A general test of association for quantitative traits in nuclear families.
paper
Cited
Public
Unavailable
- Authors
- Abecasis, G R; Cardon, L R; Cookson, W O
- Year
- 2000
- Journal
- American journal of human genetics
- PMID
- 10631157
- DOI
- 10.1086/302698
- PMCID
- PMC1288332
High-resolution mapping is an important step in the identification of complex disease genes. In outbred populations, linkage disequilibrium is expected to operate over short distances and could provide a powerful fine-mapping tool. Here we build on recently developed methods for linkage-disequilibrium mapping of quantitative traits to construct a general approach that can accommodate nuclear families of any size, with or without parental information. Variance components are used to construct a test that utilizes information from all available offspring but that is not biased in the presence of linkage or familiality. A permutation test is described for situations in which maximum-likelihood estimates of the variance components are biased. Simulation studies are used to investigate power and error rates of this approach and to highlight situations in which violations of multivariate normality assumptions warrant the permutation test. The relationship between power and the level of linkage disequilibrium for this test suggests that the method is well suited to the analysis of dense maps. The relationship between power and family structure is investigated, and these results are applicable to study design in complex disease, especially for late-onset conditions for which parents are usually not available. When parental genotypes are available, power does not depend greatly on the number of offspring in each family. Power decreases when parental genotypes are not available, but the loss in power is negligible when four or more offspring per family are genotyped. Finally, it is shown that, when siblings are available, the total number of genotypes required in order to achieve comparable power is smaller if parents are not genotyped.
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| A rapid generalized least squares model for a genome-wide quantitative trait association analysis in families. | Li X et al. | β | 2011 | β |
| Association between low density lipoprotein receptor-related protein 2 gene polymorphisms and bone mineral density variation in Chinese population. | Wang C et al. | β | 2011 | β |
| Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier. | Taylor AE et al. | β | 2011 | β |
| BDNF gene effects on brain circuitry replicated in 455 twins. | Chiang MC et al. | β | 2011 | β |
| Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies. | Wen Y et al. | β | 2011 | β |
| CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. | Hoft NR et al. | β | 2011 | β |
| Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene. | Windelinckx A et al. | β | 2011 | β |
| Correlated genotypes in friendship networks. | Fowler JH et al. | β | 2011 | β |
| Different approaches for dealing with rare variants in family-based genetic studies: application of a Genetic Analysis Workshop 17 problem. | Alfonso de Almeida MA et al. | β | 2011 | β |
| Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis. | FatjΓ³-Vilas M et al. | β | 2011 | β |
| famCNV: copy number variant association for quantitative traits in families. | Eleftherohorinou H et al. | β | 2011 | β |
| FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. | Ewens KG et al. | β | 2011 | β |
| Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure. | Carstens N et al. | β | 2011 | β |
| Genome-wide association study of the child behavior checklist dysregulation profile. | Mick E et al. | β | 2011 | β |
| Genome-wide linkage scan for resistance to muscle fatigue. | Thomis MA et al. | β | 2011 | β |
| Genomic regions associated with ventro-cranial chronic pleuritis in pig. | SΓΈrensen KK et al. | β | 2011 | β |
| Genomics and genetics in the biology of adaptation to exercise. | Bouchard C et al. | β | 2011 | β |
| IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. | Meyer CG et al. | β | 2011 | β |
| Incorporating linkage information into a common disease/rare variant framework. | Hinrichs AL et al. | β | 2011 | β |
| Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population. | Kenny EE et al. | β | 2011 | β |
| In silico genotyping of the maize nested association mapping population. | Guo B et al. | β | 2011 | β |
| Integrating social science and genetics: news from the political front. | Hatemi PK et al. | β | 2011 | β |
| Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects. | Newbury DF et al. | β | 2011 | β |
| Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. | SillanpÀÀ MJ | β | 2011 | β |
| Perspectives on genome-wide multi-stage family-based association studies. | Van Steen K | β | 2011 | β |
| phenosim--A software to simulate phenotypes for testing in genome-wide association studies. | GΓΌnther T et al. | β | 2011 | β |
| Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients. | Huang RS et al. | β | 2011 | β |
| Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population. | Grant AV et al. | β | 2011 | β |
