Genetic dissection of complex traits.
paper
Cited
Public
Unavailable
- Authors
- Lander, E S; Schork, N J
- Year
- 1994
- Journal
- Science (New York, N.Y.)
- PMID
- 8091226
- DOI
- 10.1126/science.8091226
Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most diseases and traits, however, do not follow simple inheritance patterns. Genetics have thus begun taking up the even greater challenge of the genetic dissection of complex traits. Four major approaches have been developed: linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses. This article synthesizes the current state of the genetic dissection of complex traits--describing the methods, limitations, and recent applications to biological problems.
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| Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. | Dumesic DA et al. | β | 2015 | β |
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| Proceedings: consideration of genetics in the design of induced pluripotent stem cell-based models of complex disease. | Grieshammer U et al. | β | 2014 | β |
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| A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly. | Roussotte FF et al. | β | 2013 | β |
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| Contribution of rare and common variants determine complex diseases-Hirschsprung disease as a model. | Alves MM et al. | β | 2013 | β |
| Demonstration of genome-wide association studies for identifying markers for wood property and male strobili traits in Cryptomeria japonica. | Uchiyama K et al. | β | 2013 | β |
| Detecting association of rare variants by testing an optimally weighted combination of variants for quantitative traits in general families. | Fang S et al. | β | 2013 | β |
| Dosage transmission disequilibrium test (dTDT) for linkage and association detection. | Zhang Z et al. | β | 2013 | β |
| Effectiveness of conventional drug therapy of plaque psoriasis in the context of consensus guidelines: a prospective observational study in 150 patients. | Gupta AK et al. | β | 2013 | β |
| ETHNOPRED: a novel machine learning method for accurate continental and sub-continental ancestry identification and population stratification correction. | Hajiloo M et al. | β | 2013 | β |
| Exhaustive search of the SNP-sNP interactome identifies epistatic effects on brain volume in two cohorts. | Hibar DP et al. | β | 2013 | β |
| Family-based study of HTR2A in suicide attempts: observed gene, gene Γ environment and parent-of-origin associations. | Ben-Efraim YJ et al. | β | 2013 | β |
| Family history in early-onset inflammatory bowel disease. | Bianco AM et al. | β | 2013 | β |
| Genome-wide association identifies genetic variants associated with lentiform nucleus volume in Nβ=β1345 young and elderly subjects. | Hibar DP et al. | β | 2013 | β |
| Heterozygosity at the A625C polymorphic site of the MyD88 gene is associated with Mycobacterium bovis infection in cattle. | Capparelli R et al. | β | 2013 | β |
| Impacts of population structure and analytical models in genome-wide association studies of complex traits in forest trees: a case study in Eucalyptus globulus. | Cappa EP et al. | β | 2013 | β |
| Implications of sex-specific selection for the genetic basis of disease. | Morrow EH et al. | β | 2013 | β |
| Inter-chromosomal level of genome organization and longevity-related phenotypes in humans. | Kulminski AM et al. | β | 2013 | β |
| Introduction to the special section on genomics. | Grigorenko EL et al. | β | 2013 | β |
| Mapping the genes for susceptibility and response to Leishmania tropica in mouse. | Sohrabi Y et al. | β | 2013 | β |
| Microsatellite scanning of the immunogenome associates MAPK14 and ELTD1 with graft-versus-host disease in hematopoietic stem cell transplantation. | Harkensee C et al. | β | 2013 | β |
| Potential assessment of genome-wide association study and genomic selection in Japanese pear Pyrus pyrifolia. | Iwata H et al. | β | 2013 | β |
| Rab38 modulates proteinuria in model of hypertension-associated renal disease. | Rangel-Filho A et al. | β | 2013 | β |
