Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

paper Cited Public

Authors: Heid, Iris M; Jackson, Anne U; Randall, Joshua C; Winkler, Thomas W; Qi, Lu; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Zillikens, M Carola; Speliotes, Elizabeth K; Mägi, Reedik; Workalemahu, Tsegaselassie; White, Charles C; Bouatia-Naji, Nabila; Harris, Tamara B; Berndt, Sonja I; Ingelsson, Erik; Willer, Cristen J; Weedon, Michael N; Luan, Jian'an; Vedantam, Sailaja; Esko, Tõnu; Kilpeläinen, Tuomas O; Kutalik, Zoltán; Li, Shengxu; Monda, Keri L; Dixon, Anna L; Holmes, Christopher C; Kaplan, Lee M; Liang, Liming; Min, Josine L; Moffatt, Miriam F; Molony, Cliona; Nicholson, George; Schadt, Eric E; Zondervan, Krina T; Feitosa, Mary F; Ferreira, Teresa; Lango Allen, Hana; Weyant, Robert J; Wheeler, Eleanor; Wood, Andrew R; MAGIC; Estrada, Karol; Goddard, Michael E; Lettre, Guillaume; Mangino, Massimo; Nyholt, Dale R; Purcell, Shaun; Smith, Albert Vernon; Visscher, Peter M; Yang, Jian; McCarroll, Steven A; Nemesh, James; Voight, Benjamin F; Absher, Devin; Amin, Najaf; Aspelund, Thor; Coin, Lachlan; Glazer, Nicole L; Hayward, Caroline; Heard-Costa, Nancy L; Hottenga, Jouke-Jan; Johansson, Asa; Johnson, Toby; Kaakinen, Marika; Kapur, Karen; Ketkar, Shamika; Knowles, Joshua W; Kraft, Peter; Kraja, Aldi T; Lamina, Claudia; Leitzmann, Michael F; McKnight, Barbara; Morris, Andrew P; Ong, Ken K; Perry, John R B; Peters, Marjolein J; Polasek, Ozren; Prokopenko, Inga; Rayner, Nigel W; Ripatti, Samuli; Rivadeneira, Fernando; Robertson, Neil R; Sanna, Serena; Sovio, Ulla; Surakka, Ida; Teumer, Alexander; van Wingerden, Sophie; Vitart, Veronique; Zhao, Jing Hua; Cavalcanti-Proença, Christine; Chines, Peter S; Fisher, Eva; Kulzer, Jennifer R; Lecoeur, Cecile; Narisu, Narisu; Sandholt, Camilla; Scott, Laura J; Silander, Kaisa; Stark, Klaus; Tammesoo, Mari-Liis; Teslovich, Tanya M; Timpson, Nicholas John; Watanabe, Richard M; Welch, Ryan; Chasman, Daniel I; Cooper, Matthew N; Jansson, John-Olov; Kettunen, Johannes; Lawrence, Robert W; Pellikka, Niina; Perola, Markus; Vandenput, Liesbeth; Alavere, Helene; Almgren, Peter; Atwood, Larry D; Bennett, Amanda J; Biffar, Reiner; Bonnycastle, Lori L; Bornstein, Stefan R; Buchanan, Thomas A; Campbell, Harry; Day, Ian N M; Dei, Mariano; Dörr, Marcus; Elliott, Paul; Erdos, Michael R; Eriksson, Johan G; Freimer, Nelson B; Fu, Mao; Gaget, Stefan; Geus, Eco J C; Gjesing, Anette P; Grallert, Harald; Grässler, Jürgen; Groves, Christopher J; Guiducci, Candace; Hartikainen, Anna-Liisa; Hassanali, Neelam; Havulinna, Aki S; Herzig, Karl-Heinz; Hicks, Andrew A; Hui, Jennie; Igl, Wilmar; Jousilahti, Pekka; Jula, Antti; Kajantie, Eero; Kinnunen, Leena; Kolcic, Ivana; Koskinen, Seppo; Kovacs, Peter; Kroemer, Heyo K; Krzelj, Vjekoslav; Kuusisto, Johanna; Kvaloy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lathrop, G Mark; Lokki, Marja-Liisa; Luben, Robert N; Ludwig, Barbara; McArdle, Wendy L; McCarthy, Anne; Morken, Mario A; Nelis, Mari; Neville, Matt J; Paré, Guillaume; Parker, Alex N; Peden, John F; Pichler, Irene; Pietiläinen, Kirsi H; Platou, Carl G P; Pouta, Anneli; Ridderstråle, Martin; Samani, Nilesh J; Saramies, Jouko; Sinisalo, Juha; Smit, Jan H; Strawbridge, Rona J; Stringham, Heather M; Swift, Amy J; Teder-Laving, Maris; Thomson, Brian; Usala, Gianluca; van Meurs, Joyce B J; van Ommen, Gert-Jan; Vatin, Vincent; Volpato, Claudia B; Wallaschofski, Henri; Walters, G Bragi; Widen, Elisabeth; Wild, Sarah H; Willemsen, Gonneke; Witte, Daniel R; Zgaga, Lina; Zitting, Paavo; Beilby, John P; James, Alan L; Kähönen, Mika; Lehtimäki, Terho; Nieminen, Markku S; Ohlsson, Claes; Palmer, Lyle J; Raitakari, Olli; Ridker, Paul M; Stumvoll, Michael; Tönjes, Anke; Viikari, Jorma; Balkau, Beverley; Ben-Shlomo, Yoav; Bergman, Richard N; Boeing, Heiner; Smith, George Davey; Ebrahim, Shah; Froguel, Philippe; Hansen, Torben; Hengstenberg, Christian; Hveem, Kristian; Isomaa, Bo; Jørgensen, Torben; Karpe, Fredrik; Khaw, Kay-Tee; Laakso, Markku; Lawlor, Debbie A; Marre, Michel; Meitinger, Thomas; Metspalu, Andres; Midthjell, Kristian; Pedersen, Oluf; Salomaa, Veikko; Schwarz, Peter E H; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Valle, Timo T; Wareham, Nicholas J; Arnold, Alice M; Beckmann, Jacques S; Bergmann, Sven; Boerwinkle, Eric; Boomsma, Dorret I; Caulfield, Mark J; Collins, Francis S; Eiriksdottir, Gudny; Gudnason, Vilmundur; Gyllensten, Ulf; Hamsten, Anders; Hattersley, Andrew T; Hofman, Albert; Hu, Frank B; Illig, Thomas; Iribarren, Carlos; Jarvelin, Marjo-Riitta; Kao, W H Linda; Kaprio, Jaakko; Launer, Lenore J; Munroe, Patricia B; Oostra, Ben; Penninx, Brenda W; Pramstaller, Peter P; Psaty, Bruce M; Quertermous, Thomas; Rissanen, Aila; Rudan, Igor; Shuldiner, Alan R; Soranzo, Nicole; Spector, Timothy D; Syvanen, Ann-Christine; Uda, Manuela; Uitterlinden, André; Völzke, Henry; Vollenweider, Peter; Wilson, James F; Witteman, Jacqueline C; Wright, Alan F; Abecasis, Gonçalo R; Boehnke, Michael; Borecki, Ingrid B; Deloukas, Panos; Frayling, Timothy M; Groop, Leif C; Haritunians, Talin; Hunter, David J; Kaplan, Robert C; North, Kari E; O'Connell, Jeffrey R; Peltonen, Leena; Schlessinger, David; Strachan, David P; Hirschhorn, Joel N; Assimes, Themistocles L; Wichmann, H-Erich; Thorsteinsdottir, Unnur; van Duijn, Cornelia M; Stefansson, Kari; Cupples, L Adrienne; Loos, Ruth J F; Barroso, Inês; McCarthy, Mark I; Fox, Caroline S; Mohlke, Karen L; Lindgren, Cecilia M
Year: 2010
Journal: Nature genetics
PMID: 20935629
DOI: 10.1038/ng.685
PMCID: PMC3000924

Figure 1

Genome-wide association analyses for WHR in discovery studiesA. Manhattan plot shows results of the WHR association meta-analysis in discovery studies (P on the y-axis and SNP genomic position on the x-axis). Colored genomic loci indicate significant association (P < 5 × 10−8) detected previously (blue)13, in our GWA stage (red), and after the meta-analysis combining GWA and follow-up studies (orange). Two loci tested in the follow-up stage did not achieve genome-wide significance (green).B. Quantile-quantile (QQ) plot of SNPs for the discovery meta-analysis of WHR (black) and after removing SNPs within 1 Mb of either the recently reported LYPLAL1 signal (blue) or the 14 significant associations (green). The grey area represents the 95% confidence interval around the test statistic under the null distribution.

Figure 2

Regional plots of 14 loci with genome-wide significant associationSNP association with WHR in meta-analysis of discovery studies for 14 loci (−log10 P on the y-axis and SNP genomic position on the x-axis). In each panel, an index SNP is denoted with a purple diamond and plotted using the P attained across discovery and follow-up data (Table 1). Estimated recombination rates are plotted in blue. SNPs are colored to reflect LD with the index SNP (pair-wise r2 values from HapMap CEU). Gene and microRNA annotations are from the UCSC genome browser.

Figure 3

Association of the 14 WHR loci with waist and hip circumferenceBeta-coefficients for waist circumference (WC, x-axis) and hip circumference (HIP, y-axis) in women and men derived from the joint discovery and follow-up analysis. P for WC and HIP are represented by color. In men, grey gene labels refer to those SNPs that were not significant in the male-specific WHR analysis. More details can be found in Supplementary Table 3.