| Power and robustness of three whole genome association mapping approaches in selected populations. | Erbe M et al. | β | 2011 | β |
| PSEUDOMARKER: a powerful program for joint linkage and/or linkage disequilibrium analysis on mixtures of singletons and related individuals. | Hiekkalinna T et al. | β | 2011 | β |
| The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. | Rizzi TS et al. | β | 2011 | β |
| The physiological roles of phosducin: from retinal function to stress-dependent hypertension. | Beetz N et al. | β | 2011 | β |
| The R563Q mutation of the epithelial sodium channel beta-subunit is associated with hypertension. | Jones ES et al. | β | 2011 | β |
| Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. | Ewens KG et al. | β | 2011 | β |
| Unbiased and locally efficient estimation of genetic effect on quantitative trait in the presence of population admixture. | Wang Y et al. | β | 2011 | β |
| Whole-genome association study for fatty acid composition of oleic acid in Japanese Black cattle. | Uemoto Y et al. | β | 2011 | β |
| A genetic study of ADHD and activity level in infancy. | Ilott N et al. | β | 2010 | β |
| A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI. | Yang R et al. | β | 2010 | β |
| A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels. | Bos SD et al. | β | 2010 | β |
| An association between Epac-1 gene variants and anxiety and depression in two independent samples. | Middeldorp CM et al. | β | 2010 | β |
| An Association Test for Multiple Traits Based on the Generalized Kendall's Tau. | Zhang H et al. | β | 2010 | β |
| A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia. | Huertas-Vazquez A et al. | β | 2010 | β |
| A powerful genome-wide feasible approach to detect parent-of-origin effects in studies of quantitative traits. | Belonogova NM et al. | β | 2010 | β |
| Association and gene-gene interaction of SLC6A4 and ITGB3 in autism. | Ma DQ et al. | β | 2010 | β |
| Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations. | Lepagnol-Bestel AM et al. | β | 2010 | β |
| Blood pressure response to potassium supplementation is associated with genetic variation in endothelin 1 and interactions with E selectin in rural Chinese. | Montasser ME et al. | β | 2010 | β |
| Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits. | Savitz J et al. | β | 2010 | β |
| Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. | Gamazon ER et al. | β | 2010 | β |
| Congenital sensorineural deafness in Australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to CFA10. | Sommerlad S et al. | β | 2010 | β |
| CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study. | Rankinen T et al. | β | 2010 | β |
| Designs for linkage analysis and association studies of complex diseases. | Cui Y et al. | β | 2010 | β |
| Dissecting complex phenotypes using the genomics of twins. | Tan Q et al. | β | 2010 | β |
| Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. | Lind PA et al. | β | 2010 | β |
| Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation. | Bates TC et al. | β | 2010 | β |
| European lactase persistence genotype shows evidence of association with increase in body mass index. | Kettunen J et al. | β | 2010 | β |
| Evaluation of A2BP1 as an obesity gene. | Ma L et al. | β | 2010 | β |
| Fetal genotype for the xenobiotic metabolizing enzyme NQO1 influences intrauterine growth among infants whose mothers smoked during pregnancy. | Price TS et al. | β | 2010 | β |
| Friendships Moderate an Association Between a Dopamine Gene Variant and Political Ideology. | Settle JE et al. | β | 2010 | β |
| FTO genotype is associated with exercise training-induced changes in body composition. | Rankinen T et al. | β | 2010 | β |
| Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. | Moreno-Macias H et al. | β | 2010 | β |
| Genetic advances in the study of speech and language disorders. | Newbury DF et al. | β | 2010 | β |
| Genetic influences on attention deficit hyperactivity disorder symptoms from age 2 to 3: a quantitative and molecular genetic investigation. | Ilott NE et al. | β | 2010 | β |
| Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families. | Markunas CA et al. | β | 2010 | β |
| Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families. | Kim HN et al. | β | 2010 | β |
| Genome-wide association scan for five major dimensions of personality. | Terracciano A et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. | Stark AL et al. | β | 2010 | β |
| HLA alleles and fissured tongue. | Kalifatidis A et al. | β | 2010 | β |
| Identification of candidate genes for dyslexia susceptibility on chromosome 18. | Scerri TS et al. | β | 2010 | β |
| Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism. | Correia CT et al. | β | 2010 | β |
| Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. | Weissglas-Volkov D et al. | β | 2010 | β |
| In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation. | Marballi K et al. | β | 2010 | β |
| Mixed linear model approach adapted for genome-wide association studies. | Zhang Z et al. | β | 2010 | β |
| Nested association mapping for identification of functional markers. | Guo B et al. | β | 2010 | β |
| New approaches to population stratification in genome-wide association studies. | Price AL et al. | β | 2010 | β |
