Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
paper
Primary
Public
- Authors
- Elks, Cathy E; Perry, John R B; Sulem, Patrick; Chasman, Daniel I; Franceschini, Nora; He, Chunyan; Lunetta, Kathryn L; Visser, Jenny A; Byrne, Enda M; Cousminer, Diana L; Gudbjartsson, Daniel F; Esko, TΓ΅nu; Feenstra, Bjarke; Hottenga, Jouke-Jan; Koller, Daniel L; Kutalik, ZoltΓ‘n; Lin, Peng; Mangino, Massimo; Marongiu, Mara; McArdle, Patrick F; Smith, Albert V; Stolk, Lisette; van Wingerden, Sophie H; Zhao, Jing Hua; Albrecht, Eva; Corre, Tanguy; Ingelsson, Erik; Hayward, Caroline; Magnusson, Patrik K E; Smith, Erin N; Ulivi, Shelia; Warrington, Nicole M; Zgaga, Lina; Alavere, Helen; Amin, Najaf; Aspelund, Thor; Bandinelli, Stefania; Barroso, InΓͺs; Berenson, Gerald S; Bergmann, Sven; Blackburn, Hannah; Boerwinkle, Eric; Buring, Julie E; Busonero, Fabio; Campbell, Harry; Chanock, Stephen J; Chen, Wei; Cornelis, Marilyn C; Couper, David; Coviello, Andrea D; d'Adamo, Pio; de Faire, Ulf; de Geus, Eco J C; Deloukas, Panos; DΓΆring, Angela; Smith, George Davey; Easton, Douglas F; Eiriksdottir, Gudny; Emilsson, Valur; Eriksson, Johan; Ferrucci, Luigi; Folsom, Aaron R; Foroud, Tatiana; Garcia, Melissa; Gasparini, Paolo; Geller, Frank; Gieger, Christian; GIANT Consortium; Gudnason, Vilmundur; Hall, Per; Hankinson, Susan E; Ferreli, Liana; Heath, Andrew C; Hernandez, Dena G; Hofman, Albert; Hu, Frank B; Illig, Thomas; JΓ€rvelin, Marjo-Riitta; Johnson, Andrew D; Karasik, David; Khaw, Kay-Tee; Kiel, Douglas P; KilpelΓ€inen, Tuomas O; Kolcic, Ivana; Kraft, Peter; Launer, Lenore J; Laven, Joop S E; Li, Shengxu; Liu, Jianjun; Levy, Daniel; Martin, Nicholas G; McArdle, Wendy L; Melbye, Mads; Mooser, Vincent; Murray, Jeffrey C; Murray, Sarah S; Nalls, Michael A; Navarro, Pau; Nelis, Mari; Ness, Andrew R; Northstone, Kate; Oostra, Ben A; Peacock, Munro; Palmer, Lyle J; Palotie, Aarno; ParΓ©, Guillaume; Parker, Alex N; Pedersen, Nancy L; Peltonen, Leena; Pennell, Craig E; Pharoah, Paul; Polasek, Ozren; Plump, Andrew S; Pouta, Anneli; Porcu, Eleonora; Rafnar, Thorunn; Rice, John P; Ring, Susan M; Rivadeneira, Fernando; Rudan, Igor; Sala, Cinzia; Salomaa, Veikko; Sanna, Serena; Schlessinger, David; Schork, Nicholas J; Scuteri, Angelo; SegrΓ¨, Ayellet V; Shuldiner, Alan R; Soranzo, Nicole; Sovio, Ulla; Srinivasan, Sathanur R; Strachan, David P; Tammesoo, Mar-Liis; Tikkanen, Emmi; Toniolo, Daniela; Tsui, Kim; Tryggvadottir, Laufey; Tyrer, Jonathon; Uda, Manuela; van Dam, Rob M; van Meurs, Joyce B J; Vollenweider, Peter; Waeber, Gerard; Wareham, Nicholas J; Waterworth, Dawn M; Weedon, Michael N; Wichmann, H Erich; Willemsen, Gonneke; Wilson, James F; Wright, Alan F; Young, Lauren; Zhai, Guangju; Zhuang, Wei Vivian; Bierut, Laura J; Boomsma, Dorret I; Boyd, Heather A; Crisponi, Laura; Demerath, Ellen W; van Duijn, Cornelia M; Econs, Michael J; Harris, Tamara B; Hunter, David J; Loos, Ruth J F; Metspalu, Andres; Montgomery, Grant W; Ridker, Paul M; Spector, Tim D; Streeten, Elizabeth A; Stefansson, Kari; Thorsteinsdottir, Unnur; Uitterlinden, AndrΓ© G; Widen, Elisabeth; Murabito, Joanne M; Ong, Ken K; Murray, Anna
- Year
- 2010
- Journal
- Nature genetics
- PMID
- 21102462
- DOI
- 10.1038/ng.714
- PMCID
- PMC3140055
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 Γ 10β»βΆβ°) and 9q31.2 (P = 2.2 Γ 10β»Β³Β³), we identified 30 new menarche loci (all P < 5 Γ 10β»βΈ) and found suggestive evidence for a further 10 loci (P < 1.9 Γ 10β»βΆ). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
Flow diagram of the discovery and confirmation of novel loci for age at menarche. GC: genomic control.
