Both eQTL and pQTL data were used to infer upregulated or downregulated gene expression (TWAS) or protein (PWAS) levels associated with MD. Stringent criteria were used to identify high-confidence associations with MD (STAR Methods). MD genetic associations were found to correlate and colocalize with cis-regulated expression of 75 genes (Table S3) and cis-regulated levels of 10 proteins (Table S3). Results were only regarded as high-confidence when altered expression was supported by significant SMR and COLOC findings. No gene was identified as high confidence by both TWAS and PWAS analyses.
