Genotype imputation.
paper
Cited
Public
- Authors
- Li, Yun; Willer, Cristen; Sanna, Serena; Abecasis, Gonçalo
- Year
- 2009
- Journal
- Annual review of genomics and human genetics
- PMID
- 19715440
- DOI
- 10.1146/annurev.genom.9.081307.164242
- PMCID
- PMC2925172
Genotype imputation is now an essential tool in the analysis of genome-wide association scans. This technique allows geneticists to accurately evaluate the evidence for association at genetic markers that are not directly genotyped. Genotype imputation is particularly useful for combining results across studies that rely on different genotyping platforms but also increases the power of individual scans. Here, we review the history and theoretical underpinnings of the technique. To illustrate performance of the approach, we summarize results from several gene mapping studies. Finally, we preview the role of genotype imputation in an era when whole genome resequencing is becoming increasingly common.
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|---|---|---|---|---|
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| The Influence of Dyslexia Candidate Genes on Reading Skill in Old Age. | Luciano M et al. | — | 2018 | → |
| The State of "<i>Omics</i>" Research for Farmed Penaeids: Advances in Research and Impediments to Industry Utilization. | Guppy JL et al. | — | 2018 | → |
| Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. | Gong J et al. | — | 2018 | → |
| Using Gene Genealogies to Localize Rare Variants Associated with Complex Traits in Diploid Populations. | Karunarathna CB et al. | — | 2018 | → |
| A Bayesian mathematical model of motor and cognitive outcomes in Parkinson's disease. | Hayete B et al. | — | 2017 | → |
| A comparison of different algorithms for phasing haplotypes using Holstein cattle genotypes and pedigree data. | Miar Y et al. | — | 2017 | → |
| Admixture on the northern front: population genomics of range expansion in the white-footed mouse (Peromyscus leucopus) and secondary contact with the deer mouse (Peromyscus maniculatus). | Garcia-Elfring A et al. | — | 2017 | → |
| Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study. | Crandall CJ et al. | — | 2017 | → |
| Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer. | Wang Y et al. | — | 2017 | → |
| CELSR2 is a candidate susceptibility gene in idiopathic scoliosis. | Einarsdottir E et al. | — | 2017 | → |
| Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. | de Vries PS et al. | — | 2017 | → |
| Comprehensive analysis of the association between UBAC2 polymorphisms and Behçet's disease in a Japanese population. | Yamazoe K et al. | — | 2017 | → |
| Gene-based genome-wide association study identified 19p13.3 for lean body mass. | Ran S et al. | — | 2017 | → |
| Generalized reduced rank latent factor regression for high dimensional tensor fields, and neuroimaging-genetic applications. | Tao C et al. | — | 2017 | → |
| Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS. | Kalmbach DA et al. | — | 2017 | → |
| Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index. | Chen G et al. | — | 2017 | → |
| Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. | Singh J et al. | — | 2017 | → |
| Genome-wide association studies and genomic prediction of breeding values for calving performance and body conformation traits in Holstein cattle. | Abo-Ismail MK et al. | — | 2017 | → |
| Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head. | Sakamoto Y et al. | — | 2017 | → |
| Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels. | Sennblad B et al. | — | 2017 | → |
| Genome-wide association test of multiple continuous traits using imputed SNPs. | Wu B et al. | — | 2017 | → |
| Haplotype Inference. | Song S et al. | — | 2017 | → |
| Haplotype reference consortium panel: Practical implications of imputations with large reference panels. | Iglesias AI et al. | — | 2017 | → |
| Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis. | Hitomi Y et al. | — | 2017 | → |
| Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. | Mitt M et al. | — | 2017 | → |
| Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels. | Zhou W et al. | — | 2017 | → |
| Inbred Strain Variant Database (ISVdb): A Repository for Probabilistically Informed Sequence Differences Among the Collaborative Cross Strains and Their Founders. | Oreper D et al. | — | 2017 | → |
| Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array. | Liu N et al. | — | 2017 | → |
| Influence of genetic variants associated with body mass index on eating behavior in childhood. | Monnereau C et al. | — | 2017 | → |
| Integration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci. | Reid BM et al. | — | 2017 | → |
| Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels. | Dennis J et al. | — | 2017 | → |
| Linkage disequilibrium matches forensic genetic records to disjoint genomic marker sets. | Edge MD et al. | — | 2017 | → |
| LinkImputeR: user-guided genotype calling and imputation for non-model organisms. | Money D et al. | — | 2017 | → |
| Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. | Sapkota Y et al. | — | 2017 | → |
| Misconceptions on Missing Data in RAD-seq Phylogenetics with a Deep-scale Example from Flowering Plants. | Eaton DAR et al. | — | 2017 | → |
| No prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival. | Luo L et al. | — | 2017 | → |
| Novel methods for genotype imputation to whole-genome sequence and a simple linear model to predict imputation accuracy. | Larmer SG et al. | — | 2017 | → |
| Parent-progeny imputation from pooled samples for cost-efficient genotyping in plant breeding. | Technow F et al. | — | 2017 | → |
| Peripheral Arterial Disease Genetics: Progress to Date and Challenges Ahead. | Belkin N et al. | — | 2017 | → |
| Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib. | Yeo A et al. | — | 2017 | → |
| Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH. | Canales BK et al. | — | 2017 | → |
| Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population. | Hong EP et al. | — | 2017 | → |
| Scanning indels in the 5q22.1 region and identification of the TMEM232 susceptibility gene that is associated with atopic dermatitis in the Chinese Han population. | Wu YY et al. | — | 2017 | → |
| Securing the use of existing sample collections for future human genetic research. | Kanoungi G et al. | — | 2017 | → |
| SEQSpark: A Complete Analysis Tool for Large-Scale Rare Variant Association Studies Using Whole-Genome and Exome Sequence Data. | Zhang D et al. | — | 2017 | → |
| Serum magnesium and the risk of prediabetes: a population-based cohort study. | Kieboom BCT et al. | — | 2017 | → |
| Shared genetic etiology of hypertension and stroke: evidence from bioinformatics analysis of genome-wide association studies. | Ji LD et al. | — | 2017 | → |
| Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis. | Roetker NS et al. | — | 2017 | → |
| The Analysis of Ethnic Mixtures. | Zhu X et al. | — | 2017 | → |
| The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data. | He Z et al. | — | 2017 | → |
| Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study. | Richmond RC et al. | — | 2017 | → |
| A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding. | Painter JN et al. | — | 2016 | → |
| Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression. | Zhang G et al. | — | 2016 | → |
| Age at menarche and age at natural menopause in East Asian women: a genome-wide association study. | Shi J et al. | — | 2016 | → |
| A genome-wide association study in multiple system atrophy. | Sailer A et al. | — | 2016 | → |
| A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants. | Siiskonen SJ et al. | — | 2016 | → |
| A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. | de Vries PS et al. | — | 2016 | → |
| An Adaptive Fisher's Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies. | Liang X et al. | — | 2016 | → |
| Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations. | Zanetti D et al. | — | 2016 | → |
| APOE and aging-related cognitive change in a longitudinal cohort of men. | Rantalainen V et al. | — | 2016 | → |
| Assessing the Cumulative Contribution of New and Established Common Genetic Risk Factors to Early-Onset Prostate Cancer. | Lange EM et al. | — | 2016 | → |
| Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. | Shiraishi K et al. | — | 2016 | → |
| Associations of genetic risk scores based on adult adiposity pathways with childhood growth and adiposity measures. | Monnereau C et al. | — | 2016 | → |
