BDNF regulates eating behavior and locomotor activity in mice.
paper
Cited
Public
Unavailable
- Authors
- Kernie, S G; Liebl, D J; Parada, L F
- Year
- 2000
- Journal
- The EMBO journal
- PMID
- 10716929
- DOI
- 10.1093/emboj/19.6.1290
- PMCID
- PMC305670
Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development. Ablation of this gene in mice leads to death shortly after birth, and abnormalities have been found in both the peripheral and central nervous systems. BDNF and its tyrosine kinase receptor, TrkB, are expressed in hypothalamic nuclei associated with satiety and locomotor activity. In heterozygous mice, BDNF gene expression is reduced and we find that all heterozygous mice exhibit abnormalities in eating behavior or locomotor activity. We also observe this phenotype in independently derived inbred and hybrid BDNF mutant strains. Infusion with BDNF or NT4/5 can transiently reverse the eating behavior and obesity. Thus, we identify a novel non-neurotrophic function for neurotrophins and indicate a role in behavior that is remarkably sensitive to alterations in BDNF activity.
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| Glucose concentrations modulate brain-derived neurotrophic factor responsiveness of neurones in the paraventricular nucleus of the hypothalamus. | McIsaac W et al. | β | 2017 | β |
| Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults. | Kaur S et al. | β | 2017 | β |
| Impact of intermittent fasting on health and disease processes. | Mattson MP et al. | β | 2017 | β |
| Improved method for cannula fixation for long-term intracerebral brain infusion. | Sike Γ et al. | β | 2017 | β |
| Intranasal Cerebrolysin Attenuates Learning and Memory Impairments in D-galactose-Induced Senescence in Mice. | Pourmemar E et al. | β | 2017 | β |
| <i>Rai1</i> frees mice from the repression of active wake behaviors by light. | Diessler S et al. | β | 2017 | β |
| Modification of feeding circuits in the evolution of social behavior. | Fischer EK et al. | β | 2017 | β |
| Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector. | Siu JJ et al. | β | 2017 | β |
| Obesity: Current and potential pharmacotherapeutics and targets. | Narayanaswami V et al. | β | 2017 | β |
| Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program. | McCaffery JM et al. | β | 2017 | β |
| Role of neurotrophic factors in attention deficit hyperactivity disorder. | Tsai SJ | β | 2017 | β |
| rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor Is Associated with Diabetes Mellitus Type 2 in Caucasian Females with Obesity. | de Luis DA et al. | β | 2017 | β |
| Sugars, exercise and health. | Codella R et al. | β | 2017 | β |
| 3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons. | Marosi K et al. | β | 2016 | β |
| 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. | Liu C et al. | β | 2016 | β |
| 'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue. | PΓ©rez LM et al. | β | 2016 | β |
| Association between obesity and the brain-derived neurotrophic factor gene polymorphism Val66Met in individuals with bipolar disorder in Mexican population. | Morales-MarΓn ME et al. | β | 2016 | β |
| Bardoxolone methyl prevents obesity and hypothalamic dysfunction. | Camer D et al. | β | 2016 | β |
| BDNF acting in the hypothalamus induces acute pressor responses under permissive control of angiotensin II. | Schaich CL et al. | β | 2016 | β |
| BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice. | Madra M et al. | β | 2016 | β |
| Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury-Related Mortality: Interrelationships Between Genetics and Acute Systemic and Central Nervous System BDNF Profiles. | Failla MD et al. | β | 2016 | β |
| Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels. | Xu J et al. | β | 2016 | β |
| Effect of the rs10767664 Variant of the Brain-Derived Neurotrophic Factor Gene on Weight Change and Cardiovascular Risk Factors in Morbidly Obese Patients after Biliopancreatic Diversion Surgery. | de Luis DA et al. | β | 2016 | β |
| Environmental Enrichment Mitigates Detrimental Cognitive Effects of Ketogenic Diet in Weanling Rats. | Scichilone JM et al. | β | 2016 | β |
| Epigenetic-Imprinting Changes Caused by Neonatal Fasting Stress Protect From Future Fasting Stress. | Jiang Y et al. | β | 2016 | β |
| Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity. | Josifova DJ et al. | β | 2016 | β |
| Induction of Neurorestoration From Endogenous Stem Cells. | Yu JH et al. | β | 2016 | β |
| Mendelian Randomization for the Identification of Causal Pathways in Atherosclerotic Vascular Disease. | Jansen H et al. | β | 2016 | β |
| Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice. | Takeda Y et al. | β | 2016 | β |
| Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. | Huang WH et al. | β | 2016 | β |
| Neurotrophic factor control of satiety and body weight. | Xu B et al. | β | 2016 | β |
| Neurotrophic Factors and Their Potential Applications in Tissue Regeneration. | Xiao N et al. | β | 2016 | β |
| Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study. | Reddon H et al. | β | 2016 | β |
| Rare Syndromes and Common Variants of the Brain-Derived Neurotrophic Factor Gene in Human Obesity. | Han JC | β | 2016 | β |
| Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons. | Yang H et al. | β | 2016 | β |
| Repeated transcranial direct current stimulation reduces food craving in Wistar rats. | Macedo IC et al. | β | 2016 | β |
| Serum Brain-Derived Neurotrophic Factor Mediates the Relationship between Abdominal Adiposity and Executive Function in Middle Age. | Kaur S et al. | β | 2016 | β |
| Serum Levels of Brain-Derived Neurotrophic Factor Are Associated with Diabetes Risk, Complications, and Obesity: a Cohort Study from Chinese Patients with Type 2 Diabetes. | Li B et al. | β | 2016 | β |