| No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families. | Yu JB et al. | β | 2010 | β |
| No association between polymorphisms of peroxisome [corrected] proliferator-activated receptor-gamma gene and peak bone mineral density variation in Chinese nuclear families. | Yue H et al. | β | 2010 | β |
| PACdb: a database for cell-based pharmacogenomics. | Gamazon ER et al. | β | 2010 | β |
| Polymorphic cis- and trans-regulation of human gene expression. | Cheung VG et al. | β | 2010 | β |
| Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families. | Zhang H et al. | β | 2010 | β |
| Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia. | Wedenoja J et al. | β | 2010 | β |
| Replication of GWAS of bipolar disorder: association of SNPs near CDH7 with bipolar disorder and visual processing. | Soronen P et al. | β | 2010 | β |
| SCAN: SNP and copy number annotation. | Gamazon ER et al. | β | 2010 | β |
| TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance. | Chang YC et al. | β | 2010 | β |
| Testing for genetic association in the presence of linkage and gene-covariate interactions. | Callegaro A et al. | β | 2010 | β |
| The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI. | Webster RJ et al. | β | 2010 | β |
| Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. | Nicolae DL et al. | β | 2010 | β |
| Using evidence for population stratification bias in combined individual- and family-level genetic association analyses of quantitative traits. | Mirea L et al. | β | 2010 | β |
| Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. | Timmons JA et al. | β | 2010 | β |
| Variance component methods for analysis of complex phenotypes. | Almasy L et al. | β | 2010 | β |
| Variance-components methods for linkage and association analysis of ordinal traits in general pedigrees. | Diao G et al. | β | 2010 | β |
| A combined strategy for quantitative trait loci detection by genome-wide association. | Lam AC et al. | β | 2009 | β |
| A common variant associated with dyslexia reduces expression of the KIAA0319 gene. | Dennis MY et al. | β | 2009 | β |
| A comparative study of three methods for detecting association of quantitative traits in samples of related subjects. | Saint Pierre A et al. | β | 2009 | β |
| A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families. | Shugart YY et al. | β | 2009 | β |
| A Functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly. | Bochdanovits Z et al. | β | 2009 | β |
| Application of genome-wide SNP data for uncovering pairwise relationships and quantitative trait loci. | Sham PC et al. | β | 2009 | β |
| A quantile-based method for association mapping of quantitative phenotypes: an application to rheumatoid arthritis phenotypes. | Ghosh S et al. | β | 2009 | β |
| Arterial properties in relation to genetic variation in alpha-adducin and the renin-angiotensin system in a White population. | SeidlerovΓ‘ J et al. | β | 2009 | β |
| Arterial properties in relation to genetic variations in the adducin subunits in a white population. | SeidlerovΓ‘ J et al. | β | 2009 | β |
| Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. | Rong R et al. | β | 2009 | β |
| Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. | Tomppo L et al. | β | 2009 | β |
| Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families. | Gu JM et al. | β | 2009 | β |
| Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. | PietilΓ€inen OP et al. | β | 2009 | β |
| Association of regions on chromosomes 6 and 7 with blood pressure in Nigerian families. | Tayo BO et al. | β | 2009 | β |
| Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. | Videman T et al. | β | 2009 | β |
| Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | β | 2009 | β |
| Association test for X-linked QTL in family-based designs. | Zhang L et al. | β | 2009 | β |
| A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes. | Epstein MP et al. | β | 2009 | β |
| Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies. | Kebir O et al. | β | 2009 | β |
| Choosing an optimal method to combine P-values. | Won S et al. | β | 2009 | β |
| Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome. | Fava C et al. | β | 2009 | β |
| CMIP and ATP2C2 modulate phonological short-term memory in language impairment. | Newbury DF et al. | β | 2009 | β |
| Common variation in SIM1 is reproducibly associated with BMI in Pima Indians. | Traurig M et al. | β | 2009 | β |
| Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment. | Rice ML et al. | β | 2009 | β |
| Correcting for relatedness in Bayesian models for genomic data association analysis. | Pikkuhookana P et al. | β | 2009 | β |
| Detecting genes contributing to longevity using twin data. | Begun A | β | 2009 | β |
| Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate. | Kremeyer B et al. | β | 2009 | β |
| Expression and alternative splicing of folate pathway genes in HapMap lymphoblastoid cell lines. | Duan S et al. | β | 2009 | β |
| Family-based bivariate association tests for quantitative traits. | Zhang L et al. | β | 2009 | β |
| Family-based genome-wide association studies. | Benyamin B et al. | β | 2009 | β |
