A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
paper
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- Authors
- Frayling, Timothy M; Timpson, Nicholas J; Weedon, Michael N; Zeggini, Eleftheria; Freathy, Rachel M; Lindgren, Cecilia M; Perry, John R B; Elliott, Katherine S; Lango, Hana; Rayner, Nigel W; Shields, Beverley; Harries, Lorna W; Barrett, Jeffrey C; Ellard, Sian; Groves, Christopher J; Knight, Bridget; Patch, Ann-Marie; Ness, Andrew R; Ebrahim, Shah; Lawlor, Debbie A; Ring, Susan M; Ben-Shlomo, Yoav; Jarvelin, Marjo-Riitta; Sovio, Ulla; Bennett, Amanda J; Melzer, David; Ferrucci, Luigi; Loos, Ruth J F; Barroso, InΓͺs; Wareham, Nicholas J; Karpe, Fredrik; Owen, Katharine R; Cardon, Lon R; Walker, Mark; Hitman, Graham A; Palmer, Colin N A; Doney, Alex S F; Morris, Andrew D; Smith, George Davey; Hattersley, Andrew T; McCarthy, Mark I
- Year
- 2007
- Journal
- Science (New York, N.Y.)
- PMID
- 17434869
- DOI
- 10.1126/science.1141634
- PMCID
- PMC2646098
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
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| FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases. | Breeze CE et al. | β | 2024 | β |
| From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior. | Mahishi D et al. | β | 2024 | β |
| From Sugar Spikes to Pressure Peaks: Navigating the World of Diabetes, Hypertension, Obesity, and Kidney Health. | Hlyan NP et al. | β | 2024 | β |
| From the reward network to whole-brain metrics: structural connectivity in adolescents and young adults according to body mass index and genetic risk of obesity. | Prunell-CastaΓ±Γ© A et al. | β | 2024 | β |
| FTO gene polymorphism and susceptibility to polycystic ovary syndrome: A meta-analysis. | Zhang C et al. | β | 2024 | β |
| FTO genotype and body mass index reduction in childhood obesity interventions: A systematic review and meta-analysis. | Chen J et al. | β | 2024 | β |
| FTO in health and disease. | Benak D et al. | β | 2024 | β |
| FTO in Lung Cancer: Its Progression and Therapeutic Potential. | Chen XF et al. | β | 2024 | β |
| FTO in oral diseases: Functions, mechanisms, and therapeutic potential. | Li B et al. | β | 2024 | β |
| FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions. | He J et al. | β | 2024 | β |
| FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery. | Li G et al. | β | 2024 | β |
| FTO variation and early frontostriatal brain development in children. | Thapaliya G et al. | β | 2024 | β |
| Future development trend of food-borne delivery systems of functional substances for precision nutrition. | Luo S et al. | β | 2024 | β |
| GAS5 regulated by FTO-mediated m6A modification suppresses cell proliferation via the IGF2BP2/QKI axis in breast cancer. | Yan Y et al. | β | 2024 | β |
| Genetic architecture of preeclampsia. | Manoharan A et al. | β | 2024 | β |
| Genetic associations with neural reward responsivity to food cues in children. | Yeum D et al. | β | 2024 | β |
| Genetic insights into endurance athlete status: A meta-analysis of <i>ACVR1B, AGT, FTO, IL-6, and NRF2</i> gene polymorphisms. | Δ°pekoΔlu G et al. | β | 2024 | β |
| Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring. | Benonisdottir S et al. | β | 2024 | β |
| Genetics, pharmacotherapy, and dietary interventions in childhood obesity. | Son JE | β | 2024 | β |
| Genetic studies of type 2 diabetes, and microvascular complications of diabetes. | Imamura M et al. | β | 2024 | β |
| Genetic Variants Associated with Body Mass Index Changes in Korean Adults: The Anseong and Ansan Cohorts of the Korean Genome and Epidemiology Study. | Lee SI et al. | β | 2024 | β |
| Genetic Variants in the Fat Mass and Obesity-Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta-Analysis. | Eghbali M et al. | β | 2024 | β |
| Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly. | Silva Barcelos EC et al. | β | 2024 | β |
| Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content. | Li Y et al. | β | 2024 | β |
| Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review. | SΓ‘mano R et al. | β | 2024 | β |
| Glycolysis modulation: New therapeutic strategies to improve pulmonary hypertension (Review). | Chen M et al. | β | 2024 | β |
| Human brain proteome-wide association study provides insights into the genetic components of protein abundance in obesity. | Zhao QG et al. | β | 2024 | β |
| Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression. | Liu S et al. | β | 2024 | β |
| Identifying latent genetic interactions in genome-wide association studies using multiple traits. | Bass AJ et al. | β | 2024 | β |
| <i>FTO</i> rs9939609: T>A Variant and Physical Inactivity as Important Risk Factors for Class III Obesity: A Cross-Sectional Study. | MartΓnez-LΓ³pez E et al. | β | 2024 | β |
| Immunogenetic Aspects of Sarcopenic Obesity. | Mazurkiewicz Ε et al. | β | 2024 | β |
| Implications of obesity and insulin resistance for the treatment of oestrogen receptor-positive breast cancer. | Javed SR et al. | β | 2024 | β |
| Influence of obesity on blood glucose control using continuous glucose monitoring data among patients with type 1 diabetes. | Nicolau J et al. | β | 2024 | β |
| INNOVATIONS IN DIABETES MELLITUS MANAGEMENT: A REVIEW OF USFDA-APPROVED DRUGS AND PHASE 3 CLINICAL TRIALS. | Lasure V et al. | β | 2024 | β |
| Insights into the m<sup>6</sup>A demethylases FTO and ALKBH5 : structural, biological function, and inhibitor development. | Gao Z et al. | β | 2024 | β |
| Insights into the role of RNA m<sup>6</sup>A modification in the metabolic process and related diseases. | Hu H et al. | β | 2024 | β |
| Insulin Resistance in Pediatric Obesity: From Mechanisms to Treatment Strategies. | Luo Y et al. | β | 2024 | β |
| Interactions of spontaneous abortion with <i>FTO</i> gene and dietary carotenoids; a case-control study. | Amjadi A et al. | β | 2024 | β |
| Investigating the Role of Fat Mass and Obesity-Associated (FTO) Single Nucleotide Polymorphisms and Methylation in Breast Cancer. | HernΓ‘ndez-Caballero ME et al. | β | 2024 | β |
| Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy. | Chen X et al. | β | 2024 | β |
| Lifestyle risk factors and all-cause and cause-specific mortality in the Mexico City prospective study: Assessing the influence of reverse causation. | Ferrari G et al. | β | 2024 | β |
| Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy. | Nakamura M | β | 2024 | β |
| LncRNA CCRR maintains Ca<sup>2+</sup> homeostasis against myocardial infarction through the FTO-SERCA2a pathway. | Yang H et al. | β | 2024 | β |
| Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk. | Reshetnikov E et al. | β | 2024 | β |
| Maximal Fat Oxidation During Exercise in Healthy Individuals: Lack of Genetic Association with the <i>FTO</i> rs9939609 Polymorphism. | GarcΓa-Pastor T et al. | β | 2024 | β |
| Mechanisms and risk factors of metabolic syndrome in children and adolescents. | Codazzi V et al. | β | 2024 | β |
| Mitochondrial DNA: Inherent Complexities Relevant to Genetic Analyses. | Ferreira T et al. | β | 2024 | β |
| Morphine-Driven m6A Epitranscriptomic Neuroadaptations in Primary Cortical Cultures. | Dabrowski KR et al. | β | 2024 | β |
| Multiomics Picture of Obesity in Young Adults. | Kiseleva OI et al. | β | 2024 | β |
| N6-methyladenosine RNA methylation, a new hallmark of metabolic reprogramming in the immune microenvironment. | Li X et al. | β | 2024 | β |
| Neuroendocrinological and Clinical Aspects of Leptin. | Yanik T et al. | β | 2024 | β |
| New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma. | Li YJ et al. | β | 2024 | β |
| Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs. | Agarwal T et al. | β | 2024 | β |
| Obesity, diabetes and risk of bone fragility: How BMAT behavior is affected by metabolic disturbances and its influence on bone health. | GuimarΓ£es GC et al. | β | 2024 | β |
| Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation. | Wu S et al. | β | 2024 | β |
| Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies. | Keijer J et al. | β | 2024 | β |
| [One perspective of the genetic correlations between obesity, type 2 diabetes and cancer]. | BΓ‘nhegyi RJ et al. | β | 2024 | β |
| Parental genetic effects on the offspring's phenotype without transmission of the gene itself-pathophysiology and clinical evidence. | Zhang X et al. | β | 2024 | β |
| Perspectives on genetic studies of typeβ2 diabetes from the genome-wide association studies era to precision medicine. | Imamura M et al. | β | 2024 | β |
| Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China. | Wang Y et al. | β | 2024 | β |
| Prevalence of overweight/obesity, and associated factors among adolescents aged 12Β βΌΒ 15 in Shandong Province, China: A cross-sectional study. | Huang Z et al. | β | 2024 | β |
| Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies. | Gupta MK et al. | β | 2024 | β |
| Relation between Polygenic Risk Score, Vitamin D Status and BMI-for-Age <i>z</i> Score in Chinese Preschool Children. | Peng L et al. | β | 2024 | β |
| Research progress on m6A demethylase FTO and its role in gynecological tumors. | Wang S et al. | β | 2024 | β |
| Review on GPU accelerated methods for genome-wide SNP-SNP interactions. | Ren W et al. | β | 2024 | β |
| RNA modifications in physiology and disease: towards clinical applications. | Delaunay S et al. | β | 2024 | β |
| Sex-based differences in short- and longer-term diet-induced metabolic heart disease. | Croft AJ et al. | β | 2024 | β |
| Strengthening the Evidence for a Causal Link between Type 2 Diabetes Mellitus and Pancreatic Cancer: Insights from Two-Sample and Multivariable Mendelian Randomization. | Ke TM et al. | β | 2024 | β |
| Systems genetics of metabolic health in the BXD mouse genetic reference population. | Li X et al. | β | 2024 | β |
| Tamping Down the Fire: Taming Pyroptosis through RNA Methylation in Acute Lung Injury. | Shin KWD et al. | β | 2024 | β |
| Targeted inhibition of m6A demethylase FTO by FB23 attenuates allergic inflammation in the airway epithelium. | Lian Z et al. | β | 2024 | β |
| The Combination of Resveratrol and Conjugated Linoleic Acid Dienes Enhances the Individual Effects of These Molecules on De Novo Fatty Acid Biosynthesis in 3T3-L1 Adipocytes. | Oczkowicz J et al. | β | 2024 | β |
| The complex web of obesity: from genetics to precision medicine. | M JN et al. | β | 2024 | β |
| The Impact of Haplotypes of the <i>FTO</i> Gene, Lifestyle, and Dietary Patterns on BMI and Metabolic Syndrome in Polish Young Adult Men. | GΓ³rczyΕska-Kosiorz S et al. | β | 2024 | β |
| The interactions of spontaneous abortion, dietary intake of selenium, and fat mass and obesity associated (FTO) genotype: a case-control study in Iran. | Nooriani N et al. | β | 2024 | β |
| The molecular regulated mechanism of METTL3 and FTO in lipid metabolism of Hu sheep. | Chen B et al. | β | 2024 | β |
| The Relationship between Proinflammatory Molecules and PD-L1 in Patients with Obesity Who Underwent Gastric Sleeve Surgery-A Pilot Study. | Cucoreanu C et al. | β | 2024 | β |
| The RNA N6-methyladenosine demethylase FTO regulates ATG5 to inhibit malignant progression of uveal melanoma. | Yang Y et al. | β | 2024 | β |
| The Role of FTO Risk Haplotype in Overweight/Obesity and Lipid Parameters-Results From the Central China Population Study. | Ning M et al. | β | 2024 | β |
| The role of m<sup>6</sup>A modification in type 2 diabetes: A systematic review and integrative analysis. | Li YL et al. | β | 2024 | β |
| The role of N6-methyladenosine RNA methylation in the crosstalk of circadian clock and neuroinflammation in rodent suprachiasmatic nuclei. | FilipovskΓ‘ E et al. | β | 2024 | β |
| The utility of obesity polygenic risk scores from research to clinical practice: A review. | Jansen PR et al. | β | 2024 | β |
| Translational potential of mouse models of human metabolic disease. | Farooqi IS et al. | β | 2024 | β |
| Translation of genome-wide association study: from genomic signals to biological insights. | Bruner WS et al. | β | 2024 | β |
| Ubiquitination and Metabolic Disease. | Ma M et al. | β | 2024 | β |
| Understanding the cause of type 2 diabetes. | Taylor R | β | 2024 | β |
| Unsupervised clustering identified clinically relevant metabolic syndrome endotypes in UK and Taiwan Biobanks. | Lim AMW et al. | β | 2024 | β |
| Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2. | Littleton SH et al. | β | 2024 | β |
| Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity. | Xie R et al. | β | 2023 | β |
| Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice. | Yan S et al. | β | 2023 | β |
| A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk. | Aglago EK et al. | β | 2023 | β |
| A lncRNA from the FTO locus acts as a suppressor of the m<sup>6</sup>A writer complex and p53 tumor suppression signaling. | Zhang J et al. | β | 2023 | β |
| Anti-Obesity Effects of Chitosan and Its Derivatives. | Shagdarova B et al. | β | 2023 | β |
| A single FTO gene variant rs9939609 is associated with weight change and insulin resistance improvement in response to a robotic sleeve gastrectomy in individuals with severe obesity. | de Luis DA et al. | β | 2023 | β |
| Association of common genetic variants with body mass index in Russian population. | Berseneva A et al. | β | 2023 | β |
| Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India. | Chaudhary H et al. | β | 2023 | β |
| Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia. | Bednarova A et al. | β | 2023 | β |
| Association of lipid metabolism-related metabolites with overweight/obesity based on the FTO rs1421085. | Farooq S et al. | β | 2023 | β |
| Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations. | Krishnan M et al. | β | 2023 | β |
| Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case-control study. | Wu TW et al. | β | 2023 | β |
| A study to investigate genetic factors associated with weight gain in people with diabetes: analysis of polymorphisms in four relevant genes. | Heald A et al. | β | 2023 | β |
| Biobehavioral susceptibility for obesity in childhood: Behavioral, genetic and neuroimaging studies of appetite. | Carnell S et al. | β | 2023 | β |
| Body Adiposity Partially Mediates the Association between <i>FTO</i> rs9939609 and Lower Adiponectin Levels in Chilean Children. | Ochoa-Rosales C et al. | β | 2023 | β |
| Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study. | Karageorgiou V et al. | β | 2023 | β |
| Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m<sup>6</sup>A coordinated manner. | Huang C et al. | β | 2023 | β |
| Candidate genes related to acute cerebral circulatory disorders in Preeclampsia in the Kazakh Population. | Svyatova G et al. | β | 2023 | β |
| Cell Differentiation and Aging Lead To Up-Regulation of FTO, While the ALKBH5 Protein Level Was Stable During Aging but Up-Regulated During in vitro-Induced Cardiomyogenesis. | KrejΔΓ J et al. | β | 2023 | β |
| Characteristics of N<sup>6</sup>-methyladenosine Modification During Sexual Reproduction of Chlamydomonas reinhardtii. | Lv Y et al. | β | 2023 | β |
| Childhood Obesity: Insight into Kidney Involvement. | Carullo N et al. | β | 2023 | β |
| Connecting the dots in the associations between diet, obesity, cancer, and microRNAs. | Otsuka K et al. | β | 2023 | β |
| Considerations of the Genetic Background of Obesity among Patients with Psoriasis. | Czarnecka A et al. | β | 2023 | β |
| Constructing a polygenic risk score for childhood obesity using functional data analysis. | Craig SJC et al. | β | 2023 | β |
| Construction of Multiple DNAzymes Driven by Single Base Elongation and Ligation for Single-Molecule Monitoring of FTO in Cancer Tissues. | Zhao NN et al. | β | 2023 | β |
| Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children. | SzczeΕniewska P et al. | β | 2023 | β |
| Coordination of RNA modifications in the brain and beyond. | Chen AY et al. | β | 2023 | β |
| Cross-modal autoencoder framework learns holistic representations of cardiovascular state. | Radhakrishnan A et al. | β | 2023 | β |
| Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact. | Santos-Pereira M et al. | β | 2023 | β |
| Development of genome-wide association studies on childhood obesity and its indicators: A scoping review and enrichment analysis. | Zhou F et al. | β | 2023 | β |
| Domain-adaptive neural networks improve supervised machine learning based on simulated population genetic data. | Mo Z et al. | β | 2023 | β |
| Downregulation of FTO in the hippocampus is associated with mental disorders induced by fear stress during pregnancy. | Jiang Y et al. | β | 2023 | β |
| Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma. | Wu Y et al. | β | 2023 | β |
| Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment. | Lechner L et al. | β | 2023 | β |
| Emerging Role and Mechanism of the <i>FTO</i> Gene in Cardiovascular Diseases. | Xu ZY et al. | β | 2023 | β |
| Emerging roles of biological m<sup>6</sup>A proteins in regulating virus infection: A review. | Chen Y et al. | β | 2023 | β |
| Epitranscriptomics in metabolic disease. | Matsumura Y et al. | β | 2023 | β |
| Examining paradoxical session attendance and weight loss relationships in a clinic based lifestyle modification intervention. | Azar KMJ et al. | β | 2023 | β |
| Exploring Dietary Intake in Adults with Severe Obesity and Associations with the <i>FTO</i> rs9939609 Genotypes. | de Soysa AKH et al. | β | 2023 | β |
| Exploring the Impact of Insertion/Deletion in <i>FTO</i> and <i>PLIN1</i> Genes on Morphometric Traits in Sheep. | Wang X et al. | β | 2023 | β |
| Food insecurity as a cause of adiposity: evolutionary and mechanistic hypotheses. | Bateson M et al. | β | 2023 | β |
| FTO and MC4R polymorphisms, and selected pre-, peri- and postnatal factors as determinants ofΒ body mass index and fatness in children: a thorough analysisΒ of the associations. | Bryl E et al. | β | 2023 | β |
| FTO gene variants (rs9939609, rs8050136 and rs17817449) and type 2 diabetes mellitus risk: A Meta-Analysis. | Amine Ikhanjal M et al. | β | 2023 | β |
| FTO promotes cervical cancer cell proliferation, colony formation, migration and invasion via the regulation of the BMP4/Hippo/YAP1/TAZ pathway. | Huang J et al. | β | 2023 | β |
| Functions of N6-methyladenosine in cancer metabolism: from mechanism to targeted therapy. | He J et al. | β | 2023 | β |
| Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study. | Chen J et al. | β | 2023 | β |
| Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review. | Pledger SL et al. | β | 2023 | β |
| Genetic architecture of adiposity measures among Asians: Findings from GWAS. | Agarwal T et al. | β | 2023 | β |
| Genetic contributions to risk of adverse pregnancy outcomes. | Hughes ZH et al. | β | 2023 | β |
| Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood. | Hawkes G et al. | β | 2023 | β |
| Genetic risk score for common obesity and anthropometry in Spanish schoolchildren. | CalderΓ³n GarcΓa A et al. | β | 2023 | β |
| Genetics and Epigenetics in Obesity: What Do We Know so Far? | Keller M et al. | β | 2023 | β |
| Genetics and epigenetics in the obesity phenotyping scenario. | Trang K et al. | β | 2023 | β |
| Genetics of diabetes. | Goyal S et al. | β | 2023 | β |
| Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice. | Xie X et al. | β | 2023 | β |
| Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss. | Mera-Charria A et al. | β | 2023 | β |
| Genetic variant rs9939609 in <i>FTO</i> is associated with body composition and obesity risk in Korean females. | Park HG et al. | β | 2023 | β |
| Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review. | van der Meer R et al. | β | 2023 | β |
| Genome Editing and Obesity. | Masi D et al. | β | 2023 | β |
| Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics. | Rapuano KM et al. | β | 2023 | β |
| Human abdominal subcutaneous-derived active beige adipocytes carrying <i>FTO</i> rs1421085 obesity-risk alleles exert lower thermogenic capacity. | VΓ‘mos A et al. | β | 2023 | β |
| Human height: a model common complex trait. | Conery M et al. | β | 2023 | β |
| <i>FTO</i> Gene Polymorphisms and Their Roles in Acromegaly. | Jawiarczyk-PrzybyΕowska A et al. | β | 2023 | β |
| <i>FTO</i> Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences. | PopoviΔ AM et al. | β | 2023 | β |
| <i>FTO</i> promoted adipocyte differentiation by regulating <i>ADRB1</i> gene through m<sup>6</sup>A modification in Hycole rabbits. | Luo G et al. | β | 2023 | β |
| <i>FTO</i> Regulated Intramuscular Fat by Targeting <i>APMAP</i> Gene via an m<sup>6</sup>A-YTHDF2-dependent Manner in Rex Rabbits. | Luo G et al. | β | 2023 | β |
| <i>GDF15</i> plays a critical role in insulin secretion in INS-1 cells and human pancreatic islets. | Mohammad MG et al. | β | 2023 | β |
| Impact of the FTO Gene Variation on Appetite and Fat Oxidation in Young Adults. | Ponce-Gonzalez JG et al. | β | 2023 | β |
| Improving the accuracy and internal consistency of regression-based clustering of high-dimensional datasets. | Zhang B et al. | β | 2023 | β |
| Increased meso-striatal connectivity mediates trait impulsivity in <i>FTO</i> variant carriers. | Edwin Thanarajah S et al. | β | 2023 | β |
| Influence of polymorphisms in candidate genes on carcass and meat quality traits in rabbits. | Safaa HM et al. | β | 2023 | β |
| Inhibition of Hypothalamic FTO Activates STAT3 Signal through ERK1/2 Associated with Reductions in Food Intake and Body Weight. | Hu F et al. | β | 2023 | β |
| Insights into RNA N6-methyladenosine in Glucose and Lipid Metabolic Diseases and Their Therapeutic Strategies. | Wu Y et al. | β | 2023 | β |
| Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children. | Viljakainen H et al. | β | 2023 | β |
| Investigation of associations of European, African, Amerindian genomic ancestries and MC4R, FTO, FAIM2, BDNF loci with obesity-related traits in Rio de Janeiro, Brazil. | Scharf A et al. | β | 2023 | β |
| Kinetic Studies on the 2-Oxoglutarate/Fe(II)-Dependent Nucleic Acid Modifying Enzymes from the AlkB and TET Families. | Peng Z et al. | β | 2023 | β |
| KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children. | GalmΓ©s S et al. | β | 2023 | β |
| Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis. | Lamichhane P et al. | β | 2023 | β |
| Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene. | Kentistou KA et al. | β | 2023 | β |
| Longitudinal effects of FTO gene polymorphism on body composition, cardiorespiratory fitness, physical activity, inflammatory markers, and cardiovascular risk in children and adolescents. "The UP & DOWN study". | Mier-Mota J et al. | β | 2023 | β |
| Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight. | Reshetnikova Y et al. | β | 2023 | β |
| Metabolic Syndrome: An Overview on Its Genetic Associations and Gene-Diet Interactions. | Prone-Olazabal D et al. | β | 2023 | β |
| Metabolic syndrome: Nutri-epigenetic cause or consequence? | Silva-Ochoa AD et al. | β | 2023 | β |
| Metformin alleviates the cognitive impairment induced by benzo[a]pyrene via glucolipid metabolism regulated by FTO/FoxO6 pathway in mice. | Zhao T et al. | β | 2023 | β |
| Minor alleles in the <i>FTO</i> SNPs contributed to the increased risk of obesity among Korean adults: meta-analysis from nationwide big data-based studies. | Kim OY et al. | β | 2023 | β |
| m<sup>6</sup> A demethylase Fto regulates the TNF-Ξ±-induced inflammatory response in cementoblasts. | Li B et al. | β | 2023 | β |
| m<sup>6</sup>A reader proteins: the executive factors in modulating viral replication and host immune response. | Yang D et al. | β | 2023 | β |
| N6-methyladenosine in hematological malignancies: a concise review. | Wang WJ et al. | β | 2023 | β |
| N6-methyladenosine reader YTHDF family in biological processes: Structures, roles, and mechanisms. | Chen L et al. | β | 2023 | β |
| NEFA Dynamics in Adults With Severe Obesity and Insulin Resistance: No Coupling to the rs9939609 <i>FTO</i> Risk Allele. | Mostad IL et al. | β | 2023 | β |
| New evidence for the effect of type 2 diabetes and glycemic traits on testosterone levels: a two-sample Mendelian randomization study. | Jiang C et al. | β | 2023 | β |
| N<sup>6</sup>-methyladenosine modification-a key player in viral infection. | Zhang X et al. | β | 2023 | β |
| Obesity and chronic kidney disease: A current review. | Nawaz S et al. | β | 2023 | β |
| Obesity Management in Children and Adolescents. | Wong G et al. | β | 2023 | β |
| Obesity-Related Single-Nucleotide Polymorphisms and Weight Gain Following First-Line Antiretroviral Therapy. | Berenguer J et al. | β | 2023 | β |
| Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome. | Song Y et al. | β | 2023 | β |
| Position statement on nutrition therapy for overweight and obesity: nutrition department of the Brazilian association for the study of obesity and metabolic syndrome (ABESO-2022). | Pepe RB et al. | β | 2023 | β |