1β20 of 52
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Adiposity and reproductive characteristics across the lifespan: a multi-ethnic population-based study in Northwest China. | Zhang B et al. | β | 2026 | β |
| Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network. | Plazyo O et al. | β | 2026 | β |
| Leveraging protein language models to identify complex trait associations with previously inaccessible classes of functional rare variants. | Jang SK et al. | β | 2026 | β |
| Reproductive Fitness and the Links to Chronic Disease and Systemic Aging. | Ghazi A et al. | β | 2026 | β |
| An evolutionary perspective on the genetics of anorexia nervosa. | Breton Γ et al. | β | 2025 | β |
| An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells. | Guang L et al. | β | 2025 | β |
| Association of age at menarche with type 2 diabetes mellitus among urban Indian women: results from the CARRS study. | Gupta I et al. | β | 2025 | β |
| Defective Olfactomedin-2 connects adipocyte dysfunction to obesity. | Lluch A et al. | β | 2025 | β |
| Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review. | Tsinopoulou VR et al. | β | 2025 | β |
| Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density. | Lei B et al. | β | 2025 | β |
| Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity. | Kwon SA et al. | β | 2025 | β |
| <i>Lin28b-let-7</i> Modulates mRNA Expression of <i>GnRH1</i> Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells. | Xie Y et al. | β | 2025 | β |
| LIN 28B expression is downregulated in mature spermatozoa of oligozoospermic men and associates with genetic variants previously linked to pubertal onset. | Lardone MC et al. | β | 2025 | β |
| Mendelian randomization analysis on the impacts of age at menarche on adult height: A Taiwanese population study. | Lukusa MT et al. | β | 2025 | β |
| Risk factors for precocious puberty: A systematic review and metaβanalysis. | Wang Y et al. | β | 2025 | β |
| Sweeteners and puberty: investigating genetic and dietary influences on central precocious puberty. | Tsai YJ et al. | β | 2025 | β |
| The hippo pathway: a molecular bridge between environmental cues and pace of life. | Ahi EP et al. | β | 2025 | β |
| Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility. | Zouaghi Y et al. | β | 2025 | β |
| Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty. | Xue P et al. | β | 2024 | β |
| Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts. | Farahmand M et al. | β | 2024 | β |
| Higher peak height velocity in early maturing girls depends on insulin rather than fat mass or IGF-I. | SΓΈrensen K et al. | β | 2024 | β |
| Indications of younger age at menarche in Greek adolescents but with no relation to body mass index. | Papageorgiou A et al. | β | 2024 | β |
| Interactions Between Genetic, Prenatal Substance Use, Puberty, and Parenting are Less Important for Understanding Adolescents' Internalizing, Externalizing, and Substance Use than Developmental Cascades in Multifactorial Models. | Marceau K et al. | β | 2024 | β |
| Late Age at First Birth is a Protective Factor for Preterm Labor and Delivery: The Evidence From the Genetic Study. | Zou J et al. | β | 2024 | β |
| Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk. | Reshetnikov E et al. | β | 2024 | β |
| Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work. | Anderson GM et al. | β | 2024 | β |
| Methylome analysis in girls with idiopathic central precocious puberty. | Palumbo S et al. | β | 2024 | β |
| Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture. | Schurz H et al. | β | 2024 | β |
| Reproductive risk factors across the female lifecourse and later metabolic health. | Nichols AR et al. | β | 2024 | β |
| Study of <i>rs7759938</i>, <i>rs314280</i>, and <i>rs314276</i> Polymorphisms of <i>LIN28B</i> in Relation to Age at Menarche in Girls of Greek Descent. | Tsinopoulou VR et al. | β | 2024 | β |
| The J shaped association of age at menarche and cardiovascular events: systematic review and meta-analysis. | Behboudi-Gandevan S et al. | β | 2024 | β |
| The rs2046210 Polymorphism Is Associated with Endometriosis Risk and Elevated Estrogen Receptor 1 Expression in the Eutopic Endometrium of Women with the Disease. | Proestling K et al. | β | 2024 | β |
| Understanding the genetic complexity of puberty timing across the allele frequency spectrum. | Kentistou KA et al. | β | 2024 | β |
| A Novel Perspective on Neuronal Control of Anatomical Patterning, Remodeling, and Maintenance. | Jones E et al. | β | 2023 | β |
| Chromosomal polymorphisms and susceptibility to menstrual disorders: a retrospective analysis of 24,578 women. | Ran C et al. | β | 2023 | β |
| Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene. | Tsai MC et al. | β | 2023 | β |
| Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight. | Reshetnikova Y et al. | β | 2023 | β |
| mTOR pathway candidate genes and energy intake interaction on breast cancer risk in Black women from the Women's Circle of Health Study. | Ilozumba MN et al. | β | 2023 | β |
| mTOR pathway candidate genes and obesity interaction on breast cancer risk in black women from the Women's Circle of Health Study. | Ilozumba MN et al. | β | 2023 | β |
| mTOR pathway candidate genes and physical activity interaction on breast cancer risk in black women from the women's circle of health study. | Ilozumba MN et al. | β | 2023 | β |
| Serum 25-hydroxyvitamin D levels and the risk of idiopathic central precocious puberty in girls. | Gan DM et al. | β | 2023 | β |
| Adipose tissue mitochondrial respiration in Atlantic salmon: implications for sex-dependent life-history variation | Prokkola JM et al. | β | 2022 | β |
| Analysis of the Timing of Puberty in a Recent Cohort of Italian Girls: Evidence for Earlier Onset Compared to Previous Studies. | Ferrari V et al. | β | 2022 | β |
| A review of the genetics and epigenetics of central precocious puberty. | Moise-Silverman J et al. | β | 2022 | β |