| Associations of genetic variants for adult lipid levels with lipid levels in children. The Generation R Study. | Latsuzbaia A et al. | — | 2016 | → |
| Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. | Franzén O et al. | — | 2016 | → |
| Common polygenic variation and risk for childhood-onset schizophrenia. | Ahn K et al. | — | 2016 | → |
| Comparing performance of modern genotype imputation methods in different ethnicities. | Roshyara NR et al. | — | 2016 | → |
| Comparison of three boosting methods in parent-offspring trios for genotype imputation using simulation study. | Mikhchi A et al. | — | 2016 | → |
| Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. | Arpawong TE et al. | — | 2016 | → |
| Endometrial vezatin and its association with endometriosis risk. | Holdsworth-Carson SJ et al. | — | 2016 | → |
| Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases. | Xing C et al. | — | 2016 | → |
| Exploring the Major Sources and Extent of Heterogeneity in a Genome-Wide Association Meta-Analysis. | Pei YF et al. | — | 2016 | → |
| Fine-mapping of two differentiated thyroid carcinoma susceptibility loci at 9q22.33 and 14q13.3 detects novel candidate functional SNPs in Europeans from metropolitan France and Melanesians from New Caledonia. | Tcheandjieu C et al. | — | 2016 | → |
| Genetic analysis of the aquaporin-4 gene for anti-AQP4 antibody-positive neuromyelitis optica in a Japanese population. | Ogasawara M et al. | — | 2016 | → |
| Genetics of structural connectivity and information processing in the brain. | Giddaluru S et al. | — | 2016 | → |
| Genetic variants in RBFOX3 are associated with sleep latency. | Amin N et al. | — | 2016 | → |
| Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. | Li Y et al. | — | 2016 | → |
| Genome-wide association study of myelosuppression in non-small-cell lung cancer patients with platinum-based chemotherapy. | Cao S et al. | — | 2016 | → |
| Genome-wide estimate of the heritability of Multiple System Atrophy. | Federoff M et al. | — | 2016 | → |
| Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults. | Mather KA et al. | — | 2016 | → |
| Genotype imputation in the domestic dog. | Friedenberg SG et al. | — | 2016 | → |
| GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer. | Chen MM et al. | — | 2016 | → |
| High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry. | Sun C et al. | — | 2016 | → |
| HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer. | Xu CF et al. | — | 2016 | → |
| Human Diversity in a Cell Surface Receptor that Inhibits Autophagy. | Chaudhary A et al. | — | 2016 | → |
| Identification of a new locus at 16q12 associated with time to asthma onset. | Sarnowski C et al. | — | 2016 | → |
| Influence of common genetic variants on childhood kidney outcomes. | Miliku K et al. | — | 2016 | → |
| Next-generation genotype imputation service and methods. | Das S et al. | — | 2016 | → |
| Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome. | Sinisalo J et al. | — | 2016 | → |
| Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization. | Taylor PN et al. | — | 2016 | → |
| Phenotypically Enriched Genotypic Imputation in Genetic Association Tests. | Zhuang WV et al. | — | 2016 | → |
| Population Genomics of Fungal and Oomycete Pathogens. | Grünwald NJ et al. | — | 2016 | → |
| Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity? | Herskind C et al. | — | 2016 | → |
| Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels. | Boettger LM et al. | — | 2016 | → |
| Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans. | McLachlan S et al. | — | 2016 | → |
| Retrospective Binary-Trait Association Test Elucidates Genetic Architecture of Crohn Disease. | Jiang D et al. | — | 2016 | → |
| Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism. | Dennis J et al. | — | 2016 | → |
| SLC1A1 Gene Variants and Normal Tension Glaucoma: An Association Study. | Nishisako M et al. | — | 2016 | → |
| Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method. | Li M et al. | — | 2016 | → |
| The Future is The Past: Methylation QTLs in Schizophrenia. | Hoffmann A et al. | — | 2016 | → |
| Using Mendelian randomization to investigate a possible causal relationship between adiposity and increased bone mineral density at different skeletal sites in children. | Kemp JP et al. | — | 2016 | → |
| Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility. | Finkel TH et al. | — | 2016 | → |
| Vitamin D Receptor Gene Polymorphisms Are Associated with Abdominal Visceral Adipose Tissue Volume and Serum Adipokine Concentrations but Not with Body Mass Index or Waist Circumference in African Americans: The Jackson Heart Study. | Khan RJ et al. | — | 2016 | → |
| Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study. | Vogelezang S et al. | — | 2015 | → |
| A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. | Hirokawa M et al. | — | 2015 | → |
| A genome-wide association study of myasthenia gravis. | Renton AE et al. | — | 2015 | → |
| Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population. | Tham YC et al. | — | 2015 | → |
| A guide to genome-wide association analysis and post-analytic interrogation. | Reed E et al. | — | 2015 | → |
| A holistic comparative analysis of diagnostic tests for urothelial carcinoma: a study of Cxbladder Detect, UroVysion® FISH, NMP22® and cytology based on imputation of multiple datasets. | Breen V et al. | — | 2015 | → |
| A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways. | Soave D et al. | — | 2015 | → |
| An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics. | Beam AL et al. | — | 2015 | → |
| A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches. | Bashinskaya VV et al. | — | 2015 | → |
| Association between endometriosis and the interleukin 1A (IL1A) locus. | Sapkota Y et al. | — | 2015 | → |
| Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes. | Fang S et al. | — | 2015 | → |
| Big data challenges in bone research: genome-wide association studies and next-generation sequencing. | Alonso N et al. | — | 2015 | → |
| Body Mass Index Genetic Risk Score and Endometrial Cancer Risk. | Prescott J et al. | — | 2015 | → |
| Choosing Subsamples for Sequencing Studies by Minimizing the Average Distance to the Closest Leaf. | Kang JT et al. | — | 2015 | → |
| Circadian clock genes and risk of fatal prostate cancer. | Markt SC et al. | — | 2015 | → |
| Common variants in the ARC gene are not associated with cognitive abilities. | Myrum C et al. | — | 2015 | → |
| Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors. | Lessard S et al. | — | 2015 | → |
| Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer. | O'Mara TA et al. | — | 2015 | → |
| Cross-sectional population associations between detailed adiposity measures and C-reactive protein levels at age 6 years: the Generation R Study. | Toemen L et al. | — | 2015 | → |
| Design and Implementation of the International Genetics and Translational Research in Transplantation Network. | International Genetics & Translational Research in Transplantation Network (iGeneTRAiN) | — | 2015 | → |
| Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures. | Chu AY et al. | — | 2015 | → |
| DISSCO: direct imputation of summary statistics allowing covariates. | Xu Z et al. | — | 2015 | → |
| Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain. | Kremer PH et al. | — | 2015 | → |
| Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis. | Nead KT et al. | — | 2015 | → |
| Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. | Ek WE et al. | — | 2015 | → |
| Functional evaluation of genetic variants associated with endometriosis near GREB1. | Fung JN et al. | — | 2015 | → |
| Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. | Mtatiro SN et al. | — | 2015 | → |
| Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population. | Chang TJ et al. | — | 2015 | → |
| Genetics of hand grip strength in mid to late life. | Chan JP et al. | — | 2015 | → |
| Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers. | Sidore C et al. | — | 2015 | → |
| Genome-wide association analysis of plasma B-type natriuretic peptide in blacks: the Jackson Heart Study. | Musani SK et al. | — | 2015 | → |
| Genome-wide association study of survival in early-stage non-small cell lung cancer. | Tang S et al. | — | 2015 | → |
| Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN). | Wojczynski MK et al. | — | 2015 | → |