Figure 4

#	Section	Preview
0	RESULTS — Genome-wide significant association of WHR with 14 SNPs	We conducted a two-stage study among individuals of European descent (Supplementary Table 1 and…
1	RESULTS — Genome-wide significant association of WHR with 14 SNPs	We selected SNPs representing the top 16 independent (> 1 Mb distance) regions of association…
2	RESULTS — Genome-wide significant association of WHR with 14 SNPs	Between-study heterogeneity was low (I2 < 30%) for all but two signals (GRB14 and LYPLAL1, see…
3	RESULTS — Genome-wide significant association of WHR with 14 SNPs	One of these SNPs, rs4846567, is in linkage disequilibrium (LD, r2 = 0.64, D’ = 0.84; HapMap CEU)…
4	RESULTS — Sexual dimorphism at several of the WHR loci	Given the known sexual dimorphism of WHR and evidence from variance decomposition studies that this…
5	RESULTS — Association with other anthropometric measures	By focusing on WHR after adjustment for BMI, our goal was to detect effects on body fat distribution…
6	RESULTS — Association with other anthropometric measures	We also tested the 14 WHR-associated SNPs for their effect on BMI using data from up to 242,530…
7	RESULTS — Association with other anthropometric measures	To determine whether the WHR-associated signals exert their effects primarily through an effect on…
8	RESULTS — Enrichment of association with metabolic traits	We evaluated the 14 WHR-associated loci for their relationships with related metabolic traits using…
9	RESULTS — Enrichment of association with metabolic traits	T2D, three of these (ADAMTS9, NISCH-STAB1, and ITPR2-SSPN) reaching nominal significance (P < 0.05)…
10	RESULTS — Pathway analysis of the WHR-associated loci and potential biological role	To identify potential functional connections and pathway relationships between genes mapping at the…
11	RESULTS — Pathway analysis of the WHR-associated loci and potential biological role	First, we performed a survey of the published literature using GRAIL22, to search for connectivity…
12	RESULTS — Pathway analysis of the WHR-associated loci and potential biological role	Additionally, we performed pathway analyses using the PANTHER database23 based on the same set of 95…
13	RESULTS — Pathway analysis of the WHR-associated loci and potential biological role	Finally, we examined the described functional roles of some of the most compelling candidates based…
14	RESULTS — Evaluation of copy number variants (CNVs) and nonsynonymous changes	Both common and rare CNVs have been reported to be associated with overall adiposity14,15,24,25, but…
15	RESULTS — Evaluation of copy number variants (CNVs) and nonsynonymous changes	One CNV-tagging SNP (rs1294421, LY86) was observed amongst our 14 WHR-associated loci. This SNP is…
16	RESULTS — Evaluation of copy number variants (CNVs) and nonsynonymous changes	To identify other putatively causal variants in our associated regions, we searched for…
17	RESULTS — Evaluation of effect of the WHR associations on expression in relevant tissues	Expression-QTL (eQTL) data can implicate regional transcripts that mediate trait-associations, and…
18	RESULTS — Evaluation of effect of the WHR associations on expression in relevant tissues	At six of the loci, the WHR-associated SNP was either the strongest SNP associated with significant…
19	RESULTS — Evaluation of effect of the WHR associations on expression in relevant tissues	coincidence of the WHR signal with expression for rs984222 (TBX15 in omental fat), rs1055144…

Citation	PMID	DOI	Status
Agarwal, AK et al., Annu Rev Genomics Hum Genet, 2006, Genetic disorders of adipose tissue development, differentiation, and death	16722806	10.1146/annurev.genom.7.080505.115715	Cited
Aulchenko, YS, Nat Genet, 2009, Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts	19060911	10.1038/ng.269	Cited
Benjamini, Y et al., Journal of the Royal Statistical Society Series B-Methodological, 1995, Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing	—	—	—
Bochukova, EG, Nature, 2009, Large, rare chromosomal deletions associated with severe early-onset obesity	19966786	10.1038/nature08689	Cited
Boesgaard, TW, PLoS One, 2009, Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study	19789630	10.1371/journal.pone.0007236	Cited
Candille, SI, PLoS Biol, 2004, Dorsoventral patterning of the mouse coat by Tbx15	14737183	10.1371/journal.pbio.0020003	Cited
Canoy, D, Curr Opin Cardiol, 2008, Distribution of body fat and risk of coronary heart disease in men and women	18830075	10.1097/HCO.0b013e328313133a	Cited
Carey, VJ, Am J Epidemiol, 1997, Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study	9098178	10.1093/oxfordjournals.aje.a009158	Cited
Conrad, DF, Nature, 2009, Origins and functional impact of copy number variation in the human genome	19812545	10.1038/nature08516	Cited
Cooney, GJ, EMBO J, 2004, Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice	14749734	10.1038/sj.emboj.7600082	Cited
Cox, DR et al., Theoretical Statistics, 1979	—	—	—
Devlin, B et al., Biometrics, 1999, Genomic control for association studies	11315092	10.1111/j.0006-341x.1999.00997.x	Cited
Dixon, AL, Nat Genet, 2007, A genome-wide association study of global gene expression	17873877	10.1038/ng2109	Cited
Doring, A, Nat Genet, 2008, SLC2A9 influences uric acid concentrations with pronounced sex-specific effects	18327256	10.1038/ng.107	Cited
Dupuis, J, Nat Genet, New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk	20081858	10.1038/ng.520	Cited
Emilsson, V, Nature, 2008, Genetics of gene expression and its effect on disease	18344981	10.1038/nature06758	Cited
Fox, CS, Circulation, 2007, Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study	17576866	10.1161/CIRCULATIONAHA.106.675355	Cited
Frayling, TM, Science, 2007, A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity	17434869	10.1126/science.1141634	Cited
Garcia de la Torre, N, J Clin Endocrinol Metab, 2008, Effects of weight loss after bariatric surgery for morbid obesity on vascular endothelial growth factor-A, adipocytokines, and insulin	18713823	10.1210/jc.2007-1370	Cited
Garg, A, N Engl J Med, 2004, Acquired and inherited lipodystrophies	15028826	10.1056/NEJMra025261	Cited
Gesta, S et al., Cell, 2007, Developmental origin of fat: tracking obesity to its source	17956727	10.1016/j.cell.2007.10.004	Cited
Gesta, S, Proc Natl Acad Sci U S A, 2006, Evidence for a role of developmental genes in the origin of obesity and body fat distribution	16617105	10.1073/pnas.0601752103	Cited
Kathiresan, S, Nat Genet, 2009, Common variants at 30 loci contribute to polygenic dyslipidemia	19060906	10.1038/ng.291	Cited
Krotkiewski, M et al., J Clin Invest, 1983, Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution	6350364	10.1172/JCI111040	Cited
Lanctot, C et al., Exp Cell Res, 2007, Positioning of the mouse Hox gene clusters in the nuclei of developing embryos and differentiating embryoid bodies	17346703	10.1016/j.yexcr.2007.01.027	Cited
Li, Y et al., Annu Rev Genomics Hum Genet, 2009, Genotype imputation	19715440	10.1146/annurev.genom.9.081307.164242	Cited
Lindgren, CM, PLoS Genet, 2009, Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution	19557161	10.1371/journal.pgen.1000508	Cited
Loos, RJ, Nat Genet, 2008, Common variants near MC4R are associated with fat mass, weight and risk of obesity	18454148	10.1038/ng.140	Cited
Marchini, J et al., Nat Genet, 2007, A new multipoint method for genome-wide association studies by imputation of genotypes	17572673	10.1038/ng2088	Cited
Mills, GW, Diabetologia, 2004, Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes	15298351	10.1007/s00125-004-1338-2	Cited
Nature, Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls	20360734	10.1038/nature08979	Cited
Nishimura, S, Diabetes, 2007, Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels	17389330	10.2337/db06-1749	Cited
O'Rahilly, S, Nature, 2009, Human genetics illuminates the paths to metabolic disease	19924209	10.1038/nature08532	Cited
Pennacchio, LA et al., Genome Res, 2007, Predicting tissue-specific enhancers in the human genome	17210927	10.1101/gr.5972507	Cited
Pischon, T, N Engl J Med, 2008, General and abdominal adiposity and risk of death in Europe	19005195	10.1056/NEJMoa0801891	Cited
Raychaudhuri, S, PLoS Genet, 2009, Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions	19557189	10.1371/journal.pgen.1000534	Cited
Ridker, PM, Circ Cardiovasc Genet, 2009, Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study	20031564	10.1161/CIRCGENETICS.108.817304	Cited
Rose, KM et al., Obes Res, 1998, Genetic and behavioral determinants of waist-hip ratio and waist circumference in women twins	9845227	10.1002/j.1550-8528.1998.tb00369.x	Cited
Saxena, R, Nat Genet, Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge	20081857	10.1038/ng.521	Cited
Schadt, EE, PLoS Biol, 2008, Mapping the genetic architecture of gene expression in human liver	18462017	10.1371/journal.pbio.0060107	Cited
Scherzer, R, Am J Clin Nutr, 2008, Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects	18541572	10.1093/ajcn/87.6.1809	Cited
Selby, JV, Int J Obes, 1990, Genetic and behavioral influences on body fat distribution	2228394	—	Cited
Servin, B et al., PLoS Genet, 2007, Imputation-based analysis of association studies: candidate regions and quantitative traits	17676998	10.1371/journal.pgen.0030114	Cited
Shifman, S, PLoS Genet, 2008, Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women	18282107	10.1371/journal.pgen.0040028	Cited
Silha, JV et al., Int J Obes (Lond), 2005, Angiogenic factors are elevated in overweight and obese individuals	15953938	10.1038/sj.ijo.0802987	Cited
Snijder, MB, Am J Clin Nutr, 2003, Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study	12716671	10.1093/ajcn/77.5.1192	Cited
Snijder, MB, Diabetes Care, 2004, Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study	14747216	10.2337/diacare.27.2.372	Cited
Souren, NY, Diabetologia, 2007, Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities	17694296	10.1007/s00125-007-0784-z	Cited
Speliotes, EK, Nat Genet, Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index	20935630	10.1038/ng.686	Cited
Stouffer, SA et al., Adjustment during army life, 1949	—	—	—
Thomas, PD, Genome Res, 2003, PANTHER: a library of protein families and subfamilies indexed by function	12952881	10.1101/gr.772403	Cited
Thorleifsson, G, Nat Genet, 2009, Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity	19079260	10.1038/ng.274	Cited
Vega, GL, J Clin Endocrinol Metab, 2006, Influence of body fat content and distribution on variation in metabolic risk	16926254	10.1210/jc.2006-0814	Cited
Voight, BF, Nature Genetics, Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis	20581827	10.1038/ng.609	Cited
Walters, RG, Nature, A new highly penetrant form of obesity due to deletions on chromosome 16p11.2	20130649	10.1038/nature08727	Cited
Wang, Y et al., Am J Clin Nutr, 2005, Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men	15755822	10.1093/ajcn/81.3.555	Cited
Wells, JC, Best Pract Res Clin Endocrinol Metab, 2007, Sexual dimorphism of body composition	17875489	10.1016/j.beem.2007.04.007	Cited
Whitlock, MC, Journal of Evolutionary Biology, 2005, Combining probability from independent tests: the weighted Z-method is superior to Fisher's approach	16135132	10.1111/j.1420-9101.2005.00917.x	Cited
Willer, CJ, Nat Genet, 2009, Six new loci associated with body mass index highlight a neuronal influence on body weight regulation	19079261	10.1038/ng.287	Cited
Zeggini, E, Nat Genet, 2008, Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes	18372903	10.1038/ng.120	Cited
Zillikens, MC, Diabetologia, 2008, Sex-specific genetic effects influence variation in body composition	18839131	10.1007/s00125-008-1163-0	Cited

In this knowledge base

Title	Year	PMID
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.	2015	25642630
On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis.	2014	24884913
Development and evaluation of a genetic risk score for obesity.	2013	23701538
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.	2013	23563607
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	2012	22589738
Genome-wide association of BMI in African Americans.	2012	21701570
Implication of European-derived adiposity loci in African Americans.	2012	21750520
MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.	2011	22102887
Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.	2011	21131291

