None of the 42 known, confirmed or possible novel menarche variants were amino acid changing. However two were in strong LD (r2≥0.8) with non-synonymous (ns) variants. rs1862471 (intronic in OLFM2 at 19p13.2) is in LD (r2=0.8) with rs2303100, which encodes an Arg/Gln residue change in OLFM2. Secondly, rs4929923 (3′UTR of TRIM66 at 11p15.4) is in LD (r2=0.92) with rs11042023, which encodes a His/Arg residue change in TRIM66.