| REFINING GENETICALLY INFERRED RELATIONSHIPS USING TREELET COVARIANCE SMOOTHING. | Crossett A et al. | β | 2013 | β |
| RNAi phenotypes are influenced by the genetic background of the injected strain. | Kitzmann P et al. | β | 2013 | β |
| Semi-supervised spectral clustering with application to detect population stratification. | Liu B et al. | β | 2013 | β |
| Softwares and methods for estimating genetic ancestry in human populations. | Liu Y et al. | β | 2013 | β |
| Survey of familial glaucoma shows a high incidence of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in non-consanguineous congenital forms in a Spanish population. | MillΓ‘ E et al. | β | 2013 | β |
| Systems biology approach for new target and biomarker identification. | Wang IM et al. | β | 2013 | β |
| The 2013 Novitski Prize: Jonathan Pritchard. | Noor MA | β | 2013 | β |
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| The nature of confounding in genome-wide association studies. | VilhjΓ‘lmsson BJ et al. | β | 2013 | β |
| TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis. | Meena NK et al. | β | 2013 | β |
| Windfalls and pitfalls: Applications of population genetics to the search for disease genes. | Edge MD et al. | β | 2013 | β |
| Ξ²1-adrenoceptor gene Arg389Gly polymorphism and essential hypertension risk in general population: a meta-analysis. | Wang H et al. | β | 2013 | β |
| A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability. | O'Meara CC et al. | β | 2012 | β |
| Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals. | Uricchio LH et al. | β | 2012 | β |
| A common genetic background could explain early-onset Crohn's disease. | Bianco AM et al. | β | 2012 | β |
| A comparison of methods sensitive to interactions with small main effects. | Culverhouse RC | β | 2012 | β |
| A comprehensive genetic approach for improving prediction of skin cancer risk in humans. | Vazquez AI et al. | β | 2012 | β |
| Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia. | Motazacker MM et al. | β | 2012 | β |
| A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis. | Lou J et al. | β | 2012 | β |
| Allowing for population stratification in association analysis. | Qin H et al. | β | 2012 | β |
| A Method for Inferring an Individual's Genetic Ancestry and Degree of Admixture Associated with Six Major Continental Populations. | Libiger O et al. | β | 2012 | β |
| An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. | Nelson MR et al. | β | 2012 | β |
| Ancestral susceptibility to colorectal cancer. | Huhn S et al. | β | 2012 | β |
| Assessing the joint effect of population stratification and sample selection in studies of gene-gene (environment) interactions. | Cheng KF et al. | β | 2012 | β |
| Association between paraoxonase-1 gene polymorphisms and risk of metabolic syndrome. | Kordi-Tamandani DM et al. | β | 2012 | β |
| Association of cytokine gene polymorphisms in patients with chronic obstructive pulmonary disease. | Shukla RK et al. | β | 2012 | β |
| Autoimmune Addison disease: pathophysiology and genetic complexity. | Mitchell AL et al. | β | 2012 | β |
| Bigger, better, sooner--scaling up for success. | Thun MJ et al. | β | 2012 | β |
| Bioenergy grass feedstock: current options and prospects for trait improvement using emerging genetic, genomic, and systems biology toolkits. | Feltus FA et al. | β | 2012 | β |
| Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. | Rajagopalan P et al. | β | 2012 | β |
| Correction for population stratification in random forest analysis. | Zhao Y et al. | β | 2012 | β |
| Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment. | Gemenetzi M et al. | β | 2012 | β |
| Cutting-edge issues in primary biliary cirrhosis. | Folci M et al. | β | 2012 | β |
| Cytochrome P1B1 (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis. | Gajjar K et al. | β | 2012 | β |
| Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis. | Babron MC et al. | β | 2012 | β |
| Differential confounding of rare and common variants in spatially structured populations. | Mathieson I et al. | β | 2012 | β |
| Estimating the effect of SNP genotype on quantitative traits from pooled DNA samples. | Henshall JM et al. | β | 2012 | β |