| Family-based mapping of quantitative trait loci in plant breeding populations with resistance to Fusarium head blight in wheat as an illustration. | Rosyara UR et al. | β | 2009 | β |
| Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia. | Chen PL et al. | β | 2009 | β |
| Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study. | StΓΌtz AM et al. | β | 2009 | β |
| Genetic analysis of radiation-induced changes in human gene expression. | Smirnov DA et al. | β | 2009 | β |
| Genetic association tests: a method for the joint analysis of family and case-control data. | Gray-McGuire C et al. | β | 2009 | β |
| Genetic contribution of chemokine receptor 2 (CCR2) polymorphisms towards increased serum total IgE levels in Indian asthmatics. | Batra J et al. | β | 2009 | β |
| Genetics of human gene expression: mapping DNA variants that influence gene expression. | Cheung VG et al. | β | 2009 | β |
| Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia. | Liao SY et al. | β | 2009 | β |
| Genetic variants of TCF7L2 are associated with insulin resistance and related metabolic phenotypes in Taiwanese adolescents and Caucasian young adults. | Liu PH et al. | β | 2009 | β |
| Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. | Iatan I et al. | β | 2009 | β |
| Genetic variation in female BMI increases with number of children born but failure to replicate association between GNbeta3 variants and increased BMI in parous females. | Cornes BK et al. | β | 2009 | β |
| Genome-wide association analysis of Framingham Heart Study data for the Genetics Analysis Workshop 16: effects due to medication use. | Rice TK et al. | β | 2009 | β |
| Genome-wide association studies and the genetic dissection of complex traits. | Sebastiani P et al. | β | 2009 | β |
| Genome-wide association study in humans. | Smith JG et al. | β | 2009 | β |
| Genotype imputation. | Li Y et al. | β | 2009 | β |
| High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. | Zhang H et al. | β | 2009 | β |
| Identification of common genetic variants that account for transcript isoform variation between human populations. | Zhang W et al. | β | 2009 | β |
| Identification of genomic regions contributing to etoposide-induced cytotoxicity. | Bleibel WK et al. | β | 2009 | β |
| Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. | Gu Y et al. | β | 2009 | β |
| KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. | Argyropoulos G et al. | β | 2009 | β |
| Left ventricular structure in relation to the human SAH gene in the European Project on Genes in Hypertension. | Jin Y et al. | β | 2009 | β |
| Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. | Ma D et al. | β | 2009 | β |
| Linear models for joint association and linkage QTL mapping. | Legarra A et al. | β | 2009 | β |
| Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. | Edmondson AC et al. | β | 2009 | β |
| Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: analysis of suicidality in major psychosis. | De Luca V et al. | β | 2009 | β |
| Molecular and behavioral analysis of the intron 2 repeat polymorphism in the canine dopamine D4 receptor gene. | Hejjas K et al. | β | 2009 | β |
| Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12. | Gusareva ES et al. | β | 2009 | β |
| Musical aptitude is associated with AVPR1A-haplotypes. | Ukkola LT et al. | β | 2009 | β |
| No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples. | Lind PA et al. | β | 2009 | β |
| On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. | Won S et al. | β | 2009 | β |
| Path: a tool to facilitate pathway-based genetic association analysis. | Zamar D et al. | β | 2009 | β |
| PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women. | Chen C et al. | β | 2009 | β |
| Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. | Shih PA et al. | β | 2009 | β |
| Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. | Beetz N et al. | β | 2009 | β |
| Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. | Hartford CM et al. | β | 2009 | β |
| Population-specific GSTM1 copy number variation. | Huang RS et al. | β | 2009 | β |
| Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction. | Cornes BK et al. | β | 2009 | β |
| Robust QTL fine mapping by applying a quantitative transmission disequilibrium test to the Mendelian sampling term. | Simianer H et al. | β | 2009 | β |
| Robust quantitative trait association tests in the parent-offspring triad design: conditional likelihood-based approaches. | Wang JY et al. | β | 2009 | β |
| Sex chromosomes and genetic association studies. | Clayton DG | β | 2009 | β |
| Single-nucleotide polymorphism bioinformatics: a comprehensive review of resources. | Johnson AD | β | 2009 | β |
| Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis. | Nyquist PA et al. | β | 2009 | β |
| Software engineering the mixed model for genome-wide association studies on large samples. | Zhang Z et al. | β | 2009 | β |
| Summary of contributions to GAW Group 15: family-based samples are useful in identifying common polymorphisms associated with complex traits. | Knight S et al. | β | 2009 | β |
| Supporting evidence for LRRTM1 imprinting effects in schizophrenia. | Ludwig KU et al. | β | 2009 | β |