External

Title	Authors	Journal	Year	Link
Frontiers in the physiology of male pattern androgenetic alopecia: beyond the androgen horizon.	Altendorf S et al.	—	2026	→
LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD.	Hussain R et al.	—	2026	→
A Genome-Wide Association Study of Circulating Serum Choline, Betaine, Dimethylglycine, and Their Ratios.	Louck LE et al.	—	2025	→
Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5.	Martin DR et al.	—	2025	→
Dissection of type 2 diabetes: a genetic perspective.	Bonnefond A et al.	—	2025	→
Effects of β-catenin deficiency on adipose tissue physiology.	Uranga RM et al.	—	2025	→
Endophenotype-Informed Association Analyses for Liver Fat Accumulation and Metabolic Dysfunction in the Fels Longitudinal Study.	Garza AL et al.	—	2025	→
Evaluating regional heritability mapping methods for identifying QTLs in a wild population of Soay sheep.	James C et al.	—	2025	→
Investigating the Sexual Dimorphism of Waist-to-Hip Ratio and Its Associations with Complex Traits.	Li H et al.	—	2025	→
Investigation of the impact of gynoid fat on steatotic and advanced liver diseases-Genomic and clinical perspectives from a large-scale population cohort.	Liu Z et al.	—	2025	→
Lipedema: Progress, Challenges, and the Road Ahead.	Cifarelli V	—	2025	→
Longitudinal Analysis of Placental <i>IRS1</i> DNA Methylation and Childhood Obesity.	Gómez-Vilarrubla A et al.	—	2025	→
Neuroendocrinology and the Genetics of Obesity.	Ruggiero-Ruff RE et al.	—	2025	→
Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.	Masip G et al.	—	2025	→
Realizing the promise of genome-wide association studies for effector gene prediction.	Costanzo MC et al.	—	2025	→
Reduced Growth and Inflammation in Lrp5<sup>-/-</sup> Mice Adipose Tissue.	Luquero A et al.	—	2025	→
Role of X chromosome and dosage-compensation mechanisms in complex trait genetics.	Fu Y et al.	—	2025	→
Sex and Gender Differences in Obesity: Biological, Sociocultural, and Clinical Perspectives.	Kim H et al.	—	2025	→
The 14-year cumulative genetic high blood pressure and risk of type 2 diabetes in Korean: observational and Mendelian randomization evidence.	Jeon J et al.	—	2025	→
The Association Between Weight-Adjusted-Waist Index and S-Klotho Levels in Adults: NHANES 2007-2016.	Chen J et al.	—	2025	→
Unraveling the Genetic Architecture of Obesity: A Path to Personalized Medicine.	Kunnathodi F et al.	—	2025	→
Visceral fat distribution: Interracial studies.	Banerjee S et al.	—	2025	→
Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies.	Wang S et al.	—	2024	→
A Family-Based Study of Inherited Genetic Risk in Lipedema.	Morgan S et al.	—	2024	→
Aging reveals a sex-dependent susceptibility of sarcospan-deficient mice to cardiometabolic disease.	Rahimi Kahmini A et al.	—	2024	→
A meta-analysis and polygenic score study identifies novel genetic markers for waist-hip ratio in African populations.	Zhong M et al.	—	2024	→
A new test for trait mean and variance detects unreported loci for blood-pressure variation.	Breeyear JH et al.	—	2024	→
Association between oral microbiome and breast cancer in the east Asian population: A Mendelian randomization and case-control study.	Feng K et al.	—	2024	→
Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations.	Ishida Y et al.	—	2024	→
Association of waist-to-hip ratio adjusted for body mass index with cognitive impairment in middle-aged and elderly patients with type 2 diabetes mellitus: a cross-sectional study.	Chen T et al.	—	2024	→
Better together against genetic heterogeneity: A sex-combined joint main and interaction analysis of 290 quantitative traits in the UK Biobank.	Lin B et al.	—	2024	→
Bidirectional Mendelian Randomization Reveals Causal Effects of Immune Cell Traits on Endometriosis Risk.	Wang Y et al.	—	2024	→
Deciphering the impact of genomic variation on function.	IGVF Consortium	—	2024	→
Depot-specific mRNA expression programs in human adipocytes suggest physiological specialization via distinct developmental programs.	Clemons HJ et al.	—	2024	→
Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children.	Manco L et al.	—	2024	→
Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.	Vermehren-Schmaedick A et al.	—	2024	→
Identifying latent genetic interactions in genome-wide association studies using multiple traits.	Bass AJ et al.	—	2024	→
Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.	Han HY et al.	—	2024	→
Maternal genomic profile, gestational diabetes control, and Mediterranean diet to prevent low birth weight.	Ramos-Levi AM et al.	—	2024	→
Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders.	Alser M et al.	—	2024	→
Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans.	Chakrabarty A et al.	—	2024	→
New insight into the CNC-bZIP member, NFE2L3, in human diseases.	Xiong G et al.	—	2024	→
Peripheral blood leukocyte Telomere length and endometriosis: A Mendelian randomization study.	Wang Y et al.	—	2024	→
Population structure and selective signature analysis of local sheep breeds in Xinjiang, China based on high-density SNP chip.	Li Y et al.	—	2024	→
Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip.	Yang R et al.	—	2024	→
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.	Li XQ et al.	—	2024	→
Refining the genomic profiles of North African sheep breeds through meta-analysis of worldwide genomic SNP data.	Baazaoui I et al.	—	2024	→
Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications.	Koceva A et al.	—	2024	→
Sexual dimorphism of adiposity and fat distribution among children and adolescents (8-18 year olds) from Poland.	Żegleń M et al.	—	2024	→
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease.	Lee SHT et al.	—	2024	→
The genetics of adipose tissue metabolism.	Dumbell R et al.	—	2024	→
A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners.	Yang Y et al.	—	2023	→
Adiposity and sex-specific cancer risk.	Rask-Andersen M et al.	—	2023	→
A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.	Glunk V et al.	—	2023	→
AnthropoAge, a novel approach to integrate body composition into the estimation of biological age.	Fermín-Martínez CA et al.	—	2023	→
Association of obesity and weight gain with alveolar bone loss: Results of the Northern Finland Birth Cohort 1966 study.	Tegelberg P et al.	—	2023	→
Association of the android to gynoid fat ratio with nonalcoholic fatty liver disease: a cross-sectional study.	Yang L et al.	—	2023	→
Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape.	Li Q et al.	—	2023	→
Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins.	Figaroa MNS et al.	—	2023	→
Fibrillin-1 and asprosin, novel players in metabolic syndrome.	Summers KM et al.	—	2023	→
Gene-Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity.	Kwak J et al.	—	2023	→
Genetic architecture of adiposity measures among Asians: Findings from GWAS.	Agarwal T et al.	—	2023	→
Genetics and epigenetics in the obesity phenotyping scenario.	Trang K et al.	—	2023	→
Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors.	Klimentidis YC et al.	—	2023	→
<i>Ctnnb1</i>/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue.	Chen N et al.	—	2023	→
Identification of candidate genes associated with carcass component weights in commercial crossbred pigs through a combined GWAS approach.	Qiu Y et al.	—	2023	→
Identification of ROH Islands Conserved through Generations in Pigs Belonging to the Nero Lucano Breed.	Di Gregorio P et al.	—	2023	→
Independent relevance of adiposity measures to coronary heart disease risk among 0.5 million adults in UK Biobank.	Trichia E et al.	—	2023	→
Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity.	Vohnoutka RB et al.	—	2023	→
Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study.	Bai C et al.	—	2023	→
LGR4: A New Receptor Member in Endocrine and Metabolic Diseases.	Zhang N et al.	—	2023	→
Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.	Saponara E et al.	—	2023	→
Multi-omics approaches for precision obesity management : Potentials and limitations of omics in precision prevention, treatment and risk reduction of obesity.	Woldemariam S et al.	—	2023	→
OVOL2: an epithelial lineage determiner with emerging roles in energy homeostasis.	Jiang Y et al.	—	2023	→
Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease.	Yeyeodu S et al.	—	2023	→
Sex and Race Differences in Obesity-Related Genetic Susceptibility and Risk of Cardiometabolic Disease in Older US Adults.	Yu H et al.	—	2023	→
Sex-Specific Features of the Correlation between GWAS-Noticeable Polymorphisms and Hypertension in Europeans of Russia.	Ivanova T et al.	—	2023	→
Technologies, strategies, and cautions when deconvoluting genome-wide association signals: FTO in focus.	Pahl MC et al.	—	2023	→
Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants.	Young KL et al.	—	2023	→
Adipose Tissue Dysfunction and Obesity-Related Male Hypogonadism.	Genchi VA et al.	—	2022	→
A <i>Wars2</i> mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning.	Mušo M et al.	—	2022	→
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.	Fernández-Rhodes L et al.	—	2022	→
A Novel Hierarchical Clustering Approach for Joint Analysis of Multiple Phenotypes Uncovers Obesity Variants Based on ARIC.	Fu L et al.	—	2022	→
Body composition measured by bioelectrical impedance analysis is a viable alternative to magnetic resonance imaging in children with nonalcoholic fatty liver disease.	Orkin S et al.	—	2022	→
Comparison of Anti-factor Xa Levels in Female and Male Patients with Obesity After Enoxaparin Application for Thromboprophylaxis.	Wagner J et al.	—	2022	→
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity-associated metabolic syndrome.	Akter S et al.	—	2022	→
Different genes may be involved in distal and local sensitization: A genome-wide gene-based association study and meta-analysis.	Kouraki A et al.	—	2022	→
Genetic and phenotypic links between obesity and extracellular vesicles.	Zhai R et al.	—	2022	→
Harnessing tissue-specific genetic variation to dissect putative causal pathways between body mass index and cardiometabolic phenotypes.	Leyden GM et al.	—	2022	→
Health improvements of type 2 diabetic patients through diet and diet plus fecal microbiota transplantation.	Su L et al.	—	2022	→
Hepatic adropin is regulated by estrogen and contributes to adverse metabolic phenotypes in ovariectomized mice.	Stokar J et al.	—	2022	→
Identification of genetic loci simultaneously associated with multiple cardiometabolic traits.	Wood AC et al.	—	2022	→
Insight into genetic, biological, and environmental determinants of sexual-dimorphism in type 2 diabetes and glucose-related traits.	Lamri A et al.	—	2022	→
<i>Keratinocyte-associated protein 3</i> plays a role in body weight and adiposity with differential effects in males and females.	Szalanczy AM et al.	—	2022	→
Metabolic Effects of the Waist-To-Hip Ratio Associated Locus <i>GRB14/COBLL1</i> Are Related to <i>GRB14</i> Expression in Adipose Tissue.	Sun C et al.	—	2022	→
Modeling sex differences in humans using isogenic induced pluripotent stem cells.	Waldhorn I et al.	—	2022	→
Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.	Downie CG et al.	—	2022	→
Population-based meta-analysis and gene-set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids.	Handelman SK et al.	—	2022	→
Role of Nischarin in the pathology of diseases: a special emphasis on breast cancer.	Okpechi SC et al.	—	2022	→
Shared genetic loci for body fat storage and adipocyte lipolysis in humans.	Kulyté A et al.	—	2022	→
Strategies to identify causal common genetic variants and corresponding effector genes for paediatric obesity.	Littleton SH et al.	—	2022	→
The Influence of the Differentiation of Genes Encoding Peroxisome Proliferator-Activated Receptors and Their Coactivators on Nutrient and Energy Metabolism.	Maciejewska-Skrendo A et al.	—	2022	→
The relationship of genetic risk score with cardiometabolic risk factors: a cross-sectional study.	Gholami F et al.	—	2022	→
Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line.	Arends D et al.	—	2022	→
Underrepresented Populations at the Archaic Introgression Frontier.	Villanea FA et al.	—	2022	→