| Estimation of Effective Population Size in the Sapsaree: A Korean Native Dog (Canis familiaris). | Alam M et al. | β | 2012 | β |
| Evidence of widespread selection on standing variation in Europe at height-associated SNPs. | Turchin MC et al. | β | 2012 | β |
| FASTER MT: Isolation of Pure Populations of a and Ξ± Ascospores from Saccharomycescerevisiae. | Chin BL et al. | β | 2012 | β |
| From mouse to humans: discovery of the CACNG2 pain susceptibility gene. | Nissenbaum J | β | 2012 | β |
| Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction. | Lee T et al. | β | 2012 | β |
| Genetics of nonsyndromic orofacial clefts. | Rahimov F et al. | β | 2012 | β |
| Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis. | Zou L et al. | β | 2012 | β |
| Genome-wide association mapping of milk production traits in Braunvieh cattle. | Maxa J et al. | β | 2012 | β |
| Genome-wide association studies for agronomical traits in a world wide spring barley collection. | Pasam RK et al. | β | 2012 | β |
| Genome wide linkage disequilibrium in Chinese asparagus bean (Vigna. unguiculata ssp. sesquipedialis) germplasm: implications for domestication history and genome wide association studies. | Xu P et al. | β | 2012 | β |
| Increase in harm avoidance by genetic loading of schizophrenia. | Sim M et al. | β | 2012 | β |
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| Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. | Diamanti-Kandarakis E et al. | β | 2012 | β |
| KIR genotypic diversity can track ancestries in heterogeneous populations: a potential confounder for disease association studies. | Singh KM et al. | β | 2012 | β |
| Lessons from genome-wide association studies for epidemiology. | Hunter DJ | β | 2012 | β |
| Linking preeclampsia and cardiovascular disease later in life. | GiguΓ¨re Y et al. | β | 2012 | β |
| Mapping QTL for agronomic traits in breeding populations. | WΓΌrschum T | β | 2012 | β |
| Measurement of reverse cholesterol transport pathways in humans: in vivo rates of free cholesterol efflux, esterification, and excretion. | Turner S et al. | β | 2012 | β |
| Molecular genetic studies of complex phenotypes. | Marian AJ | β | 2012 | β |
| No association between a polymorphism of the adenylate cyclase type IX gene and major depressive disorder in the Chinese Han population. | Cao S et al. | β | 2012 | β |
| On the prospects of whole-genome association mapping in Saccharomyces cerevisiae. | Connelly CF et al. | β | 2012 | β |
| Patterns of linkage disequilibrium and association mapping in diploid alfalfa (M. sativa L.). | Sakiroglu M et al. | β | 2012 | β |
| Pilot study of the association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis. | Weiss SL et al. | β | 2012 | β |
| Pleiotropy of segregating genetic variants that affect honey bee worker life expectancy. | Dixon LR et al. | β | 2012 | β |
| Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease. | Friso S et al. | β | 2012 | β |
| [Role of genomic medicine in middle and inner ear diseases]. | LΓ³pez-Escamez JA | β | 2012 | β |
| Single-marker family-based association analysis conditional on parental information. | Chung RH et al. | β | 2012 | β |
| Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study. | Harkensee C et al. | β | 2012 | β |
| Single-nucleotide polymorphisms for high-throughput genotyping of Anopheles arabiensis in East and southern Africa. | Lee Y et al. | β | 2012 | β |
| Small- and large-effect quantitative trait locus interactions underlie variation in yeast sporulation efficiency. | Lorenz K et al. | β | 2012 | β |
| The Promises and Pitfalls of Genoeconomics* | Benjamin DJ et al. | β | 2012 | β |
| Type 2 Diabetes Genetics: Beyond GWAS. | Sanghera DK et al. | β | 2012 | β |
| Using genomic data to make indirect (and unauthorized) estimates of disease risk. | Nyholt DR | β | 2012 | β |
| A comparison of association methods correcting for population stratification in case-control studies. | Wu C et al. | β | 2011 | β |
| An integrated meta-analysis of two variants in HOXA1/HOXB1 and their effect on the risk of autism spectrum disorders. | Song RR et al. | β | 2011 | β |
