paperKB
coga / coga-kb
Help
Sign in

Chunk #12 — Known Unknowns: Key Findings

Source
Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries.
Embedded
yes

Text

Although GABRA2 is listed in the table, this entry is bracketed because the result did not exceed the Bonferroni threshold for significance (α = 3.12 × 10−3). We list it, however, because, among the endophenotype-specific candidate genes we examined for EEG measures, the relationship between GABRA2 and EEG beta power has, compared to the other endophenotype-specific effects examined, perhaps the strongest track record as a replicated effect. Given that, had we examined only this one possible association, we would have been delighted to report our finding, with a p value of .014, as corroboration of prior reports. But in the context of the many tests we carried out and the assumption implicit in Bonferroni correction that all hypotheses are equally plausible, it is not significant. This indicates the dilemma every scientist faces when deciding how to separate wheat from chaff in molecular-genetic research.