To summarize, almost all of our endophenotypes showed moderate to strong biometric heritability determined at least in part by the combined effect of hundreds of thousands of SNPs. However, using a wide array of molecular-genetic analytic approaches, no solid leads were identified when examining individual genes or SNPs; these remain very much unknown. The genetics of our endophenotypes are thus like that of other complex traits, including psychiatric disorders. They are not simple and therefore not likely to lead to the identification of important risk alleles for psychiatric disorders.
