Based on combined Stage 1 plus replication results, the estimated magnitudes of per allele effects for the novel menarche loci ranged from 4.5 to 2.1 weeks per allele (Table 1) and demonstrated an inverse relationship with MAF (Supplementary Fig. 5). Among the four largest in silico replication cohorts (each comprising >800 women) the variance in age at menarche explained by all 42 known, confirmed and possible novel menarche loci ranged from 3.6% to 6.1% (Supplementary Table 6).