Abdominal and gluteofemoral fat depots show opposing associations with postprandial lipemia.	Christiansen MR et al.	—	2021	→
A Genome-Wide Association Study of Novel Genetic Variants Associated With Anthropometric Traits in Koreans.	Cho HW et al.	—	2021	→
A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation.	Bonfante B et al.	—	2021	→
A Novel Approach Integrating Hierarchical Clustering and Weighted Combination for Association Study of Multiple Phenotypes and a Genetic Variant.	Fu L et al.	—	2021	→
Association of FTO, ABCA1, ADRB3, and PPARG variants with obesity, type 2 diabetes, and metabolic syndrome in a Northwest Mexican adult population.	Velazquez-Roman J et al.	—	2021	→
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci.	Hammond RK et al.	—	2021	→
BTOB: Extending the Biased GWAS to Bivariate GWAS.	Zhu J et al.	—	2021	→
Causal Associations of Obesity With the Intervertebral Degeneration, Low Back Pain, and Sciatica: A Two-Sample Mendelian Randomization Study.	Zhou J et al.	—	2021	→
Developmental mechanisms of sex differences: from cells to organisms.	Mank JE et al.	—	2021	→
Distinct genetic subtypes of adiposity and glycemic changes in response to weight-loss diet intervention: the POUNDS Lost trial.	Chen Y et al.	—	2021	→
Genetic Diversity and Signatures of Selection for Thermal Stress in Cattle and Other Two <i>Bos</i> Species Adapted to Divergent Climatic Conditions.	Freitas PHF et al.	—	2021	→
Genetics of Body Fat Distribution: Comparative Analyses in Populations with European, Asian and African Ancestries.	Sun C et al.	—	2021	→
Genetics of Obesity: What We Have Learned Over Decades of Research.	Bouchard C	—	2021	→
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.	Lakshman Kumar P et al.	—	2021	→
Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.	Justice AE et al.	—	2021	→
Genome-wide association study of neck circumference identifies sex-specific loci independent of generalized adiposity.	Liu Y et al.	—	2021	→
Genome-wide association study of periodontal pocketing in Finnish adults.	Tegelberg P et al.	—	2021	→
Genomic Analysis of Visceral Fat Accumulation in Holstein Cows.	Novo LC et al.	—	2021	→
Genomics of body fat distribution.	Saini S et al.	—	2021	→
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.	Christakoudi S et al.	—	2021	→
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.	Pan DZ et al.	—	2021	→
Instrumental Heterogeneity in Sex-Specific Two-Sample Mendelian Randomization: Empirical Results From the Relationship Between Anthropometric Traits and Breast/Prostate Cancer.	Gao Y et al.	—	2021	→
Integration of summary data from GWAS and eQTL studies identified novel risk genes for coronary artery disease.	Zhong Y et al.	—	2021	→
Metabolically healthy obesity and metabolically obese normal weight: a review.	Gómez-Zorita S et al.	—	2021	→
Molecular characterization of the stress network in individuals at risk for schizophrenia.	Meijer M et al.	—	2021	→
Potential associations between immune signaling genes, deactivated microglia, and oligodendrocytes and cortical gray matter loss in patients with long-term remitted Cushing's disease.	Bauduin SEEC et al.	—	2021	→
Replication of European hypertension associations in a case-control study of 9,534 African Americans.	Kaur H et al.	—	2021	→
Retinol-binding protein 4 in obesity and metabolic dysfunctions.	Nono Nankam PA et al.	—	2021	→
RNA-seq Characterization of Sex-Differences in Adipose Tissue of Obesity Affected Patients: Computational Analysis of Differentially Expressed Coding and Non-Coding RNAs.	Rey F et al.	—	2021	→
Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer.	Heo JW et al.	—	2021	→
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.	Lagou V et al.	—	2021	→
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver.	Goossens GH et al.	—	2021	→
Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.	Gordon-Larsen P et al.	—	2021	→
Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions.	Bagchi DP et al.	—	2021	→
A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery.	Katsareli EA et al.	—	2020	→
Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis.	Nguyen HP et al.	—	2020	→
A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability.	Mušo M et al.	—	2020	→
Bayesian model averaging for the X-chromosome inactivation dilemma in genetic association study.	Chen B et al.	—	2020	→
Causal associations of body mass index and waist-to-hip ratio with cardiometabolic traits among Chinese children: A Mendelian randomization study.	Song Q et al.	—	2020	→
Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study.	Huerta-Chagoya A et al.	—	2020	→
Deciphering Sex-Specific Genetic Architectures Using Local Bayesian Regressions.	Funkhouser SA et al.	—	2020	→
Developmentally Driven Changes in Adipogenesis in Different Fat Depots Are Related to Obesity.	Breitfeld J et al.	—	2020	→
Discovery of small-molecule enzyme activators by activity-based protein profiling.	Kok BP et al.	—	2020	→
Distinct abdominal and gluteal adipose tissue transcriptome signatures are altered by exercise training in African women with obesity.	Nono Nankam PA et al.	—	2020	→
Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases.	Flores-Dorantes MT et al.	—	2020	→
Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis-Does Sex Matter?	Savva C et al.	—	2020	→
Evaluation of Ethnic Variations in Visceral, Subcutaneous, Intra-Pancreatic, and Intra-Hepatic Fat Depositions by Magnetic Resonance Imaging among New Zealanders.	Yang JZ et al.	—	2020	→
Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations.	Williams R et al.	—	2020	→
Genomic Scan for Selection Signature Reveals Fat Deposition in Chinese Indigenous Sheep with Extreme Tail Types.	Zhao F et al.	—	2020	→
<i>CTNNB1/</i>β<i>-catenin</i> dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes.	Chen M et al.	—	2020	→
Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome.	Ahn Y et al.	—	2020	→
Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction.	Ding X et al.	—	2020	→
Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian.	Alsulami S et al.	—	2020	→
Low Elevation and Physical Inactivity are Associated with a Higher Prevalence of Metabolic Syndrome in Ecuadorian Adults: A National Cross-Sectional Study.	Juna CF et al.	—	2020	→
Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences.	Tsatsoulis A et al.	—	2020	→
Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene <i>TBX15</i>.	Zhang X et al.	—	2020	→
Sex differences in the response to oxidative and proteolytic stress.	Tower J et al.	—	2020	→
Two Variants in the <i>NOTCH4</i> and <i>HLA-C</i> Genes Contribute to Familial Clustering of Psoriasis.	Cai M et al.	—	2020	→
Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.	Bagchi DP et al.	—	2020	→
Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells.	Bagchi DP et al.	—	2020	→
Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics.	Friesen M et al.	—	2019	→
A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover.	Wang LW et al.	—	2019	→
A general statistic to test an optimally weighted combination of common and/or rare variants.	Zhang J et al.	—	2019	→
A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.	van der Lee SJ et al.	—	2019	→
Aldehyde Dehydrogenases Genetic Polymorphism and Obesity: From Genomics to Behavior and Health.	Hu C	—	2019	→
A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study.	Umano GR et al.	—	2019	→
A modified association test for rare and common variants based on affected sib-pair design.	Guo Y et al.	—	2019	→
Android fat as a determinant of metabolic syndrome: Sex differences.	Bi X et al.	—	2019	→
An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion.	Trinh I et al.	—	2019	→
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.	Kraja AT et al.	—	2019	→
Bayesian multivariate reanalysis of large genetic studies identifies many new associations.	Turchin MC et al.	—	2019	→
Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation.	Castillejo-Lopez C et al.	—	2019	→
Determinants of body fat distribution in humans may provide insight about obesity-related health risks.	Frank AP et al.	—	2019	→
Disparity in Adiposity among Adults with Normal Body Mass Index and Waist-to-Height Ratio.	Dybala MP et al.	—	2019	→
EDAR, LYPLAL1, PRDM16, PAX3, DKK1, TNFSF12, CACNA2D3, and SUPT3H gene variants influence facial morphology in a Eurasian population.	Li Y et al.	—	2019	→
Functional genomic characterization of the <i>FTO</i> locus in African Americans.	Gill R et al.	—	2019	→
GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals.	Iotchkova V et al.	—	2019	→
Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.	Norheim F et al.	—	2019	→
Genetic Architecture of Human Obesity Traits in the Rhesus Macaque.	Raboin MJ et al.	—	2019	→
Genetic contribution to waist-to-hip ratio in Mexican children and adolescents based on 12 loci validated in European adults.	Turcotte M et al.	—	2019	→
Genetic Determinants of Weight Loss After Bariatric Surgery.	Aasbrenn M et al.	—	2019	→
Genetic risk score predicts risk for overweight and obesity in Finnish preadolescents.	Viljakainen H et al.	—	2019	→
Genetic variants in the ITPR2 gene are associated with Kashin-Beck Disease in Tibetan.	He X et al.	—	2019	→
Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.	Rask-Andersen M et al.	—	2019	→
Genome-wide association study reveals sex-specific genetic architecture of facial attractiveness.	Hu B et al.	—	2019	→
Genome-wide study to detect single nucleotide polymorphisms associated with visceral and subcutaneous fat deposition in Holstein dairy cows.	Melendez P et al.	—	2019	→
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.	Hübel C et al.	—	2019	→
Genomic structure of a crossbred Landrace pig population.	Joaquim LB et al.	—	2019	→
Health endowment and later-life outcomes in the labour market: Evidence using genetic risk scores and reduced-form models.	Pehkonen J et al.	—	2019	→
How youth cognitive and sociodemographic factors relate to the development of overweight and obesity in the UK and the USA: a prospective cross-cohort study of the National Child Development Study and National Longitudinal Study of Youth 1979.	Altschul DM et al.	—	2019	→
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism.	Hochreuter MY et al.	—	2019	→
Letter regarding article, "Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis".	Tan VY et al.	—	2019	→
Metabolically healthy versus metabolically unhealthy obesity.	Iacobini C et al.	—	2019	→
MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.	Hilton C et al.	—	2019	→
Powerful and efficient SNP-set association tests across multiple phenotypes using GWAS summary data.	Guo B et al.	—	2019	→
Relationship of Anthropometric Indices to Abdominal Body Composition: A Multi-Ethnic New Zealand Magnetic Resonance Imaging Study.	Cervantes A et al.	—	2019	→
RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer.	Mesci A et al.	—	2019	→
Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse.	González-Granillo M et al.	—	2019	→
Sex-specific moderation by lifestyle and psychosocial factors on the genetic contributions to adiposity in 112,151 individuals from UK Biobank.	Calvin CM et al.	—	2019	→
Sexual dimorphism in the expression of GKN2 and FOXA2 genes in the human stomach.	Mohammadi R et al.	—	2019	→
Sexual Dimorphism of a Genetic Risk Score for Obesity and Related Traits among Chinese Patients with Type 2 Diabetes.	Kong X et al.	—	2019	→
Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway.	Sun W et al.	—	2019	→
The Impact of Early Human Migration on Brown Adipose Tissue Evolution and Its Relevance to the Modern Obesity Pandemic.	Sellayah D	—	2019	→
The role of sex in the genomics of human complex traits.	Khramtsova EA et al.	—	2019	→
ADAMTS proteins in human disorders.	Mead TJ et al.	—	2018	→
Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.	Hou Y et al.	—	2018	→
Adjustment for covariates using summary statistics of genome-wide association studies.	Wang T et al.	—	2018	→
A fine-mapping study of central obesity loci incorporating functional annotation and imputation.	Zhang X et al.	—	2018	→
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.	van Zuydam NR et al.	—	2018	→