| Association between Age at Menarche and Hyperhomocysteinemia among Women in Hunan, China: A Cross-Sectional Study. | Yang Y et al. | β | 2022 | β |
| Casual Associations and Shape Between Prepuberty Body Mass Index and Early Onset of Puberty: A Mendelian Randomization and Dose-Response Relationship Analysis. | Fang J et al. | β | 2022 | β |
| Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine. | SΓ‘nchez-Garrido MA et al. | β | 2022 | β |
| Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats. | Mindang ELN et al. | β | 2022 | β |
| Estimation of Causal Effect of Age at Menarche on Pubertal Height Growth Using Mendelian Randomization. | Jo EJ et al. | β | 2022 | β |
| Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies. | Camilleri M et al. | β | 2022 | β |
| Genetics of pubertal timing. | Mancini A et al. | β | 2022 | β |
| Genome-wide causal mediation analysis identifies genetic loci associated with uterine fibroids mediated by age at menarche. | Tai AS et al. | β | 2022 | β |
| "GENYAL" Study to Childhood Obesity Prevention: Methodology and Preliminary Results. | Marcos-Pasero H et al. | β | 2022 | β |
| Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis. | Lu M et al. | β | 2022 | β |
| Insights from genomic studies on the role of sex steroids in the aetiology of endometriosis. | Saunders PTK | β | 2022 | β |
| Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study. | Kim YS et al. | β | 2022 | β |
| Long-term health outcomes of early menarche in women: an umbrella review. | Lee JS et al. | β | 2022 | β |
| MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis. | LaPierre MP et al. | β | 2022 | β |
| MKRN3 role in regulating pubertal onset: the state of art of functional studies. | Palumbo S et al. | β | 2022 | β |
| Sex Bias and Autoimmune Diseases. | Xing E et al. | β | 2022 | β |
| Shared genetic basis between reproductive behaviors and anxiety-related disorders. | Ohi K et al. | β | 2022 | β |
| Adolescent growth and BMI and their associations with early childhood growth in an urban South African cohort. | Nyati LH et al. | β | 2021 | β |
| Age at first birth and lung cancer: a two-sample Mendelian randomization study. | Peng H et al. | β | 2021 | β |
| Diet-Induced Hypothalamic Inflammation, Phoenixin, and Subsequent Precocious Puberty. | Valsamakis G et al. | β | 2021 | β |
| Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis. | Dai Z et al. | β | 2021 | β |
| Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility. | McGrath IM et al. | β | 2021 | β |
| Novel loci and Mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys. | VicuΓ±a L et al. | β | 2021 | β |
| Prenatal exposure to maternal stressful life events and earlier age at menarche: the Raine Study. | BrΓ€uner EV et al. | β | 2021 | β |
| Reflection on modern methods: causal inference considerations for heterogeneous disease etiology. | Nevo D et al. | β | 2021 | β |
| Why should we be concerned about early menarche? | Lee HS | β | 2021 | β |
| A Complex Systems Model of Breast Cancer Etiology: The Paradigm II Conceptual Model. | Hiatt RA et al. | β | 2020 | β |
| Age at onset of different pubertal signs in boys and girls and differential DNA methylation at age 10 and 18Β years: an epigenome-wide follow-up study. | Chen S et al. | β | 2020 | β |
| Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts. | Sanz-de-Galdeano A et al. | β | 2020 | β |
| Association of body composition and age at menarche in girls and adolescents in the Brazilian Legal Amazon. | Gemelli IFB et al. | β | 2020 | β |
| Association of Early-Life Adversity With Measures of Accelerated Biological Aging Among Children in China. | Sun Y et al. | β | 2020 | β |
| Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. | Schredelseker T et al. | β | 2020 | β |
| Candidate genes for age at menarche are associated with endometrial hyperplasia. | Ponomarenko I et al. | β | 2020 | β |
| Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma. | Ponomarenko I et al. | β | 2020 | β |
| Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility. | Sciarra F et al. | β | 2020 | β |
| Early pubertal maturation and risk of childhood asthma: A Mendelian randomization and longitudinal study. | Chen YC et al. | β | 2020 | β |
| Estimated Number of Lifetime Ovulatory Years and Its Determinants in Relation to Levels of Circulating Inflammatory Biomarkers. | Huang T et al. | β | 2020 | β |
| Huang et al. Respond to "Ovulation and Systemic and Localized Inflammation Markers" and "Capturing Women's Reproductive Life Spans". | Huang T et al. | β | 2020 | β |
| Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic. | Stagi S et al. | β | 2020 | β |
| Key steps for effective breast cancer prevention. | Britt KL et al. | β | 2020 | β |
| Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do. | Ribitsch I et al. | β | 2020 | β |
| LGR4 deficiency results in delayed puberty through impaired Wnt/Ξ²-catenin signaling. | Mancini A et al. | β | 2020 | β |
| Lin28 gene and mammalian puberty. | Cao G et al. | β | 2020 | β |
| Novel Mutations and Genes That Impact on Growth in Short Stature of Undefined Aetiology: The EPIGROW Study. | Perchard R et al. | β | 2020 | β |
| Onset and tempo of sexual maturation is differentially associated with gestational phthalate exposure between boys and girls in a Mexico City birth cohort. | Cathey A et al. | β | 2020 | β |
| Physiological and genomic insight into neuroendocrine regulation of puberty in gilts. | Lents CA et al. | β | 2020 | β |
| RANKL is a new Epigenetic Biomarker for the Vasomotor Symptom During Menopause. | Kalkan R et al. | β | 2020 | β |
| Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS. | Wu X et al. | β | 2020 | β |
| Study on the Function and Mechanism of Lin28B in the Formation of Chicken Primordial Germ Cells. | Zuo Q et al. | β | 2020 | β |
| The relationship among the age at menarche, anthropometric characteristics, and socio-economic factors in Bengali girls from Kolkata, India. | Ε»egleΕ M et al. | β | 2020 | β |
