To complement our genome wide study, we examined whether our study replicated genes with prior evidence for association with AD, a priori selecting 48 genes. We assessed gene-wise and experiment-wise significance by conducting permutation tests to correct for the number of genes and for the variable number of SNPs per gene and the LD structure of those SNPs. We note that although the analysis did not produce experiment-wise significance for any of the genes, the results for gene-wise analysis indicated several genes achieving significance. Furthermore, given the prior evidence for association of each of these genes with AD, it could be argued that an experiment-wise correction is too conservative. In the combined analysis, ADH1C was the most significant finding and considering that ADH genes are the most plausible candidates for alcoholism, it is encouraging that our set-based analysis confirmed prior results with this gene. Previous association studies between ADH genes and AD have been widely replicated (Birley et al. 2009; Edenberg and Foroud 2006; Macgregor et al. 2009; Whitfield 2002). Allelic variants in ADH1C have generally demonstrated association in East