| Tests of association for quantitative traits in nuclear families using principal components to correct for population stratification. | Zhang L et al. | β | 2009 | β |
| The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits. | Webster RJ et al. | β | 2009 | β |
| The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. | Karsak M et al. | β | 2009 | β |
| The ordered transmission disequilibrium test: detection of modifier genes. | Perdry H et al. | β | 2009 | β |
| Univariate/multivariate genome-wide association scans using data from families and unrelated samples. | Zhang L et al. | β | 2009 | β |
| Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. | Benyamin B et al. | β | 2009 | β |
| A functional genetic link between distinct developmental language disorders. | Vernes SC et al. | β | 2008 | β |
| A general test for gene-environment interaction in sib pair-based association analysis of quantitative traits. | van der Sluis S et al. | β | 2008 | β |
| Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. | Palomino-Doza J et al. | β | 2008 | β |
| Analysis of quantitative trait loci. | Falchi M | β | 2008 | β |
| Ancestry-related differences in gene expression: findings may enhance understanding of health disparities between populations. | Zhang W et al. | β | 2008 | β |
| An entropy-based measure for QTL mapping using extreme samples of population. | Li YM et al. | β | 2008 | β |
| An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method. | Roy-Gagnon MH et al. | β | 2008 | β |
| A powerful and flexible multilocus association test for quantitative traits. | Kwee LC et al. | β | 2008 | β |
| Application of association mapping to understanding the genetic diversity of plant germplasm resources. | Abdurakhmonov IY et al. | β | 2008 | β |
| A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. | Mangino M et al. | β | 2008 | β |
| A review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker. | Ewens WJ et al. | β | 2008 | β |
| Association analysis of KrΓΌppel-like factor 11 variants with type 2 diabetes in Pima Indians. | Ma L et al. | β | 2008 | β |
| Association between myostatin gene polymorphisms and peak BMD variation in Chinese nuclear families. | Zhang ZL et al. | β | 2008 | β |
| Association genetics in Pinus taeda L. II. Carbon isotope discrimination. | GonzΓ‘lez-MartΓnez SC et al. | β | 2008 | β |
| Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample. | Soronen P et al. | β | 2008 | β |
| Association of insulin sensitivity and glucose tolerance with the c.825C>T variant of the G protein beta-3 subunit gene. | Kopf D et al. | β | 2008 | β |
| Association of the dopamine transporter gene and ADHD symptoms in a Canadian population-based sample of same-age twins. | Ouellet-Morin I et al. | β | 2008 | β |
| Bipolar disorder and neurophysiologic mechanisms. | McCrea SM | β | 2008 | β |
| Blood pressure and metabolic phenotypes in relation to the ADRB1 Arg389Gly and ADRA2B I/D polymorphisms in a White population. | Tikhonoff V et al. | β | 2008 | β |
| Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. | Staessen JA et al. | β | 2008 | β |
| Calculation of IBD probabilities with dense SNP or sequence data. | Keith JM et al. | β | 2008 | β |
| Catechol O-methyl transferase and dopamine D2 receptor gene polymorphisms: evidence of positive heterosis and gene-gene interaction on working memory functioning. | Gosso MF et al. | β | 2008 | β |
| Cell-based Models for Discovery of Pharmacogenomic Markers of Anticancer Agent Toxicity. | Zhang W et al. | β | 2008 | β |
| Characteristics of a spina bifida population including North American Caucasian and Hispanic individuals. | Au KS et al. | β | 2008 | β |
| Characterization of LD structures and the utility of HapMap in genetic association studies. | Gu CC et al. | β | 2008 | β |
| Combined linkage and association mapping of quantitative trait Loci with missing completely at random genotype data. | Fan R et al. | β | 2008 | β |
| Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study. | Rahman T et al. | β | 2008 | β |
| Common variants underlying cognitive ability: further evidence for association between the SNAP-25 gene and cognition using a family-based study in two independent Dutch cohorts. | Gosso MF et al. | β | 2008 | β |
| Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians. | Yang TL et al. | β | 2008 | β |
| Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: assessment of the extent to which an association can account for the linkage. | Hanson RL et al. | β | 2008 | β |
| Design considerations in a sib-pair study of linkage for susceptibility loci in cancer. | Kerber RA et al. | β | 2008 | β |
| Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population. | Kuznetsova T et al. | β | 2008 | β |
| EMK: a novel program for family-based allelic and genotypic association tests on quantitative traits. | Li YW et al. | β | 2008 | β |
| Evaluation of genetic variation contributing to differences in gene expression between populations. | Zhang W et al. | β | 2008 | β |
| Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia. | Barbier M et al. | β | 2008 | β |
| Family-based association study of polymorphisms in the RUNX2 locus with hand bone length and hand BMD. | Ermakov S et al. | β | 2008 | β |