| Precision medicine of obesity as an integral part of type 2 diabetes management - past, present, and future. | Szczerbinski L et al. | β | 2023 | β |
| Precision Nutrition to Improve Risk Factors of Obesity and Type 2 Diabetes. | Antwi J | β | 2023 | β |
| Pre-eclampsia. | Dimitriadis E et al. | β | 2023 | β |
| Rare genetic forms of obesity in childhood and adolescence, a comprehensive review of their molecular mechanisms and diagnostic approach. | Mainieri F et al. | β | 2023 | β |
| RNA modification: mechanisms and therapeutic targets. | Qiu L et al. | β | 2023 | β |
| RNA Modifications in Cancer Metabolism and Tumor Microenvironment. | Qing Y et al. | β | 2023 | β |
| RNA N6-methyladenosine methylation and skin diseases. | Yu Y et al. | β | 2023 | β |
| RNA N<sup>6</sup>-methyladenosine modification in female reproductive biology and pathophysiology. | Huang E et al. | β | 2023 | β |
| Role of TNF-Ξ±-induced m6A RNA methylation in diseases: a comprehensive review. | Wang Y et al. | β | 2023 | β |
| Sex and Race Differences in Obesity-Related Genetic Susceptibility and Risk of Cardiometabolic Disease in Older US Adults. | Yu H et al. | β | 2023 | β |
| Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases. | Huang C et al. | β | 2023 | β |
| Technologies, strategies, and cautions when deconvoluting genome-wide association signals: FTO in focus. | Pahl MC et al. | β | 2023 | β |
| The Causal Effect of Dietary Composition on the Risk of Breast Cancer: A Mendelian Randomization Study. | Dong H et al. | β | 2023 | β |
| The crucial roles of m<sup>6</sup>A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies. | Huang C et al. | β | 2023 | β |
| The Emerging Role of m6A Modification in Endocrine Cancer. | Ji X et al. | β | 2023 | β |
| The genetic basis of major depressive disorder. | Flint J | β | 2023 | β |
| The impact of acute exercise on appetite control: Current insights and future perspectives. | Thackray AE et al. | β | 2023 | β |
| The obesity associated FTO gene polymorphism and the risk of preeclampsia in Iranian women: A case-control study. | Azizi-Tabesh G et al. | β | 2023 | β |
| The Proteins of mRNA Modification: Writers, Readers, and Erasers. | Flamand MN et al. | β | 2023 | β |
| The regulation of m<sup>6</sup>A-related proteins during whole-body freezing of the freeze-tolerant wood frog. | Rehman S et al. | β | 2023 | β |
| The role of m<sup>6</sup>A demethylase FTO in chemotherapy resistance mediating acute myeloid leukemia relapse. | Zhang ZW et al. | β | 2023 | β |
| The rs1421085 variant within FTO promotes brown fat thermogenesis. | Zhang Z et al. | β | 2023 | β |
| Timing of Meals and Sleep in the Mediterranean Population: The Effect of Taste, Genetics, Environmental Determinants, and Interactions on Obesity Phenotypes. | BarragΓ‘n R et al. | β | 2023 | β |
| Tree-based QTL mapping with expected local genetic relatedness matrices. | Link V et al. | β | 2023 | β |
| Understanding the contemporary high obesity rate from an evolutionary genetic perspective. | Wu T et al. | β | 2023 | β |
| Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders. | Singh S et al. | β | 2023 | β |
| Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. | Palermo J et al. | β | 2023 | β |
| A Comprehensive Survey of Prospective Structure-Based Virtual Screening for Early Drug Discovery in the Past Fifteen Years. | Zhu H et al. | β | 2022 | β |
| A Deep-Learning Approach for Inference of Selective Sweeps from the Ancestral Recombination Graph. | Hejase HA et al. | β | 2022 | β |
| Analysis of coding variants in the human FTO gene from the gnomAD database. | Souza Junior MLF et al. | β | 2022 | β |
| Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index. | Gurtan A et al. | β | 2022 | β |
| A Novel Hierarchical Clustering Approach for Joint Analysis of Multiple Phenotypes Uncovers Obesity Variants Based on ARIC. | Fu L et al. | β | 2022 | β |
| A novel inhibitor of <i>N</i> <sup>6</sup>-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities. | Xie G et al. | β | 2022 | β |
| Anti-obesity drug discovery: advances and challenges. | MΓΌller TD et al. | β | 2022 | β |
| Arrhythmic Sudden Cardiac Death in Heart Failure With Preserved Ejection Fraction: Mechanisms, Genetics, and Future Directions. | Safabakhsh S et al. | β | 2022 | β |
| Association between FTO (rs17817449) genetic variant, gamma-glutamyl transferase, and hypertension in Slovak midlife women. | FalbovΓ‘ D et al. | β | 2022 | β |
| Association of ADIPOQ-rs2241766 and FTO-rs9939609 genetic variants with body mass index trajectory in women of reproductive age over 6 years of follow-up: the PREDI study. | Kroll C et al. | β | 2022 | β |
| Associations between <i>FTO</i> rs9939609 polymorphism, serum vitamin D, mental health, and eating behaviors in overweight adults. | Mehrdad M et al. | β | 2022 | β |
| Biological roles of the RNA m<sup>6</sup>A modification and its implications in cancer. | Hong J et al. | β | 2022 | β |
| Breastfeeding moderates the relationship between <i>fat mass and obesity-associated gene</i> rs9939609 and body mass index among adolescents. | Kanders SH et al. | β | 2022 | β |
| CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue. | Bai N et al. | β | 2022 | β |
| Cohort Profile: 46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966). | NordstrΓΆm T et al. | β | 2022 | β |
| Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles. | Tan B et al. | β | 2022 | β |
| Comprehensive mutations analyses of <i>FTO</i> (fat mass and obesity-associated gene) and their effects on FTO's substrate binding implicated in obesity. | Kumar R et al. | β | 2022 | β |
| Computational Genomics in the Era of Precision Medicine: Applications to Variant Analysis and Gene Therapy. | Wang YC et al. | β | 2022 | β |
| Computational study of potential inhibitors for fat mass and obesity-associated protein from seaweed and plant compounds. | Prabhakar L et al. | β | 2022 | β |
| Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders. | Yang Z et al. | β | 2022 | β |
| Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities. | Son JE et al. | β | 2022 | β |
| Detailed resume of RNA m<sup>6</sup>A demethylases. | Shen D et al. | β | 2022 | β |
| Distinct causal effects of body fat distribution on cardiometabolic traits among children: Findings from the BCAMS study. | Fu L et al. | β | 2022 | β |
| Do adverse childhood experiences and genetic obesity risk interact in relation to body mass index in young adulthood? Findings from the National Longitudinal Study of Adolescent to Adult Health. | Inoue Y et al. | β | 2022 | β |
| Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data. | Guo F et al. | β | 2022 | β |
| Effect of the m6ARNA gene on the prognosis of thyroid cancer, immune infiltration, and promising immunotherapy. | Xia M et al. | β | 2022 | β |
| Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia. | Abramova M et al. | β | 2022 | β |
| Emerging Roles of FTO in Neuropsychiatric Disorders. | Chang R et al. | β | 2022 | β |
| Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores. | Bond TA et al. | β | 2022 | β |
| Exploring the genetic correlation between obesity-related traits and regional brain volumes: Evidence from UK Biobank cohort. | Pan X et al. | β | 2022 | β |
| Factors Associated with Eating in the Absence of Hunger among Children and Adolescents: A Systematic Review. | Savard C et al. | β | 2022 | β |
| Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight. | Thompson WD et al. | β | 2022 | β |
| Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region. | FernΓ‘ndez LP et al. | β | 2022 | β |
| FTO and Anthropometrics: The Role of Modifiable Factors. | Evans C et al. | β | 2022 | β |
| FTO in cancer: functions, molecular mechanisms, and therapeutic implications. | Li Y et al. | β | 2022 | β |
| FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms. | Azzam SK et al. | β | 2022 | β |
| FTO Prevents Thyroid Cancer Progression by SLC7A11 m6A Methylation in a Ferroptosis-Dependent Manner. | Ji FH et al. | β | 2022 | β |
| FTO Regulates Apoptosis in CPB2-Treated IPEC-J2 Cells by Targeting Caspase 3 Apoptotic Protein. | Yang J et al. | β | 2022 | β |
| FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression. | McFadden MJ et al. | β | 2022 | β |
| Functional roles of epitranscriptomic marks in the cardiovascular system and disease: a narrative review. | Ilieva M et al. | β | 2022 | β |
| Gene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer. | Li Y et al. | β | 2022 | β |
| Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. | Gorski M et al. | β | 2022 | β |
| Genetics and Epigenetics in Personalized Nutrition: Evidence, Expectations, and Experiences. | Holzapfel C et al. | β | 2022 | β |
| Genetics, epigenetics and transgenerational transmission of obesity in children. | Panera N et al. | β | 2022 | β |
| Genetics of murine type 2 diabetes and comorbidities. | Lone IM et al. | β | 2022 | β |
| Genetics of Obesity in Humans: A Clinical Review. | Mahmoud R et al. | β | 2022 | β |
| Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? | GaluΕ‘ka D et al. | β | 2022 | β |
| Genetic variation in satiety signaling and hypothalamic inflammation: merging fields for the study of obesity. | Szalanczy AM et al. | β | 2022 | β |
| Genetic variation rs1121980 in the fat mass and obesity-associated gene (<i>FTO</i>) is associated with dietary intake in Koreans. | Goh Y et al. | β | 2022 | β |
| Genome-Wide Association Study of Exercise-Induced Fat Loss Efficiency. | Bojarczuk A et al. | β | 2022 | β |
| Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis. | Liu Q et al. | β | 2022 | β |
| Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy. | Czapiewski R et al. | β | 2022 | β |
| Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. | Tsao CW et al. | β | 2022 | β |
| Higher Waist Hip Ratio Genetic Risk Score Is Associated with Reduced Weight Loss in Patients with Severe Obesity Completing a Meal Replacement Programme. | Handley D et al. | β | 2022 | β |
| Identification of genetic variants related to metabolic syndrome by next-generation sequencing. | Lee S et al. | β | 2022 | β |
| Identification of molecular patterns and diagnostic biomarkers in juvenile idiopathic arthritis based on the gene expression of m<sup>6</sup>A regulators. | Zhang S et al. | β | 2022 | β |
| <i>FTO</i> Common Obesity SNPs Interact with Actionable Environmental Factors: Physical Activity, Sugar-Sweetened Beverages and Wine Consumption. | Chermon D et al. | β | 2022 | β |
| <i>FTO</i> gene polymorphisms and hepatoblastoma susceptibility among Chinese children. | Fan J et al. | β | 2022 | β |
| Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders? | Breton E et al. | β | 2022 | β |
| Impact of N6-methyladenosine (m<sup>6</sup>A) modification on immunity. | Elsabbagh RA et al. | β | 2022 | β |
| Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots. | Agrawal S et al. | β | 2022 | β |
| Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects. | Vitacolonna E et al. | β | 2022 | β |
| Insights Into Genome-Wide Association Study for Diabetes: A Bibliometric and Visual Analysis From 2001 to 2021. | Liu Y et al. | β | 2022 | β |
| Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle. | Rakha A et al. | β | 2022 | β |
| Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank. | Dashti HS et al. | β | 2022 | β |
| Interactive effects of the low-carbohydrate diet score and genetic risk score on Hypo-HDL-cholesterolemia among Korean adults: A cross-sectional analysis from the Ansan and Ansung Study of the Korean Genome and Epidemiology Study. | Park S et al. | β | 2022 | β |
| Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysis. | Pudjihartono M et al. | β | 2022 | β |
| Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis. | Takaoka R et al. | β | 2022 | β |
| Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits. | Sonti S et al. | β | 2022 | β |
| Long-term exercise training down-regulates m<sup>6</sup>A RNA demethylase FTO expression in the hippocampus and hypothalamus: an effective intervention for epigenetic modification. | Liu SJ et al. | β | 2022 | β |
| Lower miR-21/ROS/HNE levels associate with lower glycemia after habit-intervention: DIAPASON study 1-year later. | La Sala L et al. | β | 2022 | β |
| Low expression of exosomal miR-150 predicts poor prognosis in colorectal cancer patients after surgical resections. | Zhang Y et al. | β | 2022 | β |