| Annotating individual human genomes. | Torkamani A et al. | β | 2011 | β |
| A novel method to detect gene-gene interactions in structured populations: MDR-SP. | Niu A et al. | β | 2011 | β |
| A robust statistical method for association-based eQTL analysis. | Jiang N et al. | β | 2011 | β |
| Association mapping and gene-gene interaction for stem rust resistance in CIMMYT spring wheat germplasm. | Yu LX et al. | β | 2011 | β |
| Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. | Gizer IR et al. | β | 2011 | β |
| Association of COL1A1 and TGFB1 polymorphisms with otosclerosis in a Tunisian population. | Khalfallah A et al. | β | 2011 | β |
| A test of Hardy-Weinberg equilibrium in structured populations. | Sha Q et al. | β | 2011 | β |
| A unified approach to the estimation and interpretation of resistance costs in plants. | Vila-Aiub MM et al. | β | 2011 | β |
| Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity. | Timpano KR et al. | β | 2011 | β |
| Contemporary human genetic strategies in aging research. | Bloss CS et al. | β | 2011 | β |
| Correcting for Population Stratification in Genomewide Association Studies. | Lin DY et al. | β | 2011 | β |
| Dog models of naturally occurring cancer. | Rowell JL et al. | β | 2011 | β |
| Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. | Fairbanks LA et al. | β | 2011 | β |
| GCKR mutations in Japanese families with clustered type 2 diabetes. | Tanaka D et al. | β | 2011 | β |
| Genetic association and gene-environment interaction: a new method for overcoming the lack of exposure information in controls. | Kazma R et al. | β | 2011 | β |
| Genetic control of resistance to Trypanosoma brucei brucei infection in mice. | SΓma M et al. | β | 2011 | β |
| Genetics of the HLA region in the prediction of type 1 diabetes. | Noble JA et al. | β | 2011 | β |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | β | 2011 | β |
| Genomics for disease treatment and prevention. | Bloss CS et al. | β | 2011 | β |
| Haplo2Ped: a tool using haplotypes as markers for linkage analysis. | Cheng F et al. | β | 2011 | β |
| Identification of candidate gene regions in the rat by co-localization of QTLs for bone density, size, structure and strength. | Lagerholm S et al. | β | 2011 | β |
| Identification of enzymatic and regulatory genes of plant metabolism through QTL analysis in Arabidopsis. | Brotman Y et al. | β | 2011 | β |
| Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees. | Chen WM et al. | β | 2011 | β |
| Inflammatory bowel disease aggregation in Utah kindreds. | Guthery SL et al. | β | 2011 | β |
| Integrating multiple protein-protein interaction networks to prioritize disease genes: a Bayesian regression approach. | Zhang W et al. | β | 2011 | β |
| Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms. | Lahey BB et al. | β | 2011 | β |
| Joint analysis for genome-wide association studies in family-based designs. | Sha Q et al. | β | 2011 | β |
| Life or death? A physiogenomic approach to understand individual variation in responses to hemorrhagic shock. | Klemcke HG et al. | β | 2011 | β |
| Linkage analyses of stimulant dependence, craving, and heavy use in American Indians. | Ehlers CL et al. | β | 2011 | β |
| Mapping 49 quantitative trait loci at high resolution through sequencing-based genotyping of rice recombinant inbred lines. | Wang L et al. | β | 2011 | β |
| mGluR7 genetics and alcohol: intersection yields clues for addiction. | Gyetvai B et al. | β | 2011 | β |
| Natural allelic variation defines a role for ATMYC1: trichome cell fate determination. | Symonds VV et al. | β | 2011 | β |
| Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. | SillanpÀÀ MJ | β | 2011 | β |
| Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations. | Kumar S et al. | β | 2011 | β |
| Population structure in sorghum accessions from West Africa differing in race and maturity class. | Bhosale SU et al. | β | 2011 | β |
| Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV. | RodrΓguez SM et al. | β | 2011 | β |
| "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. | Drgon T et al. | β | 2011 | β |
| Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands. | Das M et al. | β | 2011 | β |
| The distribution of SNP marker effects for faecal worm egg count in sheep, and the feasibility of using these markers to predict genetic merit for resistance to worm infections. | Kemper KE et al. | β | 2011 | β |
| The genetics of asthma and allergic disease: a 21st century perspective. | Ober C et al. | β | 2011 | β |
| The relevance of individual genetic background and its role in animal models of epilepsy. | Schauwecker PE | β | 2011 | β |
| Uncover disease genes by maximizing information flow in the phenome-interactome network. | Chen Y et al. | β | 2011 | β |
| Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. | Culverhouse RC et al. | β | 2011 | β |
| Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects. | Hibar DP et al. | β | 2011 | β |
| A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder. | Zhang J et al. | β | 2010 | β |
| A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. | Ho AJ et al. | β | 2010 | β |
| Analyzing complex traits with congenic strains. | Shao H et al. | β | 2010 | β |
| A protein allergen microarray detects specific IgE to pollen surface, cytoplasmic, and commercial allergen extracts. | Vigh-Conrad KA et al. | β | 2010 | β |
| A SPECTRAL GRAPH APPROACH TO DISCOVERING GENETIC ANCESTRY. | Lee AB et al. | β | 2010 | β |
| Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. | Adkins RM et al. | β | 2010 | β |
| Association of maternally inherited GNAS alleles with African-American male birth weight. | Adkins RM et al. | β | 2010 | β |
| Bovine tuberculosis: the genetic basis of host susceptibility. | Allen AR et al. | β | 2010 | β |
| Child and adolescent psychiatric genetics. | Hebebrand J et al. | β | 2010 | β |
| Chronic kidney disease and GWAS: "the proper study of mankind is man". | Price PM et al. | β | 2010 | β |
| CoAIMs: a cost-effective panel of ancestry informative markers for determining continental origins. | Londin ER et al. | β | 2010 | β |
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| Recent advances in the genetics of autoimmune diseases. | AlarcΓ³n-Riquelme ME | β | 2007 | β |
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| The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration. | Calkins ME et al. | β | 2007 | β |
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| The epidemiology of childhood leukemia with a focus on birth weight and diet. | Tower RL et al. | β | 2007 | β |
| The genetics of IgA nephropathy. | Beerman I et al. | β | 2007 | β |
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| The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. | Alizadeh BZ et al. | β | 2007 | β |
| The heritability of abstract reasoning in Caribbean Latinos with familial Alzheimer disease. | Johnson B et al. | β | 2007 | β |
| The Nramp1AA genotype confers susceptibility to Brucella abortus in water buffalo. | Capparelli R et al. | β | 2007 | β |
| The PAH gene, phenylketonuria, and a paradigm shift. | Scriver CR | β | 2007 | β |
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| A brief update of glucocorticoid receptor variants and obesity risk. | Rosmond R et al. | β | 2006 | β |
| Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats. | van Dijk SJ et al. | β | 2006 | β |
| A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. | Kittles RA et al. | β | 2006 | β |
| Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes. | Liu QR et al. | β | 2006 | β |
| Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations. | Tsai HJ et al. | β | 2006 | β |
| A general population-genetic model for the production by population structure of spurious genotype-phenotype associations in discrete, admixed or spatially distributed populations. | Rosenberg NA et al. | β | 2006 | β |
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| An interaction between the serotonin transporter promoter region and dopamine transporter polymorphisms contributes to harm avoidance and reward dependence traits in normal healthy subjects. | Kim SJ et al. | β | 2006 | β |
| A non-parametric approach to population structure inference using multilocus genotypes. | Liu N et al. | β | 2006 | β |