| The effect of serum BDNF levels on central serotonin transporter availability in obese versus non-obese adults: A [(11)C]DASB positron emission tomography study. | Hinderberger P et al. | β | 2016 | β |
| The impact of exercise training on basal BDNF in athletic adolescents. | Kim YI | β | 2016 | β |
| The Medial Orbitofrontal Cortex Regulates Sensitivity to Outcome Value. | Gourley SL et al. | β | 2016 | β |
| Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia. | Kamitakahara A et al. | β | 2016 | β |
| 7,8-Dihydroxyflavone reduces sleep during dark phase and suppresses orexin A but not orexin B in mice. | Feng P et al. | β | 2015 | β |
| Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance. | Ozek C et al. | β | 2015 | β |
| Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice. | Chan CB et al. | β | 2015 | β |
| Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type. | Eddy KT et al. | β | 2015 | β |
| Association between BDNF gene polymorphisms and attention deficit hyperactivity disorder in Korean children. | Kwon HJ et al. | β | 2015 | β |
| Brain Amyloidosis and BDNF Deficiency Have Opposite Effects on Brain Volumes in AΞ²PP/PS1 Mice Both in vivo and ex vivo. | KΓ€rkkΓ€inen E et al. | β | 2015 | β |
| Brain-derived neurotrophic factor and its clinical implications. | Bathina S et al. | β | 2015 | β |
| Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment. | Gururajan A et al. | β | 2015 | β |
| Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats. | Erdos B et al. | β | 2015 | β |
| Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning. | Petzold A et al. | β | 2015 | β |
| Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community. | Kaess BM et al. | β | 2015 | β |
| Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity. | Ohta H et al. | β | 2015 | β |
| Developmental specification of metabolic circuitry. | Elson AE et al. | β | 2015 | β |
| Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure. | An JJ et al. | β | 2015 | β |
| Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders. | Gervasini G et al. | β | 2015 | β |
| FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity. | Xin YL et al. | β | 2015 | β |
| Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate. | Liu J et al. | β | 2015 | β |
| Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity. | Apalasamy YD et al. | β | 2015 | β |
| Obesity genetics in mouse and human: back and forth, and back again. | Yazdi FT et al. | β | 2015 | β |
| Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats. | NegrΓ³n AL et al. | β | 2015 | β |
| Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies. | Andersen MK et al. | β | 2015 | β |
| Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. | Nakagomi A et al. | β | 2015 | β |
| Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models. | Samsom JN et al. | β | 2015 | β |
| Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice. | Kusakari S et al. | β | 2015 | β |
| The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy. | Notaras M et al. | β | 2015 | β |
| The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia. | Bonaccorso S et al. | β | 2015 | β |
| The Physiology of BDNF and Its Relationship with ADHD. | Liu DY et al. | β | 2015 | β |
| Variation in the BDNF gene interacts with age to predict mortality in a prospective, longitudinal cohort with severe TBI. | Failla MD et al. | β | 2015 | β |
| When Feeding Difficulties Are due to Genetics: The Case of Familial Partial 9q Duplication. | Travan L et al. | β | 2015 | β |
| Altered peripheral BDNF mRNA expression and BDNF protein concentrations in blood of children and adolescents with autism spectrum disorder. | Taurines R et al. | β | 2014 | β |
| Anxiolytic drug discovery: what are the novel approaches and how can we improve them? | Stewart AM et al. | β | 2014 | β |
| A possible link between BDNF and mTOR in control of food intake. | Takei N et al. | β | 2014 | β |
| BDNF genetic variability modulates psychopathological symptoms in patients with eating disorders. | Gamero-Villarroel C et al. | β | 2014 | β |
| BDNF mediates adaptive brain and body responses to energetic challenges. | Marosi K et al. | β | 2014 | β |
| Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants. | Hohenadel MG et al. | β | 2014 | β |
| Brain-derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both species. | GarcΓ©s MF et al. | β | 2014 | β |
| Cell-based delivery of brain-derived neurotrophic factor in experimental allergic encephalomyelitis. | Makar TK et al. | β | 2014 | β |
| Controversies about a common etiology for eating and mood disorders. | Rossetti C et al. | β | 2014 | β |
| Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. | Uutela M et al. | β | 2014 | β |
| Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor in children and adolescents with attention deficit and hyperactivity disorder. | Sahin S et al. | β | 2014 | β |
| Effects of energy status and diet on Bdnf expression in the ventromedial hypothalamus of male and female rats. | Liu X et al. | β | 2014 | β |
| Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro. | Sousa-Ferreira L et al. | β | 2014 | β |
| Human NR5A1/SF-1 mutations show decreased activity on BDNF (brain-derived neurotrophic factor), an important regulator of energy balance: testing impact of novel SF-1 mutations beyond steroidogenesis. | Malikova J et al. | β | 2014 | β |
| Hypothalamic dysfunction of the thrombospondin receptor Ξ±2Ξ΄-1 underlies the overeating and obesity triggered by brain-derived neurotrophic factor deficiency. | Cordeira JW et al. | β | 2014 | β |
| Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile. | Mera P et al. | β | 2014 | β |
| Meta-analyses between 18 candidate genetic markers and overweight/obesity. | Tang L et al. | β | 2014 | β |