| Genome-wide Association Study on Platinum-induced Hepatotoxicity in Non-Small Cell Lung Cancer Patients. | Cao S et al. | — | 2015 | → |
| Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. | Law MH et al. | — | 2015 | → |
| Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies. | Niu T et al. | — | 2015 | → |
| Identification of novel genetic markers of breast cancer survival. | Guo Q et al. | — | 2015 | → |
| Improving accuracy of rare variant imputation with a two-step imputation approach. | Kreiner-Møller E et al. | — | 2015 | → |
| Imputation of genotypes in Danish purebred and two-way crossbred pigs using low-density panels. | Xiang T et al. | — | 2015 | → |
| Imputation of missing genotypes from low- to high-density SNP panel in different population designs. | He S et al. | — | 2015 | → |
| Independent Replication and Meta-Analysis for Endometriosis Risk Loci. | Sapkota Y et al. | — | 2015 | → |
| Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk. | Brossard M et al. | — | 2015 | → |
| Integrative analysis of sequencing and array genotype data for discovering disease associations with rare mutations. | Hu YJ et al. | — | 2015 | → |
| Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. | Ferguson JF et al. | — | 2015 | → |
| Investigating the genetics of hippocampal volume in older adults without dementia. | Mather KA et al. | — | 2015 | → |
| Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals. | Kawai Y et al. | — | 2015 | → |
| Lifetime Socioeconomic Status, Historical Context, and Genetic Inheritance in Shaping Body Mass in Middle and Late Adulthood. | Liu H et al. | — | 2015 | → |
| LinkImpute: Fast and Accurate Genotype Imputation for Nonmodel Organisms. | Money D et al. | — | 2015 | → |
| Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome. | Tak YG et al. | — | 2015 | → |
| Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. | He M et al. | — | 2015 | → |
| MGAS: a powerful tool for multivariate gene-based genome-wide association analysis. | Van der Sluis S et al. | — | 2015 | → |
| minimac2: faster genotype imputation. | Fuchsberger C et al. | — | 2015 | → |
| Multiple comparison procedures for neuroimaging genomewide association studies. | Hua WY et al. | — | 2015 | → |
| One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies. | Yuan S et al. | — | 2015 | → |
| Peer Influence, Genetic Propensity, and Binge Drinking: A Natural Experiment and a Replication. | Guo G et al. | — | 2015 | → |
| PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population. | Livne OE et al. | — | 2015 | → |
| Prospects and limits of marker imputation in quantitative genetic studies in European elite wheat (Triticum aestivum L.). | He S et al. | — | 2015 | → |
| Scanning and Filling: Ultra-Dense SNP Genotyping Combining Genotyping-By-Sequencing, SNP Array and Whole-Genome Resequencing Data. | Torkamaneh D et al. | — | 2015 | → |
| Serum 25-hydroxyvitamin D level and kidney function decline in a Swiss general adult population. | Guessous I et al. | — | 2015 | → |
| Statistical analysis for genome-wide association study. | Zeng P et al. | — | 2015 | → |
| Strategies for Imputing and Analyzing Rare Variants in Association Studies. | Hoffmann TJ et al. | — | 2015 | → |
| Systematic assessment of imputation performance using the 1000 Genomes reference panels. | Liu Q et al. | — | 2015 | → |
| Targeted sequencing of the Paget's disease associated 14q32 locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone. | Vallet M et al. | — | 2015 | → |
| TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. | Chittani M et al. | — | 2015 | → |
| The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. | Winkler TW et al. | — | 2015 | → |
| The Influence of Known Genetic Variants on Subclinical Cardiovascular Outcomes in Childhood: Generation R Study. | Punwasi RV et al. | — | 2015 | → |
| Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide. | Del-Aguila JL et al. | — | 2015 | → |
| Uric Acid and Cardiovascular Events: A Mendelian Randomization Study. | Kleber ME et al. | — | 2015 | → |
| Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. | Wood AR et al. | — | 2015 | → |
| Whole genome SNP genotype piecemeal imputation. | Wang Y et al. | — | 2015 | → |
| A central role for GRB10 in regulation of islet function in man. | Prokopenko I et al. | — | 2014 | → |
| A genome-wide association meta-analysis of preschool internalizing problems. | Benke KS et al. | — | 2014 | → |
| A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. | Davies G et al. | — | 2014 | → |
| A genome-wide association study of severe teenage acne in European Americans. | Zhang M et al. | — | 2014 | → |
| A multi-marker molecular signature approach for treatment-specific subgroup identification with survival outcomes. | Li L et al. | — | 2014 | → |
| A new approach for efficient genotype imputation using information from relatives. | Sargolzaei M et al. | — | 2014 | → |
| A new genotype imputation method with tolerance to high missing rate and rare variants. | Yang Y et al. | — | 2014 | → |
| Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity. | Smith TF et al. | — | 2014 | → |
| A population-based study of genetic variation and psychotic experiences in adolescents. | Zammit S et al. | — | 2014 | → |
| Assessing accuracy of genotype imputation in American Indians. | Malhotra A et al. | — | 2014 | → |
| Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. | Richmond RC et al. | — | 2014 | → |
| Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data. | Yang J et al. | — | 2014 | → |
| Association studies with imputed variants using expectation-maximization likelihood-ratio tests. | Huang KC et al. | — | 2014 | → |
| A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1. | Fachal L et al. | — | 2014 | → |
| Bioinformatics challenges in genome-wide association studies (GWAS). | De R et al. | — | 2014 | → |
| Characterizing bias in population genetic inferences from low-coverage sequencing data. | Han E et al. | — | 2014 | → |
| Cis and trans effects of human genomic variants on gene expression. | Bryois J et al. | — | 2014 | → |
| Combining family- and population-based imputation data for association analysis of rare and common variants in large pedigrees. | Saad M et al. | — | 2014 | → |
| Common DNA variants predict tall stature in Europeans. | Liu F et al. | — | 2014 | → |
| Early diagnosis of complex diseases by molecular biomarkers, network biomarkers, and dynamical network biomarkers. | Liu R et al. | — | 2014 | → |
| Evaluating the coverage and potential of imputing the exome microarray with next-generation imputation using the 1000 Genomes Project. | Tantoso E et al. | — | 2014 | → |
| Evaluation of replication of variants associated with genetic risk of otitis media. | Allen EK et al. | — | 2014 | → |
| Exploring the associations between genetic variants in genes encoding for subunits of calcium channel and subtypes of bipolar disorder. | Jan WC et al. | — | 2014 | → |
| FISH: fast and accurate diploid genotype imputation via segmental hidden Markov model. | Zhang L et al. | — | 2014 | → |
| Flexible and scalable genotyping-by-sequencing strategies for population studies. | Heffelfinger C et al. | — | 2014 | → |
| Frontotemporal dementia and its subtypes: a genome-wide association study. | Ferrari R et al. | — | 2014 | → |
| Functional interpretation of non-coding sequence variation: concepts and challenges. | Paul DS et al. | — | 2014 | → |
| Gene-by-age effects on BMI from birth to adulthood: the Fels Longitudinal Study. | Choh AC et al. | — | 2014 | → |
| Gene-gene and gene-environment interactions in ulcerative colitis. | Wang MH et al. | — | 2014 | → |
| Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3. | Rye MS et al. | — | 2014 | → |
| Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme <i>CYP24A1</i> in multiple sclerosis. | Ramasamy A et al. | — | 2014 | → |
| Genetic prediction of quantitative lipid traits: comparing shrinkage models to gene scores. | Warren H et al. | — | 2014 | → |
| Genetics of disc-related disorders: current findings and lessons from other complex diseases. | Näkki A et al. | — | 2014 | → |
| Genetic studies of Crohn's disease: past, present and future. | Liu JZ et al. | — | 2014 | → |
| Genetic variability in the regulation of gene expression in ten regions of the human brain. | Ramasamy A et al. | — | 2014 | → |