| A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. | Kim CH et al. | β | 2006 | β |
| Association mapping of complex trait loci with context-dependent effects and unknown context variable. | SillanpÀÀ MJ et al. | β | 2006 | β |
| Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women. | Mitra S et al. | β | 2006 | β |
| Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. | Koh JM et al. | β | 2006 | β |
| A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. | Yu J et al. | β | 2006 | β |
| Bayesian mapping of genotype x expression interactions in quantitative and qualitative traits. | Hoti F et al. | β | 2006 | β |
| Biomarkers of cardiovascular disease: molecular basis and practical considerations. | Vasan RS | β | 2006 | β |
| Cia27 is a novel non-MHC arthritis severity locus on rat chromosome 10 syntenic to the rheumatoid arthritis 17q22-q25 locus. | Brenner M et al. | β | 2006 | β |
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| Detecting the polymorphisms of paraoxonase (PON) cluster in Chinese Han population based on a rapid method. | Zhang Y et al. | β | 2006 | β |
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| Enemy at the gates: forward genetics of the mouse antiviral response. | Kielczewska A et al. | β | 2006 | β |
| Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's disease. | Bassett SS et al. | β | 2006 | β |
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| Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology. | Banus HA et al. | β | 2006 | β |
| Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. | Malison RT et al. | β | 2006 | β |
| Identification of susceptibility loci for cervical carcinoma by genome scan of affected sib-pairs. | Engelmark MT et al. | β | 2006 | β |
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| Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. | Green AD et al. | β | 2006 | β |
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| Review of quantitative trait loci identified in the chicken. | Abasht B et al. | β | 2006 | β |
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| A comprehensive literature review of haplotyping software and methods for use with unrelated individuals. | Salem RM et al. | β | 2005 | β |
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| Quantitative analysis of nucleic acids--the last few years of progress. | Ding C et al. | β | 2004 | β |
| Quantitative trait loci affecting natural variation in Drosophila longevity. | Geiger-Thornsberry GL et al. | β | 2004 | β |
| 'Racial' differences in genetic effects for complex diseases. | Ioannidis JP et al. | β | 2004 | β |
| Recombination hotspots and block structure of linkage disequilibrium in the human genome exemplified by detailed analysis of PGM1 on 1p31. | Rana NA et al. | β | 2004 | β |
| Replication in genetic studies of complex traits. | SillanpÀÀ MJ et al. | β | 2004 | β |
| Sequence variants and haplotype analysis of serotonin transporter gene and association with bipolar affective disorder in Taiwan. | Sun HS et al. | β | 2004 | β |
| Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. | Sen S et al. | β | 2004 | β |
| Sex- and lineage-specific inheritance of depression-like behavior in the rat. | Solberg LC et al. | β | 2004 | β |
| Simultaneous detection of linkage disequilibrium and genetic differentiation of subdivided populations. | Kitada S et al. | β | 2004 | β |
| Single nucleotide polymorphism (SNP) analysis of mouse quantitative trait loci for identification of candidate genes. | Yan Y et al. | β | 2004 | β |
| The future of association studies: gene-based analysis and replication. | Neale BM et al. | β | 2004 | β |
| The genes for schizophrenia: finally a breakthrough? | Shirts BH et al. | β | 2004 | β |
| The genetic architecture of response to long-term artificial selection for oil concentration in the maize kernel. | Laurie CC et al. | β | 2004 | β |
| The genetic contribution towards preterm delivery. | Adams KM et al. | β | 2004 | β |
| The genetics of eating disorders. | Berrettini W | β | 2004 | β |
