Changes in dimeric inhibin A and B during normal early puberty in boys and girls.
- Authors
- Crofton, P M; Illingworth, P J; Groome, N P; Stirling, H F; Swanston, I; Gow, S; Wu, F C; McNeilly, A; Kelnar, C J
- Year
- 1997
- Journal
- Clinical endocrinology
- PMID
- 9059566
- DOI
- 10.1046/j.1365-2265.1997.d01-1744.x
OBJECTIVE: Although recently developed specific and sensitive assays of bioactive dimeric inhibin A and B have given new insights into the pituitary-gonadal axis in adult men and during the adult female menstrual cycle, there have been no reports on circulating inhibin A and B during normal human puberty. The aim of this study was to assess the relationship of dimeric inhibin A and B to pubertal stage, FSH and testosterone or oestradiol in late prepuberty and in early puberty. STUDY DESIGN AND SUBJECTS: Serial samples were collected during a prospective longitudinal trial of GH treatment in short normal children. Seven boys were studied from late prepuberty to genital stage 3, and six pre-menarche girls from late prepuberty to breast stage 4. MEASUREMENTS: Dimeric inhibin A (girls only) and inhibin B (boys and girls) were measured by highly specific and sensitive two-site ELISAs, FSH by IRMA, testosterone and oestradiol by RIA. RESULTS: In boys, inhibin B increased progressively from pubertal stages 1 to 3 (ANOVA P < 0.0001) and correlated strongly with mean testicular volume (r = 0.72, P = 0.0005). Prepubertal boys showed a positive correlation between inhibin B and FSH (r = 0.65, P = 0.056), whereas pubertal boys gave a strong negative correlation (r = 0.75, P = 0.012). In both prepubertal and pubertal boys positive correlations were observed between inhibin B (y) and testosterone (x) (r = 0.81, P = 0.008 and r = 0.62, P = 0.054 respectively), but the slope of the regression line between the two was much steeper before than after the onset of clinical puberty. In girls, both inhibin A and B increased through pubertal stages 1-4 (ANOVA P = 0.01 and P = 0.047 respectively). Both showed strong positive correlations with oestradiol (r = 0.80 and 0.79, P = 0.001) and with FSH (r = 0.83, P = 0.0004 and r = 0.80, P = 0.001). Inhibin A and B were also strongly correlated with each other (r = 0.92, P = 0.0001). CONCLUSIONS: In boys, testicular production of inhibin B increases as puberty progresses. Our results show for the first time that the initiation of puberty is accompanied by a dramatic switch from a positive to a negative relation between inhibin B and FSH as inhibin B begins to exert the expected negative feedback on FSH. The results in girls suggest that, prior to menarche, the ovarian follicles produce inhibin A and B in strict proportion, and in progressively greater amounts as puberty proceeds. Measurement of dimeric inhibin A and B may provide a sensitive new tool for determining gonadal maturity in late prepuberty and early puberty.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Basal and Stimulated Inhibin B in Pubertal Disorders. | Chaudhary S et al. | — | 2025 | → |
| Puberty and Inhibin B in 35 Adolescents With Pituitary Stalk Interruption Syndrome. | Corvest V et al. | — | 2020 | → |
| Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males. | Campo S et al. | — | 2019 | → |
| Hypogonadism and Cryptorchidism. | Rodprasert W et al. | — | 2019 | → |
| Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice. | Li Y et al. | — | 2018 | → |
| Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty. | Tencer J et al. | — | 2018 | → |
| Hyperstimulation syndrome: the levels of inhibin A and B in sera and follicular fluids. | Ulcova-Gallova Z et al. | — | 2014 | → |
| Spreading the clinical window for diagnosing fetal-onset hypogonadism in boys. | Grinspon RP et al. | — | 2014 | → |
| Comparison of detection of normal puberty in girls by a hormonal sleep test and a gonadotropin-releasing hormone agonist test. | Rosenfield RL et al. | — | 2013 | → |
| SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures. | Dere E et al. | — | 2013 | → |
| Anti-Müllerian hormone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer: a prospective study. | Brougham MF et al. | — | 2012 | → |
| Boys with undescended testes: endocrine, volumetric and morphometric studies on testicular function before and after orchidopexy at nine months or three years of age. | Kollin C et al. | — | 2012 | → |
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| Feedback regulation by inhibins A and B of the pituitary secretion of follicle-stimulating hormone. | Makanji Y et al. | — | 2011 | → |
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| Inhibition of the progesterone nuclear receptor during the bone linear growth phase increases peak bone mass in female mice. | Yao W et al. | — | 2010 | → |
| Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. | Elks CE et al. | — | 2010 | → |
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| Inhibin B in boys from birth to adulthood: relationship with age, pubertal stage, FSH and testosterone. | Crofton PM et al. | — | 2002 | → |
| Clinical studies: inhibin in the adult male. | Anderson RA | — | 2001 | → |
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