| Transcription Profiles of Age-at-Maturity-Associated Genes Suggest Cell Fate Commitment Regulation as a Key Factor in the Atlantic Salmon Maturation Process. | Kurko J et al. | β | 2020 | β |
| Trends in the Incidence of Central Precocious Puberty and Normal Variant Puberty Among Children in Denmark, 1998 to 2017. | BrΓ€uner EV et al. | β | 2020 | β |
| Unravelling the role of epigenetics in reproductive adaptations to early-life environment. | Bar-Sadeh B et al. | β | 2020 | β |
| Age at menarche and epithelial ovarian cancer risk: A meta-analysisΒ and Mendelian randomization study. | Yang H et al. | β | 2019 | β |
| Cloning and expression of lin-28 homolog B gene in the onset of puberty in Duolang sheep. | Xing F et al. | β | 2019 | β |
| Dataset of allele, genotype and haplotype frequencies of four <i>LIN28B</i> gene polymorphisms analyzed for association with age at menarche in Russian women. | Ponomarenko I et al. | β | 2019 | β |
| Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries. | Howard SR et al. | β | 2019 | β |
| Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls. | Lee JE et al. | β | 2019 | β |
| Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence. | Aylwin CF et al. | β | 2019 | β |
| Expression of TRA2B in endometrial carcinoma and its regulatory roles in endometrial carcinoma cells. | Paudel D et al. | β | 2019 | β |
| Genome-wide association analysis of 95β549 individuals identifies novel loci and genes influencing optic disc morphology. | Han X et al. | β | 2019 | β |
| Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis. | BrΔiΔ L et al. | β | 2019 | β |
| Genomics of Reproductive Traits and Cardiometabolic Disease Risk in African American Women. | Hardy TM et al. | β | 2019 | β |
| Heritability of Age at Menarche in South Korean Female Twins. | Hur YM et al. | β | 2019 | β |
| Interdisciplinary Work Is Essential for Research on Puberty: Complexity and Dynamism in Action. | Susman EJ et al. | β | 2019 | β |
| Is there a causal relationship between obesity and puberty? | Reinehr T et al. | β | 2019 | β |
| LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels. | Leinonen JT et al. | β | 2019 | β |
| Links between age at menarche, antral follicle count, and body mass index in African American and European American women. | Schuh SM et al. | β | 2019 | β |
| MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence <i>GNRH1</i> Expression. | Yellapragada V et al. | β | 2019 | β |
| Puberty and the Evolution of Developmental Science. | Worthman CM et al. | β | 2019 | β |
| Review of the Literature on Current Changes in the Timing of Pubertal Development and the Incomplete Forms of Early Puberty. | Farello G et al. | β | 2019 | β |
| The Genetic Basis of Delayed Puberty. | Howard SR | β | 2019 | β |
| The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis. | Devesa J et al. | β | 2019 | β |
| Transient modification of lin28b expression - Permanent effects on zebrafish growth. | Leinonen JT et al. | β | 2019 | β |
| Age at menarche and risk of all-cause and cardiovascular mortality: a systematic review and dose-response meta-analysis. | Chen X et al. | β | 2018 | β |
| An Ancient Fecundability-Associated Polymorphism Creates a GATA2 Binding Site in a Distal Enhancer of HLA-F. | Mika KM et al. | β | 2018 | β |
| Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility. | Manfredi-Lozano M et al. | β | 2018 | β |
| Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty. | Howard SR et al. | β | 2018 | β |
| Elucidating the genetic architecture of reproductive ageing in the Japanese population. | Horikoshi M et al. | β | 2018 | β |
| Ethnicity and breast cancer characteristics in Kenya. | Sayed S et al. | β | 2018 | β |
| Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States. | Gaydosh L et al. | β | 2018 | β |
| Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome. | Bonfiglio F et al. | β | 2018 | β |
| Genes underlying delayed puberty. | Howard SR | β | 2018 | β |
| Genetics of pubertal timing. | Zhu J et al. | β | 2018 | β |
| Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes. | Thompson EE et al. | β | 2018 | β |
| Hypothalamic epigenetics driving female puberty. | Toro CA et al. | β | 2018 | β |
| Identification and characterization of microRNAs in the pituitary of pubescent goats. | Ye J et al. | β | 2018 | β |
| <i>STAT6</i>, <i>PBX2</i>, and <i>PBRM1</i> Emerge as Predicted Regulators of 452 Differentially Expressed Genes Associated With Puberty in Brahman Heifers. | Nguyen LT et al. | β | 2018 | β |
| On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations. | Qasim A et al. | β | 2018 | β |
| Pre- and post-puberty expression of genes and proteins in the uterus of Bos indicus heifers: the luteal phase effect post-puberty. | Fortes MRS et al. | β | 2018 | β |
| Precocious Puberty and the Lin28/Let7 Pathway: The Therapeutic Effect of the Nourishing "Yin" and Purging "Fire" Traditional Chinese Medicine Mixture in a Rat Model. | He Y et al. | β | 2018 | β |
| Predictive accuracy of combined genetic and environmental risk scores. | Dudbridge F et al. | β | 2018 | β |
| Relatedness disequilibrium regression estimates heritability without environmental bias. | Young AI et al. | β | 2018 | β |
| Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. | Ostrom QT et al. | β | 2018 | β |
| The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis. | FernΓ‘ndez-Rhodes L et al. | β | 2018 | β |
| Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. | Gong J et al. | β | 2018 | β |
| Trio, a novel high fecundity allele: I. Transcriptome analysis of granulosa cells from carriers and noncarriers of a major gene for bovine ovulation rate. | Kamalludin MH et al. | β | 2018 | β |
| Why monkeys do not get multiple sclerosis (spontaneously): An evolutionary approach. | Bove RM | β | 2018 | β |
| Women's reproductive factors and incident cardiovascular disease in the UK Biobank. | Peters SA et al. | β | 2018 | β |
| Adiposity in relation to age at menarche and other reproductive factors among 300β000 Chinese women: findings from China Kadoorie Biobank study. | Yang L et al. | β | 2017 | β |