| Mediterranean Diet and Genetic Determinants of Obesity and Metabolic Syndrome in European Children and Adolescents. | Seral-Cortes M et al. | β | 2022 | β |
| Molecular modelling of novel ADCY3 variantΒ predicts a molecular target for tackling obesity. | Toumba M et al. | β | 2022 | β |
| M<sup>6</sup>A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression. | Lv D et al. | β | 2022 | β |
| m<sup>6</sup>A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte. | Li K et al. | β | 2022 | β |
| m<sup>6</sup>A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2. | Wang W et al. | β | 2022 | β |
| Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance. | Lin H et al. | β | 2022 | β |
| Nanoparticle-Induced m<sup>6</sup>A RNA Modification: Detection Methods, Mechanisms and Applications. | Wang Y et al. | β | 2022 | β |
| Novel insights into the interaction between N6-methyladenosine modification and circular RNA. | Xu T et al. | β | 2022 | β |
| Novel insights into the N<sup>6</sup>-methyladenosine RNA modification and phytochemical intervention in lipid metabolism. | Li L et al. | β | 2022 | β |
| Novel Noninvasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy. | Angelidi AM et al. | β | 2022 | β |
| N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA modification as a metabolic switch between plant cell survival and death in leaf senescence. | Rudy E et al. | β | 2022 | β |
| Obesity and Attention-Deficit Hyperactivity Disorder. | Lanoye A et al. | β | 2022 | β |
| Obesity, Bone Loss, and Periodontitis: The Interlink. | Zhao P et al. | β | 2022 | β |
| Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO. | Zuidhof HR et al. | β | 2022 | β |
| Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus. | Ortega-Contreras B et al. | β | 2022 | β |
| Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation. | Fabozzi G et al. | β | 2022 | β |
| Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women. | Khanal P et al. | β | 2022 | β |
| Polymorphisms, diet and nutrigenomics. | Kiani AK et al. | β | 2022 | β |
| Polymorphisms of hypertension susceptibility genes as a risk factors of preeclampsia in the Caucasian population of central Russia. | Churnosov M et al. | β | 2022 | β |
| Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics. | Miller EC et al. | β | 2022 | β |
| Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases. | You Y et al. | β | 2022 | β |
| Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort. | Saqlain M et al. | β | 2022 | β |
| RNAME: A comprehensive database of RNA modification enzymes. | Nie F et al. | β | 2022 | β |
| RNA methylation in vascular disease: a systematic review. | Shu Y et al. | β | 2022 | β |
| RNA modifications as emerging therapeutic targets. | Cayir A | β | 2022 | β |
| Role of N6-methyladenosine modification in pathogenesis of ischemic stroke. | Chang H et al. | β | 2022 | β |
| Roles of N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modifications in gynecologic cancers: mechanisms and therapeutic targeting. | Chen J et al. | β | 2022 | β |
| Roles of RNA Modifications in Diverse Cellular Functions. | Wilkinson E et al. | β | 2022 | β |
| Smooth muscle cell FTO regulates contractile function. | Luse MA et al. | β | 2022 | β |
| Socioeconomic and genomic roots of verbal ability from current evidence. | Guo G et al. | β | 2022 | β |
| Strategies to identify causal common genetic variants and corresponding effector genes for paediatric obesity. | Littleton SH et al. | β | 2022 | β |
| Syndromic and Nonsyndromic Obesity: Underlying Genetic Causes in Humans. | Duis J et al. | β | 2022 | β |
| The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis. | Kisielnicka A et al. | β | 2022 | β |
| The effect of air pollution and emotional and behavioral problems on preschoolers' overweight and obesity. | Su W et al. | β | 2022 | β |
| The genetics of obesity: from discovery to biology. | Loos RJF et al. | β | 2022 | β |
| The <i>FTO</i> rs9939609 Variant Is Associated with Cardiometabolic Disease Risk and Dietary Energy Intakes in Children with Mental Health Disorders. | Wiedeman AM et al. | β | 2022 | β |
| The Impact of ACEs on BMI: An Investigation of the Genotype-Environment Effects of BMI. | Schlauch KA et al. | β | 2022 | β |
| The importance of considering regulatory domains in genome-wide analyses - the nearest gene is often wrong! | Chua EHZ et al. | β | 2022 | β |
| The Influence of <i>FTO, FABP2, LEP, LEPR,</i> and <i>MC4R</i> Genes on Obesity Parameters in Physically Active Caucasian Men. | Maculewicz E et al. | β | 2022 | β |
| The interaction between genetic polymorphisms in FTO, MC4R and MTHFR genes and adherence to the Mediterranean Diet in relation to obesity. | Aoun C et al. | β | 2022 | β |
| The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility. | Comas-Armangue G et al. | β | 2022 | β |
| The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology. | Mejhert N et al. | β | 2022 | β |
| The m6A(m)-independent role of FTO in regulating WNT signaling pathways. | Kim H et al. | β | 2022 | β |
| The Mechanism and Role of <i>N</i><sup>6</sup>-Methyladenosine (m<sup>6</sup>A) Modification in Atherosclerosis and Atherosclerotic Diseases. | Tan Q et al. | β | 2022 | β |
| The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants. | Lin WY | β | 2022 | β |
| The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells. | Relier S et al. | β | 2022 | β |
| The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders. | Lei C et al. | β | 2022 | β |
| The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits. | Hinney A et al. | β | 2022 | β |
| The Role of FTO in Tumors and Its Research Progress. | Wei H et al. | β | 2022 | β |
| The roles of personalized nutrition in obesity and diabetes management: a review. | Zeinalian R et al. | β | 2022 | β |
| The sex-specific influence of <i>FTO</i> genotype on exercise intervention for weight loss in adult with obesity. | Wang W et al. | β | 2022 | β |
| The Significance of the <i>FTO</i> Gene for Weight and Body Composition in Swedish Women With Severe Anorexia Nervosa During Intensive Nutrition Therapy. | Svedlund A et al. | β | 2022 | β |
| The UK Biobank: A Shining Example of Genome-Wide Association Study Science with the Power to Detect the Murky Complications of Real-World Epidemiology. | Tan VY et al. | β | 2022 | β |
| The weight of childhood adversity: evidence that childhood adversity moderates the impact of genetic risk on waist circumference in adulthood. | Cuevas AG et al. | β | 2022 | β |
| Validation of Candidate Sleep Disorder Risk Genes Using Zebrafish. | Tran S et al. | β | 2022 | β |
| A Broad m6A Modification Landscape in Inflammatory Bowel Disease. | Nie K et al. | β | 2021 | β |
| ADHD and Risk of Childhood Adiposity: a Review of Recent Research. | Turan S et al. | β | 2021 | β |
| A Genome-Wide Association Study of Childhood Body Fatness. | Warner ET et al. | β | 2021 | β |
| Aging through an epitranscriptomic lens. | McMahon M et al. | β | 2021 | β |
| Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice. | Li CM et al. | β | 2021 | β |
| Analysis of the Interaction between Polygenic Risk Score and Calorie Intake in Obesity in the Korean Population. | Lee WJ et al. | β | 2021 | β |
| A Novel Approach Integrating Hierarchical Clustering and Weighted Combination for Association Study of Multiple Phenotypes and a Genetic Variant. | Fu L et al. | β | 2021 | β |
| A photo-responsive chemical modulation of m<sup>6</sup>A RNA demethylase FTO. | Lan L et al. | β | 2021 | β |
| APOL1 renal risk variants are associated with obesity and body composition in African ancestry adults: An observational genotype-phenotype association study. | Nadkarni GN et al. | β | 2021 | β |
| A Retrospective Chart Review of Patients Who Underwent Cardiac Evaluation Before Bariatric Surgery. | Nasser M et al. | β | 2021 | β |
| Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea. | Hoang T et al. | β | 2021 | β |
| Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents. | InandiklioΔlu N et al. | β | 2021 | β |
| Association between Single Nucleotide Polymorphisms and Weight Reduction in Behavioural Interventions-A Pooled Analysis. | Holzapfel C et al. | β | 2021 | β |
| Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIEβ’ phase 2. | Dorling JL et al. | β | 2021 | β |
| Association between the <i>FTO</i> A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers. | Zmijewski P et al. | β | 2021 | β |
| Association between the <i>FTO</i> SNP rs9939609 and Metabolic Syndrome in Chilean Children. | Molina-Luque R et al. | β | 2021 | β |
| Association Between Weight Change and Leukocyte Telomere Length in U.S. Adults. | Zhang Y et al. | β | 2021 | β |
| Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults. | Al-Jawadi AA et al. | β | 2021 | β |
| Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico. | Ortega PEN et al. | β | 2021 | β |
| Association of SNPs in Lipid Metabolism Gene Single Nucleotide Polymorphism with the Risk of Obesity in Children. | Kulaeva ED et al. | β | 2021 | β |
| A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery. | Gupta SR et al. | β | 2021 | β |
| Bioinformatical identification of key genes regulated by IGF2BP2-mediated RNA N6-methyladenosine and prediction of prognosis in hepatocellular carcinoma. | Wei Q | β | 2021 | β |
| Biological Parts for Plant Biodesign to Enhance Land-Based Carbon Dioxide Removal. | Yang X et al. | β | 2021 | β |
| Changes in N6-Methyladenosine Modification Modulate Diabetic Cardiomyopathy by Reducing Myocardial Fibrosis and Myocyte Hypertrophy. | Ju W et al. | β | 2021 | β |
| Characterization of Enterovirus Associated m6A RNA Methylation in Children With Neurological Symptoms: A Prospective Cohort Study. | Zhu D et al. | β | 2021 | β |
| Cilia signaling and obesity. | Engle SE et al. | β | 2021 | β |
| Common genetic variants associated with obesity in an African-American and Hispanic/Latino population. | Chalazan B et al. | β | 2021 | β |
| Comparison of anthropometric and body composition indices in the identification of metabolic risk factors. | Lee BJ et al. | β | 2021 | β |
| Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies. | Kumar SU et al. | β | 2021 | β |
| Consequences for Pancreatic Ξ²-Cell Identity and Function of Unregulated Transcript Processing. | Ghiasi SM et al. | β | 2021 | β |
| Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases. | Wilkinson E et al. | β | 2021 | β |
| Correlations between FTO Gene Polymorphisms and TSH Level in Uyghur Chinese Patients with Type 2 Diabetes. | Wang L et al. | β | 2021 | β |
| Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome. | Tong Z et al. | β | 2021 | β |
| CTNNA3 genetic polymorphism may be a new genetic signal of type 2 diabetes in the Chinese Han population: a case control study. | Zhang Y et al. | β | 2021 | β |
| Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study. | Seral-Cortes M et al. | β | 2021 | β |
| Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study. | Iwase M et al. | β | 2021 | β |
| Direct-to-Consumer Genetic Testing in Korea: Current Status and Significance in Clinical Nutrition. | Lee GY et al. | β | 2021 | β |
| Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation. | Zhuang J et al. | β | 2021 | β |
| Dynamic regulation of N<sup>6</sup>,2'-O-dimethyladenosine (m<sup>6</sup>Am) in obesity. | Ben-Haim MS et al. | β | 2021 | β |
| Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression. | Song W et al. | β | 2021 | β |
| EDLm<sup>6</sup>APred: ensemble deep learning approach for mRNA m<sup>6</sup>A site prediction. | Zhang L et al. | β | 2021 | β |
| Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase. | Marcinkowski M et al. | β | 2021 | β |
| Effects of epigallocatechin gallate on total antioxidant capacity, biomarkers of systemic low-grade inflammation and metabolic risk factors in patients with type 2 diabetes mellitus: the role of <i>FTO</i>-rs9939609 polymorphism. | Hosseini S et al. | β | 2021 | β |
| Effects of FTO and PPARΞ³ variants on intrauterine growth restriction in a Brazilian birth cohort. | Barbieri MR et al. | β | 2021 | β |
| Effects of m6A RNA methylation regulators on endometrial cancer. | Zhang Y et al. | β | 2021 | β |
| Emerging role of m6A methylation modification in ovarian cancer. | Chang LL et al. | β | 2021 | β |
| Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology. | Malovic E et al. | β | 2021 | β |
