Chunk #14 — MATERIALS AND METHODS — Multiple test correction

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Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

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A Bonferroni correction for our 226 SNPs is overly conservative due to LD among SNPs and would require an individual p-value of 0.000221 for an experiment-wide significance level of 0.05. A more precise Sidak correction would require a p-value of α’ = 0.000227, so that 0.05 = 1 - (1-α’)226.