M et al.	—	2010	→
Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis.	Crews L et al.	—	2010	→
Insights into neurogenesis and aging: potential therapy for degenerative disease?	Marr RA et al.	—	2010	→
Molecular mechanisms of neurodegeneration in Alzheimer's disease.	Crews L et al.	—	2010	→
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells.	Ables JL et al.	—	2010	→
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53.	Gonzalez-Cano L et al.	—	2010	→
When neurogenesis encounters aging and disease.	Lazarov O et al.	—	2010	→
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.	Hamilton LK et al.	—	2010	→
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.	Origlia N et al.	—	2009	→