| The human genome project and the discovery of genetic determinants of cancer susceptibility. | Taramelli R et al. | β | 2004 | β |
| The policy and ethical implications of genetic research on attention deficit hyperactivity disorder. | Yeh M et al. | β | 2004 | β |
| Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. | Wu SJ et al. | β | 2004 | β |
| Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate in Brazilian patients: results of a large case-control study. | Passos-Bueno MR et al. | β | 2004 | β |
| Transmission disequilibrium test (TDT) for case-control studies. | Ruiz-NarvΓ‘ez EA et al. | β | 2004 | β |
| Type 2 diabetes in South Asians: a pathophysiologic focus on the Asian-Indian epidemic. | Bajaj M et al. | β | 2004 | β |
| Update on human systemic lupus erythematosus genetics. | Tsao BP | β | 2004 | β |
| Using denaturing HPLC for SNP discovery and genotyping, and establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase (RDH8) gene. | Han W et al. | β | 2004 | β |
| Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. | Uitterlinden AG et al. | β | 2004 | β |
| Absence of linkage of familial intracranial aneurysms to 7q11 in highly aggregated Japanese families. | Yamada S et al. | β | 2003 | β |
| A general statistical framework for mapping quantitative trait loci in nonmodel systems: issue for characterizing linkage phases. | Lin M et al. | β | 2003 | β |
| Alpha-adducin gene polymorphism is associated with essential hypertension in Chinese: a case-control and family-based study. | Ju Z et al. | β | 2003 | β |
| "Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. | Page GP et al. | β | 2003 | β |
| Association studies of genetic polymorphisms in central obesity: a critical review. | Rosmond R | β | 2003 | β |
| A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. | Wiesner GL et al. | β | 2003 | β |
| Candidate gene analysis of the human metabotropic glutamate receptor type 4 (GRM4) in patients with juvenile myoclonic epilepsy. | Izzi C et al. | β | 2003 | β |
| Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis. | Barber RC et al. | β | 2003 | β |
| Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. | Pajukanta P et al. | β | 2003 | β |
| Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls. | WiΕniewski A et al. | β | 2003 | β |
| Editorial comment--The pendulum's swing: the way forward in the genetics of stroke. | Bangash MA et al. | β | 2003 | β |
| Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation. | Swan GE et al. | β | 2003 | β |
| Establishment of a high-efficiency SNP-based framework marker set for Arabidopsis. | TΓΆrjΓ©k O et al. | β | 2003 | β |
| Estrogen and other female reproductive risk factors are not strongly associated with the development of rheumatoid arthritis in elderly women. | Merlino LA et al. | β | 2003 | β |
| Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. | Qin YJ et al. | β | 2003 | β |
| Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder. | Ekholm JM et al. | β | 2003 | β |
| Extent and distribution of linkage disequilibrium around the SLC11A1 locus. | Yip SP et al. | β | 2003 | β |
| Fitness-associated recombination on rugged adaptive landscapes. | Hadany L et al. | β | 2003 | β |
| Functional genomics of sleep. | Mackiewicz M et al. | β | 2003 | β |
| Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. | Bomprezzi R et al. | β | 2003 | β |
| Genetic approaches to stature, pubertal timing, and other complex traits. | Palmert MR et al. | β | 2003 | β |
| Genetic determinants of susceptibility to osteoporosis. | Albagha OM et al. | β | 2003 | β |
| Genetic epidemiology of type 1 diabetes. | Hirschhorn JN | β | 2003 | β |
| Genetic linkage studies in alopecia areata. | Martinez-Mir A et al. | β | 2003 | β |
| Genetics of preeclampsia: what are the challenges? | Bernard N et al. | β | 2003 | β |
| Genetic studies in complex disease: the case pro association studies. | Rosendaal FR | β | 2003 | β |
| Genetic susceptibility to variant Creutzfeldt-Jakob disease. | Partanen J | β | 2003 | β |
| Genome mapping of the orange blotch colour pattern in cichlid fishes. | Streelman JT et al. | β | 2003 | β |
| Genomics and homeostasis. | Cowley AW | β | 2003 | β |
