Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.
paper
Cited
Public
Unavailable
- Authors
- Xu, Baoji; Goulding, Evan H; Zang, Keling; Cepoi, David; Cone, Roger D; Jones, Kevin R; Tecott, Laurence H; Reichardt, Louis F
- Year
- 2003
- Journal
- Nature neuroscience
- PMID
- 12796784
- DOI
- 10.1038/nn1073
- PMCID
- PMC2710100
The melanocortin-4 receptor (MC4R) is critically involved in regulating energy balance, and obesity has been observed in mice with mutations in the gene for brain-derived neurotrophic factor (BDNF). Here we report that BDNF is expressed at high levels in the ventromedial hypothalamus (VMH) where its expression is regulated by nutritional state and by MC4R signaling. In addition, similar to MC4R mutants, mouse mutants that expresses the BDNF receptor TrkB at a quarter of the normal amount showed hyperphagia and excessive weight gain on higher-fat diets. Furthermore, BDNF infusion into the brain suppressed the hyperphagia and excessive weight gain observed on higher-fat diets in mice with deficient MC4R signaling. These results show that MC4R signaling controls BDNF expression in the VMH and support the hypothesis that BDNF is an important effector through which MC4R signaling controls energy balance.
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| NTRK fusion-positive cancers and TRK inhibitor therapy. | Cocco E et al. | β | 2018 | β |
| Primary Afferent-Derived BDNF Contributes Minimally to the Processing of Pain and Itch. | Dembo T et al. | β | 2018 | β |
| Relevance of polymorphisms in MC4R and BDNF in short normal stature. | Herrfurth N et al. | β | 2018 | β |
| SORCS1 and SORCS3 control energy balance and orexigenic peptide production. | Subkhangulova A et al. | β | 2018 | β |
| The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF. | Scabia G et al. | β | 2018 | β |
| The BDNF rs6265 variant may interact with overweight and obesity to influence obesity-related physical, metabolic and behavioural traits in Pakistani individuals. | Rana S et al. | β | 2018 | β |
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| Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus. | Eyileten C et al. | β | 2017 | β |
| BDNF and AMPA receptors in the cNTS modulate the hyperglycemic reflex after local carotid body NaCN stimulation. | CuΓ©llar R et al. | β | 2017 | β |
| BDNF/TrkB signaling mediates the anorectic action of estradiol in the nucleus tractus solitarius. | Shen L et al. | β | 2017 | β |
| Central and peripheral control of food intake. | Abdalla MM | β | 2017 | β |
| Dietary Protein Modifies the Effect of the <i>MC4R</i> Genotype on 2-Year Changes in Appetite and Food Craving: The POUNDS Lost Trial. | Huang T et al. | β | 2017 | β |
| Effect of food deprivation or short-term Western diet feeding on BDNF protein expression in the hypothalamic arcuate, paraventricular, and ventromedial nuclei. | Gilland KE et al. | β | 2017 | β |
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| High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies. | Hamdan FF et al. | β | 2017 | β |
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| Injection of Anti-proBDNF in Anterior Cingulate Cortex (ACC) Reverses Chronic Stress-Induced Adverse Mood Behaviors in Mice. | Yang CR et al. | β | 2017 | β |
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| Sustained endocrine profiles of a girl with WAGR syndrome. | Takada Y et al. | β | 2017 | β |
| The Arcuate Estrogen-Regulated Transcriptome: Estrogen Response Element-Dependent and -Independent Signaling of ERΞ± in Female Mice. | Yang JA et al. | β | 2017 | β |
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| Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. | Roh E et al. | β | 2016 | β |
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| Epigenetic-Imprinting Changes Caused by Neonatal Fasting Stress Protect From Future Fasting Stress. | Jiang Y et al. | β | 2016 | β |
| GsΞ± Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet. | Berger A et al. | β | 2016 | β |
| Gut Commensal E.Β coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth. | Breton J et al. | β | 2016 | β |
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| Physical Activity, Energy Expenditure, and Defense of Body Weight in Melanocortin 4 Receptor-Deficient Male Rats. | Almundarij TI et al. | β | 2016 | β |
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| Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons. | Yang H et al. | β | 2016 | β |
| Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice. | Foglesong GD et al. | β | 2016 | β |
| Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases. | You HJ et al. | β | 2016 | β |
| Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia. | Kamitakahara A et al. | β | 2016 | β |
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| Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats. | Kim JY et al. | β | 2015 | β |
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| Brain-derived neurotrophic factor and its clinical implications. | Bathina S et al. | β | 2015 | β |
| Brain-derived neurotrophic factor and substrate utilization following acute aerobic exercise in obese individuals. | Slusher AL et al. | β | 2015 | β |
| Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus. | Liao GY et al. | β | 2015 | β |
| Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats. | Erdos B et al. | β | 2015 | β |
| Developmental specification of metabolic circuitry. | Elson AE et al. | β | 2015 | β |
| Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure. | An JJ et al. | β | 2015 | β |
| Evaluation of neurotrophic tyrosine receptor kinase 2 (NTRK2) as a positional candidate gene for variation in estimated glomerular filtration rate (eGFR) in Mexican American participants of San Antonio Family Heart study. | Thameem F et al. | β | 2015 | β |
| Exposure to sub-chronic unpredictable stress accounts for antidepressant-like effects in hamsters treated with BDNF and CNQX. | AlΓ² R et al. | β | 2015 | β |
| First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes. | Anderson D et al. | β | 2015 | β |
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| Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. | Mou Z et al. | β | 2015 | β |
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| Loxapine add-on for adolescents and adults with autism spectrum disorders and irritability. | Hellings JA et al. | β | 2015 | β |
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| Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus. | RamΓrez D et al. | β | 2015 | β |
| Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding. | Waterson MJ et al. | β | 2015 | β |
| Obesity genetics in mouse and human: back and forth, and back again. | Yazdi FT et al. | β | 2015 | β |
| Pituitary Adenylate Cyclase-Activating Peptide in the Central Amygdala Causes Anorexia and Body Weight Loss via the Melanocortin and the TrkB Systems. | Iemolo A et al. | β | 2015 | β |
| Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats. | NegrΓ³n AL et al. | β | 2015 | β |
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| Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. | Nakagomi A et al. | β | 2015 | β |
| Surgical and Nonsurgical Interventions for Obesity in Service of Preserving Cognitive Function. | Haley AP et al. | β | 2015 | β |
| Testing the Critical Window Hypothesis of Timing and Duration of Estradiol Treatment on Hypothalamic Gene Networks in Reproductively Mature and Aging Female Rats. | Yin W et al. | β | 2015 | β |
| The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia. | Bonaccorso S et al. | β | 2015 | β |
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| Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity. | Geibel M et al. | β | 2014 | β |
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| Anxiolytic drug discovery: what are the novel approaches and how can we improve them? | Stewart AM et al. | β | 2014 | β |
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| BDNF local translation in viable synaptosomes: implication in spine maturation. | Gharami K et al. | β | 2014 | β |
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| Genes and the hypothalamic control of metabolism in humans. | Hinney A et al. | β | 2014 | β |
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| Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. | Mao XY et al. | β | 2014 | β |
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| Hypothalamic dysfunction of the thrombospondin receptor Ξ±2Ξ΄-1 underlies the overeating and obesity triggered by brain-derived neurotrophic factor deficiency. | Cordeira JW et al. | β | 2014 | β |
| Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice. | Liu X et al. | β | 2014 | β |
| Increase of circulating BDNF levels and its relation to improvement of physical fitness following 12 weeks of combined exercise in chronic patients with schizophrenia: a pilot study. | Kim HJ et al. | β | 2014 | β |
| Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons. | Wang X et al. | β | 2014 | β |
| LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats. | Li JY et al. | β | 2014 | β |
| Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome. | Suriyaprom K et al. | β | 2014 | β |
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| Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner. | Barrett CE et al. | β | 2014 | β |
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| Obesity as a risk factor for poor neurocognitive outcomes in older adults with heart failure. | Alosco ML et al. | β | 2014 | β |
| Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling. | Ozek C et al. | β | 2014 | β |
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| Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity. | Liao GY et al. | β | 2013 | β |
| Activation of TrkB with TAM-163 results in opposite effects on body weight in rodents and non-human primates. | Perreault M et al. | β | 2013 | β |
| Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome. | Han JC et al. | β | 2013 | β |
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| Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior. | Gotoh K et al. | β | 2013 | β |
| Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia. | Shu X et al. | β | 2013 | β |
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| Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. | Robiou-du-Pont S et al. | β | 2013 | β |
| Developing 'integrative' zebrafish models of behavioral and metabolic disorders. | Nguyen M et al. | β | 2013 | β |
| Early postweaning exercise improves central leptin sensitivity in offspring of rat dams fed high-fat diet during pregnancy and lactation. | Sun B et al. | β | 2013 | β |
| Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model. | Komarnytsky S et al. | β | 2013 | β |
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| Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle. | Toda C et al. | β | 2013 | β |
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| Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. | Bernhard F et al. | β | 2013 | β |
| Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. | Guo Y et al. | β | 2013 | β |
| Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory. | Beck B et al. | β | 2013 | β |
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| Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. | Urabe H et al. | β | 2013 | β |
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| Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite. | Byerly MS et al. | β | 2013 | β |
| Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake. | Gao S et al. | β | 2013 | β |
| Improved leptin sensitivity as a potential candidate responsible for the spontaneous food restriction of the Lou/C rat. | Veyrat-Durebex C et al. | β | 2013 | β |
| Insight into the mechanisms of action of estrogen receptor Ξ² in the breast, prostate, colon, and CNS. | Dey P et al. | β | 2013 | β |
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| Lifestyle modification and behavior therapy effectively reduce body weight and increase serum level of brain-derived neurotrophic factor in obese non-diabetic patients with schizophrenia. | Kuo FC et al. | β | 2013 | β |
| Maintained expression of genes associated with metabolism in the ventromedial hypothalamic nucleus despite development of leptin resistance during pregnancy in the rat. | Phillipps HR et al. | β | 2013 | β |
| Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice. | Fox EA et al. | β | 2013 | β |
| Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism. | Shen Y et al. | β | 2013 | β |
| Melanocortin MC(4) receptor-mediated feeding and grooming in rodents. | Mul JD et al. | β | 2013 | β |
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| Molecular mechanisms involved in interleukin 1-beta (IL-1Ξ²)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (Ξ±-MSH). | Gonzalez P et al. | β | 2013 | β |
| Novel neuropeptides in the control of food intake: neuronostatin and nesfatin-1. | Yosten GL | β | 2013 | β |
| Obesogenic phenotype of offspring of dams fed a high multivitamin diet is prevented by a post-weaning high multivitamin or high folate diet. | Cho CE et al. | β | 2013 | β |
| Orexin-A suppresses postischemic glucose intolerance and neuronal damage through hypothalamic brain-derived neurotrophic factor. | Harada S et al. | β | 2013 | β |
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| Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis. | Choi YH et al. | β | 2013 | β |
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| BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. | Waterhouse EG et al. | β | 2012 | β |
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