| Family-based methods for linkage and association analysis. | Laird NM et al. | β | 2008 | β |
| Genetic architecture of transcript-level variation in humans. | Duan S et al. | β | 2008 | β |
| Genetic variants associated with carboplatin-induced cytotoxicity in cell lines derived from Africans. | Huang RS et al. | β | 2008 | β |
| Genetic variants contributing to daunorubicin-induced cytotoxicity. | Huang RS et al. | β | 2008 | β |
| Genome-wide association studies of quantitative traits with related individuals: little (power) lost but much to be gained. | Visscher PM et al. | β | 2008 | β |
| Genome-wide linkage analysis for circulating levels of adipokines and C-reactive protein in the Quebec family study (QFS). | Ruchat SM et al. | β | 2008 | β |
| Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study. | De Mars G et al. | β | 2008 | β |
| Genome-wide linkage scan for maximum and length-dependent knee muscle strength in young men: significant evidence for linkage at chromosome 14q24.3. | De Mars G et al. | β | 2008 | β |
| Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. | GayΓ‘n J et al. | β | 2008 | β |
| Goldsurfer2 (Gs2): a comprehensive tool for the analysis and visualization of genome wide association studies. | Pettersson F et al. | β | 2008 | β |
| Haplotype-association analysis. | Liu N et al. | β | 2008 | β |
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| CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study. | Spielmann N et al. | β | 2007 | β |
| Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population. | Hall AJ et al. | β | 2007 | β |
| Contribution of the putative genetic factors and ANKH gene polymorphisms to variation of circulating calciotropic molecules, PTH and BGP. | Vistoropsky Y et al. | β | 2007 | β |
| Corticotropin releasing hormone is a promising candidate gene for marbling and subcutaneous fat depth in beef cattle. | Wibowo TA et al. | β | 2007 | β |
| Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model. | Du ZQ et al. | β | 2007 | β |
| DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease. | Biank V et al. | β | 2007 | β |
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| Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study. | Gosso FM et al. | β | 2007 | β |
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| Family-based association study of ROR2 polymorphisms with an array of radiographic hand bone strength phenotypes. | Ermakov S et al. | β | 2007 | β |
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| Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. | Levy D et al. | β | 2007 | β |
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| Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. | Pare G et al. | β | 2007 | β |
| Genetic component of identification, intensity and pleasantness of odours: a Finnish family study. | Knaapila A et al. | β | 2007 | β |
| Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. | Seshadri S et al. | β | 2007 | β |
| Genetics in psychosomatic medicine: research designs and statistical approaches. | McCaffery JM et al. | β | 2007 | β |
| Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. | Scuteri A et al. | β | 2007 | β |
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| GenSalt: rationale, design, methods and baseline characteristics of study participants. | GenSalt Collaborative Research Group | β | 2007 | β |
| Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach. | Huang RS et al. | β | 2007 | β |
| Identification of promoter variants in baboon endothelial lipase that regulate high-density lipoprotein cholesterol levels. | Cox LA et al. | β | 2007 | β |
| Immunogenetic control of antibody responsiveness in a malaria endemic area. | Carpenter D et al. | β | 2007 | β |
| Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. | Thein SL et al. | β | 2007 | β |
| Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. | Gregory SG et al. | β | 2007 | β |
| Investigation of the PARK10 gene in Parkinson disease. | Li YJ et al. | β | 2007 | β |
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| No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. | Bell CG et al. | β | 2007 | β |
| Non-B27 MHC associations of ankylosing spondylitis. | Sims AM et al. | β | 2007 | β |
| One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies. | Rohlfs RV et al. | β | 2007 | β |
| Osteoprotegerin plasma levels are strongly associated with polymorphisms in human homologue of the mouse progressive ankylosis (ANKH) gene. | Vistoropsky Y et al. | β | 2007 | β |
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| PLINK: a tool set for whole-genome association and population-based linkage analyses. | Purcell S et al. | β | 2007 | β |
| Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females. | Zhao J et al. | β | 2007 | β |
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| Prospects for association mapping in classical inbred mouse strains. | Payseur BA et al. | β | 2007 | β |
| PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton. | VilariΓ±o-GΓΌell C et al. | β | 2007 | β |