| Mice over-expressing BDNF in forebrain neurons develop an altered behavioral phenotype with age. | Weidner KL et al. | β | 2014 | β |
| Mice with altered BDNF signaling as models for mood disorders and antidepressant effects. | Lindholm JS et al. | β | 2014 | β |
| Modulation of neurotrophin signaling by monoclonal antibodies. | Rosenthal A et al. | β | 2014 | β |
| Neurotrophins and the regulation of energy balance and body weight. | Rios M | β | 2014 | β |
| Peripheral brain derived neurotrophic factor (BDNF) in bulimia nervosa: a systematic review. | Phillips K et al. | β | 2014 | β |
| Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation. | Biddinger JE et al. | β | 2014 | β |
| Screening for genetic variants in BDNF that contribute to childhood obesity. | Zegers D et al. | β | 2014 | β |
| Serum brain-derived neurotrophic factor and cognitive functioning in underweight, weight-recovered and partially weight-recovered females with anorexia nervosa. | Zwipp J et al. | β | 2014 | β |
| SH2B1 regulation of energy balance, body weight, and glucose metabolism. | Rui L | β | 2014 | β |
| Squaring the circle? On the search for circulating biomarkers in polygenic psychiatric disorders. | Hebebrand J et al. | β | 2014 | β |
| The neuroanatomical function of leptin in the hypothalamus. | van Swieten MM et al. | β | 2014 | β |
| The role of BDNF, leptin, and catecholamines in reward learning in bulimia nervosa. | Homan P et al. | β | 2014 | β |
| Treadmill exercise enhances NMDA receptor expression in schizophrenia mice. | Park JK et al. | β | 2014 | β |
| Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity. | Liao GY et al. | β | 2013 | β |
| Alcohol, Brain Derived Neurotrophic Factor and Obesity among People Living with HIV. | MΓguez-Burbano MJ et al. | β | 2013 | β |
| Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome. | Han JC et al. | β | 2013 | β |
| BDNF and the central control of feeding: accidental bystander or essential player? | Rios M | β | 2013 | β |
| Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation. | Frias B et al. | β | 2013 | β |
| Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss. | Roth CL et al. | β | 2013 | β |
| Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior. | Gotoh K et al. | β | 2013 | β |
| Brain-derived neurotrophic factor in neuroimmunology: lessons learned from multiple sclerosis patients and experimental autoimmune encephalomyelitis models. | LΓΌhder F et al. | β | 2013 | β |
| Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats. | Maekawa F et al. | β | 2013 | β |
| Brain regulation of energy balance and body weight. | Rui L | β | 2013 | β |
| Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels. | Zhu Z et al. | β | 2013 | β |
| Changes in plasma Brain-derived neurotrophic factor (BDNF) levels induced by methylphenidate in children with Attention deficit-hyperactivity disorder (ADHD). | Amiri A et al. | β | 2013 | β |
| Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. | Albayrak Γ et al. | β | 2013 | β |
| Decreased serum levels of brain-derived neurotrophic factor in adults with attention-deficit hyperactivity disorder. | Corominas-Roso M et al. | β | 2013 | β |
| Developing 'integrative' zebrafish models of behavioral and metabolic disorders. | Nguyen M et al. | β | 2013 | β |
| Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry. | Sharma S et al. | β | 2013 | β |
| Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: beyond the homeostatic control of food intake. | Monteleone P et al. | β | 2013 | β |
| Effects of risperidone on energy balance in female C57BL/6J mice. | Li X et al. | β | 2013 | β |
| FTO predicts weight regain in the Look AHEAD clinical trial. | McCaffery JM et al. | β | 2013 | β |
| Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. | Bernhard F et al. | β | 2013 | β |
| Functional Val66Met polymorphism of Brain-derived neurotrophic factor in type 2 diabetes with depression in Han Chinese subjects. | Zhou JX et al. | β | 2013 | β |
| Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. | Guo Y et al. | β | 2013 | β |
| Gene expression of BDNF and its receptors, TrkB and p75 in the uterus and oviduct of pregnant and non-pregnant ewes. | Mirshokraei P et al. | β | 2013 | β |
| Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. | Urabe H et al. | β | 2013 | β |
| Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite. | Byerly MS et al. | β | 2013 | β |
| Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake. | Gao S et al. | β | 2013 | β |
| Lifestyle modification and behavior therapy effectively reduce body weight and increase serum level of brain-derived neurotrophic factor in obese non-diabetic patients with schizophrenia. | Kuo FC et al. | β | 2013 | β |
| Maintained expression of genes associated with metabolism in the ventromedial hypothalamic nucleus despite development of leptin resistance during pregnancy in the rat. | Phillipps HR et al. | β | 2013 | β |
| Mania: not the opposite of depression, but an extension? Neuronal plasticity and polarity. | Mizuno T et al. | β | 2013 | β |
| Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice. | Fox EA et al. | β | 2013 | β |
| Molecular and neural bases underlying roles of BDNF in the control of body weight. | Vanevski F et al. | β | 2013 | β |
| Obesogenic phenotype of offspring of dams fed a high multivitamin diet is prevented by a post-weaning high multivitamin or high folate diet. | Cho CE et al. | β | 2013 | β |
| Rodent models for mania: practical approaches. | Kara NZ et al. | β | 2013 | β |
| Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index. | Han X et al. | β | 2013 | β |
| Serum neurotrophin concentrations in polish adolescent girls with anorexia nervosa. | Dmitrzak-Weglarz M et al. | β | 2013 | β |
| Stage-specific inhibition of TrkB activity leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression. | Byerly MS et al. | β | 2013 | β |
