Chunk #15 — MATERIALS AND METHODS — Multiple test correction

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Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

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However, we may take LD into account by selecting an r2 tagging subset with an r2 threshold of 0.8 as described above. This approach results in 111 proxy SNPs, corresponding to no more than 111 distinct tests and a Sidak corrected p-value of 0.000462.