| Adult Consequences of Self-Limited Delayed Puberty. | Zhu J et al. | β | 2017 | β |
| Age at menarche and risk of major cardiovascular diseases: Evidence of birth cohort effects from a prospective study of 300,000 Chinese women. | Yang L et al. | β | 2017 | β |
| Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women's Health Initiative. | Shadyab AH et al. | β | 2017 | β |
| Association between age at menarche and cardiovascular disease: A systematic review on risk and potential mechanisms. | Luijken J et al. | β | 2017 | β |
| Association study of LIN28B in girls with precocious puberty. | Chen YC et al. | β | 2017 | β |
| Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. | Eriksson J et al. | β | 2017 | β |
| Copper and zinc isotope ratios in human bone and enamel. | Jaouen K et al. | β | 2017 | β |
| Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty. | AvendaΓ±o MS et al. | β | 2017 | β |
| Diversity in non-repetitive human sequences not found in the reference genome. | Kehr B et al. | β | 2017 | β |
| Early puberty in 11-year-old girls: Millennium Cohort Study findings. | Kelly Y et al. | β | 2017 | β |
| Editorial: How Reproductive History Influences Our Breast Cancer Risk. | Anderson RL et al. | β | 2017 | β |
| Estrogen Effects on the Mammary Gland in Early and Late Life and Breast Cancer Risk. | Dall GV et al. | β | 2017 | β |
| Gene expression profiling of puberty-associated genes reveals abundant tissue and sex-specific changes across postnatal development. | Hou H et al. | β | 2017 | β |
| GenePANDA-a novel network-based gene prioritizing tool for complex diseases. | Yin T et al. | β | 2017 | β |
| Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. | Zhang G et al. | β | 2017 | β |
| Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. | Coignet MV et al. | β | 2017 | β |
| Global differential gene expression in the pituitary gland and the ovaries of pre- and postpubertal Brahman heifers. | Nguyen LT et al. | β | 2017 | β |
| Hypothalamic microRNAs flip the switch for fertility. | Messina A et al. | β | 2017 | β |
| Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. | Zillikens MC et al. | β | 2017 | β |
| Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. | Heilmann-Heimbach S et al. | β | 2017 | β |
| Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways. | Higgins GA et al. | β | 2017 | β |
| Predicting phenotypes from microarrays using amplified, initially marginal, eigenvector regression. | Ding L et al. | β | 2017 | β |
| Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies. | Stalder O et al. | β | 2017 | β |
| The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). | Leka-Emiri S et al. | β | 2017 | β |
| Using the Neandertal genome to study the evolution of small insertions and deletions in modern humans. | Chintalapati M et al. | β | 2017 | β |
| Age at menarche and age at natural menopause in East Asian women: a genome-wide association study. | Shi J et al. | β | 2016 | β |
| Age at Menarche and Its Association with Excess Weight and Body Fat Percentage in Girls in the Southwestern Region of the Brazilian Amazon. | Barcellos Gemelli IF et al. | β | 2016 | β |
| Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue. | Oh H et al. | β | 2016 | β |
| An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression. | Mika KM et al. | β | 2016 | β |
| A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP. | ΓaΔlayan AO et al. | β | 2016 | β |
| Association between reproductive variables and metabolic syndrome in chinese community elderly women. | Liu M et al. | β | 2016 | β |
| Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls. | Hu Z et al. | β | 2016 | β |
| C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility. | GΓ³mez-H L et al. | β | 2016 | β |
| Common Variants Confer Susceptibility to Barrett's Esophagus: Insights from the First Genome-Wide Association Studies. | Palles C et al. | β | 2016 | β |
| Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset. | Bove R et al. | β | 2016 | β |
| Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? | Belsky J et al. | β | 2016 | β |
| Detection and interpretation of shared genetic influences on 42 human traits. | Pickrell JK et al. | β | 2016 | β |
| DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats. | Yang C et al. | β | 2016 | β |
| Early pubertal timing is common among adolescent girl-to-boy sex reassignment applicants. | Sumia M et al. | β | 2016 | β |
| Evolutionary perspectives on human height variation. | Stulp G et al. | β | 2016 | β |
| Genetics of Obesity. | Srivastava A et al. | β | 2016 | β |
| Genetic variants in the mTOR pathway and breast cancer risk in African American women. | Cheng TD et al. | β | 2016 | β |
| Genome-wide analysis identifies 12 loci influencing human reproductive behavior. | Barban N et al. | β | 2016 | β |
| Genome-wide association and identification of candidate genes for age at puberty in swine. | Nonneman DJ et al. | β | 2016 | β |
| Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. | Ruth KS et al. | β | 2016 | β |
| High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers for Measuring Puberty Onset in Chicken (Gallus gallus). | Han W et al. | β | 2016 | β |
| IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. | Howard SR et al. | β | 2016 | β |
| Infection and pubertal timing: a systematic review. | McDonald JA et al. | β | 2016 | β |
| Is age at menarche a good predictor of future body fat? The case of a developing country. | Sohn K | β | 2016 | β |
| Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. | Liu C et al. | β | 2016 | β |
| microRNAs and the adolescent brain: Filling the knowledge gap. | Rao YS et al. | β | 2016 | β |
| Novel regional age-associated DNA methylation changes within human common disease-associated loci. | Bell CG et al. | β | 2016 | β |
| Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond. | Laisk-Podar T et al. | β | 2016 | β |
| Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort. | Bonilla C et al. | β | 2016 | β |
| Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood. | Almstrup K et al. | β | 2016 | β |
| Pubertal Onset in Boys and Girls Is Influenced by Pubertal Timing of Both Parents. | Wohlfahrt-Veje C et al. | β | 2016 | β |
| Puberty, Socioeconomic Status, and Depression in Girls: Evidence for Gene Γ Environment Interactions. | Mendle J et al. | β | 2016 | β |
| Recent advances in the understanding and management of delayed puberty. | Wei C et al. | β | 2016 | β |
| Sex-specific regulation of weight and puberty by the Lin28/let-7 axis. | Corre C et al. | β | 2016 | β |
| The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity. | Cousminer DL et al. | β | 2016 | β |
| Using Super-Imposition by Translation And Rotation (SITAR) to relate pubertal growth to bone health in later life: the Medical Research Council (MRC) National Survey of Health and Development. | Cole TJ et al. | β | 2016 | β |
| Women's reproductive health factors and body adiposity: findings from the UK Biobank. | Peters SA et al. | β | 2016 | β |
| A Major Gene for Bovine Ovulation Rate. | Kirkpatrick BW et al. | β | 2015 | β |
| A new pathway in the control of the initiation of puberty: the MKRN3 gene. | Abreu AP et al. | β | 2015 | β |
| Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis). | Banerji J | β | 2015 | β |
| Associations between menarche-related genetic variants and pubertal growth in male and female adolescents. | Tu W et al. | β | 2015 | β |
| Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health. | Marceau K et al. | β | 2015 | β |
| Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents. | Parent AS et al. | β | 2015 | β |
| Differential Effects of Alcohol on Excitatory and Inhibitory Puberty-Related Peptides in the Basal Hypothalamus of the Female Rat. | Srivastava VK et al. | β | 2015 | β |
| Epigenetic regulation of female puberty. | Lomniczi A et al. | β | 2015 | β |
| Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression. | Lomniczi A et al. | β | 2015 | β |
| Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1. | Yuan R et al. | β | 2015 | β |
| Genetic Regulation of Puberty Timing in Humans. | Day FR et al. | β | 2015 | β |
| Genetic studies of body mass index yield new insights for obesity biology. | Locke AE et al. | β | 2015 | β |
| High-Throughput Sequencing Reveals Hypothalamic MicroRNAs as Novel Partners Involved in Timing the Rapid Development of Chicken (Gallus gallus) Gonads. | Han W et al. | β | 2015 | β |
| Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk. | Wang Z et al. | β | 2015 | β |
| Menopause. | Davis SR et al. | β | 2015 | β |
| New genetic loci link adipose and insulin biology to body fat distribution. | Shungin D et al. | β | 2015 | β |
| Prenatal smoking and age at menarche: influence of the prenatal environment on the timing of puberty. | Behie AM et al. | β | 2015 | β |
| Reversal of idiopathic hypogonadotropic hypogonadism: a cohort study in Chinese patients. | Mao JF et al. | β | 2015 | β |
| Shared genetic aetiology of puberty timing between sexes and with health-related outcomes. | Day FR et al. | β | 2015 | β |
| Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty. | Cousminer DL et al. | β | 2015 | β |
| The Biodemography of Fertility: A Review and Future Research Frontiers. | Mills MC et al. | β | 2015 | β |
| The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients. | Bandstein M et al. | β | 2015 | β |
| A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene. | Halley YA et al. | β | 2014 | β |
| A genome-wide association meta-analysis of preschool internalizing problems. | Benke KS et al. | β | 2014 | β |
| Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan. | Warren Andersen S et al. | β | 2014 | β |
| Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3. | Macedo DB et al. | β | 2014 | β |
| Child maltreatment and household dysfunction: associations with pubertal development in a British birth cohort. | Li L et al. | β | 2014 | β |
| Confounding by linkage disequilibrium. | Aissani B | β | 2014 | β |
| DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. | Perry JR et al. | β | 2014 | β |
| Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. | Tragante V et al. | β | 2014 | β |
| Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. | Arking DE et al. | β | 2014 | β |
| Genetic influences on adolescent sexual behavior: Why genes matter for environmentally oriented researchers. | Harden KP | β | 2014 | β |
| Genome-wide association analyses identify variants in developmental genes associated with hypospadias. | Geller F et al. | β | 2014 | β |
| Genome-wide association analysis identifies six new loci associated with forced vital capacity. | Loth DW et al. | β | 2014 | β |
| Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population. | Pyun JA et al. | β | 2014 | β |
| Genome-wide association studies of age at menarche and age at natural menopause. | He C et al. | β | 2014 | β |
| Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. | Cousminer DL et al. | β | 2014 | β |
| Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. | Vimaleswaran KS et al. | β | 2014 | β |
| Lin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma. | Xie R et al. | β | 2014 | β |
| Long-term secular trends in the age at menarche in Israel: a systematic literature review and pooled analysis. | Flash-Luzzatti S et al. | β | 2014 | β |
| MKRN3 mutations in familial central precocious puberty. | Schreiner F et al. | β | 2014 | β |
| Multi-tissue omics analyses reveal molecular regulatory networks for puberty in composite beef cattle. | CΓ‘novas A et al. | β | 2014 | β |
| New causes of central precocious puberty: the role of genetic factors. | Bulcao Macedo D et al. | β | 2014 | β |
| Nutrigenomics and its role in male puberty of cattle: a mini review. | Deb R et al. | β | 2014 | β |
| On individual genome-wide association studies and their meta-analysis. | Pei YF et al. | β | 2014 | β |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | Perry JR et al. | β | 2014 | β |