| Epidemiological Influences and Requirements of Global Childhood Obesity Research. | KlingelhΓΆfer D et al. | β | 2021 | β |
| Epigenetic regulation of energy metabolism in obesity. | Gao W et al. | β | 2021 | β |
| Epigenetic regulation of N6-methyladenosine modifications in obesity. | Sun M et al. | β | 2021 | β |
| Erasing m<sup>6</sup>A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions. | Wu PF et al. | β | 2021 | β |
| Evidence for shared genetics between physical activity, sedentary behaviour and adiposity-related traits. | Schnurr TM et al. | β | 2021 | β |
| Evidence from a meta-analysis for association of MC4R rs17782313 and FTO rs9939609 polymorphisms with susceptibility to obesity in children. | Dastgheib SA et al. | β | 2021 | β |
| Fat mass and obesity-associated (FTO) gene epigenetic modifications in gestational diabetes: new insights and possible pathophysiological connections. | Franzago M et al. | β | 2021 | β |
| Fat mass and obesity-associated (<i>FTO</i>) and leptin receptor (<i>LEPR</i>) gene polymorphisms in Egyptian obese subjects. | Ali EMM et al. | β | 2021 | β |
| Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin. | Wang Y et al. | β | 2021 | β |
| Fat mass and obesity-associated protein regulates lipogenesis via m<sup>6</sup> A modification in fatty acid synthase mRNA. | Sun D et al. | β | 2021 | β |
| Formaldehyde and De/Methylation in Age-Related Cognitive Impairment. | Li T et al. | β | 2021 | β |
| FTO gene polymorphism and longitudinal changes in nutritional/obesity status in children and adolescents: Schoolchildren's health cohort study. | Reuter ΓM et al. | β | 2021 | β |
| FTO inhibits UPR<sup>mt</sup>-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes. | Shen Z et al. | β | 2021 | β |
| FTO regulates myoblast proliferation by controlling CCND1 expression in an m<sup>6</sup>A-YTHDF2-dependent manner. | Deng K et al. | β | 2021 | β |
| Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. | Strausz S et al. | β | 2021 | β |
| Genetic basis of elite combat sports athletes: a systematic review. | Youn BY et al. | β | 2021 | β |
| Genetic polymorphisms associated with obesity in the Arab world: a systematic review. | Younes S et al. | β | 2021 | β |
| Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management? | Vrablik M et al. | β | 2021 | β |
| Genetics of Obesity: What We Have Learned Over Decades of Research. | Bouchard C | β | 2021 | β |
| Genetics of Sleep and Insights into Its Relationship with Obesity. | Dashti HS et al. | β | 2021 | β |
| Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes. | Sherva R et al. | β | 2021 | β |
| Gut Hormones in Health and Obesity: The Upcoming Role of Short Chain Fatty Acids. | Alhabeeb H et al. | β | 2021 | β |
| Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. | Virani SS et al. | β | 2021 | β |
| Hidden Role of Gut Microbiome Dysbiosis in Schizophrenia: Antipsychotics or Psychobiotics as Therapeutics? | Munawar N et al. | β | 2021 | β |
| <i>FTO</i> and <i>PLAG1</i> Genes Expression and <i>FTO</i> Methylation Predict Changes in Circulating Levels of Adipokines and Gastrointestinal Peptides in Children. | CzogaΕa W et al. | β | 2021 | β |
| <i>Irx3</i> and <i>Irx5</i> - Novel Regulatory Factors of Postnatal Hypothalamic Neurogenesis. | Dou Z et al. | β | 2021 | β |
| Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals. | Chen Y et al. | β | 2021 | β |
| Independent and combined associations between fast-food outlet exposure and genetic risk for obesity: a population-based, cross-sectional study in the UK. | Burgoine T et al. | β | 2021 | β |
| Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. | Perry GS et al. | β | 2021 | β |
| Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping. | Kang JH et al. | β | 2021 | β |
| Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case-control study. | Doaei S et al. | β | 2021 | β |
| Irx3 and Irx5 in Ins2-Cre<sup>+</sup> cells regulate hypothalamic postnatal neurogenesis and leptin response. | Son JE et al. | β | 2021 | β |
| Kidney Disease in Diabetic Patients: From Pathophysiology to Pharmacological Aspects with a Focus on Therapeutic Inertia. | Gembillo G et al. | β | 2021 | β |
| Knowledge, opinions and expectations of adults concerning personalised genotype-based dietary recommendations: a German survey. | Bayer S et al. | β | 2021 | β |
| Linking the <i>FTO</i> obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo. | Laber S et al. | β | 2021 | β |
| <i>FTO</i> gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population. | Isgin-Atici K et al. | β | 2021 | β |
| M6A2Target: a comprehensive database for targets of m6A writers, erasers and readers. | Deng S et al. | β | 2021 | β |
| m6A Modification in Non-Coding RNA: The Role in Cancer Drug Resistance. | Chen C et al. | β | 2021 | β |
| m6A Regulators in Human Adipose Tissue - Depot-Specificity and Correlation With Obesity. | RΓΈnningen T et al. | β | 2021 | β |
| m6A RNA Methylation in Systemic Autoimmune Diseases-A New Target for Epigenetic-Based Therapy? | Wardowska A | β | 2021 | β |
| Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation. | Yao J et al. | β | 2021 | β |
| Methylation and Expression of <i>FTO</i> and <i>PLAG1</i> Genes in Childhood Obesity: Insight into Anthropometric Parameters and Glucose-Lipid Metabolism. | CzogaΕa W et al. | β | 2021 | β |
| Multi-substrate selectivity based on key loops and non-homologous domains: new insight into ALKBH family. | Xu B et al. | β | 2021 | β |
| No Association Between <i>FTO</i> Gene Polymorphisms and Central Nervous System Tumor Susceptibility in Chinese Children. | Liao Y et al. | β | 2021 | β |
| N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) in pancreatic cancer: Regulatory mechanisms and future direction. | Li J et al. | β | 2021 | β |
| Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts. | Pistis G et al. | β | 2021 | β |
| Obesity and Bone: A Complex Relationship. | Rinonapoli G et al. | β | 2021 | β |
| Obesity and polycystic ovary syndrome. | Barber TM et al. | β | 2021 | β |
| Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction. | Li Y et al. | β | 2021 | β |
| Physical Exercise: An Overview of Benefits From Psychological Level to Genetics and Beyond. | Wang Y et al. | β | 2021 | β |
| Polygenic risk modeling with latent trait-related genetic components. | Aguirre M et al. | β | 2021 | β |
| Predicting anthropometric and metabolic traits with a genetic risk score for obesity in a sample of Pakistanis. | Rana S et al. | β | 2021 | β |
| Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index. | Ruiz-Ramos D et al. | β | 2021 | β |
| Ramadan Diurnal Intermittent Fasting Is Associated With Attenuated FTO Gene Expression in Subjects With Overweight and Obesity: A Prospective Cohort Study. | Madkour MI et al. | β | 2021 | β |
| Randomized controlled trials of self-monitoring interventions with or without incentives for diet and exercise among individuals with overweight or obesity: Psychological and behavioural effects. | Gardiner CK et al. | β | 2021 | β |
| Regulation of Activating Transcription Factor 4 (ATF4) Expression by Fat Mass and Obesity-Associated (FTO) in Mouse Hepatocyte Cells. | Mizuno TM et al. | β | 2021 | β |
| Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health. | Chao Y et al. | β | 2021 | β |
| Relationship between the FTO Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria. | Marchetti J et al. | β | 2021 | β |
| Relevance of N6-methyladenosine regulators for transcriptome: Implications for development and the cardiovascular system. | Sweaad WK et al. | β | 2021 | β |
| RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis. | Kim H et al. | β | 2021 | β |
| RNA demethylation increases the yield and biomass of rice and potato plants in field trials. | Yu Q et al. | β | 2021 | β |
| RNA m6A methylation regulators in ovarian cancer. | Guo J et al. | β | 2021 | β |
| RNA Modification by m<sup>6</sup>A Methylation in Cardiovascular Disease. | Chen J et al. | β | 2021 | β |
| RNA N6-methyladenosine modification, spermatogenesis, and human male infertility. | Cai Z et al. | β | 2021 | β |
| Role of m6A in osteoporosis, arthritis and osteosarcoma (Review). | Hu Y et al. | β | 2021 | β |
| Role of N6-methyl-adenosine modification in mammalian embryonic development. | Li C et al. | β | 2021 | β |
| Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors. | Liu S et al. | β | 2021 | β |
| Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia. | Frost J et al. | β | 2021 | β |
| Roles of N6-Methyladenosine Demethylase FTO in Malignant Tumors Progression. | Zheng QK et al. | β | 2021 | β |
| Search for Possible Associations of <i>FTO</i> Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients. | Boiko AS et al. | β | 2021 | β |
| Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity. | Akbari P et al. | β | 2021 | β |
| Sex hormone-binding globulin: biomarker and hepatokine? | Simons PIHG et al. | β | 2021 | β |
| Sperm DNA Methylation at Metabolism-Related Genes in Vegan Subjects. | Franzago M et al. | β | 2021 | β |
| Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. | Shishodia S et al. | β | 2021 | β |
| Targeting the RNA demethylase FTO for cancer therapy. | Zhou LL et al. | β | 2021 | β |
| The Association of Fat-Mass-and Obesity-Associated Gene Polymorphism (rs9939609) With Colorectal Cancer: A Case-Control Study. | Gholamalizadeh M et al. | β | 2021 | β |
| The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases. | Zhang B et al. | β | 2021 | β |
| The current review of adolescent obesity: the role of genetic factors. | YΔ±lmaz B et al. | β | 2021 | β |
| The detection and functions of RNA modification m<sup>6</sup>A based on m<sup>6</sup>A writers and erasers. | Zhang W et al. | β | 2021 | β |
| The emerging roles of m<sup>6</sup>A modification in liver carcinogenesis. | Pan XY et al. | β | 2021 | β |
| The fat mass and obesity-associated (FTO) gene allele rs9939609 and glucose tolerance, hepatic and total insulin sensitivity, in adults with obesity. | de Soysa AKH et al. | β | 2021 | β |
| The FTO m<sup>6</sup>A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m<sup>6</sup>A levels. | Zhu K et al. | β | 2021 | β |
| The interaction between FTO rs9939609 and physical activity is associated with a 2-fold reduction in the risk of obesity in Korean population. | Cho HW et al. | β | 2021 | β |
| The m6A epitranscriptome opens a new charter in immune system logic. | Ma Z et al. | β | 2021 | β |
| The role of m6A modification in the biological functions and diseases. | Jiang X et al. | β | 2021 | β |
| The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis. | Chaudhary H et al. | β | 2021 | β |
| The role of the FTO gene in the relationship between depression and obesity. A systematic review. | Zarza-Rebollo JA et al. | β | 2021 | β |
| The Roles of Genetic and Early-Life Environmental Factors in the Association Between Overweight or Obesity and Hypertension: A Population-Based Twin Study. | Xi Y et al. | β | 2021 | β |
| tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors. | Arroyo MN et al. | β | 2021 | β |
| Valproate-Induced Epigenetic Upregulation of Hypothalamic Fto Expression Potentially Linked with Weight Gain. | Zhang H et al. | β | 2021 | β |
| Variable expression quantitative trait loci analysis of breast cancer risk variants. | Wiggins GAR et al. | β | 2021 | β |
| Variants in the Obesity-Linked FTO gene locus modulates psychopathological features of patients with Anorexia Nervosa. | GonzΓ‘lez LM et al. | β | 2021 | β |
| A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort. | Schlauch KA et al. | β | 2020 | β |
| A developmental framework of binge-eating disorder based on pediatric loss of control eating. | Tanofsky-Kraff M et al. | β | 2020 | β |
| Ancestry specific associations of FTO gene variant and metabolic syndrome: A longitudinal ARIC study. | Hardy DS et al. | β | 2020 | β |
| An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs. | Kibble M et al. | β | 2020 | β |
| A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population. | Alathari BE et al. | β | 2020 | β |
| Association between exposure to fine particulate matter and obesity in children: A national representative cross-sectional study in China. | Guo Q et al. | β | 2020 | β |
| Association between the FTO gene polymorphism and obesity in Brazilian adolescents from the Northeast region. | Rodrigues LDS et al. | β | 2020 | β |
