was not associated with alcohol use or misuse (Irons et al., 2014; McGue et al., 2013; Vrieze et al., 2013). GRIK3, one of the COGS genes selected for its relevance to schizophrenia, is involved in the glutamate system. It has not previously been associated with startle. In the exome chip paper, the endophenotype-general candidate genes were also evaluated for the influence of rare variant effects if they possessed sufficient nonsynonymous variation. None of the gene-based tests was significant.