| Genetic variants associated with lung function: the long life family study. | Thyagarajan B et al. | — | 2014 | → |
| Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. | Knipe DW et al. | — | 2014 | → |
| Genome-scale neurogenetics: methodology and meaning. | McCarroll SA et al. | — | 2014 | → |
| Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. | Del-Aguila JL et al. | — | 2014 | → |
| Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines. | Brown CC et al. | — | 2014 | → |
| Genome-wide association scan for variants associated with early-onset prostate cancer. | Lange EM et al. | — | 2014 | → |
| Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration. | Cooke Bailey JN et al. | — | 2014 | → |
| Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response. | An P et al. | — | 2014 | → |
| Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus. | Oei L et al. | — | 2014 | → |
| Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). | An P et al. | — | 2014 | → |
| Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3. | Stergiakouli E et al. | — | 2014 | → |
| Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. | Foroud T et al. | — | 2014 | → |
| Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. | Cousminer DL et al. | — | 2014 | → |
| Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes. | Sandholm N et al. | — | 2014 | → |
| Harmonization of study and reference data by PhaseLift: saving time when imputing study data. | Gorski M et al. | — | 2014 | → |
| Identification of pathways for bipolar disorder: a meta-analysis. | Nurnberger JI et al. | — | 2014 | → |
| Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'. | Deelen P et al. | — | 2014 | → |
| Imputation and quality control steps for combining multiple genome-wide datasets. | Verma SS et al. | — | 2014 | → |
| Imputation of non-genotyped individuals based on genotyped relatives: assessing the imputation accuracy of a real case scenario in dairy cattle. | Bouwman AC et al. | — | 2014 | → |
| Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. | Cao Y et al. | — | 2014 | → |
| Insulin resistance: regression and clustering. | Yoon S et al. | — | 2014 | → |
| Lack of association of the rs1344706 ZNF804A variant with cognitive functions and DTI indices of white matter microstructure in two independent healthy populations. | Fernandes CP et al. | — | 2014 | → |
| Maternal genetic variation accounts in part for the associations of maternal size during pregnancy with offspring cardiometabolic risk in adulthood. | Wander PL et al. | — | 2014 | → |
| Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. | Pei YF et al. | — | 2014 | → |
| Meta-analysis of loci associated with age at natural menopause in African-American women. | Chen CT et al. | — | 2014 | → |
| Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. | Matteini AM et al. | — | 2014 | → |
| Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. | Jiang L et al. | — | 2014 | → |
| PedBLIMP: extending linear predictors to impute genotypes in pedigrees. | Chen W et al. | — | 2014 | → |
| Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. | Kemp JP et al. | — | 2014 | → |
| Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). | Chhibber A et al. | — | 2014 | → |
| Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer. | Zhao Y et al. | — | 2014 | → |
| Salt-inducible kinase 3, SIK3, is a new gene associated with hearing. | Wolber LE et al. | — | 2014 | → |
| Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. | Wang S et al. | — | 2014 | → |
| Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. | Nguyen JD et al. | — | 2014 | → |
| The future for genetic studies in reproduction. | Montgomery GW et al. | — | 2014 | → |
| The impact of the human genome project on complex disease. | Bailey JN et al. | — | 2014 | → |
| The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype. | Dizier MH et al. | — | 2014 | → |
| Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. | Guthridge JM et al. | — | 2014 | → |
| Two-stage family-based designs for sequencing studies. | Yang Z et al. | — | 2014 | → |
| Variant association tools for quality control and analysis of large-scale sequence and genotyping array data. | Wang GT et al. | — | 2014 | → |
| A comparison study of succinct data structures for use in GWAS. | Putnam PP et al. | — | 2013 | → |
| A comprehensive SNP and indel imputability database. | Duan Q et al. | — | 2013 | → |
| A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines. | Liang L et al. | — | 2013 | → |
| Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. | Molineros JE et al. | — | 2013 | → |
| A generalized Kruskal-Wallis test incorporating group uncertainty with application to genetic association studies. | Acar EF et al. | — | 2013 | → |
| A genome-wide association study for reading and language abilities in two population cohorts. | Luciano M et al. | — | 2013 | → |
| A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. | Tang W et al. | — | 2013 | → |
| A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. | Weidinger S et al. | — | 2013 | → |
| A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. | Allen EK et al. | — | 2013 | → |
| A genome-wide association study of sleep habits and insomnia. | Byrne EM et al. | — | 2013 | → |
| Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people. | Hou L et al. | — | 2013 | → |
| A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk. | Revez JA et al. | — | 2013 | → |
| A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease. | Wang MH et al. | — | 2013 | → |
| Assessment of MDA efficiency for genotyping using cloned embryo biopsies. | Lauri A et al. | — | 2013 | → |
| Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. | Adams LA et al. | — | 2013 | → |
| Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study. | Merle BM et al. | — | 2013 | → |
| Association study of fibroblast growth factor 10 (FGF10) polymorphisms with susceptibility to extreme myopia in a Japanese population. | Yoshida M et al. | — | 2013 | → |
| Breakdown of methods for phasing and imputation in the presence of double genotype sharing. | Nettelblad C | — | 2013 | → |
| Building a genome analysis pipeline to predict disease risk and prevent disease. | Bromberg Y | — | 2013 | → |
| Coalescent theory has many new branches. | Wakeley J | — | 2013 | → |
| Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. | Ho JE et al. | — | 2013 | → |
| Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. | Deo R et al. | — | 2013 | → |
| Common genetic variation of the calcium-sensing receptor and lethal prostate cancer risk. | Shui IM et al. | — | 2013 | → |
| Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. | Albayrak Ö et al. | — | 2013 | → |
| Common variation contributes to the genetic architecture of social communication traits. | St Pourcain B et al. | — | 2013 | → |
| Comparison of different imputation methods from low- to high-density panels using Chinese Holstein cattle. | Weng Z et al. | — | 2013 | → |
| Deconstructing Mus gemischus: advances in understanding ancestry, structure, and variation in the genome of the laboratory mouse. | Didion JP et al. | — | 2013 | → |
| Detecting association of rare variants by testing an optimally weighted combination of variants for quantitative traits in general families. | Fang S et al. | — | 2013 | → |
| DIST: direct imputation of summary statistics for unmeasured SNPs. | Lee D et al. | — | 2013 | → |
| Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. | Gamazon ER et al. | — | 2013 | → |
| FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain. | Rizzi TS et al. | — | 2013 | → |
| Fast association tests for genes with FAST. | Chanda P et al. | — | 2013 | → |
| Fast linear mixed model computations for genome-wide association studies with longitudinal data. | Sikorska K et al. | — | 2013 | → |
| Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. | Trabzuni D et al. | — | 2013 | → |
| Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy. | Wooten EC et al. | — | 2013 | → |
| Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients. | Galarneau G et al. | — | 2013 | → |
| Gene expression changes with age in skin, adipose tissue, blood and brain. | Glass D et al. | — | 2013 | → |
| Genetic risk for earlier menarche also influences peripubertal body mass index. | Johnson W et al. | — | 2013 | → |
| Genetics of obesity and type 2 diabetes in African Americans. | McCormack S et al. | — | 2013 | → |
| Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. | Xie W et al. | — | 2013 | → |
| Genetic variants regulating immune cell levels in health and disease. | Orrù V et al. | — | 2013 | → |
| Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. | Graff M et al. | — | 2013 | → |
| Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis. | Umiċeviċ Mirkov M et al. | — | 2013 | → |
| Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. | Zhang M et al. | — | 2013 | → |
| Genome-wide association study for levels of total serum IgE identifies HLA-C in a Japanese population. | Yatagai Y et al. | — | 2013 | → |
| Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium. | Kleber ME et al. | — | 2013 | → |
| Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. | Ma RC et al. | — | 2013 | → |
| Genome-wide association study in Han Chinese identifies three novel loci for human height. | Hao Y et al. | — | 2013 | → |
| Genome-wide association study of age at menarche in African-American women. | Demerath EW et al. | — | 2013 | → |
| Genome wide association study of age at menarche in the Japanese population. | Tanikawa C et al. | — | 2013 | → |
| Genome-wide association study of gene by smoking interactions in coronary artery calcification. | Polfus LM et al. | — | 2013 | → |
| Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver. | Schröder A et al. | — | 2013 | → |
| Genotype imputation in a coalescent model with infinitely-many-sites mutation. | Huang L et al. | — | 2013 | → |
| Genotype imputation reference panel selection using maximal phylogenetic diversity. | Zhang P et al. | — | 2013 | → |
| Genotype imputation via matrix completion. | Chi EC et al. | — | 2013 | → |
| GWAS on your notebook: fast semi-parallel linear and logistic regression for genome-wide association studies. | Sikorska K et al. | — | 2013 | → |
| Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. | den Hoed M et al. | — | 2013 | → |
| Imputation of coding variants in African Americans: better performance using data from the exome sequencing project. | Duan Q et al. | — | 2013 | → |
| Imputation of high-density genotypes in the Fleckvieh cattle population. | Pausch H et al. | — | 2013 | → |
| Informatics and clinical genome sequencing: opening the black box. | Moorthie S et al. | — | 2013 | → |
| Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. | Holliday EG et al. | — | 2013 | → |
| Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. | Carbonetto P et al. | — | 2013 | → |
| Linear score tests for variance components in linear mixed models and applications to genetic association studies. | Qu L et al. | — | 2013 | → |
| MaCH-admix: genotype imputation for admixed populations. | Liu EY et al. | — | 2013 | → |
| Multi-population classical HLA type imputation. | Dilthey A et al. | — | 2013 | → |
| Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. | Davis LK et al. | — | 2013 | → |
| Pathway-based analysis using genome-wide association data from a Korean non-small cell lung cancer study. | Lee D et al. | — | 2013 | → |
| Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. | Shah T et al. | — | 2013 | → |
| Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data. | Gerasimova A et al. | — | 2013 | → |
| Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score. | Kwak SH et al. | — | 2013 | → |
| Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years. | Julvez J et al. | — | 2013 | → |
| Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals. | Bettencourt BF et al. | — | 2013 | → |
| Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies. | Ramasamy A et al. | — | 2013 | → |
| Seven new loci associated with age-related macular degeneration. | Fritsche LG et al. | — | 2013 | → |
| Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. | Randall JC et al. | — | 2013 | → |
| Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data. | Li Y et al. | — | 2013 | → |
| Splice site SNPs of phospholipase PLCXD3 are significantly associated with variant and sporadic Creutzfeldt-Jakob disease. | Bishop MT et al. | — | 2013 | → |
| Support Vector Machine classifier for estrogen receptor positive and negative early-onset breast cancer. | Upstill-Goddard R et al. | — | 2013 | → |
| Target sequencing, cell experiments, and a population study establish endothelial nitric oxide synthase (eNOS) gene as hypertension susceptibility gene. | Salvi E et al. | — | 2013 | → |
| TATES: efficient multivariate genotype-phenotype analysis for genome-wide association studies. | van der Sluis S et al. | — | 2013 | → |
| The positive association of obesity variants with adulthood adiposity strengthens over an 80-year period: a gene-by-birth year interaction. | Demerath EW et al. | — | 2013 | → |
| The power of meta-analysis in genome-wide association studies. | Panagiotou OA et al. | — | 2013 | → |
| The use of imputed sibling genotypes in sibship-based association analysis: on modeling alternatives, power and model misspecification. | Minică CC et al. | — | 2013 | → |
| The value of statistical or bioinformatics annotation for rare variant association with quantitative trait. | Byrnes AE et al. | — | 2013 | → |
| Two-phase and family-based designs for next-generation sequencing studies. | Thomas DC et al. | — | 2013 | → |
| Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. | Giraldo M et al. | — | 2013 | → |
| Widespread sex differences in gene expression and splicing in the adult human brain. | Trabzuni D et al. | — | 2013 | → |
| Windfalls and pitfalls: Applications of population genetics to the search for disease genes. | Edge MD et al. | — | 2013 | → |
| 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. | Huang J et al. | — | 2012 | → |
| Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals. | Uricchio LH et al. | — | 2012 | → |
| A coalescent model for genotype imputation. | Jewett EM et al. | — | 2012 | → |
| A family-based probabilistic method for capturing de novo mutations from high-throughput short-read sequencing data. | Cartwright RA et al. | — | 2012 | → |
| A follow-up association study of two genetic variants for bone mineral density variation in Caucasians. | Zhang LS et al. | — | 2012 | → |
| A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. | Manning AK et al. | — | 2012 | → |
| A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT. | Brown CC et al. | — | 2012 | → |
| A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese. | Okada Y et al. | — | 2012 | → |
| A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. | Kim HC et al. | — | 2012 | → |
| A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study. | Jylhävä J et al. | — | 2012 | → |
| A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. | Osman W et al. | — | 2012 | → |
| A genome-wide association study of attempted suicide. | Willour VL et al. | — | 2012 | → |
| A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. | Byrne EM et al. | — | 2012 | → |
| A genome-wide association study of gestational diabetes mellitus in Korean women. | Kwak SH et al. | — | 2012 | → |
| A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q. | Heit JA et al. | — | 2012 | → |
| A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation. | Jenkins RB et al. | — | 2012 | → |
| An ensemble-based approach to imputation of moderate-density genotypes for genomic selection with application to Angus cattle. | Sun C et al. | — | 2012 | → |
| An eQTL biological data visualization challenge and approaches from the visualization community. | Bartlett CW et al. | — | 2012 | → |
| Artifact due to differential error when cases and controls are imputed from different platforms. | Sinnott JA et al. | — | 2012 | → |
| Assessment of gene-by-sex interaction effect on bone mineral density. | Liu CT et al. | — | 2012 | → |
| Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA). | Omoyinmi E et al. | — | 2012 | → |
| Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black population. | Liu X et al. | — | 2012 | → |
| A two-platform design for next generation genome-wide association studies. | Sampson JN et al. | — | 2012 | → |
| A unified framework for detecting rare variant quantitative trait associations in pedigree and unrelated individuals via sequence data. | Liu DJ et al. | — | 2012 | → |
| Beyond the fourth wave of genome-wide obesity association studies. | Sandholt CH et al. | — | 2012 | → |
| Chapter 11: Genome-wide association studies. | Bush WS et al. | — | 2012 | → |
| Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. | Holliday EG et al. | — | 2012 | → |
| Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. | Wiggs JL et al. | — | 2012 | → |
| Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia. | Karns R et al. | — | 2012 | → |
| Comparison of requirements and capabilities of major multipurpose software packages. | Igo RP et al. | — | 2012 | → |
| Comprehensive evaluation of imputation performance in African Americans. | Chanda P et al. | — | 2012 | → |
| Consistent divergence times and allele sharing measured from cross-species application of SNP chips developed for three domestic species. | Miller JM et al. | — | 2012 | → |
| Correction for population stratification in random forest analysis. | Zhao Y et al. | — | 2012 | → |
| Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. | Tejera P et al. | — | 2012 | → |
| Effect of genome-wide genotyping and reference panels on rare variants imputation. | Zheng HF et al. | — | 2012 | → |
| Evaluation of the imputation performance of the program IMPUTE in an admixed sample from Mexico City using several model designs. | Krithika S et al. | — | 2012 | → |
| Evidence of differential allelic effects between adolescents and adults for plasma high-density lipoprotein. | Middelberg RP et al. | — | 2012 | → |
| Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts. | Lopez LM et al. | — | 2012 | → |
| Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. | Howie B et al. | — | 2012 | → |
| Finding genes and variants for lipid levels after genome-wide association analysis. | Willer CJ et al. | — | 2012 | → |
| Finding missing heritability in less significant Loci and allelic heterogeneity: genetic variation in human height. | Zhang G et al. | — | 2012 | → |
| Fine-mapping of IL16 gene and prostate cancer risk in African Americans. | Batai K et al. | — | 2012 | → |
| Functional analysis of HapMap SNPs. | Liu CT et al. | — | 2012 | → |
| Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese. | Myouzen K et al. | — | 2012 | → |
| Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids. | Ameur A et al. | — | 2012 | → |
| Genetic association of cyclic AMP signaling genes with bipolar disorder. | McDonald ML et al. | — | 2012 | → |
| Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. | Tang W et al. | — | 2012 | → |
| Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits. | Ding K et al. | — | 2012 | → |
| Genetics of multiple sclerosis: swimming in an ocean of data. | Baranzini SE et al. | — | 2012 | → |
| Genome wide assessment of young onset Parkinson's disease from Finland. | Hernandez DG et al. | — | 2012 | → |
| Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. | Amin N et al. | — | 2012 | → |
| Genome-wide association meta-analysis identifies new endometriosis risk loci. | Nyholt DR et al. | — | 2012 | → |
| Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. | Karns R et al. | — | 2012 | → |
| Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations. | Candille SI et al. | — | 2012 | → |
| Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. | Shi Y et al. | — | 2012 | → |
| Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. | Hirota T et al. | — | 2012 | → |
| Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate. | Frazier-Wood AC et al. | — | 2012 | → |
| Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. | Lu X et al. | — | 2012 | → |
| Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. | Prescott J et al. | — | 2012 | → |
| Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). | Deshmukh HA et al. | — | 2012 | → |
| Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. | Foroud T et al. | — | 2012 | → |
| Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. | Hu L et al. | — | 2012 | → |
| Genome-wide association uncovers shared genetic effects among personality traits and mood states. | Luciano M et al. | — | 2012 | → |
| Genome-wide meta-analyses of smoking behaviors in African Americans. | David SP et al. | — | 2012 | → |
| Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. | Estrada K et al. | — | 2012 | → |
| Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | Kristiansson K et al. | — | 2012 | → |
| Genomic variation in seven Khoe-San groups reveals adaptation and complex African history. | Schlebusch CM et al. | — | 2012 | → |
| Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels. | Gao X et al. | — | 2012 | → |
| Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative. | Liu EY et al. | — | 2012 | → |
| Genotyping-by-Sequencing in Plants. | Deschamps S et al. | — | 2012 | → |
| How to deal with the early GWAS data when imputing and combining different arrays is necessary. | Uh HW et al. | — | 2012 | → |
| Human complex trait genetics: lifting the lid of the genomics toolbox - from pathways to prediction. | Rowe SJ et al. | — | 2012 | → |
| Identification of a novel percent mammographic density locus at 12q24. | Stevens KN et al. | — | 2012 | → |
| Identification of cis-regulatory variation influencing protein abundance levels in human plasma. | Lourdusamy A et al. | — | 2012 | → |
| Imputation of genotypes with low-density chips and its effect on reliability of direct genomic values in Dutch Holstein cattle. | Mulder HA et al. | — | 2012 | → |
| Imputation of rare variants in next-generation association studies. | Asimit JL et al. | — | 2012 | → |
| Incorporating genotype uncertainties into the genotypic TDT for main effects and gene-environment interactions. | Taub MA et al. | — | 2012 | → |
| Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. | Timofeeva MN et al. | — | 2012 | → |
| Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus. | Greenawalt DM et al. | — | 2012 | → |
| Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma. | Zhang M et al. | — | 2012 | → |
| Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip. | Gaunt TR et al. | — | 2012 | → |
| KAREBrowser: SNP database of Korea Association REsource Project. | Hong CB et al. | — | 2012 | → |
| Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2. | Ibrahim-Verbaas CA et al. | — | 2012 | → |
| Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci. | Davis LK et al. | — | 2012 | → |
| Low-pass genome-wide sequencing and variant inference using identity-by-descent in an isolated human population. | Gusev A et al. | — | 2012 | → |
| Mammographic breast density and breast cancer: evidence of a shared genetic basis. | Varghese JS et al. | — | 2012 | → |
| MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. | Trabzuni D et al. | — | 2012 | → |
| Massively parallel haplotyping on microscopic beads for the high-throughput phase analysis of single molecules. | Boulanger J et al. | — | 2012 | → |
| Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. | Medina-Gomez C et al. | — | 2012 | → |
| Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence. | Gögele M et al. | — | 2012 | → |
| Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. | Sun L et al. | — | 2012 | → |
| Next-generation sequencing approaches for genetic mapping of complex diseases. | Casals F et al. | — | 2012 | → |
| Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. | Inouye M et al. | — | 2012 | → |
| OMERO: flexible, model-driven data management for experimental biology. | Allan C et al. | — | 2012 | → |
| Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium. | Zhu Q et al. | — | 2012 | → |
| Rare and common variants: twenty arguments. | Gibson G | — | 2012 | → |
| Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma. | Kelemen LE et al. | — | 2012 | → |
| Replication of a genome-wide association study of birth weight in preterm neonates. | Ryckman KK et al. | — | 2012 | → |
| SNP set association analysis for familial data. | Schifano ED et al. | — | 2012 | → |
| Some surprising twists on the road to discovering the contribution of rare variants to complex diseases. | Thomas DC | — | 2012 | → |
| Structural haplotypes and recent evolution of the human 17q21.31 region. | Boettger LM et al. | — | 2012 | → |
| Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25. | Rizzi TS et al. | — | 2012 | → |
| The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma. | Dizier MH et al. | — | 2012 | → |
| The expanding scope of DNA sequencing. | Shendure J et al. | — | 2012 | → |
| The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. | Vrieze SI et al. | — | 2012 | → |
| The role of large pedigrees in an era of high-throughput sequencing. | Wijsman EM | — | 2012 | → |
