In total, across SNP-based fine-mapping, eQTL, and pQTL analyses, 308 high-confidence associations were identified (Table S8). Fourteen eQTL genes and 1 pQTL gene also identified as high confidence by SNP-based fine-mapping. For example, SNP-based fine-mapping found all SNPs in one 95% credible set were within the cytochrome P450 gene CYP7B1, which was also inferred to have decreased expression in the dorsolateral prefrontal cortex of individuals with MD (TWAS p = 2.92 × 10−15, COLOC PP4 = 0.939, FOCUS PIP = 1). Additional signals identified by both fine-mapping and expression-based analyses included the genes SP4, FURIN, DCC, and the neurotrophin receptor kinase NTRK3.