| Association ofΒ FTO rs1421085Β with obesity, diet, physical activity, and socioeconomic status: A longitudinal birth cohort study. | Katus U et al. | β | 2020 | β |
| Association of <i>FTO</i> rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults. | Mehrdad M et al. | β | 2020 | β |
| Associations between Genotype-Diet Interactions and Weight Loss-A Systematic Review. | Bayer S et al. | β | 2020 | β |
| Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects. | BaΓ±ales-Luna M et al. | β | 2020 | β |
| Bioinformatics approaches for deciphering the epitranscriptome: Recent progress and emerging topics. | Liu L et al. | β | 2020 | β |
| Can a Lifestyle Genomics Intervention Motivate Patients to Engage in Greater Physical Activity than a Population-Based Intervention? Results from the NOW Randomized Controlled Trial. | Horne JR et al. | β | 2020 | β |
| Canalization and Robustness in Human Genetics and Disease. | Gibson G et al. | β | 2020 | β |
| Carriership of the rs113883650/rs2287120 haplotype of the <i>SLC7A5</i> (<i>LAT1</i>) gene increases the risk of obesity in infants with phenylketonuria. | Bik-Multanowski M et al. | β | 2020 | β |
| Changes in Body Composition and <i>FTO</i> Whole Blood DNA Methylation Among Japanese Women: A Randomized Clinical Trial of Weight-Loss Program. | Nishida H et al. | β | 2020 | β |
| Childhood obesity and the associated rise in cardiometabolic complications. | Caprio S et al. | β | 2020 | β |
| Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits | Pahl MC et al. | β | 2020 | β |
| Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis. | Nagrani R et al. | β | 2020 | β |
| Common mechanisms for type 2 diabetes and psychosis: Findings from a prospective birth cohort. | Perry BI et al. | β | 2020 | β |
| Common polymorphisms in MC4R and FTO genes are associated with BMI and metabolic indicators in Mexican children: Differences by sex and genetic ancestry. | LΓ³pez-RodrΓguez G et al. | β | 2020 | β |
| Developmental programming: Transcriptional regulation of visceral and subcutaneous adipose by prenatal bisphenol-A in female sheep. | Dou JF et al. | β | 2020 | β |
| Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators. | Jayaraj RL et al. | β | 2020 | β |
| Differences in brain structure and function in children with the <i>FTO</i> obesity-risk allele. | Lugo-Candelas C et al. | β | 2020 | β |
| Dynamic landscape and evolution of m6A methylation in human. | Zhang H et al. | β | 2020 | β |
| Environmental epitranscriptomics. | Cayir A et al. | β | 2020 | β |
| Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases. | Flores-Dorantes MT et al. | β | 2020 | β |
| Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail. | Sheehan NA et al. | β | 2020 | β |
| Epitranscriptomics in the Heart: a Focus on m<sup>6</sup>A. | Longenecker JZ et al. | β | 2020 | β |
| Excessive BCAA regulates fat metabolism partially through the modification of m<sup>6</sup>A RNA methylation in weanling piglets. | Heng J et al. | β | 2020 | β |
| Exploring Therapeutic Targets to Reverse or Prevent the Transition from Metabolically Healthy to Unhealthy Obesity. | Dagpo TD et al. | β | 2020 | β |
| Fat mass- and obesity-associated (FTO) geneΒ promoted myoblast differentiation through the focal adhesion pathway in chicken. | Huang H et al. | β | 2020 | β |
| Fat Mass and Obesity-Associated (FTO) Stimulates Osteogenic Differentiation of C3H10T1/2 Cells by Inducing Mild Endoplasmic Reticulum Stress via a Positive Feedback Loop with p-AMPK. | Son HE et al. | β | 2020 | β |
| Fat mass and obesity-associated gene polymorphisms, pre-diagnostic plasma adipokine levels and the risk of colorectal cancer: The Japan Public Health Center-based Prospective Study. | Yamaji T et al. | β | 2020 | β |
| FTO - A Common Genetic Basis for Obesity and Cancer. | Lan N et al. | β | 2020 | β |
| FTO-Dependent <i>N</i> <sup>6</sup>-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling. | Huang H et al. | β | 2020 | β |
| FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation. | Ding Y et al. | β | 2020 | β |
| FTO Inhibition Enhances the Antitumor Effect of Temozolomide by Targeting MYC-miR-155/23a Cluster-MXI1 Feedback Circuit in Glioma. | Xiao L et al. | β | 2020 | β |
| Gene co-expression networks are associated with obesity-related traits in kidney transplant recipients. | Jaime-Lara RB et al. | β | 2020 | β |
| Genes and Diet in the Prevention of Chronic Diseases in Future Generations. | Franzago M et al. | β | 2020 | β |
| Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology. | Eslam M et al. | β | 2020 | β |
| Genetic Determinants of Childhood Obesity. | Littleton SH et al. | β | 2020 | β |
| Genetic Epidemiology in Latin America: Identifying Strong Genetic Proxies for Complex Disease Risk Factors. | Bonilla C et al. | β | 2020 | β |
| Genetic Markers at ANRIL, FTO and 2q36.3 Locus in Czech Patients Undergoing Coronary Artery Bypass Graft Surgery. | Kacer P et al. | β | 2020 | β |
| Genetic Polymorphisms, Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes can Predict Obesity in Childhood-Adolescence. | CortΓ©s-MartΓn A et al. | β | 2020 | β |
| Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. | Steinthorsdottir V et al. | β | 2020 | β |
| Genetics of Obesity in East Asians. | Sun C et al. | β | 2020 | β |
| Genetic test for the prescription of diets in support of physical activity. | Naureen Z et al. | β | 2020 | β |
| Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population. | Fonseca ACPD et al. | β | 2020 | β |
| Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations. | Bakos B et al. | β | 2020 | β |
| Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival. | Timmins IR et al. | β | 2020 | β |
| Genomic resources for dissecting the role of non-protein coding variation in gene-environment interactions. | Levings D et al. | β | 2020 | β |
| Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes. | LΓΆfvenborg JE et al. | β | 2020 | β |
| GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m<sup>6</sup>A on lipogenic mRNAs. | Hu Y et al. | β | 2020 | β |
| Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association. | Virani SS et al. | β | 2020 | β |
| Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development inΒ vivo. | MittenbΓΌhler MJ et al. | β | 2020 | β |
| High intensity exercise downregulates <i>FTO</i> mRNA expression during the early stages of recovery in young males and females. | Danaher J et al. | β | 2020 | β |
| Hunger and BMI modulate neural responses to sweet stimuli: fMRI meta-analysis. | Chen EY et al. | β | 2020 | β |
| Hypothalamic IRX3: A New Player in the Development of Obesity. | de AraΓΊjo TM et al. | β | 2020 | β |
| Identification of ALK in Thinness. | Orthofer M et al. | β | 2020 | β |
| Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome. | Ahn Y et al. | β | 2020 | β |
| Identification of Specific <i>N</i><sup>6</sup>-Methyladenosine RNA Demethylase FTO Inhibitors by Single-Quantum-Dot-Based FRET Nanosensors. | Zhang Y et al. | β | 2020 | β |
| <i>FTO</i> Polymorphisms are Associated with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Susceptibility in the Older Chinese Han Population. | Gu Z et al. | β | 2020 | β |
| Impact of the gut microbiota on the m<sup>6</sup>A epitranscriptome of mouse cecum and liver. | Jabs S et al. | β | 2020 | β |
| Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates. | El Hajj Chehadeh S et al. | β | 2020 | β |
| In depth analysis of the association of FTO SNP (rs9939609) with theΒ expression of classical phenotype of PCOS: a Sri Lankan study. | Branavan U et al. | β | 2020 | β |
| Influence of FTO (Fat mass and obesity) gene and parental obesity on Brazilian children and adolescents adiposity. | Todendi PF et al. | β | 2020 | β |
| Insights into the multifactorial causation of obesity by integrated genetic and epigenetic analysis. | Diels S et al. | β | 2020 | β |
| Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes. | Liu Q et al. | β | 2020 | β |
| Integrative Genomic Analysis Predicts Regulatory Role of <i>N</i> <sup>6</sup>-Methyladenosine-Associated SNPs for Adiposity. | Lin W et al. | β | 2020 | β |
| Invited Review: Epigenetics in neurodevelopment. | Salinas RD et al. | β | 2020 | β |
| IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis. | Tan Z et al. | β | 2020 | β |
| Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study. | Yuan S et al. | β | 2020 | β |
| Long-range chromatin interactions in pathogenic gene expression control. | Kong N et al. | β | 2020 | β |
| Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. | KrΓΌger N et al. | β | 2020 | β |
| m6A RNA Methylation: Ramifications for Gene Expression and Human Health. | Karthiya R et al. | β | 2020 | β |
| Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults. | Rauschert S et al. | β | 2020 | β |
| Mechanisms of RNA N<sup>6</sup>-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology. | Lu J et al. | β | 2020 | β |
| Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R). | Hainer V et al. | β | 2020 | β |
| Metabolic Syndrome in Inflammatory Bowel Disease: Association with Genetic Markers of Obesity and Inflammation. | Dragasevic S et al. | β | 2020 | β |
| Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers. | Li Q et al. | β | 2020 | β |
| METTL3 regulates inflammatory pain by modulating m<sup>6</sup>A-dependent pri-miR-365-3p processing. | Zhang C et al. | β | 2020 | β |
| Molecular Mechanisms Driving mRNA Degradation by m<sup>6</sup>A Modification. | Lee Y et al. | β | 2020 | β |
| m<sup>6</sup> A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis. | Nagaki Y et al. | β | 2020 | β |
| N6-methyladenine RNA modification and cancer. | Yang J et al. | β | 2020 | β |
| N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation. | Gu X et al. | β | 2020 | β |
| No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males. | Dorling JL et al. | β | 2020 | β |
| N<sup>6</sup> -methyladenosine (m<sup>6</sup>A) RNA modification in human cancer. | Huo FC et al. | β | 2020 | β |
| Obesity and Bone. | Proietto J | β | 2020 | β |
| Obesity and eating behavior from the perspective of twin and genetic research. | Silventoinen K et al. | β | 2020 | β |
| Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk. | Regan JA et al. | β | 2020 | β |
| Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms. | Priliani L et al. | β | 2020 | β |
| Obesity: novel and unusual predisposing factors. | Hanson P et al. | β | 2020 | β |
| Obesity subtypes, related biomarkers & heterogeneity. | Mayoral LP et al. | β | 2020 | β |
| Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice. | Skowronski AA et al. | β | 2020 | β |
| Piloting the objective measurement of eating weight and speed at a population scale: a nested study within the Avon Longitudinal Study of Parents and Children. | Wade KH et al. | β | 2020 | β |
| Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants. | Crouch DJM et al. | β | 2020 | β |
| Prevalence and association of single nucleotide polymorphisms with sarcopenia in older women depends on definition. | Khanal P et al. | β | 2020 | β |
| Prevention of Diabetes and Cardiovascular Disease in Obesity. | La Sala L et al. | β | 2020 | β |
| Quantile-dependent heritability of computed tomography, dual-energy x-ray absorptiometry, anthropometric, and bioelectrical measures of adiposity. | Williams PT | β | 2020 | β |
| Relation of FTO to BOLD response to receipt and anticipated receipt of food and monetary reward, food images, and weight gain in healthy weight adolescents. | Stice E et al. | β | 2020 | β |
| Replication of FTO Gene associated with lean mass in a Meta-Analysis of Genome-Wide Association Studies. | Ran S et al. | β | 2020 | β |
| RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice. | Karunakaran D et al. | β | 2020 | β |
| RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells. | Tsuruta N et al. | β | 2020 | β |
| RNA N<sup>6</sup>-methyladenosine modification in solid tumors: new therapeutic frontiers. | Melstrom L et al. | β | 2020 | β |
| Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population. | Khan S et al. | β | 2020 | β |
| Role of m6A RNA methylation in cardiovascular disease (Review). | Qin Y et al. | β | 2020 | β |
| Rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene and metabolic syndrome susceptibility in the Chinese population: a meta-analysis. | Wang D et al. | β | 2020 | β |
| Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children. | Meng Y et al. | β | 2020 | β |
| Skeletal Muscle Immunometabolism in Women With Polycystic Ovary Syndrome: A Meta-Analysis. | Manti M et al. | β | 2020 | β |
| Somatotypes trajectories during adulthood and their association with COPD phenotypes. | Divo MJ et al. | β | 2020 | β |
| The association between FTO rs9939609 gene polymorphism and anthropometric indices in adults. | Mehrdad M et al. | β | 2020 | β |
| The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women. | Khanal P et al. | β | 2020 | β |
| The connection between microbiome and schizophrenia. | Golofast B et al. | β | 2020 | β |
| The contribution of non-coding regulatory elements to cardiovascular disease. | Villar D et al. | β | 2020 | β |
| The Effect Sizes of <i>PPARΞ³</i> rs1801282<i>, FTO</i> rs9939609, and <i>MC4R</i> rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study. | Bakhashab S et al. | β | 2020 | β |
| The Impact of <i>FTO</i> Genetic Variants on Obesity and Its Metabolic Consequences is Dependent on Daily Macronutrient Intake. | Czajkowski P et al. | β | 2020 | β |
| The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India. | Gulati S et al. | β | 2020 | β |
| The New Frontier of Functional Genomics: From Chromatin Architecture and Noncoding RNAs to Therapeutic Targets. | Papanicolaou N et al. | β | 2020 | β |
| The obesity epidemic - Nature via nurture: A narrative review of high-income countries. | Jackson SE et al. | β | 2020 | β |
| The Pathophysiology of Type 2 Diabetes Mellitus in Non-obese Individuals: An Overview of the Current Understanding. | Olaogun I et al. | β | 2020 | β |
| The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers. | Wang JY et al. | β | 2020 | β |
| The Role of Diet in Cancer Prevention and Chemotherapy Efficacy. | Mittelman SD | β | 2020 | β |
| The role of genetics and epigenetics in the pathogenesis of gestational diabetes mellitus. | Rosik J et al. | β | 2020 | β |
| The role of m<sup>6</sup>A modification in physiology and disease. | Yang C et al. | β | 2020 | β |
| The Shared Genetic Basis of Hyperuricemia, Gout, and Kidney Function. | Leask MP et al. | β | 2020 | β |
| Using Genetic Risk Score Approaches to Infer Whether an Environmental Factor Attenuates or Exacerbates the Adverse Influence of a Candidate Gene. | Lin WY et al. | β | 2020 | β |
| Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. | Zhao X et al. | β | 2020 | β |
| A Bayesian approach to Mendelian randomisation with dependent instruments. | Shapland CY et al. | β | 2019 | β |
| A dynamic reversible RNA N<sup>6</sup> -methyladenosine modification: current status and perspectives. | Bi Z et al. | β | 2019 | β |
| A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome. | GalmΓ©s S et al. | β | 2019 | β |
| Aldehyde Dehydrogenases Genetic Polymorphism and Obesity: From Genomics to Behavior and Health. | Hu C | β | 2019 | β |
| A network embedding model for pathogenic genes prediction by multi-path random walking on heterogeneous network. | Xu B et al. | β | 2019 | β |
| An overview of microbiome based strategies on anti-obesity. | Chang CS et al. | β | 2019 | β |
| A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism. | Dorling JL et al. | β | 2019 | β |
| A resource-efficient tool for mixed model association analysis of large-scale data. | Jiang L et al. | β | 2019 | β |
| A Scientific Perspective of Personalised Gene-Based Dietary Recommendations for Weight Management. | Drabsch T et al. | β | 2019 | β |
| Assessment of FTO Gene Polymorphism and its Association with Type 2 Diabetes Mellitus in North Indian Populations. | Naaz K et al. | β | 2019 | β |
| Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents. | He F et al. | β | 2019 | β |
| Association of FTO common variant (rs9939609) with body fat in Turkish individuals. | AΔagΓΌndΓΌz D et al. | β | 2019 | β |
| Association of Obesity-Related Genetic Variants (FTO and MC4R) with Breast Cancer Risk: A Population-Based Case-Control Study in Iran. | Mozafarizadeh M et al. | β | 2019 | β |
| Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes. | Khoshi A et al. | β | 2019 | β |
| Associations between pretherapeutic body mass index, outcome, and cytogenetic abnormalities in pediatric acute myeloid leukemia. | LΓΈhmann DJA et al. | β | 2019 | β |
| A test of famine-induced developmental programming in utero. | Catalano R et al. | β | 2019 | β |
| Betaine increases mitochondrial content and improves hepatic lipid metabolism. | Zhang L et al. | β | 2019 | β |
| Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth. | Alvarez-Pitti J et al. | β | 2019 | β |
| BMI-associated gene variants in <i>FTO</i> and cardiometabolic and brain disease: obesity or pleiotropy? | Ganeff IMM et al. | β | 2019 | β |
| Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. | Wang L et al. | β | 2019 | β |
| Clinical phenotype and genetic risk factors for bipolar disorder with binge eating: an update. | Cuellar-Barboza AB et al. | β | 2019 | β |
| Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos. | JimΓ©nez-Osorio AS et al. | β | 2019 | β |
| Comprehensive analysis of differences of N<sup>6</sup>-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers. | Luo Z et al. | β | 2019 | β |
| Data-driven biological subtypes of depression: systematic review of biological approaches to depression subtyping. | Beijers L et al. | β | 2019 | β |
| Decreased nuclear expression of FTO in human primary hepatocellular carcinoma is associated with poor prognosis. | Zhao Y et al. | β | 2019 | β |
| Diagnosis of obesity and use of obesity biomarkers in science and clinical medicine. | Nimptsch K et al. | β | 2019 | β |
| Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level. | Doaei S et al. | β | 2019 | β |
| Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population. | Saucedo-Uribe E et al. | β | 2019 | β |
| Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood. | Lillycrop KA et al. | β | 2019 | β |
| Differentiating SGBS adipocytes respond to PPARΞ³ stimulation, irisin and BMP7 by functional browning and beige characteristics. | KlusΓ³czki Γ et al. | β | 2019 | β |
| Dynamic and reversible RNA N<sup>6</sup> -methyladenosine methylation. | Duan HC et al. | β | 2019 | β |
| Eating Behaviours and Food Cravings; Influence of Age, Sex, BMI and <i>FTO</i> Genotype. | Abdella HM et al. | β | 2019 | β |
| Environmental monitoring and the developmental origins of health and disease. | Almeida DL et al. | β | 2019 | β |
| Epigenetic Methylations on N6-Adenine and N6-Adenosine with the same Input but Different Output. | Li Z et al. | β | 2019 | β |
| Established and emerging strategies to crack the genetic code of obesity. | Tam V et al. | β | 2019 | β |
| Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study. | Tan AG et al. | β | 2019 | β |
| Evaluation of the possible association of body mass index and four metabolic gene polymorphisms with longevity in an Italian cohort: a role for <i>APOE</i>, <i>eNOS</i> and <i>FTO</i> gene polymorphisms. | Santovito A et al. | β | 2019 | β |
| Evidence for the association between <i>FTO</i> gene variants and vitamin B12 concentrations in an Asian Indian population. | Surendran S et al. | β | 2019 | β |
| Exploration of associations between the FTO rs9939609 genotype, fasting and postprandial appetite-related hormones and perceived appetite in healthy men and women. | Goltz FR et al. | β | 2019 | β |
| Exposing the Causal Effect of Body Mass Index on the Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study. | Cheng L et al. | β | 2019 | β |
| Exposure to environmental toxicants reduces global N6-methyladenosine RNA methylation and alters expression of RNA methylation modulator genes. | Cayir A et al. | β | 2019 | β |
| FTO: An Emerging Molecular Player in Neuropsychiatric Diseases. | Annapoorna PK et al. | β | 2019 | β |
| FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis. | Zhao NN et al. | β | 2019 | β |
| FTO haplotyping underlines high obesity risk for European populations. | Babenko V et al. | β | 2019 | β |
| FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight. | Liu SJ et al. | β | 2019 | β |
| Functional genomic characterization of the <i>FTO</i> locus in African Americans. | Gill R et al. | β | 2019 | β |
| Gene Lifestyle Interactions With Relation to Obesity, Cardiometabolic, and Cardiovascular Traits Among South Asians. | Ahmad S et al. | β | 2019 | β |
| Genes and Elite Marathon Running Performance: A Systematic Review. | Moir HJ et al. | β | 2019 | β |
| Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine. | Doumatey AP et al. | β | 2019 | β |
| Genetic Factors Associated With Human Physical Activity: Are Your Genes Too Tight To Prevent You Exercising? | Zhang X et al. | β | 2019 | β |
| Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents. | Todendi PF et al. | β | 2019 | β |
| Genetics and epigenetics in obesity. | Rohde K et al. | β | 2019 | β |
| Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese. | Kou I et al. | β | 2019 | β |
| Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. | Dashti HS et al. | β | 2019 | β |
| Genome-wide association study of morbid obesity in Han Chinese. | Chiang KM et al. | β | 2019 | β |
| Genomics of Reproductive Traits and Cardiometabolic Disease Risk in African American Women. | Hardy TM et al. | β | 2019 | β |
| Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. | Wang H et al. | β | 2019 | β |
| GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations. | Chen HH et al. | β | 2019 | β |
| Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. | Benjamin EJ et al. | β | 2019 | β |
| <i>Anaerotruncus</i> <i>massiliensis</i> sp. nov., a succinate-producing bacterium isolated from human stool from an obese patient after bariatric surgery. | Togo AH et al. | β | 2019 | β |
| Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. | Wang Y et al. | β | 2019 | β |
| Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. | Peng S et al. | β | 2019 | β |
| <i>Fto</i> Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice via Alterations in Gut Microbiota. | Sun L et al. | β | 2019 | β |
| <i>FTO</i> Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population. | Hebbar P et al. | β | 2019 | β |
| Interaction between genes involved in energy intake regulation and diet in obesity. | Crovesy L et al. | β | 2019 | β |
| Investigation of potential genomic biomarkers for obesity and personalized medicine. | ErgΓΆren MC et al. | β | 2019 | β |
| Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China. | Tao J et al. | β | 2019 | β |
| Irx3, a new leader on obesity genetics. | Schneeberger M | β | 2019 | β |
| It's complicatedβ¦ m<sup>6</sup>A-dependent regulation of gene expression in cancer. | Fitzsimmons CM et al. | β | 2019 | β |
| Learning one's genetic risk changes physiology independent of actual genetic risk. | Turnwald BP et al. | β | 2019 | β |
| m6A modification of non-coding RNA and the control of mammalian gene expression. | Coker H et al. | β | 2019 | β |
| Mapping causal pathways from genetics to neuropsychiatric disorders using genome-wide imaging genetics: Current status and future directions. | Le BD et al. | β | 2019 | β |
| Maternal heat stress regulates the early fat deposition partly through modification of m<sup>6</sup>A RNA methylation in neonatal piglets. | Heng J et al. | β | 2019 | β |
| Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk. | Rauschert S et al. | β | 2019 | β |
| Media Multitasking Is Associated With Higher Body Mass Index in Pre-adolescent Children. | Lopez RB et al. | β | 2019 | β |
| Meta-analysis of genome-wide association studies for body fat distribution in 694Β 649 individuals of European ancestry. | Pulit SL et al. | β | 2019 | β |
| Metabolic fitness in relation to genetic variation and leukocyte DNA methylation. | Caspers M et al. | β | 2019 | β |
| Methylation of RNA N<sup>6</sup>-methyladenosine in modulation of cytokine responses and tumorigenesis. | Chang G et al. | β | 2019 | β |
| m<sup>6</sup>A methylation modulates adipogenesis through JAK2-STAT3-C/EBPΞ² signaling. | Wu R et al. | β | 2019 | β |
| New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. | Hwang LD et al. | β | 2019 | β |
| Novel positioning from obesity to cancer: FTO, an m<sup>6</sup>A RNA demethylase, regulates tumour progression. | Chen J et al. | β | 2019 | β |