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| Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. | Luchtefeld M et al. | β | 2007 | β |
| Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy. | Fanous AH et al. | β | 2007 | β |
| TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals. | Guo T et al. | β | 2007 | β |
| The bipolar disorder phenome database: a resource for genetic studies. | Potash JB et al. | β | 2007 | β |
| The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension. | Baker M et al. | β | 2007 | β |
| The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. | Yang F et al. | β | 2007 | β |
| The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence. | Mekel-Bobrov N et al. | β | 2007 | β |
| Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight. | Fradin D et al. | β | 2007 | β |
| Using linkage and association to identify and model genetic effects: summary of GAW15 Group 4. | Yang Q et al. | β | 2007 | β |
| Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. | Ma L et al. | β | 2007 | β |
| Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians. | Muller YL et al. | β | 2007 | β |
| Visualizing genotype x phenotype relationships in the GAW15 simulated data. | Qin X et al. | β | 2007 | β |
| WHAP: haplotype-based association analysis. | Purcell S et al. | β | 2007 | β |
| 24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes. | Fava C et al. | β | 2006 | β |
| ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. | Noguchi E et al. | β | 2006 | β |
| Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations. | Tsai HJ et al. | β | 2006 | β |
| Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. | Schmidt S et al. | β | 2006 | β |
| A method for using incomplete triads to test maternally mediated genetic effects and parent-of-origin effects in relation to a quantitative trait. | Kistner EO et al. | β | 2006 | β |
| An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health. | Timberlake DS et al. | β | 2006 | β |
| A new test for family-based association mapping with inbred lines from plant breeding programs. | Stich B et al. | β | 2006 | β |
| An integrated system for genetic analysis. | Fiddy S et al. | β | 2006 | β |
| A quantitative linkage score for an association study following a linkage analysis. | Wang T et al. | β | 2006 | β |
| A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: linkage and association studies. | Aissani B et al. | β | 2006 | β |
| A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention. | Liu YL et al. | β | 2006 | β |
| A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. | Harold D et al. | β | 2006 | β |
| Assessment of linkage and association of 13 genetic loci with bone mineral density. | Lau HH et al. | β | 2006 | β |
| Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families. | Yang TL et al. | β | 2006 | β |
| Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene. | Imrie H et al. | β | 2006 | β |
| Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. | Gosso MF et al. | β | 2006 | β |
| Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. | Hutter CM et al. | β | 2006 | β |
| A tutorial on statistical methods for population association studies. | Balding DJ | β | 2006 | β |
| A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. | Yu J et al. | β | 2006 | β |
| Beta 2-adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics. | Tsai HJ et al. | β | 2006 | β |
| Blood pressure and urinary sodium excretion in relation to the A-1984G adrenomedullin polymorphism in a Chinese population. | Li Y et al. | β | 2006 | β |
| CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations. | Huang QY et al. | β | 2006 | β |
| Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression. | Beem AL et al. | β | 2006 | β |
| Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French-Canadian population. | Bailey SD et al. | β | 2006 | β |
| Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes. | PihlajamΓ€ki J et al. | β | 2006 | β |
| Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease. | Babusukumar U et al. | β | 2006 | β |
| Cross species association examination of UCN3 and CRHR2 as potential pharmacological targets for antiobesity drugs. | Jiang Z et al. | β | 2006 | β |
| Current perspectives on the genetic analysis of autism. | Coon H | β | 2006 | β |
| Endophenotypes in the genetic analyses of mental disorders. | Cannon TD et al. | β | 2006 | β |
| Evaluation of RGS4 as a candidate gene for schizophrenia. | Liu YL et al. | β | 2006 | β |
| Family-based association test of the 5HTTLPR and aggressive behavior in a general population sample of children. | Haberstick BC et al. | β | 2006 | β |
| Family-based designs in the age of large-scale gene-association studies. | Laird NM et al. | β | 2006 | β |
| Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis. | Jaakkola E et al. | β | 2006 | β |
| Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. | Harold D et al. | β | 2006 | β |
| Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring. | Allen AS et al. | β | 2006 | β |
| Genetic influence on thrombotic risk markers in the elderly--a Danish twin study. | Bladbjerg EM et al. | β | 2006 | β |
| HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. | Zhang F et al. | β | 2006 | β |