| The brain-liver connection between BDNF and glucose control. | Jo YH et al. | β | 2013 | β |
| The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease. | RantamΓ€ki T et al. | β | 2013 | β |
| The influence of exercise on cognitive abilities. | Gomez-Pinilla F et al. | β | 2013 | β |
| The skinny on brain-derived neurotrophic factor: evidence from animal models to GWAS. | Waterhouse EG et al. | β | 2013 | β |
| The study of candidate genes related to the neurodevelopmental hypothesis of anorexia nervosa: classical association study versus decision tree. | Dmitrzak-Weglarz M et al. | β | 2013 | β |
| Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight. | Mason BL et al. | β | 2013 | β |
| Aberrant striatal dopamine transmitter dynamics in brain-derived neurotrophic factor-deficient mice. | Bosse KE et al. | β | 2012 | β |
| A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. | Shimada Y et al. | β | 2012 | β |
| Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: the utility of behavior-recognition tools to characterize mutant mouse phenotypes. | Kyzar EJ et al. | β | 2012 | β |
| A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia. | Nurjono M et al. | β | 2012 | β |
| Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study. | Ma XY et al. | β | 2012 | β |
| Brain-derived neurotrophic factor and neuropsychiatric disorders. | Autry AE et al. | β | 2012 | β |
| Brain Derived Neurotrophic Factor: a novel neurotrophin involved in psychiatric and neurological disorders. | Balaratnasingam S et al. | β | 2012 | β |
| Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health. | Rothman SM et al. | β | 2012 | β |
| Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways. | Markham A et al. | β | 2012 | β |
| Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination. | Lee DH et al. | β | 2012 | β |
| Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent. | Al-Eitan LN et al. | β | 2012 | β |
| Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice. | Breuillaud L et al. | β | 2012 | β |
| Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin. | Liao GY et al. | β | 2012 | β |
| Early postnatal overnutrition: potential roles of gastrointestinal vagal afferents and brain-derived neurotrophic factor. | Fox EA et al. | β | 2012 | β |
| Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus. | Jo YH | β | 2012 | β |
| Evolutionary aspects of human exercise--born to run purposefully. | Mattson MP | β | 2012 | β |
| Leptin and leptin receptor-related monogenic obesity. | Dubern B et al. | β | 2012 | β |
| Metabolic reserve as a determinant of cognitive aging. | Stranahan AM et al. | β | 2012 | β |
| Mouse models of genetic effects on cognition: relevance to schizophrenia. | Papaleo F et al. | β | 2012 | β |
| Obesity and ADHD: clinical and neurobiological implications. | Cortese S et al. | β | 2012 | β |
| Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. | McCaffery JM et al. | β | 2012 | β |
| Plasma BDNF levels vary in relation to body weight in females. | Pillai A et al. | β | 2012 | β |
| Possible involvement of brain-derived neurotrophic factor in eating disorders. | Nakazato M et al. | β | 2012 | β |
| Recapitulation of the association of the Val66Met polymorphism of BDNF gene with BMI in Koreans. | Hong KW et al. | β | 2012 | β |
| Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy. | Ola MS et al. | β | 2012 | β |
| Recovery of low plasma BDNF over the course of treatment among patients with bulimia nervosa. | Yamada H et al. | β | 2012 | β |
| Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits. | Uutela M et al. | β | 2012 | β |
| Role of neurotrophins in the development and function of neural circuits that regulate energy homeostasis. | Fargali S et al. | β | 2012 | β |
| Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior. | Vigers AJ et al. | β | 2012 | β |
| The effects of chronic administration of tranylcypromine and rimonabant on behaviour and protein expression in brain regions of the rat. | Assareh N et al. | β | 2012 | β |
| TrkB inhibition as a therapeutic target for CNS-related disorders. | Boulle F et al. | β | 2012 | β |
| TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. | Spaeth AM et al. | β | 2012 | β |
| Unraveling the brain regulation of appetite: lessons from genetics. | Yeo GS et al. | β | 2012 | β |
| 11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity. | Shinawi M et al. | β | 2011 | β |
| Adipocytokines, gut hormones and growth factors in anorexia nervosa. | Kowalska I et al. | β | 2011 | β |
| Altering BDNF expression by genetics and/or environment: impact for emotional and depression-like behaviour in laboratory mice. | Chourbaji S et al. | β | 2011 | β |
| A meta-analysis of circulating BDNF concentrations in anorexia nervosa. | Brandys MK et al. | β | 2011 | β |
| A review of psychostimulant-induced neuroadaptation in developing animals. | Carrey N et al. | β | 2011 | β |
| A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress. | Razzoli M et al. | β | 2011 | β |
| Autonomic nervous system dysfunction in obesity and Prader-Willi syndrome: current evidence and implications for future obesity therapies. | Haqq AM et al. | β | 2011 | β |
| BDNF contributes to the genetic variance of milk fat yield in german holstein cattle. | Zielke LG et al. | β | 2011 | β |
| Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. | Hill RA et al. | β | 2011 | β |
| Brain-derived neurotrophic factor, food intake regulation, and obesity. | Rosas-Vargas H et al. | β | 2011 | β |
| Cell adhesion signaling pathways: First responders to cocaine exposure? | Gourley SL et al. | β | 2011 | β |
| Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbens. | Huang CC et al. | β | 2011 | β |
| Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity. | Timpano KR et al. | β | 2011 | β |
| Effects of BDNF polymorphisms on brain function and behavior in health and disease. | Hong CJ et al. | β | 2011 | β |
| Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. | Boger HA et al. | β | 2011 | β |
| Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice. | Mughal MR et al. | β | 2011 | β |
| Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. | Harlow DE et al. | β | 2011 | β |
| Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. | Takeda A et al. | β | 2011 | β |
| Genetic animal models of schizophrenia related with the hypothesis of abnormal neurodevelopment. | Lu L et al. | β | 2011 | β |
| Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. | Croteau-Chonka DC et al. | β | 2011 | β |
| Hypothalamic inflammation: a double-edged sword to nutritional diseases. | Cai D et al. | β | 2011 | β |
| Impaired adaptive cellular responses to oxidative stress and the pathogenesis of Alzheimer's disease. | Texel SJ et al. | β | 2011 | β |
| Lipotoxicity of palmitic Acid on neural progenitor cells and hippocampal neurogenesis. | Park HR et al. | β | 2011 | β |
| Melanocortin control of energy balance: evidence from rodent models. | De Jonghe BC et al. | β | 2011 | β |
| Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression. | Sigwalt AR et al. | β | 2011 | β |
| Molecular basis of obesity: current status and future prospects. | Choquet H et al. | β | 2011 | β |
| Neurobiology of overeating and obesity: the role of melanocortins and beyond. | Pandit R et al. | β | 2011 | β |
| New frontiers in endocrinology of eating disorders. | Monteleone P | β | 2011 | β |
| Plasma brain-derived neurotrophic factor concentrations in children and adolescents. | Iughetti L et al. | β | 2011 | β |
| Reduction of high-fat diet-induced obesity after chronic administration of brain-derived neurotrophic factor in the hypothalamic ventromedial nucleus. | Godar R et al. | β | 2011 | β |
| Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice. | Hill RA et al. | β | 2011 | β |
| Successful methylphenidate treatment of early onset extreme obesity in a child with a melanocortin-4 receptor gene mutation and attention deficit/hyperactivity disorder. | Albayrak O et al. | β | 2011 | β |
| The central effects of thyroid hormones on appetite. | Amin A et al. | β | 2011 | β |
| The lighter side of BDNF. | Noble EE et al. | β | 2011 | β |
| Viral depletion of VTA BDNF in rats modulates social behavior, consequences of intermittent social defeat stress, and long-term weight regulation. | Fanous S et al. | β | 2011 | β |
| Weighing in the role of BDNF in the central control of eating behavior. | Cordeira J et al. | β | 2011 | β |
| A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. | Park HR et al. | β | 2010 | β |
| An intrastriatal brain-derived neurotrophic factor infusion restores striatal gene expression in Bdnf heterozygous mice. | Saylor AJ et al. | β | 2010 | β |
| Anti-obesity effect of phosphatidylinositol on diet-induced obesity in mice. | Shimizu K et al. | β | 2010 | β |
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| Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure. | Wang C et al. | β | 2010 | β |
| Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system. | Cordeira JW et al. | β | 2010 | β |
| Central leptin signalling: beyond the arcuate nucleus. | Jovanovic Z et al. | β | 2010 | β |
| Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. | Klein AB et al. | β | 2010 | β |
| Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet. | Wang C et al. | β | 2010 | β |
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| Gene expression profiling in rodent models for schizophrenia. | Schijndel JE et al. | β | 2010 | β |
| Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. | Rauskolb S et al. | β | 2010 | β |
| Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model. | Kohjima M et al. | β | 2010 | β |
| Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. | Taliaz D et al. | β | 2010 | β |
| Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity. | UΓ§eyler N et al. | β | 2010 | β |
| Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. | Toriya M et al. | β | 2010 | β |
| Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects. | Han JC et al. | β | 2010 | β |
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| Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. | Elks CE et al. | β | 2010 | β |
| Adult type 3 adenylyl cyclase-deficient mice are obese. | Wang Z et al. | β | 2009 | β |
| Alternative splicing variants and DNA methylation status of BDNF in inbred chicken lines. | Yu Y et al. | β | 2009 | β |
| Brain-derived neurotrophic factor and TrkB receptor in experimental autoimmune encephalomyelitis and multiple sclerosis. | De Santi L et al. | β | 2009 | β |
| Brain-derived neurotrophic factor (BDNF) and set-shifting in currently ill and recovered anorexia nervosa (AN) patients. | Nakazato M et al. | β | 2009 | β |
| Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. | Cunha C et al. | β | 2009 | β |
| Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control. | Bariohay B et al. | β | 2009 | β |
| Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress. | Ibarguen-Vargas Y et al. | β | 2009 | β |
| Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro. | Byerly MS et al. | β | 2009 | β |
| Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo. | Carim-Todd L et al. | β | 2009 | β |
| Energy-restricted pair-feeding normalizes low levels of brain-derived neurotrophic factor/tyrosine kinase B mRNA expression in the hippocampus, but not ventromedial hypothalamic nucleus, in diet-induced obese mice. | Yu Y et al. | β | 2009 | β |
| Genetic gains on the obesity and metabolic disease fronts. | Clee SM | β | 2009 | β |
