Here we report a much expanded meta-analysis of GWAS for age at menarche. By combining data from the previous studies8–11 plus several further studies to form the ReproGen Consortium, we have identified at least 30 novel loci associated with age at menarche at genome-wide significance levels. Our findings demonstrate a close link between the genetic regulation of energy homeostasis and pubertal timing, and suggest the presence of other diverse pathways.