| Nutrigenomics and RNA methylation: Role of micronutrients. | Mosca P et al. | β | 2019 | β |
| Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies. | Barber TM et al. | β | 2019 | β |
| Obesity genetics and cardiometabolic health: Potential for risk prediction. | Sanghera DK et al. | β | 2019 | β |
| Obesity: global epidemiology and pathogenesis. | BlΓΌher M | β | 2019 | β |
| Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity. | Ferris E et al. | β | 2019 | β |
| Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population. | Luo C et al. | β | 2019 | β |
| Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11βyears. | Manco L et al. | β | 2019 | β |
| Polycystic ovary syndrome (PCOS) and kisspeptin - A Sri Lankan study. | Umayal B et al. | β | 2019 | β |
| Polygenic approaches to detect gene-environment interactions when external information is unavailable. | Lin WY et al. | β | 2019 | β |
| Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification. | Monies D et al. | β | 2019 | β |
| Repeat length variations in polyglutamine disease-associated genes affect body mass index. | Gardiner SL et al. | β | 2019 | β |
| Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study. | de Marco G et al. | β | 2019 | β |
| RNA methylation and diseases: experimental results, databases, Web servers and computational models. | Chen X et al. | β | 2019 | β |
| RNA modifications and the link to human disease. | Yanas A et al. | β | 2019 | β |
| RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3. | Niu Y et al. | β | 2019 | β |
| RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases. | Salem ESB et al. | β | 2019 | β |
| Robust Reference Powered Association Test of Genome-Wide Association Studies. | Wang Y et al. | β | 2019 | β |
| Role of eating disorders-related polymorphisms in obesity pathophysiology. | Nicoletti CF et al. | β | 2019 | β |
| Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization. | Millard LAC et al. | β | 2019 | β |
| Sequence-specific m<sup>6</sup>A demethylation in RNA by FTO fused to RCas9. | Rau K et al. | β | 2019 | β |
| Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge. | Danaher J et al. | β | 2019 | β |
| Single-nucleotide polymorphisms in a cohort of significantly obese women without cardiometabolic diseases. | Schlauch KA et al. | β | 2019 | β |
| Soy Products Ameliorate Obesity-Related Anthropometric Indicators in Overweight or Obese Asian and Non-Menopausal Women: A Meta-Analysis of Randomized Controlled Trials. | Mu Y et al. | β | 2019 | β |
| Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. | Zhang X et al. | β | 2019 | β |
| The A-allele of the FTO Gene rs9939609 Polymorphism Is Associated With Decreased Proportion of Slow Oxidative Muscle Fibers and Over-represented in Heavier Athletes. | Guilherme JPLF et al. | β | 2019 | β |
| The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study. | Hubacek JA et al. | β | 2019 | β |
| The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. | da Fonseca ACP et al. | β | 2019 | β |
| The Challenge of Stratifying Obesity: Attempts in the Quebec Family Study. | de Toro-MartΓn J et al. | β | 2019 | β |
| The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients. | Al-Serri A et al. | β | 2019 | β |
| The FTOΒ genetic variants are associated with dietary intake and body mass index amongst Emirati population. | Saber-Ayad M et al. | β | 2019 | β |
| The FTO rs9939609 "A" allele is associated with impaired fasting glucose and insulin resistance in Emirati population. | Saber-Ayad M et al. | β | 2019 | β |
| The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome. | Li M et al. | β | 2019 | β |
| The Influence of FTO Polymorphism rs9939609 on Obesity, Some Clinical Features, and Disturbance of Carbohydrate Metabolism in Patients with Psoriasis. | Tupikowska-Marzec M et al. | β | 2019 | β |
| The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA. | Li J et al. | β | 2019 | β |
| The Many Faces of Obesity and Its Influence on Breast Cancer Risk. | Agurs-Collins T et al. | β | 2019 | β |
| The m<sup>6</sup>A eraser FTO facilitates proliferation and migration of human cervical cancer cells. | Zou D et al. | β | 2019 | β |
| The m<sup>6</sup>A Writer: Rise of a Machine for Growing Tasks. | Balacco DL et al. | β | 2019 | β |
| The partial inhibition of hypothalamic IRX3 exacerbates obesity. | de Araujo TM et al. | β | 2019 | β |
| The relationship between sleep duration, cognition and dementia: a Mendelian randomization study. | Henry A et al. | β | 2019 | β |
| The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage. | Zhang Q et al. | β | 2019 | β |
| The role of chlorine atom on the binding between 2-phenyl-1H-benzimidazole analogues and fat mass and obesity-associated protein. | Li J et al. | β | 2019 | β |
| The Role of FTO Genotype in the Association Between FTO Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys. | Doaei S et al. | β | 2019 | β |
| The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI. | Do EK et al. | β | 2019 | β |
| The role of RNA adenosine demethylases in the control of gene expression. | Rajecka V et al. | β | 2019 | β |
| The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells. | Tang X et al. | β | 2019 | β |
| The virtuous cycle of human genetics and mouse models in drug discovery. | Nadeau JH et al. | β | 2019 | β |
| True Interindividual Variability Exists in Postprandial Appetite Responses in Healthy Men But Is Not Moderated by the FTO Genotype. | Goltz FR et al. | β | 2019 | β |
| Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors. | Witka BZ et al. | β | 2019 | β |
| Understanding m<sup>6</sup>A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins. | Zhao YL et al. | β | 2019 | β |
| Up-regulation of FTO gene expression was associated with increase in skeletal muscle mass in overweight male adolescents. | Doaei S et al. | β | 2019 | β |
| Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis. | Zheng J et al. | β | 2019 | β |
| Aberrant Regulation of mRNA mβΆA Modification in Cancer Development. | Luo J et al. | β | 2018 | β |
| A complete linkage disequilibrium in a haplotype of three SNPs in Fat Mass and Obesity associated (FTO) gene was strongly associated with anthropometric indices after controlling for calorie intake and physical activity. | Kalantari N et al. | β | 2018 | β |
| Acute and Chronic Effects of Exercise on Appetite, Energy Intake, and Appetite-Related Hormones: The Modulating Effect of Adiposity, Sex, and Habitual Physical Activity. | Dorling J et al. | β | 2018 | β |
| Aetiology of eating behaviours: A possible mechanism to understand obesity development in early childhood. | Boswell N et al. | β | 2018 | β |
| A fat mass and obesity-associated gene polymorphism influences fat mass in exercise-trained individuals. | Antonio J et al. | β | 2018 | β |
| A fluorescent methylation-switchable probe for highly sensitive analysis of FTO <i>N</i> <sup>6</sup>-methyladenosine demethylase activity in cells. | Cheong A et al. | β | 2018 | β |
| A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity. | He G et al. | β | 2018 | β |
| Association between FTO gene polymorphism and excess body weight in women from before to after pregnancy: A cohort study. | Kroll C et al. | β | 2018 | β |
| Association between polymorphisms in <i>SLC15A1</i> and <i>PLA2G16</i> genes and development of obesity in Chinese subjects. | Wang CY et al. | β | 2018 | β |
| Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis. | Lin Z et al. | β | 2018 | β |
| Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements. | Sidiropoulou EJ et al. | β | 2018 | β |
| Blood-Based DNA Methylation Biomarkers for Type 2 Diabetes: Potential for Clinical Applications. | Willmer T et al. | β | 2018 | β |
| Causal association of body mass index with hypertension using a Mendelian randomization design. | Lee MR et al. | β | 2018 | β |
| Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine. | Sabarneh A et al. | β | 2018 | β |
| Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents. | MartΓnez-MartΓnez MD et al. | β | 2018 | β |
| Critical Enzymatic Functions of FTO in Obesity and Cancer. | Deng X et al. | β | 2018 | β |
| Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring. | Kaspi A et al. | β | 2018 | β |
| DNA damage in obesity: Initiator, promoter and predictor of cancer. | Usman M et al. | β | 2018 | β |
| Effect of a Physical Activity Consultation in the Management of Adolescent Overweight (the PAC-MAnO project): study rationale, design and methods. | Videira-Silva A et al. | β | 2018 | β |
| Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C-reactive protein levels in multi-ethnic Malaysian adults. | Mitra SR et al. | β | 2018 | β |
| Emerging function of N6-methyladenosine in cancer. | Hong K | β | 2018 | β |
| Epigenetic Modifications in Cardiovascular Aging and Diseases. | Zhang W et al. | β | 2018 | β |
| Exploring the associations between systemic inflammation, obesity and healthy days: a health related quality of life (HRQOL) analysis of NHANES 2005-2008. | Wilkins J et al. | β | 2018 | β |
| Fat Mass and Obesity Associated (<i>FTO</i>) Gene and Hepatic Glucose and Lipid Metabolism. | Mizuno TM | β | 2018 | β |
| FTO, GCKR, CDKAL1 and CDKN2A/B gene polymorphisms and the risk of gestational diabetes mellitus: a meta-analysis. | Guo F et al. | β | 2018 | β |
| FTO regulates adipogenesis by controlling cell cycle progression via m<sup>6</sup>A-YTHDF2 dependent mechanism. | Wu R et al. | β | 2018 | β |
| Genetics of obesity and its measures in India. | Saini S et al. | β | 2018 | β |
| Genetics of Severe Obesity. | Fairbrother U et al. | β | 2018 | β |
| Genomic Insights Into the Multiple Factors Controlling Abdominal Fat Deposition in a Chicken Model. | Abdalla BA et al. | β | 2018 | β |
| Glycaemic Index of Maternal Dietary Carbohydrate Differentially Alters <i>Fto</i> and <i>Lep</i> Expression in Offspring in C57BL/6 Mice. | Sideratou T et al. | β | 2018 | β |
| GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. | Speakman JR et al. | β | 2018 | β |
| Identification of genetic basis of obesity and mechanistic link of genes and lipids in Pakistani population. | Shabana et al. | β | 2018 | β |
| Identification of Natural Compound Radicicol as a Potent FTO Inhibitor. | Wang R et al. | β | 2018 | β |
| <i>In silico</i> approach to identify non-synonymous SNPs with highest predicted deleterious effect on protein function in human obesity related gene, <i>neuronal growth regulator 1</i> (<i>NEGR1</i>). | Kumar P et al. | β | 2018 | β |
| Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial. | Di Renzo L et al. | β | 2018 | β |
| Interethnic analyses of blood pressure loci in populations of East Asian and European descent. | Takeuchi F et al. | β | 2018 | β |
| Low Salivary Amylase Gene (<i>AMY1</i>) Copy Number Is Associated with Obesity and Gut <i>Prevotella</i> Abundance in Mexican Children and Adults. | LeΓ³n-Mimila P et al. | β | 2018 | β |
| Machine Learning-Based Method for Obesity Risk Evaluation Using Single-Nucleotide Polymorphisms Derived from Next-Generation Sequencing. | Wang HY et al. | β | 2018 | β |
| Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice. | Abu-Toamih Atamni HJ et al. | β | 2018 | β |
| Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3. | Das M et al. | β | 2018 | β |
| Nutrigenomics: Opportunities & challenges for public health nutrition. | Reddy VS et al. | β | 2018 | β |
| Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms. | Corbin KD et al. | β | 2018 | β |
| Perceived neighborhood social cohesion and cardiometabolic risk: a geneΒ ΓΒ environment study. | Robinette JW et al. | β | 2018 | β |
| Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the <i>FTO</i> gene. | Skuladottir GV et al. | β | 2018 | β |
| RNA m<sup>6</sup>A modification and its function in diseases. | Tong J et al. | β | 2018 | β |
| South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology. | Palaniappan L et al. | β | 2018 | β |
| The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI. | KjΓΈllesdal MKR et al. | β | 2018 | β |
| The dual role of N6-methyladenosine modification of RNAs is involved in human cancers. | He L et al. | β | 2018 | β |
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| The GDF11-FTO-PPARΞ³ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. | Shen GS et al. | β | 2018 | β |
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