| Pros and cons of GnRHa treatment for early puberty in girls. | Willemsen RH et al. | β | 2014 | β |
| Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action. | Hagen CP et al. | β | 2014 | β |
| Pubertal timing, bone acquisition, and risk of fracture throughout life. | Bonjour JP et al. | β | 2014 | β |
| The future for genetic studies in reproduction. | Montgomery GW et al. | β | 2014 | β |
| The Lin28/Let-7 system in early human embryonic tissue and ectopic pregnancy. | Lozoya T et al. | β | 2014 | β |
| Adult stature and risk of cancer at different anatomic sites in a cohort of postmenopausal women. | Kabat GC et al. | β | 2013 | β |
| Age at menarche and risk of colorectal cancer: a meta-analysis. | Li CY et al. | β | 2013 | β |
| A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. | Levine DM et al. | β | 2013 | β |
| Analysis on cDNA sequence, alternative splicing and polymorphisms associated with timing of puberty of Lin28B gene in goats. | Cao G et al. | β | 2013 | β |
| Association of a body mass index genetic risk score with growth throughout childhood and adolescence. | Warrington NM et al. | β | 2013 | β |
| Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. | FernΓ‘ndez-Rhodes L et al. | β | 2013 | β |
| Association of female reproductive factors with body composition: the Framingham Heart Study. | Trikudanathan S et al. | β | 2013 | β |
| Associations between age at menarche and menopause with cardiovascular disease, diabetes, and osteoporosis in Chinese women. | Qiu C et al. | β | 2013 | β |
| A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates. | Lomniczi A et al. | β | 2013 | β |
| Birth size and age at menarche: a twin perspective. | SΓΈrensen K et al. | β | 2013 | β |
| Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche. | Ran S et al. | β | 2013 | β |
| Central precocious puberty caused by mutations in the imprinted gene MKRN3. | Abreu AP et al. | β | 2013 | β |
| Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty. | Sangiao-Alvarellos S et al. | β | 2013 | β |
| Circadian regulation of renal function and potential role in hypertension. | Bonny O et al. | β | 2013 | β |
| Cohort Profile: TwinsUK and healthy ageing twin study. | Moayyeri A et al. | β | 2013 | β |
| Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism. | Gaytan F et al. | β | 2013 | β |
| Efficient identification of rare variants in large populations: deep re-sequencing the CRP locus in the CARDIA study. | Chen CT et al. | β | 2013 | β |
| Epigenetic control of female puberty. | Lomniczi A et al. | β | 2013 | β |
| Evaluation of GWAS-identified genetic variants for age at menarche among Chinese women. | Delahanty RJ et al. | β | 2013 | β |
| FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimΓΌllerian hormone in healthy girls: a longitudinal cohort study. | Hagen CP et al. | β | 2013 | β |
| Genetic association studies in female reproduction: from candidate-gene approaches to genome-wide mapping. | Zhao H et al. | β | 2013 | β |
| Genetic instrumental variable studies of effects of prenatal risk factors. | Wehby GL et al. | β | 2013 | β |
| Genetic risk for earlier menarche also influences peripubertal body mass index. | Johnson W et al. | β | 2013 | β |
| Genetics of the first seven proprotein convertase enzymes in health and disease. | Turpeinen H et al. | β | 2013 | β |
| Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. | Spencer KL et al. | β | 2013 | β |
| Genome-wide association analysis implicates elastic microfibrils in the development of nonsyndromic striae distensae. | Tung JY et al. | β | 2013 | β |
| Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. | Cousminer DL et al. | β | 2013 | β |
| Genome-wide association study of age at menarche in African-American women. | Demerath EW et al. | β | 2013 | β |
| Genome wide association study of age at menarche in the Japanese population. | Tanikawa C et al. | β | 2013 | β |
| Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. | Fatemifar G et al. | β | 2013 | β |
| Identifying opportunities for cancer prevention during preadolescence and adolescence: puberty as a window of susceptibility. | Biro FM et al. | β | 2013 | β |
| Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice. | Grieco A et al. | β | 2013 | β |
| Molecular and gene network analysis of thyroid transcription factor 1 (TTF1) and enhanced at puberty (EAP1) genes in patients with GnRH-dependent pubertal disorders. | Cukier P et al. | β | 2013 | β |
| Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis. | Prentice P et al. | β | 2013 | β |
| Puberty and dispersal in a wild primate population. | Onyango PO et al. | β | 2013 | β |
| Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study. | Carty CL et al. | β | 2013 | β |
| Replication of LIN28B SNP association with age of menarche in young Filipino women. | Croteau-Chonka DC et al. | β | 2013 | β |
| Reproductive factors and its association with peripheral arterial disease in women aged 52-81 years: the KORA F4 study. | StΓΆckl D et al. | β | 2013 | β |
| Role of puberty in multiple sclerosis risk and course. | Chitnis T | β | 2013 | β |
| Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort. | Graff M et al. | β | 2013 | β |
| The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. | Willemsen G et al. | β | 2013 | β |
| The UK Adult Twin Registry (TwinsUK Resource). | Moayyeri A et al. | β | 2013 | β |
| Treatment of children and adolescents with idiopathic short stature. | Ranke MB | β | 2013 | β |
| Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. | Silveira-Neto AP et al. | β | 2012 | β |
| Age at menarche is associated with prediabetes and diabetes in women (aged 32-81 years) from the general population: the KORA F4 Study. | StΓΆckl D et al. | β | 2012 | β |
| ApoE genotypes are associated with age at natural menopause in Chinese females. | Meng FT et al. | β | 2012 | β |
| Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study. | Lombard Z et al. | β | 2012 | β |
