Comparing our results with recently published GWAS studies (Bierut et al. 2010; Edenberg et al. 2010; Lind et al. 2010; Treutlein et al. 2009) we see little overlap with genes identified in these studies, apart from the notable exception of KCNMA1. In the GWAS performed in the Collaborative Study of Genetics of Alcoholism (COGA) sample, one SNP (rs12219105) produced p=1.5×10-4 with AD in the EA case-control subset and p=3.9×10-2 in the AA case-control subset. A further test in the family sample produced nominal results (p=0.036) in individuals with early onset of AD. A meta-analysis of two GWAS studies, examining nicotine and AD in Australian and Dutch population samples showed that rs592676 in KCNMA1 was associated with nicotine dependence (Lind et al. 2010). Some of the top signals from the German GWAS (Treutlein et al. 2009) were examined in our set-based analysis and these are discussed in the section below.