A Genomewide Integrative Analysis of GWAS and eQTLs Data Identifies Multiple Genes and Gene Sets Associated with Obesity.	Liu L et al.	—	2018	→
A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics.	Corella D et al.	—	2018	→
A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.	Hoffmann TJ et al.	—	2018	→
A transcript-wide association study in physical activity intervention implicates molecular pathways in chronic disease	Claypool K et al.	—	2018	—
A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways.	Agnew T et al.	—	2018	→
Biochemical and cellular properties of insulin receptor signalling.	Haeusler RA et al.	—	2018	→
Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?	Yarmolinsky J et al.	—	2018	→
Clinical and Genetic Determinants of Varicose Veins.	Fukaya E et al.	—	2018	→
Cohort Profile: The Oxford Biobank.	Karpe F et al.	—	2018	→
Comprehensive review and annotation of susceptibility SNPs associated with obesity-related traits.	Dong SS et al.	—	2018	→
Deep phenotyping in zebrafish reveals genetic and diet-induced adiposity changes that may inform disease risk.	Minchin JEN et al.	—	2018	→
[Definition, description, clinicopathological features, pathogenesis and natural history of endometriosis: CNGOF-HAS Endometriosis Guidelines].	Borghese B et al.	—	2018	→
Discovery of a stem-like multipotent cell fate.	Paffhausen ES et al.	—	2018	→
DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism.	Keller M et al.	—	2018	→
Does education protect against depression? Evidence from the Young Finns Study using Mendelian randomization.	Viinikainen J et al.	—	2018	→
Epigenome-wide association in adipose tissue from the METSIM cohort.	Orozco LD et al.	—	2018	→
Epigenome-wide association study of adiposity and future risk of obesity-related diseases.	Campanella G et al.	—	2018	→
Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization.	Skaaby T et al.	—	2018	→
FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study.	Lundbäck V et al.	—	2018	→
Genes that make you fat, but keep you healthy.	Loos RJF et al.	—	2018	→
Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.	Eriksson AL et al.	—	2018	→
Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention.	Svendstrup M et al.	—	2018	→
Genetics of obesity and its measures in India.	Saini S et al.	—	2018	→
Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study.	Yan J et al.	—	2018	→
Genetic variants in SEC16B are associated with body composition in black South Africans.	Sahibdeen V et al.	—	2018	→
Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations.	Endo C et al.	—	2018	→
Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans.	Gao C et al.	—	2018	→
Heterogeneity of adipose tissue in development and metabolic function.	Schoettl T et al.	—	2018	→
<i>Cynoglossus semilaevis Rspo3</i> Regulates Embryo Development by Inhibiting the Wnt/β-Catenin Signaling Pathway.	Niu J et al.	—	2018	→
Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.	Hu Y et al.	—	2018	→
Impact of visceral fat on surgical complications and long-term survival of patients with gastric cancer after radical gastrectomy.	Wang SL et al.	—	2018	→
In-vivo metabolic studies of regional adipose tissue.	Melvin A et al.	—	2018	→
Localization of adaptive variants in human genomes using averaged one-dependence estimation.	Sugden LA et al.	—	2018	→
Machine Learning-Based Method for Obesity Risk Evaluation Using Single-Nucleotide Polymorphisms Derived from Next-Generation Sequencing.	Wang HY et al.	—	2018	→
Meta-analysis of exome array data identifies six novel genetic loci for lung function.	Jackson VE et al.	—	2018	→
Metabolic syndrome and psoriasis: a study in 97 patients.	Ferdinando LB et al.	—	2018	→
Method to estimate the approximate samples size that yield a certain number of significant GWAS signals in polygenic traits.	Bacanu SA et al.	—	2018	→
Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.	Cao Y et al.	—	2018	→
Physiologic Interpretation of GWAS Signals for Type 2 Diabetes.	Watanabe RM	—	2018	→
Response to 'Fat is not just an energy store'.	Speakman JR	—	2018	→
Sex Chromosome Effects on Male-Female Differences in Mammals.	Snell DM et al.	—	2018	→
Sex differences in lipid and lipoprotein metabolism.	Palmisano BT et al.	—	2018	→
Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones.	Bürger M et al.	—	2018	→
Transcriptional Regulatory Mechanisms in Adipose and Muscle Tissue Associated with Composite Glucometabolic Phenotypes.	Langefeld CD et al.	—	2018	→
Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.	Gong J et al.	—	2018	→
Using Adipose Measures from Health Care Provider-Based Imaging Data for Discovery.	Cha EDK et al.	—	2018	→
Waist-hip ratio related genetic loci are associated with risk of impaired fasting glucose in Chinese children: a case control study.	Song QY et al.	—	2018	→
Wnt/β-Catenin Signaling and Obesity.	Chen N et al.	—	2018	→
A cellular model for the investigation of depot specific human adipocyte biology.	Todorčević M et al.	—	2017	→
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts.	Lindström S et al.	—	2017	→
A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.	He L et al.	—	2017	→
A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents.	Nielsen TR et al.	—	2017	→
Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight.	Rohde JF et al.	—	2017	→
Applications of the 1000 Genomes Project resources.	Zheng-Bradley X et al.	—	2017	→
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.	Winkler TW et al.	—	2017	→
Archaic Adaptive Introgression in TBX15/WARS2.	Racimo F et al.	—	2017	→
A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution.	Guo H et al.	—	2017	→
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.	Mendelson MM et al.	—	2017	→
BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort.	Graff M et al.	—	2017	→
CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation.	Quteineh L et al.	—	2017	→
De novo RNA sequence assembly during in vivo inflammatory stress reveals hundreds of unannotated lincRNAs in human blood CD14<sup>+</sup> monocytes and in adipose tissue.	Xue C et al.	—	2017	→
Detecting Multiethnic Rare Variants.	Ouyang W et al.	—	2017	→
Differential investment in body girths by sex: Evidence from 3D photonic scanning in a Thai cohort.	Shirley MK et al.	—	2017	→
Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.	Ng MCY et al.	—	2017	→
Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study.	Sardahaee FS et al.	—	2017	→
Elucidating the role of plexin D1 in body fat distribution and susceptibility to metabolic disease using a zebrafish model system.	Minchin JEN et al.	—	2017	→
Epidemiology in Germany-general development and personal experience.	Wichmann HE	—	2017	→
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.	Hinney A et al.	—	2017	→
Exploring single nucleotide polymorphisms previously related to obesity and metabolic traits in pediatric-onset type 2 diabetes.	Miranda-Lora AL et al.	—	2017	→
Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans.	Houweling PJ et al.	—	2017	→
Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.	Yoneyama S et al.	—	2017	→
Genetic association of FTO/IRX region with obesity and overweight in the Polish population.	Sobalska-Kwapis M et al.	—	2017	→
Genetic Basis for Sex Differences in Obesity and Lipid Metabolism.	Link JC et al.	—	2017	→
Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child.	Miettinen ME et al.	—	2017	→
Genetic determination of body fat distribution and the attributive influence on metabolism.	Fehlert E et al.	—	2017	→
Genetic endowments, parental resources and adult health: Evidence from the Young Finns Study.	Pehkonen J et al.	—	2017	→
Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma.	Tang R et al.	—	2017	→
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.	Civelek M et al.	—	2017	→
Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms.	van 't Hof FN et al.	—	2017	→
Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.	Mychaleckyj JC et al.	—	2017	→
Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity.	Keller M et al.	—	2017	→
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.	Graff M et al.	—	2017	→
Genomic Evidence for Bacterial Determinants Influencing Obesity Development.	Isokpehi RD et al.	—	2017	→
Identification of insulin-sensitizing molecules acting by disrupting the interaction between the Insulin Receptor and Grb14.	Gondoin A et al.	—	2017	→
IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits.	Rohde K et al.	—	2017	→
Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions.	Ruggiero A et al.	—	2017	→
<i>Lyplal1</i> is dispensable for normal fat deposition in mice.	Watson RA et al.	—	2017	→
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.	Chu AY et al.	—	2017	→
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals.	Kraja AT et al.	—	2017	→
Recent Advances in Human Genetics and Epigenetics of Adiposity: Pathway to Precision Medicine?	Fall T et al.	—	2017	→
Recent insights on the genetics and epigenetics of endometriosis.	Borghese B et al.	—	2017	→
Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.	Hardin M et al.	—	2017	→
Sexual dimorphisms in genetic loci linked to body fat distribution.	Pulit SL et al.	—	2017	→
Signatures of Archaic Adaptive Introgression in Present-Day Human Populations.	Racimo F et al.	—	2017	→
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases.	Laakso M et al.	—	2017	→
The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications.	Schultz TE et al.	—	2017	→
Unveiling genomic regions that underlie differences between Afec-Assaf sheep and its parental Awassi breed.	Seroussi E et al.	—	2017	→
Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues.	Rahmioglu N et al.	—	2017	→
A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus.	Li QS et al.	—	2016	→
Accuracy of heritability estimations in presence of hidden population stratification.	Dandine-Roulland C et al.	—	2016	→
Admixture mapping identifies introgressed genomic regions in North American canids.	vonHoldt BM et al.	—	2016	→
A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery.	Bandstein M et al.	—	2016	→
A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery.	Bandstein M et al.	—	2016	→
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits.	Volkov P et al.	—	2016	→
A GWAS follow-up of obesity-related SNPs in SYPL2 reveals sex-specific association with hip circumference.	de Toro-Martín J et al.	—	2016	→
Analysis of multiple related phenotypes in genome-wide association studies.	Oh S et al.	—	2016	→
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.	Ried JS et al.	—	2016	→
A Simple Test of Class-Level Genetic Association Can Reveal Novel Cardiometabolic Trait Loci.	Qian J et al.	—	2016	→
Association of genetic risk scores with body mass index in Swiss psychiatric cohorts.	Saigi-Morgui N et al.	—	2016	→
Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population.	Hao RH et al.	—	2016	→
Beyond Endometriosis Genome-Wide Association Study: From Genomics to Phenomics to the Patient.	Zondervan KT et al.	—	2016	→
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.	Keenan T et al.	—	2016	→
Circulating vascular endothelial growth factor and the risk of cardiovascular events.	Kaess BM et al.	—	2016	→
Commentary: Two-sample Mendelian randomization: opportunities and challenges.	Lawlor DA	—	2016	→
Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits.	Golbus JR et al.	—	2016	→
Consensus Genome-Wide Expression Quantitative Trait Loci and Their Relationship with Human Complex Trait Disease.	Yu CH et al.	—	2016	→
Early developmental gene enhancers affect subcortical volumes in the adult human brain.	Becker M et al.	—	2016	→
Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects.	Shabana et al.	—	2016	→
Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis.	Strawbridge RJ et al.	—	2016	→
Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population.	Wang T et al.	—	2016	→
Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits.	Polimanti R et al.	—	2016	→
Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits.	Brune JE et al.	—	2016	→
ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis.	Kang EY et al.	—	2016	→
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41.	Bigot P et al.	—	2016	→
Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.	Saldaña-Alvarez Y et al.	—	2016	→
Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases.	Nakka P et al.	—	2016	→
Gene set analysis for interpreting genetic studies.	Pers TH	—	2016	→
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.	Morton NM et al.	—	2016	→
Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.	Wang Y et al.	—	2016	→
Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus.	Kasim NB et al.	—	2016	→
Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer.	Painter JN et al.	—	2016	→
Genetic risk scores link body fat distribution with specific cardiometabolic profiles.	Svendstrup M et al.	—	2016	→
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.	Felix JF et al.	—	2016	→
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.	Wen W et al.	—	2016	→
Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.	Sung YJ et al.	—	2016	→
Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene.	Barreto-Luis A et al.	—	2016	→
Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits.	Ballantyne RL et al.	—	2016	→
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.	Teumer A et al.	—	2016	→
Genomics of Atrial Fibrillation.	Gutierrez A et al.	—	2016	→
Genomic structure and marker-derived gene networks for growth and meat quality traits of Brazilian Nelore beef cattle.	Mudadu MA et al.	—	2016	→
[Genomwide association studies on obesity: what can we learn from these studies].	Kronenberg F et al.	—	2016	→
Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors.	LeBlanc M et al.	—	2016	→
Impact of the X Chromosome and sex on regulatory variation.	Kukurba KR et al.	—	2016	→
Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference.	Olsen NJ et al.	—	2016	→
Investigation of Genetic Variation Underlying Central Obesity amongst South Asians.	Scott WR et al.	—	2016	→
Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.	Buzaglo-Azriel L et al.	—	2016	→
Maternal obesity legacy: exercise it away!	Alm PS et al.	—	2016	→
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.	Jarvis D et al.	—	2016	→
Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer.	Gao C et al.	—	2016	→
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.	Liu C et al.	—	2016	→
Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium.	Park H et al.	—	2016	→
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.	Lu Y et al.	—	2016	→
Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function.	Dahlman I et al.	—	2016	→
PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries.	Wen Y et al.	—	2016	→
PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders.	Stijnen P et al.	—	2016	→
Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers.	Pedersen HK et al.	—	2016	→
Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project.	Kan M et al.	—	2016	→
Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity.	Pigeyre M et al.	—	2016	→
Replication of <i>Early B-cell Factor 1 (EBF1)</i> Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population.	Kim HJ et al.	—	2016	→
Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity.	Larsen SC et al.	—	2016	→
Sex-Specific Selection and Sex-Biased Gene Expression in Humans and Flies.	Cheng C et al.	—	2016	→
Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women.	Merz B et al.	—	2016	→
Sweet Taste Perception is Associated with Body Mass Index at the Phenotypic and Genotypic Level.	Hwang LD et al.	—	2016	→
The importance of gene-environment interactions in human obesity.	Reddon H et al.	—	2016	→
The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter?	Graff M et al.	—	2016	→
UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.	Yermachenko A et al.	—	2016	→
Wars2 is a determinant of angiogenesis.	Wang M et al.	—	2016	→
Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations.	Saigi-Morgui N et al.	—	2016	→
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.	Nikpay M et al.	—	2015	→
A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).	Gao C et al.	—	2015	→
Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis.	Luna-Luna M et al.	—	2015	→
Adjusting for heritable covariates can bias effect estimates in genome-wide association studies.	Aschard H et al.	—	2015	→
Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study.	Vogelezang S et al.	—	2015	→
Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies.	Wang T et al.	—	2015	→
Advances in exercise, fitness, and performance genomics in 2014.	Loos RJ et al.	—	2015	→
Age- and gender-dependent heterogeneous proportion of variation explained by SNPs in quantitative traits reflecting human health.	Lee D et al.	—	2015	→
Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.	Huebbe P et al.	—	2015	→
Apple or pear: size and shape matter.	Fu J et al.	—	2015	→
Association Between LYPLAL1 rs12137855 Polymorphism With Ultrasound-Defined Non-Alcoholic Fatty Liver Disease in a Chinese Han Population.	Yuan C et al.	—	2015	→
Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments.	Saigi-Morgui N et al.	—	2015	→
Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes.	Rask-Andersen M et al.	—	2015	→
Associations between TRPV4 genotypes and body mass index in Taiwanese subjects.	Duan DM et al.	—	2015	→
Bayesian semiparametric copula estimation with application to psychiatric genetics.	Rosen O et al.	—	2015	→
Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.	Karpe F et al.	—	2015	→
Cross-sectional population associations between detailed adiposity measures and C-reactive protein levels at age 6 years: the Generation R Study.	Toemen L et al.	—	2015	→
Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.	Albuquerque D et al.	—	2015	→
Determination of obesity associated gene variants related to TMEM18 through ultra-deep targeted re-sequencing in a case-control cohort for pediatric obesity.	Rask-Andersen M et al.	—	2015	→
Diets and morbid tissues--history counts, present counts.	Henkin Y et al.	—	2015	→
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.	Horikoshi M et al.	—	2015	→
EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data.	Winkler TW et al.	—	2015	→
eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.	Huang J et al.	—	2015	→
Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.	Fox CS et al.	—	2015	→
Gender-specific association between tobacco smoking and central obesity among 0.5 million Chinese people: the China Kadoorie Biobank Study.	Lv J et al.	—	2015	→
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.	Nettleton JA et al.	—	2015	→
Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume.	Giri A et al.	—	2015	→
Genetic Predisposition to Central Obesity and Risk of Type 2 Diabetes: Two Independent Cohort Studies.	Huang T et al.	—	2015	→
Genetic Regulation of Puberty Timing in Humans.	Day FR et al.	—	2015	→
Genetics of cardiovascular disease: Importance of sex and ethnicity.	Winham SJ et al.	—	2015	→
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.	Rahmioglu N et al.	—	2015	→
Genome-wide patterns of selection in 230 ancient Eurasians.	Mathieson I et al.	—	2015	→
Greenlandic Inuit show genetic signatures of diet and climate adaptation.	Fumagalli M et al.	—	2015	→
Human CD180 Transmits Signals via the PIM-1L Kinase.	Egli N et al.	—	2015	→
Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments.	Quteineh L et al.	—	2015	→
Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.	Delacrétaz A et al.	—	2015	→
Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits.	Karaderi T et al.	—	2015	→
Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	Dubail J et al.	—	2015	→
Integrated genomic and BMI analysis for type 2 diabetes risk assessment.	Lebrón-Aldea D et al.	—	2015	→
Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health.	Young KL et al.	—	2015	→
Latest approaches for the treatment of obesity.	Jackson VM et al.	—	2015	→
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.	Bulik-Sullivan BK et al.	—	2015	→
LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.	Loh NY et al.	—	2015	→
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.	Voisin S et al.	—	2015	→
Mendelian Randomization: New Applications in the Coming Age of Hypothesis-Free Causality.	Evans DM et al.	—	2015	→
Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome.	Levy M et al.	—	2015	→
MicroRNAs enrichment in GWAS of complex human phenotypes.	Goulart LF et al.	—	2015	→
Multilevel-analysis identify a cis-expression quantitative trait locus associated with risk of renal cell carcinoma.	Shu X et al.	—	2015	→
New developments in the pathogenesis of obesity-induced hypertension.	Kotsis V et al.	—	2015	→
New genetic loci link adipose and insulin biology to body fat distribution.	Shungin D et al.	—	2015	→
Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity.	Apalasamy YD et al.	—	2015	→
Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation.	Lei X et al.	—	2015	→
Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population.	Tomei S et al.	—	2015	→
Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS.	Wang Q et al.	—	2015	→
Rationale, Design, and Methodological Aspects of the BUDAPEST-GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions).	Maurovich-Horvat P et al.	—	2015	→
Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies.	Andersen MK et al.	—	2015	→
rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.	Rasmussen-Torvik LJ et al.	—	2015	→
Shaping fat distribution: New insights into the molecular determinants of depot- and sex-dependent adipose biology.	Fried SK et al.	—	2015	→
Strong evidence of sexual dimorphic effect of adiposity excess on insulin sensitivity.	Marucci A et al.	—	2015	→
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.	Lee KY et al.	—	2015	→
The Curse of Curves: Sex Differences in the Associations Between Body Shape and Pain Expression.	Vigil JM et al.	—	2015	→
The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women.	Arner P et al.	—	2015	→
The Genetics of Pediatric Obesity.	Chesi A et al.	—	2015	→
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.	Winkler TW et al.	—	2015	→
The Keap1-Nrf2 system and diabetes mellitus.	Uruno A et al.	—	2015	→
Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes.	Fall T et al.	—	2015	→
Abdominal obesity and lower gray matter volume: a Mendelian randomization study.	Debette S et al.	—	2014	→
Adipocyte dysfunction, inflammation and metabolic syndrome.	Klöting N et al.	—	2014	→
Adipose tissue depot specific promoter methylation of TMEM18.	Rohde K et al.	—	2014	→
A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease.	Ghanbari M et al.	—	2014	→
A genome-wide association study of renal cell carcinoma among African Americans.	Purdue MP et al.	—	2014	→
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.	Dubail J et al.	—	2014	→
Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.	Tukiainen T et al.	—	2014	→
Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.	Scott RA et al.	—	2014	→
Common genetic variation in sFRP5 is associated with fat distribution in men.	Van Camp JK et al.	—	2014	→
[Control of insulin signalisation and action by the Grb14 protein].	Gondoin A et al.	—	2014	→
Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity--a prospective study of three independent cohorts.	Larsen SC et al.	—	2014	→
Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.	Pinnick KE et al.	—	2014	→
EPAS1 gene variants are associated with sprint/power athletic performance in two cohorts of European athletes.	Voisin S et al.	—	2014	→
Ethnic disparities in the prevalence of the metabolic syndrome in American adults: data from the Examination of National Health and Nutrition Examination Survey 1999-2010.	Ramphal L et al.	—	2014	→
Evaluating the association of APOA2 polymorphism with insulin resistance in adolescents.	Zaki ME et al.	—	2014	→
Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.	Keildson S et al.	—	2014	→
Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio.	Schleinitz D et al.	—	2014	→
FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians.	Vasan SK et al.	—	2014	→
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations.	Yoneyama S et al.	—	2014	→
Gene-diet interaction and weight loss.	Qi L	—	2014	→
Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss.	Goni L et al.	—	2014	→
Genetic dissection of susceptibility genes for diabetes and related phenotypes on mouse chromosome 14 by means of congenic strains.	Babaya N et al.	—	2014	→
Genetic & epigenetic approach to human obesity.	Rao KR et al.	—	2014	→
Genetic risk score does not predict the outcome of obesity surgery.	Käkelä P et al.	—	2014	→
Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth.	Chawla R et al.	—	2014	→
Genetics of metabolic syndrome.	Stančáková A et al.	—	2014	→
Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond.	Grarup N et al.	—	2014	→
Genetic variants determining body fat distribution and sex hormone-binding globulin among Chinese female young adults.	Shi J et al.	—	2014	→
Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets.	Rahmioglu N et al.	—	2014	→
Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.	Stergiakouli E et al.	—	2014	→
Genome-wide interaction studies reveal sex-specific asthma risk alleles.	Myers RA et al.	—	2014	→
Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.	Rothammer S et al.	—	2014	→
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.	DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium et al.	—	2014	→
Germline genetic variations at 11q13 and 12p11 locus modulate age at onset for renal cell carcinoma.	Audenet F et al.	—	2014	→
Gut microbiota composition and its effects on obesity and insulin resistance.	Caricilli AM et al.	—	2014	→
Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.	Heymsfield SB et al.	—	2014	→
Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation.	Divoux A et al.	—	2014	→
Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network.	Gubelmann C et al.	—	2014	→
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.	Andreassen OA et al.	—	2014	→
Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference.	Ankarfeldt MZ et al.	—	2014	→
Interaction between genetic predisposition to obesity and dietary calcium in relation to subsequent change in body weight and waist circumference.	Larsen SC et al.	—	2014	→
Joint association of genome-wide association study-identified susceptibility loci and dietary patterns in risk of renal cell carcinoma among non-Hispanic whites.	Melkonian SC et al.	—	2014	→
Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.	Zhu Y et al.	—	2014	→
Lack of association between DRD2 and OPRM1 genotypes and adiposity.	Hardman CA et al.	—	2014	→
Meta-analysis of sequencing studies with heterogeneous genetic associations.	Tang ZZ et al.	—	2014	→
Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.	Richardson AS et al.	—	2014	→
Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study.	Johnson W et al.	—	2014	→
Multi-ethnic fine-mapping of 14 central adiposity loci.	Liu CT et al.	—	2014	→
Multiple metabolic genetic risk scores and type 2 diabetes risk in three racial/ethnic groups.	Klimentidis YC et al.	—	2014	→
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.	Hoggart CJ et al.	—	2014	→
On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis.	Peterson RE et al.	—	2014	→
Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants.	Sayols-Baixeras S et al.	—	2014	→
Quality control and conduct of genome-wide association meta-analyses.	Winkler TW et al.	—	2014	→
RTeQTL: Real-Time Online Engine for Expression Quantitative Trait Loci Analyses.	Ma B et al.	—	2014	→
Sex- and age-interacting eQTLs in human complex diseases.	Yao C et al.	—	2014	→
Sex differences in disease genetics: evidence, evolution, and detection.	Gilks WP et al.	—	2014	→
Sex dimorphism and depot differences in adipose tissue function.	White UA et al.	—	2014	→
Sexually dimorphic genetic architecture of complex traits in a large-scale F2 cross in pigs.	Cui L et al.	—	2014	→
Shared common variants in prostate cancer and blood lipids.	Andreassen OA et al.	—	2014	→
Single-nucleotide polymorphisms and DNA methylation markers associated with central obesity and regulation of body weight.	Goni L et al.	—	2014	→
SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.	TenNapel MJ et al.	—	2014	→
Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network, and pathway analyses.	Kogelman LJ et al.	—	2014	→
The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings.	Abdullah N et al.	—	2014	→
The association of common variants in PCSK1 with obesity: a HuGE review and meta-analysis.	Stijnen P et al.	—	2014	→
The genetics of fat distribution.	Schleinitz D et al.	—	2014	→
The genetics of human obesity.	Waalen J	—	2014	→
Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.	Hirotsu Y et al.	—	2014	→
Weight change, body composition, and risk of mobility disability and mortality in older adults: a population-based cohort study.	Murphy RA et al.	—	2014	→
Zinc: an underappreciated modulatory factor of brain function.	Marger L et al.	—	2014	→
A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents.	Vasan SK et al.	—	2013	→
A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines.	Liang L et al.	—	2013	→
Adipose tissue dysfunction contributes to obesity related metabolic diseases.	Blüher M	—	2013	→
A gene-centric study of common carotid artery remodelling.	Harrison SC et al.	—	2013	→
A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations.	Hu Z et al.	—	2013	→
A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila.	Allebrandt KV et al.	—	2013	→
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.	Schork AJ et al.	—	2013	→
Analysis of multiple phenotypes in genome-wide genetic mapping studies.	Suo C et al.	—	2013	→
APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism.	Zaki ME et al.	—	2013	→
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.	Rönn T et al.	—	2013	→
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.	Fernández-Rhodes L et al.	—	2013	→
Association of DXA-derived bone mineral density and fat mass with African ancestry.	Ochs-Balcom HM et al.	—	2013	→
Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1,443 Czech adolescents.	Dušátková L et al.	—	2013	→
Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs.	Gupta V et al.	—	2013	→
Candidate gene association study of BMI-related loci, weight, and adiposity in old age.	Murphy RA et al.	—	2013	→
Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.	Hsu MC et al.	—	2013	→
Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study.	Lim S et al.	—	2013	→
Development and evaluation of a genetic risk score for obesity.	Belsky DW et al.	—	2013	→
Discovery and refinement of loci associated with lipid levels.	Willer CJ et al.	—	2013	→
Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.	Karastergiou K et al.	—	2013	→
Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples.	den Hoed M et al.	—	2013	→
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.	Albrechtsen A et al.	—	2013	→
Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women.	Mutschler J et al.	—	2013	→
Gene × environment interactions in obesity: the state of the evidence.	Ahmad S et al.	—	2013	→
Generalization of adiposity genetic loci to US Hispanic women.	Graff M et al.	—	2013	→
Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study.	Jääskeläinen T et al.	—	2013	→
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits.	Civelek M et al.	—	2013	→
Genetics of type 2 diabetes and potential clinical implications.	Kwak SH et al.	—	2013	→
Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study.	Rukh G et al.	—	2013	→
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.	Franceschini N et al.	—	2013	→
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.	Liu CT et al.	—	2013	→
Genome-wide association study of gene by smoking interactions in coronary artery calcification.	Polfus LM et al.	—	2013	→
Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations.	Yang J et al.	—	2013	→
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.	Berndt SI et al.	—	2013	→
Identification of seven loci affecting mean telomere length and their association with disease.	Codd V et al.	—	2013	→
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.	Andreassen OA et al.	—	2013	→
Large-scale association analysis identifies new risk loci for coronary artery disease.	CARDIoGRAMplusC4D Consortium et al.	—	2013	→
Mechanisms and metabolic implications of regional differences among fat depots.	Tchkonia T et al.	—	2013	→
Meta-analysis methods for genome-wide association studies and beyond.	Evangelou E et al.	—	2013	→
Microbiota conservation and BMI signatures in adult monozygotic twins.	Tims S et al.	—	2013	→
Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake.	Karunakaran S et al.	—	2013	→
Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study.	Carlsson AC et al.	—	2013	→
NUDT3 rs206936 is associated with body mass index in obese Japanese women.	Kitamoto A et al.	—	2013	→
Obesity genomics: assessing the transferability of susceptibility loci across diverse populations.	Lu Y et al.	—	2013	→
Personalized cardiovascular medicine: concepts and methodological considerations.	Völzke H et al.	—	2013	→
Personalized medicine in women's obesity prevention and treatment: implications for research, policy and practice.	Yang N et al.	—	2013	→
Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms.	Sharma NK et al.	—	2013	→
Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.	van Vliet-Ostaptchouk JV et al.	—	2013	→
Pleiotropy between genetic markers of obesity and risk of prostate cancer.	Edwards TL et al.	—	2013	→
Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia.	Nakayama K et al.	—	2013	→
QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study.	Zhu Y et al.	—	2013	→
Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.	Walters RG et al.	—	2013	→
Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins.	Desbuquois B et al.	—	2013	→
Relationship between obesity phenotypes and genetic determinants in a mouse model for juvenile obesity.	Brockmann GA et al.	—	2013	→
Replication study of 15 recently published Loci for body fat distribution in the Japanese population.	Hotta K et al.	—	2013	→
Richness of human gut microbiome correlates with metabolic markers.	Le Chatelier E et al.	—	2013	→
Risk of type 2 diabetes according to traditional and emerging anthropometric indices in Spain, a Mediterranean country with high prevalence of obesity: results from a large-scale prospective cohort study.	Huerta JM et al.	—	2013	→
Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.	Chen IC et al.	—	2013	→
Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.	Kvaløy K et al.	—	2013	→
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.	Randall JC et al.	—	2013	→
SNPflow: a lightweight application for the processing, storing and automatic quality checking of genotyping assays.	Weissensteiner H et al.	—	2013	→
Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults.	Reiner AP et al.	—	2013	→
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance.	Goodarzi MO et al.	—	2013	→
The genetic contribution to disease risk and variability in response to diet: where is the hidden heritability?	Minihane AM	—	2013	→
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.	Drong AW et al.	—	2013	→
The risk of type 2 diabetes in men is synergistically affected by parental history of diabetes and overweight.	Wikner C et al.	—	2013	→
The value of extended pedigrees for next-generation analysis of complex disease in the rhesus macaque.	Vinson A et al.	—	2013	→
Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma.	Li L et al.	—	2013	→
Visceral adiposity in gastrointestinal and hepatic carcinogenesis.	Vongsuvanh R et al.	—	2013	→
Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults.	Beydoun MA et al.	—	2013	→
What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?	Bonnefond A et al.	—	2013	→
A finger on the pulse of Wnt receptor signaling.	MacDonald BT et al.	—	2012	→
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	Manning AK et al.	—	2012	→