| A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates. | Lomniczi A et al. | β | 2012 | β |
| Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle. | LirΓ³n JP et al. | β | 2012 | β |
| Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women. | Akter S et al. | β | 2012 | β |
| Association of LIN28B with adult adiposity-related traits in females. | Leinonen JT et al. | β | 2012 | β |
| Cell adhesion molecules contribute to Alzheimer's disease: multiple pathway analyses of two genome-wide association studies. | Liu G et al. | β | 2012 | β |
| Clinical practice. Delayed puberty. | Palmert MR et al. | β | 2012 | β |
| Deciphering puberty: novel partners, novel mechanisms. | Tena-Sempere M | β | 2012 | β |
| Developmental origins of genotype-phenotype correlations in chronic diseases of old age. | McCormack S et al. | β | 2012 | β |
| Early menarche as an alternative reproductive tactic in human females: an evolutionary approach to reproductive health issues. | Gillette MT et al. | β | 2012 | β |
| Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome. | Carroll J et al. | β | 2012 | β |
| Environmental and genetic pathways between early pubertal timing and dieting in adolescence: distinguishing between objective and subjective timing. | Harden KP et al. | β | 2012 | β |
| Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health. | Graff M et al. | β | 2012 | β |
| Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer. | Lu L et al. | β | 2012 | β |
| Genetic markers of ovarian follicle number and menopause in women of multiple ethnicities. | Schuh-Huerta SM et al. | β | 2012 | β |
| Genetics of age at menarche: a systematic review. | Dvornyk V et al. | β | 2012 | β |
| Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. | Prescott J et al. | β | 2012 | β |
| Genome-wide copy number variation association analyses for age at menarche. | Liu YZ et al. | β | 2012 | β |
| Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. | Hancock DB et al. | β | 2012 | β |
| Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians. | Thearle MS et al. | β | 2012 | β |
| High urinary phthalate concentration associated with delayed pubarche in girls. | Frederiksen H et al. | β | 2012 | β |
| Insights into Assessing the Genetics of Endometriosis. | Rahmioglu N et al. | β | 2012 | β |
| LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls. | Park SW et al. | β | 2012 | β |
| Mechanisms affecting neuroendocrine and epigenetic regulation of body weight and onset of puberty: potential implications in the child born small for gestational age (SGA). | Roth CL et al. | β | 2012 | β |
| Modernization and the onset of overweight and obesity in Bougainville and Solomon Islands children: cross-sectional and longitudinal comparisons between 1966 and 1986. | Weitz CA et al. | β | 2012 | β |
| Pairwise shared genomic segment analysis in three Utah high-risk breast cancer pedigrees. | Cai Z et al. | β | 2012 | β |
| Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study. | Chen CT et al. | β | 2012 | β |
| Reproductive aging-associated common genetic variants and the risk of breast cancer. | He C et al. | β | 2012 | β |
| Reproductive factors and serum uric acid levels in females from the general population: the KORA F4 study. | StΓΆckl D et al. | β | 2012 | β |
| Serum IGF1 and insulin levels in girls with normal and precocious puberty. | SΓΈrensen K et al. | β | 2012 | β |
| Shared genetic effects between age at menarche and disordered eating. | Baker JH et al. | β | 2012 | β |
| Study of leptin levels and gene polymorphisms in patients with central precocious puberty. | Su PH et al. | β | 2012 | β |
| The evolution of human adiposity and obesity: where did it all go wrong? | Wells JC | β | 2012 | β |
| The genetics of obesity in transition. | Demerath EW | β | 2012 | β |
| The Minnesota Center for Twin and Family Research genome-wide association study. | Miller MB et al. | β | 2012 | β |
| The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals. | Murabito JM et al. | β | 2012 | β |
| Age at menarche and its association with the metabolic syndrome and its components: results from the KORA F4 study. | StΓΆckl D et al. | β | 2011 | β |
| Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. | Delahanty RJ et al. | β | 2011 | β |
| Dual function of Sec16B: Endoplasmic reticulum-derived protein secretion and peroxisome biogenesis in mammalian cells. | Tani K et al. | β | 2011 | β |
| Estrogen Increases c-Fos expression in the paraventricular nucleus along with its anorexic effect in developing rats. | Chi JH et al. | β | 2011 | β |
| Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory. | Mitchell AL et al. | β | 2011 | β |
| Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. | Soler Artigas M et al. | β | 2011 | β |
| Genome-wide association study identifies four loci associated with eruption of permanent teeth. | Geller F et al. | β | 2011 | β |
| Linking nutrition, maturation and aging: from thrifty genes to the spendthrift phenotype. | Stipp D | β | 2011 | β |
| Mendelian Randomisation Study of Childhood BMI and Early Menarche. | Mumby HS et al. | β | 2011 | β |
| Missing heritability in the tails of quantitative traits? A simulation study on the impact of slightly altered true genetic models. | PΓΌtter C et al. | β | 2011 | β |
| Neurokinin B signalling in the human reproductive axis. | Topaloglu AK et al. | β | 2011 | β |
| New genetic factors implicated in human GnRH-dependent precocious puberty: the role of kisspeptin system. | Teles MG et al. | β | 2011 | β |
| Piecing together the FTO jigsaw. | Frayling TM et al. | β | 2011 | β |
| Recent progress in the study of the genetics of height. | Lettre G | β | 2011 | β |
| Re-examining heritability: genetics, life history and plasticity. | Wells JC et al. | β | 2011 | β |
| The genetics of bone loss: challenges and prospects. | Mitchell BD et al. | β | 2011 | β |
| Vitamin D deficiency and age at menarche: a prospective study. | Villamor E et al. | β | 2011 | β |