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| Intestinal microbiota regulate xenobiotic metabolism in the liver. | BjΓΆrkholm B et al. | β | 2009 | β |
| Lorcaserin and adiposopathy: 5-HT2c agonism as a treatment for 'sick fat' and metabolic disease. | Bays HE | β | 2009 | β |
| Low serum BDNF and food intake regulation: a possible new explanation of the pathophysiology of eating disorders. | Saito S et al. | β | 2009 | β |
| Perinatal undernutrition modifies cell proliferation and brain-derived neurotrophic factor levels during critical time-windows for hypothalamic and hippocampal development in the male rat. | CoupΓ© B et al. | β | 2009 | β |
| Recent advances in understanding leptin signaling and leptin resistance. | Morris DL et al. | β | 2009 | β |
| Recent progress in the genetics of common obesity. | Loos RJ | β | 2009 | β |
| Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. | Choi SH et al. | β | 2009 | β |
| Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals. | Pedersen BK et al. | β | 2009 | β |
| Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosa. | Ehrlich S et al. | β | 2009 | β |
| The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives. | Pinheiro AP et al. | β | 2009 | β |
| Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. | Shugart YY et al. | β | 2009 | β |
| Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. | Haskell-Luevano C et al. | β | 2009 | β |
| AAV-BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment. | Kells AP et al. | β | 2008 | β |
| A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. | Hong EJ et al. | β | 2008 | β |
| Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone. | Gourley SL et al. | β | 2008 | β |
| A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosa. | Kaplan AS et al. | β | 2008 | β |
| Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates. | Lin JC et al. | β | 2008 | β |
| Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. | Mercader JM et al. | β | 2008 | β |
| Association of the BDNF Val66Met variation with obesity in women. | Beckers S et al. | β | 2008 | β |
| Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. | RibasΓ©s M et al. | β | 2008 | β |
| Attention-deficit/hyperactivity disorder (ADHD) and obesity: a systematic review of the literature. | Cortese S et al. | β | 2008 | β |
| BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake. | Mannari C et al. | β | 2008 | β |
| BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. | Zhang XY et al. | β | 2008 | β |
| BDNF-TrkB signaling interacts with the GABAergic system to inhibit rhythmic swallowing in the rat. | Bariohay B et al. | β | 2008 | β |
| Brain-derived neurotrophic factor and obesity in the WAGR syndrome. | Han JC et al. | β | 2008 | β |
| Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. | Gomez-Pinilla F et al. | β | 2008 | β |
| Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats. | GalvΓ£o RP et al. | β | 2008 | β |
| Brain foods: the effects of nutrients on brain function. | GΓ³mez-Pinilla F | β | 2008 | β |
| Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. | Hodges A et al. | β | 2008 | β |
| Central and peripheral regulation of food intake and physical activity: pathways and genes. | Lenard NR et al. | β | 2008 | β |
| Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. | Zhao L et al. | β | 2008 | β |
| Cross-talk between estrogen and leptin signaling in the hypothalamus. | Gao Q et al. | β | 2008 | β |
| Decreased serum brain-derived neurotrophic factor in trained men. | Nofuji Y et al. | β | 2008 | β |
| Does excessive daytime sleepiness contribute to explaining the association between obesity and ADHD symptoms? | Cortese S et al. | β | 2008 | β |
| Ethanol-BDNF interactions: still more questions than answers. | Davis MI | β | 2008 | β |
| Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences. | Araya AV et al. | β | 2008 | β |
| Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. | Gray M et al. | β | 2008 | β |
| Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD). | Shim SH et al. | β | 2008 | β |
| Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice. | Tucker K et al. | β | 2008 | β |
| Lessons from extreme human obesity: monogenic disorders. | Ranadive SA et al. | β | 2008 | β |
| Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. | Farooqi IS et al. | β | 2008 | β |
| Nature vs. nurture: can enrichment rescue the behavioural phenotype of BDNF heterozygous mice? | Chourbaji S et al. | β | 2008 | β |
| Neuroendocrine dysregulation of food intake in eating disorders. | Monteleone P et al. | β | 2008 | β |
| Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats. | Bahi A et al. | β | 2008 | β |
| Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. | Adachi M et al. | β | 2008 | β |
| The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. | Johnson AW et al. | β | 2008 | β |
| The impact of voluntary exercise on mental health in rodents: a neuroplasticity perspective. | Pietropaolo S et al. | β | 2008 | β |
| The influences of diet and exercise on mental health through hormesis. | Gomez-Pinilla F | β | 2008 | β |
| TrkB agonists ameliorate obesity and associated metabolic conditions in mice. | Tsao D et al. | β | 2008 | β |
| Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia. | Mercader JM et al. | β | 2007 | β |
| Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. | Beuten J et al. | β | 2007 | β |
| Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking. | Lang UE et al. | β | 2007 | β |
| Attention-deficit/hyperactivity disorder (ADHD) and binge eating. | Cortese S et al. | β | 2007 | β |
| Attention-deficit hyperactivity disorder may be associated with decreased central brain-derived neurotrophic factor activity: clinical and therapeutic implications. | Tsai SJ | β | 2007 | β |
| Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. | Krabbe KS et al. | β | 2007 | β |
| Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. | Monteggia LM et al. | β | 2007 | β |
| Brain-derived neurotrophic factor enhances glucose utilization in peripheral tissues of diabetic mice. | Yamanaka M et al. | β | 2007 | β |
| Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate. | Wang C et al. | β | 2007 | β |
| Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake. | Wang C et al. | β | 2007 | β |
| Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake. | Wang C et al. | β | 2007 | β |
| Central neural and endocrine mechanisms of non-exercise activity thermogenesis and their potential impact on obesity. | Novak CM et al. | β | 2007 | β |
| Chronic mild stressors and diet affect gene expression differently in male and female rats. | Liang S et al. | β | 2007 | β |
| Differential expression of BDNF mRNA splice variants in mouse brain and immune cells. | Kruse N et al. | β | 2007 | β |
| Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice. | Sha H et al. | β | 2007 | β |
| Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. | Gray J et al. | β | 2007 | β |
| [Genetic obesities]. | Pigeyre M et al. | β | 2007 | β |
| Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. | HΓΌnnerkopf R et al. | β | 2007 | β |
| Methylphenidate regulates activity regulated cytoskeletal associated but not brain-derived neurotrophic factor gene expression in the developing rat striatum. | Chase T et al. | β | 2007 | β |
| Neurotrophins in the dentate gyrus. | Binder DK | β | 2007 | β |
| Neurotrophism and energy homeostasis: perfect together. | Levin BE | β | 2007 | β |
| Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. | Xu K et al. | β | 2007 | β |
| Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood. | Ize-Ludlow D et al. | β | 2007 | β |
| S18986: a positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures. | Lockhart BP et al. | β | 2007 | β |
| Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. | Unger TJ et al. | β | 2007 | β |
| Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. | Zhang XY et al. | β | 2007 | β |
| The genetics of anorexia nervosa. | Bulik CM et al. | β | 2007 | β |
| The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. | Oswal A et al. | β | 2007 | β |
| The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. | Kurrasch DM et al. | β | 2007 | β |
| A genetic approach for investigating vagal sensory roles in regulation of gastrointestinal function and food intake. | Fox EA | β | 2006 | β |
| BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expression. | Saylor AJ et al. | β | 2006 | β |
| BDNF regulation in the rat dorsal vagal complex during stress-induced anorexia. | Charrier C et al. | β | 2006 | β |
| BDNF Val66Met polymorphism is associated with body mass index in healthy adults. | Gunstad J et al. | β | 2006 | β |
| Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. | Lebrun B et al. | β | 2006 | β |
| Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder. | Einat H et al. | β | 2006 | β |
| Continuous carbachol infusion promotes peripheral cell proliferation and mimics vagus hyperactivity in a rat model of hypothalamic obesity. | Yoshimura R et al. | β | 2006 | β |
| Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity. | Vaynman S et al. | β | 2006 | β |
| Differential expression of the four untranslated BDNF exons in the adult mouse brain. | Malkovska I et al. | β | 2006 | β |
| Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. | Tran PV et al. | β | 2006 | β |
| Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice. | Chan JP et al. | β | 2006 | β |
| Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies. | Ren-Patterson RF et al. | β | 2006 | β |
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| Genetics of human obesity. | Mutch DM et al. | β | 2006 | β |
| Genetics of obesity. | O'Rahilly S et al. | β | 2006 | β |
| Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. | Gray J et al. | β | 2006 | β |
| Inactivation of 5HT transport in mice: modeling altered 5HT homeostasis implicated in emotional dysfunction, affective disorders, and somatic syndromes. | Lesch KP et al. | β | 2006 | β |
| Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. | Komori T et al. | β | 2006 | β |
| Modeling madness in mice: one piece at a time. | Arguello PA et al. | β | 2006 | β |
| Molecular genetics of bipolar disorder. | Hayden EP et al. | β | 2006 | β |
| No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery. | Nakazato M et al. | β | 2006 | β |
| Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity. | Vaynman S et al. | β | 2006 | β |
| Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. | El-Gharbawy AH et al. | β | 2006 | β |
| Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. | Suwa M et al. | β | 2006 | β |
| Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. | Rios M et al. | β | 2006 | β |
| The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder. | Monteleone P et al. | β | 2006 | β |
| The impact of diet and exercise on brain plasticity and disease. | Pinilla FG | β | 2006 | β |
| Unraveling the genetics of human obesity. | Mutch DM et al. | β | 2006 | β |
| Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. | RibasΓ©s M et al. | β | 2005 | β |
| Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index. | Ribases M et al. | β | 2005 | β |
| Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse. | Kraemer R et al. | β | 2005 | β |
| Different expression of brain-derived neurotrophic factor in the nucleus accumbens of alcohol-preferring (P) and -nonpreferring (NP) rats. | Yan QS et al. | β | 2005 | β |
| Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. | Kuwako K et al. | β | 2005 | β |
| License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. | Vaynman S et al. | β | 2005 | β |
| Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. | Ren-Patterson RF et al. | β | 2005 | β |
| Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. | Friedel S et al. | β | 2005 | β |
| Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism. | Duman RS | β | 2005 | β |
| Neurotrophins in clinical diagnostics: pathophysiology and laboratory investigation. | Nockher WA et al. | β | 2005 | β |
| Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. | Kermani P et al. | β | 2005 | β |
| Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor. | Lyckman AW et al. | β | 2005 | β |
| Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity. | CastaΓ±eda TR et al. | β | 2005 | β |
| ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. | Teng HK et al. | β | 2005 | β |
| Repetitive transcranial magnetic stimulation: a possible novel therapeutic approach to eating disorders. | Tsai SJ | β | 2005 | β |
| Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications. | Hashimoto K et al. | β | 2005 | β |
| Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. | Beuten J et al. | β | 2005 | β |
| Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions. | Komori T et al. | β | 2005 | β |
| TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. | Luikart BW et al. | β | 2005 | β |
| TrkB signaling regulates the developmental maturation of the somatosensory cortex. | Lush ME et al. | β | 2005 | β |
| A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. | Yeo GS et al. | β | 2004 | β |
| A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants. | Fox EA et al. | β | 2004 | β |
| Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders. | Koizumi H et al. | β | 2004 | β |
| Brain-derived neurotrophic factor. | Binder DK et al. | β | 2004 | β |
| Brain insulin and feeding: a bi-directional communication. | Gerozissis K | β | 2004 | β |
| Control of hyperphagia prevents obesity in BDNF heterozygous mice. | Coppola V et al. | β | 2004 | β |
| Critical role of brain-derived neurotrophic factor in mood disorders. | Hashimoto K et al. | β | 2004 | β |
| Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus. | Kuma H et al. | β | 2004 | β |
| Emerging aspects of pharmacotherapy for obesity and metabolic syndrome. | Nisoli E et al. | β | 2004 | β |
| Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neurons. | Deogracias R et al. | β | 2004 | β |
| Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. | Chourbaji S et al. | β | 2004 | β |
| Minireview: A hypothalamic role in energy balance with special emphasis on leptin. | Sahu A | β | 2004 | β |
| Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. | Zhang EE et al. | β | 2004 | β |
| No changes in serum ghrelin levels in female patients with bulimia nervosa. | Nakazato M et al. | β | 2004 | β |
| Obesity wars: molecular progress confronts an expanding epidemic. | Flier JS | β | 2004 | β |
| Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity. | Monteleone P et al. | β | 2004 | β |
| RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. | McGough NN et al. | β | 2004 | β |
| Spreading depression induces long-lasting brain protection against infarcted lesion development via BDNF gene-dependent mechanism. | Yanamoto H et al. | β | 2004 | β |
| Anti-obesity and anti-diabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance. | Nakagawa T et al. | β | 2003 | β |
| Anxiety-related traits in mice with modified genes of the serotonergic pathway. | Lesch KP et al. | β | 2003 | β |
| Brain-derived neurotrophic factor ameliorates hepatic insulin resistance in Zucker fatty rats. | Kuroda A et al. | β | 2003 | β |
| Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. | Gorski JA et al. | β | 2003 | β |
| Brain-derived neurotrophic factor modulates glucagon secretion from pancreatic alpha cells: its contribution to glucose metabolism. | Hanyu O et al. | β | 2003 | β |
| Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. | Xu B et al. | β | 2003 | β |
| Control of body weight: a physiologic and transgenic perspective. | FrΓΌhbeck G et al. | β | 2003 | β |
| Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders. | Nakazato M et al. | β | 2003 | β |
| Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. | Duan W et al. | β | 2003 | β |
| Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. | Murphy DL et al. | β | 2003 | β |
| Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive". | ZΓΆrner B et al. | β | 2003 | β |
| Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice. | Kamitani W et al. | β | 2003 | β |
| Increased expression of neurotrophins and their receptors in the mechanically compressed spinal cord of the spinal hyperostotic mouse (twy/twy). | Uchida K et al. | β | 2003 | β |
| In vivo role of truncated trkb receptors during sensory ganglion neurogenesis. | Luikart BW et al. | β | 2003 | β |
| Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. | Gorski JA et al. | β | 2003 | β |
| Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. | RibasΓ©s M et al. | β | 2003 | β |
| Neuronal growth factors and development of respiratory control. | Katz DM | β | 2003 | β |
| Neurotrophins and their receptors: a convergence point for many signalling pathways. | Chao MV | β | 2003 | β |
| Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. | Hall FS et al. | β | 2003 | β |
| Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. | Tran PV et al. | β | 2003 | β |
| Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. | Duan W et al. | β | 2003 | β |
| Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain. | Sugiyama N et al. | β | 2003 | β |
| The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. | Einat H et al. | β | 2003 | β |
| Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice. | Nakagawa T et al. | β | 2002 | β |
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