| Growing evidence for diabetes susceptibility genes from genome scan data. | McCarthy MI | β | 2003 | β |
| HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore. | Wu AH et al. | β | 2003 | β |
| Human chromosome 17 in essential hypertension. | Knight J et al. | β | 2003 | β |
| Human population structure and genetic association studies. | Ziv E et al. | β | 2003 | β |
| Influence of polymorphisms in VDR and COLIA1 genes on the risk of osteoporotic fractures in aged men. | Alvarez-HernΓ‘ndez D et al. | β | 2003 | β |
| Lack of association between the G protein beta3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study. | Huang X et al. | β | 2003 | β |
| Mapping of genomic regions (quantitative trait loci) controlling production and quality in industrial cultures of the edible basidiomycete Pleurotus ostreatus. | Larraya LM et al. | β | 2003 | β |
| Measured haplotype analysis of the aldosterone synthase gene and heart size. | Mayosi BM et al. | β | 2003 | β |
| Measuring and using admixture to study the genetics of complex diseases. | Halder I et al. | β | 2003 | β |
| Multipoint linkage disequilibrium mapping for complex diseases. | Liang KY et al. | β | 2003 | β |
| Mutation screen of the gene encoding GABRB3 in Chinese patients with childhood absence epilepsy. | Lu J et al. | β | 2003 | β |
| New approaches to investigating heterogeneity in complex traits. | Bomprezzi R et al. | β | 2003 | β |
| Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. | Neri TM et al. | β | 2003 | β |
| Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis. | Invernizzi P et al. | β | 2003 | β |
| Periodic breathing and genetics. | Strohl KP | β | 2003 | β |
| Physical mapping of autonomic/sympathetic candidate genetic loci for hypertension in the human genome: a somatic cell radiation hybrid library approach. | Chitbangonsyn SW et al. | β | 2003 | β |
| Polycystic ovary syndrome: syndrome XX? | Sam S et al. | β | 2003 | β |
| Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis. | Todhunter RJ et al. | β | 2003 | β |
| Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning. | Zheng CQ et al. | β | 2003 | β |
| Quantitative trait locus mapping of pyrethroid resistance in Colorado potato beetle, Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae). | Hawthorne DJ | β | 2003 | β |
| Regression to the truth: replication of association in pharmacogenetic studies. | Ryan SG | β | 2003 | β |
| Results of a genome-wide linkage analysis in prostate cancer families ascertained through the ACTANE consortium. | Edwards S et al. | β | 2003 | β |
| Study of human SP-A, SP-B and SP-D loci: allele frequencies, linkage disequilibrium and heterozygosity in different races and ethnic groups. | Liu W et al. | β | 2003 | β |
| The genetics of human systemic lupus erythematosus. | Tsao BP | β | 2003 | β |
| The impact of genomics on the study of natural variation in Arabidopsis. | Borevitz JO et al. | β | 2003 | β |
| The lowdown on linkage disequilibrium. | Gaut BS et al. | β | 2003 | β |
| The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. | Mogil JS et al. | β | 2003 | β |
| Theory of the effects of population structure and sampling on patterns of linkage disequilibrium applied to genomic data from humans. | Wakeley J et al. | β | 2003 | β |
| The peroxisome proliferator-activated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study. | Li S et al. | β | 2003 | β |
| Transforming growth factor-beta3 gene SfaN1 polymorphism in Korean nonsyndromic cleft lip and palate patients. | Kim MH et al. | β | 2003 | β |
| Twenty-first century tobacco use: it is not just a risk factor anymore. | Khurana S et al. | β | 2003 | β |
| Twin study of genetic and environmental influences on glucose tolerance and indices of insulin sensitivity and secretion. | Schousboe K et al. | β | 2003 | β |
| Two-loci interaction confirms arthritis-regulating quantitative trait locus on rat chromosome 6. | Olofsson P et al. | β | 2003 | β |
| Update on the genetics of inflammatory bowel disease. | Duerr RH | β | 2003 | β |
| Where are the prostate cancer genes?--A summary of eight genome wide searches. | Easton DF et al. | β | 2003 | β |