| The search for genetic modifiers of disease severity in the β-hemoglobinopathies. | Lettre G | — | 2012 | → |
| Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans. | Hosseini M et al. | — | 2012 | → |
| Two-phase stratified sampling designs for regional sequencing. | Chen Z et al. | — | 2012 | → |
| Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study. | Chen MH et al. | — | 2012 | → |
| Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. | Keller MF et al. | — | 2012 | → |
| Using genomic data to make indirect (and unauthorized) estimates of disease risk. | Nyholt DR | — | 2012 | → |
| Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies. | Schaid DJ et al. | — | 2012 | → |
| Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study. | Shui IM et al. | — | 2012 | → |
| β-Carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms in relation to plasma carotenoid and retinol concentrations in women of European descent. | Hendrickson SJ et al. | — | 2012 | → |
| A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. | Farrell JJ et al. | — | 2011 | → |
| Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. | Moyer AM et al. | — | 2011 | → |
| A combined long-range phasing and long haplotype imputation method to impute phase for SNP genotypes. | Hickey JM et al. | — | 2011 | → |
| A comparison of approaches to account for uncertainty in analysis of imputed genotypes. | Zheng J et al. | — | 2011 | → |
| ADAMTSL3 as a candidate gene for schizophrenia: gene sequencing and ultra-high density association analysis by imputation. | Dow DJ et al. | — | 2011 | → |
| A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. | Taylor KC et al. | — | 2011 | → |
| A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. | Sampietro ML et al. | — | 2011 | → |
| A genome-wide association study identifies two new risk loci for Graves' disease. | Chu X et al. | — | 2011 | → |
| A genome-wide association study of aging. | Walter S et al. | — | 2011 | → |
| A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. | Bradfield JP et al. | — | 2011 | → |
| A latent model for prioritization of SNPs for functional studies. | Fridley BL et al. | — | 2011 | → |
| An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. | Yu H et al. | — | 2011 | → |
| An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design. | Vrieze SI et al. | — | 2011 | → |
| ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. | Meyer NJ et al. | — | 2011 | → |
| A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. | Kanetsky PA et al. | — | 2011 | → |
| Association mapping. | Painter JN et al. | — | 2011 | → |
| Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population. | Danoy P et al. | — | 2011 | → |
| A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Li H | — | 2011 | → |
| Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study. | Healey CS et al. | — | 2011 | → |
| Canine hip dysplasia is predictable by genotyping. | Guo G et al. | — | 2011 | → |
| Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. | Haiman CA et al. | — | 2011 | → |
| CHEK2, MGMT, SULT1E1 and SULT1A1 polymorphisms and endometrial cancer risk. | O'Mara TA et al. | — | 2011 | → |
| Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data. | Armistead PM et al. | — | 2011 | → |
| Common variation in GPC5 is associated with acquired nephrotic syndrome. | Okamoto K et al. | — | 2011 | → |
| Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts. | Raitoharju E et al. | — | 2011 | → |
| Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction. | Shea J et al. | — | 2011 | → |
| Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. | Kullo IJ et al. | — | 2011 | → |
| Current status of genome-wide association studies in cancer. | Chung CC et al. | — | 2011 | → |
| Discovery and genotyping of genome structural polymorphism by sequencing on a population scale. | Handsaker RE et al. | — | 2011 | → |
| Empirical evaluations of analytical issues arising from predicting HLA alleles using multiple SNPs. | Zhang XC et al. | — | 2011 | → |
| Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. | Pasaniuc B et al. | — | 2011 | → |
| Evaluating the influence of quality control decisions and software algorithms on SNP calling for the affymetrix 6.0 SNP array platform. | de Andrade M et al. | — | 2011 | → |
| Extent of height variability explained by known height-associated genetic variants in an isolated population of the Adriatic coast of Croatia. | Zhang G et al. | — | 2011 | → |
| Ex-Vivo Modeling for Heritability Assessment and Genetic Mapping in Pharmacogenomics. | Motsinger-Reif A et al. | — | 2011 | → |
| FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children. | Rye MS et al. | — | 2011 | → |
| Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans. | Chen F et al. | — | 2011 | → |
| Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. | Sanna S et al. | — | 2011 | → |
| Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. | Liu X et al. | — | 2011 | → |
| Fine mapping of the NRG1 Hirschsprung's disease locus. | Tang CS et al. | — | 2011 | → |
| Gene-based interaction analysis by incorporating external linkage disequilibrium information. | He J et al. | — | 2011 | → |
| Gene-environment interaction for childhood asthma and exposure to farming in Central Europe. | Ege MJ et al. | — | 2011 | → |
| Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans. | Lo KS et al. | — | 2011 | → |
| Genetic associations in the vitamin D receptor and colorectal cancer in African Americans and Caucasians. | Kupfer SS et al. | — | 2011 | → |
| Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis. | Juran BD et al. | — | 2011 | → |
| Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster. | Del Greco M F et al. | — | 2011 | → |
| Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. | Belmonte Mahon P et al. | — | 2011 | → |
| Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. | Below JE et al. | — | 2011 | → |
| Genome-wide association approaches for identifying loci for human height genes. | Perola M | — | 2011 | → |
| Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. | Smith EN et al. | — | 2011 | → |
| Genome-wide association studies of antidepressant outcome: a brief review. | Laje G et al. | — | 2011 | → |
| Genome-wide association studies of the PR interval in African Americans. | Smith JG et al. | — | 2011 | → |
| Genome-wide association studies: results from the first few years and potential implications for clinical medicine. | Hirschhorn JN et al. | — | 2011 | → |
| Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. | Okada Y et al. | — | 2011 | → |
| Genome-wide association study identifies a common variant associated with risk of endometrial cancer. | Spurdle AB et al. | — | 2011 | → |
| Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. | Kong X et al. | — | 2011 | → |
| Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. | Noguchi E et al. | — | 2011 | → |
| Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. | Burdon KP et al. | — | 2011 | → |
| Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. | Kutalik Z et al. | — | 2011 | → |
| Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. | Lettre G et al. | — | 2011 | → |
| Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. | Haiman CA et al. | — | 2011 | → |
| Genome-wide association study of smoking behaviours in patients with COPD. | Siedlinski M et al. | — | 2011 | → |
| Genome-wide association study reveals three susceptibility loci for common migraine in the general population. | Chasman DI et al. | — | 2011 | → |
| Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. | Duncan EL et al. | — | 2011 | → |
| Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases. | Liu Y et al. | — | 2011 | → |
| Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. | Patsopoulos NA et al. | — | 2011 | → |
| Genomic evaluations with many more genotypes. | VanRaden PM et al. | — | 2011 | → |
| Genotype imputation with thousands of genomes. | Howie B et al. | — | 2011 | → |
| Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record. | Ding K et al. | — | 2011 | → |
| Global analysis of the impact of environmental perturbation on cis-regulation of gene expression. | Grundberg E et al. | — | 2011 | → |
| Haplotype variation and genotype imputation in African populations. | Huang L et al. | — | 2011 | → |
| Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. | Pichler I et al. | — | 2011 | → |
| Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. | Okada Y et al. | — | 2011 | → |
| Implication of next-generation sequencing on association studies. | Siu H et al. | — | 2011 | → |
| Imputation of low-frequency variants using the HapMap3 benefits from large, diverse reference sets. | Jostins L et al. | — | 2011 | → |
| Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. | International Parkinson Disease Genomics Consortium et al. | — | 2011 | → |
| Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. | Evans DM et al. | — | 2011 | → |
| Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. | Lin X et al. | — | 2011 | → |
| Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation. | Cappola TP et al. | — | 2011 | → |
| Low-coverage sequencing: implications for design of complex trait association studies. | Li Y et al. | — | 2011 | → |
| Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease. | Hu X et al. | — | 2011 | → |
| Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. | Lanktree MB et al. | — | 2011 | → |
| Methods for testing association between uncertain genotypes and quantitative traits. | Kutalik Z et al. | — | 2011 | → |
| Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. | Williams HJ et al. | — | 2011 | → |
| Multiple imputation of missing phenotype data for QTL mapping. | Bobb JF et al. | — | 2011 | → |
| Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. | Oexle K et al. | — | 2011 | → |
| Novel locus FER is associated with serum HMW adiponectin levels. | Qi L et al. | — | 2011 | → |
| ParaHaplo 3.0: A program package for imputation and a haplotype-based whole-genome association study using hybrid parallel computing. | Misawa K et al. | — | 2011 | → |
| Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience. | Bennett SN et al. | — | 2011 | → |
| Planning a genome-wide association study: points to consider. | Hakonarson H et al. | — | 2011 | → |
| Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium. | Amankwah EK et al. | — | 2011 | → |
| Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays. | Gross A et al. | — | 2011 | → |
| Practical Consideration of Genotype Imputation: Sample Size, Window Size, Reference Choice, and Untyped Rate. | Zhang B et al. | — | 2011 | → |
| Progress and promise of genome-wide association studies for human complex trait genetics. | Stranger BE et al. | — | 2011 | → |
| Sequence imputation of HPV16 genomes for genetic association studies. | Smith B et al. | — | 2011 | → |
| Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM). | Chen WM et al. | — | 2011 | → |
| SNPpy--database management for SNP data from genome wide association studies. | Mitha F et al. | — | 2011 | → |
| The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. | Castaldi PJ et al. | — | 2011 | → |
| The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. | Rizzi TS et al. | — | 2011 | → |
| The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. | Middeldorp CM et al. | — | 2011 | → |
| The importance of phase information for human genomics. | Tewhey R et al. | — | 2011 | → |
| The norepinephrine transporter gene is a candidate gene for panic disorder. | Buttenschøn HN et al. | — | 2011 | → |
| Using imputed genotypes for relative risk estimation in case-parent studies. | Shi M et al. | — | 2011 | → |
| Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis. | Cai T et al. | — | 2011 | → |
| Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects. | Hibar DP et al. | — | 2011 | → |
| Accurate detection and genotyping of SNPs utilizing population sequencing data. | Bansal V et al. | — | 2010 | → |
| A map of human genome variation from population-scale sequencing. | 1000 Genomes Project Consortium et al. | — | 2010 | → |
| An alternative to the search for single polymorphisms: toward molecular personality scales for the five-factor model. | McCrae RR et al. | — | 2010 | → |
| Analyses and comparison of imputation-based association methods. | Pei YF et al. | — | 2010 | → |
| Analysing biological pathways in genome-wide association studies. | Wang K et al. | — | 2010 | → |
| Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. | Speliotes EK et al. | — | 2010 | → |
| Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. | Fushan AA et al. | — | 2010 | → |
| Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. | Corneveaux JJ et al. | — | 2010 | → |
| A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. | Koide T et al. | — | 2010 | → |
| Case-control association study of TGOLN2 in attempted suicide. | Mahon PB et al. | — | 2010 | → |
| Digital quantification of human eye color highlights genetic association of three new loci. | Liu F et al. | — | 2010 | → |
| E2-2 protein and Fuchs's corneal dystrophy. | Baratz KH et al. | — | 2010 | → |
| Exploring genetic susceptibility to cancer in diverse populations. | Haiman CA et al. | — | 2010 | → |
| Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes. | Zawistowski M et al. | — | 2010 | → |
| Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus. | Johanneson B et al. | — | 2010 | → |
| Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs. | Zhang P et al. | — | 2010 | → |
| Founder population-specific HapMap panel increases power in GWA studies through improved imputation accuracy and CNV tagging. | Surakka I et al. | — | 2010 | → |
| Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. | Ding J et al. | — | 2010 | → |
| Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. | Li J et al. | — | 2010 | → |
| Genome-wide association analysis identifies three psoriasis susceptibility loci. | Stuart PE et al. | — | 2010 | → |
| Genome-wide association of anthropometric traits in African- and African-derived populations. | Kang SJ et al. | — | 2010 | → |
| Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression. | Rietschel M et al. | — | 2010 | → |
| Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. | Ingle JN et al. | — | 2010 | → |
| Genome-wide association scan of trait depression. | Terracciano A et al. | — | 2010 | → |
| Genome-wide association studies in diverse populations. | Rosenberg NA et al. | — | 2010 | → |
| Genome-wide association studies in nephrology research. | Köttgen A | — | 2010 | → |
| Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. | Ellinghaus E et al. | — | 2010 | → |
| Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. | Hor H et al. | — | 2010 | → |
| Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone. | Albagha OM et al. | — | 2010 | → |
| Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults. | Lange LA et al. | — | 2010 | → |
| Genome-wide meta-analyses identify multiple loci associated with smoking behavior. | Tobacco and Genetics Consortium | — | 2010 | → |
| Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene. | Kapur K et al. | — | 2010 | → |
| Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. | Carrasquillo MM et al. | — | 2010 | → |
| Integrating pathway analysis and genetics of gene expression for genome-wide association studies. | Zhong H et al. | — | 2010 | → |
| Linking variants from genome-wide association analysis to function via transcriptional network analysis. | Keller B et al. | — | 2010 | → |
| MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. | Li Y et al. | — | 2010 | → |
| Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. | Heid IM et al. | — | 2010 | → |
| Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. | Koutros S et al. | — | 2010 | → |
| ProbABEL package for genome-wide association analysis of imputed data. | Aulchenko YS et al. | — | 2010 | → |
| Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. | Thorgeirsson TE et al. | — | 2010 | → |
| Statistical analysis strategies for association studies involving rare variants. | Bansal V et al. | — | 2010 | → |
| The genome-wide association study--a new era for common polygenic disorders. | Roberts R et al. | — | 2010 | → |
| The pursuit of genome-wide association studies: where are we now? | Ku CS et al. | — | 2010 | → |
| To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests. | Li Y et al. | — | 2010 | → |
| Transcriptome analysis and molecular signature of human retinal pigment epithelium. | Strunnikova NV et al. | — | 2010 | → |
| Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations. | Struchalin MV et al. | — | 2010 | → |
| Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. | Sanna S et al. | — | 2010 | → |
| Voxelwise genome-wide association study (vGWAS). | Stein JL et al. | — | 2010 | → |