A genome wide association study for backfat thickness in Italian Large White pigs highlights new regions affecting fat deposition including neuronal genes.	Fontanesi L et al.	—	2012	→
A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23.	Wu X et al.	—	2012	→
Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals.	Linder K et al.	—	2012	→
A multi-SNP locus-association method reveals a substantial fraction of the missing heritability.	Ehret GB et al.	—	2012	→
An atlas of DNA methylomes in porcine adipose and muscle tissues.	Li M et al.	—	2012	→
An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes.	Gburcik V et al.	—	2012	→
Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity.	Smith CE et al.	—	2012	→
Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study.	Vimaleswaran KS et al.	—	2012	→
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.	Li H et al.	—	2012	→
Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals.	Burgdorf KS et al.	—	2012	→
Association study of sirtuin 1 polymorphisms with bone mineral density and body mass index.	Zarrabeitia MT et al.	—	2012	→
Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners.	Williams PT	—	2012	→
Bayesian method to predict individual SNP genotypes from gene expression data.	Schadt EE et al.	—	2012	→
Beyond the fourth wave of genome-wide obesity association studies.	Sandholt CH et al.	—	2012	→
Body fat distribution in relation to smoking and exogenous hormones in British women.	Kwok S et al.	—	2012	→
Bone mineral density-associated polymorphisms are associated with obesity-related traits in Korean adults in a sex-dependent manner.	Cha S et al.	—	2012	→
Causes and consequences of obesity: the contribution of recent twin studies.	Naukkarinen J et al.	—	2012	→
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.	Min JL et al.	—	2012	→
Cohort Profile: the Corogene study.	Vaara S et al.	—	2012	→
Comparison of adiposity measures as risk factors in postmenopausal women.	Hartz A et al.	—	2012	→
Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases.	Bürger M et al.	—	2012	→
Current opportunities and challenges: genome-wide association studies on pigmentation and skin cancer.	Meng S et al.	—	2012	→
Detecting association of rare and common variants by testing an optimally weighted combination of variants.	Sha Q et al.	—	2012	→
Dietary factors impact on the association between CTSS variants and obesity related traits.	Hooton H et al.	—	2012	→
Evaluation of gene-obesity interaction effects on cholesterol levels: a genetic predisposition score on HDL-cholesterol is modified by obesity.	Lamina C et al.	—	2012	→
Excess body fat in obese and normal-weight subjects.	Thomas EL et al.	—	2012	→
Expression of fourteen novel obesity-related genes in Zucker diabetic fatty rats.	Schmid PM et al.	—	2012	→
Finding genes and variants for lipid levels after genome-wide association analysis.	Willer CJ et al.	—	2012	→
Five years of GWAS discovery.	Visscher PM et al.	—	2012	→
Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics.	Szymańska E et al.	—	2012	→
Gene-Lifestyle Interactions in Obesity.	van Vliet-Ostaptchouk JV et al.	—	2012	→
Genetic determinants of common obesity and their value in prediction.	Loos RJ	—	2012	→
Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.	Fan Q et al.	—	2012	→
Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women.	Hotta K et al.	—	2012	→
Genome-wide analysis of copy number variations reveals that aging processes influence body fat distribution in Korea Associated Resource (KARE) cohorts.	Lee BY et al.	—	2012	→
Genome-wide analysis of epistasis in body mass index using multiple human populations.	Wei WH et al.	—	2012	→
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	Fox CS et al.	—	2012	→
Genome-wide association of BMI in African Americans.	Ng MC et al.	—	2012	→
Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.	Fox CS et al.	—	2012	→
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.	Boraska V et al.	—	2012	→
Genome-wide scan with nearly 700,000 SNPs in two Sardinian sub-populations suggests some regions as candidate targets for positive selection.	Piras IS et al.	—	2012	→
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.	Morán I et al.	—	2012	→
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.	Mercader JM et al.	—	2012	→
Implication of European-derived adiposity loci in African Americans.	Hester JM et al.	—	2012	→
Insights into Assessing the Genetics of Endometriosis.	Rahmioglu N et al.	—	2012	→
Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma.	Zhang M et al.	—	2012	→
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.	Scott RA et al.	—	2012	→
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.	Morris AP et al.	—	2012	→
Leisure time activities in adolescence in the presence of susceptibility genes for obesity: risk or resilience against overweight in adulthood? The HUNT study.	Cuypers K et al.	—	2012	→
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits.	McKnite AM et al.	—	2012	→
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence.	Gordon L et al.	—	2012	→
New susceptibility loci associated with kidney disease in type 1 diabetes.	Sandholm N et al.	—	2012	→
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.	Dastani Z et al.	—	2012	→
Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice.	Kraja AT et al.	—	2012	→
Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study.	Cuypers KF et al.	—	2012	→
Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets.	de las Fuentes L et al.	—	2012	→
Relation of vascular growth factors with CT-derived measures of body fat distribution: the Framingham Heart Study.	Kaess BM et al.	—	2012	→
Sex-biased genetic effects on gene regulation in humans.	Dimas AS et al.	—	2012	→
Sex differences in disease risk from reported genome-wide association study findings.	Liu LY et al.	—	2012	→
Sex differences in human adipose tissues - the biology of pear shape.	Karastergiou K et al.	—	2012	→
Sex-specific differences in effect size estimates at established complex trait loci.	Orozco G et al.	—	2012	→
Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies.	Lim U et al.	—	2012	→
Susceptibility variants for waist size in relation to abdominal, visceral, and hepatic adiposity in postmenopausal women.	Lim U et al.	—	2012	→
TFAP2B influences the effect of dietary fat on weight loss under energy restriction.	Stocks T et al.	—	2012	→
The evolution of human adiposity and obesity: where did it all go wrong?	Wells JC	—	2012	→
The genetic and epigenetic basis of type 2 diabetes and obesity.	Drong AW et al.	—	2012	→
The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO.	Jacobsson JA et al.	—	2012	→
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.	Voight BF et al.	—	2012	→
Twins and the mystery of missing heritability: the contribution of gene-environment interactions.	Kaprio J	—	2012	→
3.7 Mb tandem microduplication in chromosome 5p13.1-p13.2 associated with developmental delay, macrocephaly, obesity, and lymphedema. Further characterization of the dup(5p13) syndrome.	Oexle K et al.	—	2011	→
Advances in exercise, fitness, and performance genomics in 2010.	Hagberg JM et al.	—	2011	→
A genome-wide association study on obesity and obesity-related traits.	Wang K et al.	—	2011	→
An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects.	Das SK et al.	—	2011	→
Association between variants of the leptin receptor gene (LEPR) and overweight: a systematic review and an analysis of the CoLaus study.	Bender N et al.	—	2011	→
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.	Taylor AE et al.	—	2011	→
Chronic kidney disease: novel insights from genome-wide association studies.	Böger CA et al.	—	2011	→
Defining the power limits of genome-wide association scan meta-analyses.	Chapman K et al.	—	2011	→
Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS).	Feng T et al.	—	2011	→
Developments in obesity genetics in the era of genome-wide association studies.	Day FR et al.	—	2011	→
Dose-response relationship between walking and the attenuation of inherited weight.	Williams PT	—	2011	→
Ectopic fat depots and cardiovascular disease.	Britton KA et al.	—	2011	→
Evaluation of the obesity genes FTO and MC4R and the type 2 diabetes mellitus gene TCF7L2 for contribution to stroke risk: The Mannheim-Heidelberg Stroke Study.	Winter Y et al.	—	2011	→
Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance.	Goodarzi MO et al.	—	2011	→
From expression QTLs to personalized transcriptomics.	Montgomery SB et al.	—	2011	→
From GWAS to biology: lessons from FTO.	Tung YC et al.	—	2011	→
Gender- and obesity-specific effect of apolipoprotein C3 gene (APOC3) -482C>T polymorphism on triglyceride concentration in Turkish adults.	Coban N et al.	—	2011	→
Gene by sex interaction for measures of obesity in the framingham heart study.	Benjamin AM et al.	—	2011	→
Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.	Vassy JL et al.	—	2011	→
Genetics and epigenetics of obesity.	Herrera BM et al.	—	2011	→
Genetics of Obesity: What have we Learned?	Choquet H et al.	—	2011	→
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.	Kilpeläinen TO et al.	—	2011	→
Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.	Ketterer C et al.	—	2011	→
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.	Smith EN et al.	—	2011	→
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.	Kooner JS et al.	—	2011	→
Genome-wide association study of circulating retinol levels.	Mondul AM et al.	—	2011	→
Genomic inflation factors under polygenic inheritance.	Yang J et al.	—	2011	→
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.	Foster MC et al.	—	2011	→
High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery.	Still CD et al.	—	2011	→
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.	Small KS et al.	—	2011	→
Implications for reproductive medicine: Sex differences in cardiovascular disease.	Miller VM et al.	—	2011	→
Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes.	Bille DS et al.	—	2011	→
Inherited destiny? Genetics and gestational diabetes mellitus.	Watanabe RM	—	2011	→
Look beyond one's own nose: combination of information from publicly available sources reveals an association of GATA4 polymorphisms with plasma triglycerides.	Lamina C et al.	—	2011	→
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.	Gesta S et al.	—	2011	→
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.	Kato N et al.	—	2011	→
MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.	Rantalainen M et al.	—	2011	→
Molecular basis of obesity: current status and future prospects.	Choquet H et al.	—	2011	→
Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity.	Cox RD et al.	—	2011	→
New IBD genetics: common pathways with other diseases.	Lees CW et al.	—	2011	→
NFE2L3 (NRF3): the Cinderella of the Cap'n'Collar transcription factors.	Chevillard G et al.	—	2011	→
Novel abdominal adiposity genes and the risk of type 2 diabetes: findings from two prospective cohorts.	Yeung E et al.	—	2011	→
Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.	Jarick I et al.	—	2011	→
Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability.	Kutalik Z et al.	—	2011	→
[Obesity, adipogenesis and insulin resistance].	Ros Pérez M et al.	—	2011	→
Obesity, diabetes, and risk of Parkinson's disease.	Palacios N et al.	—	2011	→
Perivascular adipose tissue and vascular disease.	Britton KA et al.	—	2011	→
Pleiotropy of type 2 diabetes with obesity.	Hasstedt SJ et al.	—	2011	→
Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies.	Han B et al.	—	2011	→
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.	Hirschey MD et al.	—	2011	→
T2DM: Why Epigenetics?	Fradin D et al.	—	2011	→
The impact of cis-acting polymorphisms on the human phenotype.	Jones BL et al.	—	2011	→
The importance of global studies of the genetics of type 2 diabetes.	McCarthy MI	—	2011	→
To stratify or not to stratify: power considerations for population-based genome-wide association studies of quantitative traits.	Behrens G et al.	—	2011	→
Type 2 diabetes and obesity: genomics and the clinic.	Travers ME et al.	—	2011	→
Genomics, type 2 diabetes, and obesity.	McCarthy MI	—	2010	→