| Heritability of cardiovascular and personality traits in 6,148 Sardinians. | Pilia G et al. | β | 2006 | β |
| Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers. | Opherk C et al. | β | 2006 | β |
| High-resolution association mapping of quantitative trait loci: a population-based approach. | Fan R et al. | β | 2006 | β |
| Human ALOX12, but not ALOX15, is associated with BMD in white men and women. | Ichikawa S et al. | β | 2006 | β |
| Implementation of a combined association-linkage model for quantitative traits in linear mixed model procedures of statistical packages. | Beem AL et al. | β | 2006 | β |
| Improvement of mapping accuracy by unifying linkage and association analysis. | Lou XY et al. | β | 2006 | β |
| Improving the power of association tests for quantitative traits in family studies. | Diao G et al. | β | 2006 | β |
| INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families. | Hall DH et al. | β | 2006 | β |
| In silico method for inferring genotypes in pedigrees. | Burdick JT et al. | β | 2006 | β |
| Joint linkage and association of six single-nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus. | de Lange M et al. | β | 2006 | β |
| Lack of association between UBQLN1 and Alzheimer disease. | Slifer MA et al. | β | 2006 | β |
| Linkage and association between CA repeat polymorphism of the TNFR2 gene and obesity phenotypes in two independent Caucasian populations. | Huang QY et al. | β | 2006 | β |
| Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. | Andrew T et al. | β | 2006 | β |
| Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophrenia. | Cannon TD et al. | β | 2006 | β |
| Optimal haplotype structure for linkage disequilibrium-based fine mapping of quantitative trait loci using identity by descent. | Grapes L et al. | β | 2006 | β |
| PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. | Allen-Brady K et al. | β | 2006 | β |
| Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or women. | Ichikawa S et al. | β | 2006 | β |
| Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females. | Guo Y et al. | β | 2006 | β |
| Possible involvement of alpha-2A adrenergic receptors in attention deficit hyperactivity disorder: radioligand binding and polymorphism studies. | Deupree JD et al. | β | 2006 | β |
| Quantitative trait linkage analysis using Gaussian copulas. | Li M et al. | β | 2006 | β |
| Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study. | Lakka TA et al. | β | 2006 | β |
| Resting metabolic rate and respiratory quotient: results from a genome-wide scan in the Quebec Family Study. | Jacobson P et al. | β | 2006 | β |
| Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases. | Li YJ et al. | β | 2006 | β |
| Semiparametric variance-component models for linkage and association analyses of censored trait data. | Diao G et al. | β | 2006 | β |
| Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. | Groves CJ et al. | β | 2006 | β |
| Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures. | Hunt SC et al. | β | 2006 | β |
| Statistical methods for the analysis of genetic association studies. | Zou GY | β | 2006 | β |
| Strong association between polymorphisms in ANKH locus and skeletal size traits. | Malkin I et al. | β | 2006 | β |
| Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. | Schumacher J et al. | β | 2006 | β |
| The human calcium-sensing receptor and interleukin-6 genes are associated with bone mineral density in Chinese. | Wang YB et al. | β | 2006 | β |
| The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. | Sharma M et al. | β | 2006 | β |
| The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts. | Gosso MF et al. | β | 2006 | β |
| The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study. | Rosa A et al. | β | 2006 | β |
| Transmission disequilibrium test for quantitative trait loci detection in livestock populations. | Kolbehdari D et al. | β | 2006 | β |
| Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians. | Wolford JK et al. | β | 2006 | β |
| Variation in femoral length is associated with polymorphisms in RUNX2 gene. | Ermakov S et al. | β | 2006 | β |
| Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. | Zeggini E et al. | β | 2006 | β |
| A genome-wide scan for carotid artery intima-media thickness: the Mexican-American Coronary Artery Disease family study. | Wang D et al. | β | 2005 | β |
| A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. | Hennah W et al. | β | 2005 | β |
| Alcohol intake modulates the genetic association between HDL cholesterol and the PPARgamma2 Pro12Ala polymorphism. | Brand-Herrmann SM et al. | β | 2005 | β |
| Ambulatory blood pressure, left ventricular mass and vascular phenotypes in relation to the endothelial nitric oxide synthase gene Glu298Asp and intron 4 polymorphisms in a population-based family study. | Czarnecka D et al. | β | 2005 | β |
| A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents. | Kistner EO et al. | β | 2005 | β |
| A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: a study of 1428 individuals in 248 families. | Gaukrodger N et al. | β | 2005 | β |
| Assessing the power of tag SNPs in the mapping of quantitative trait loci (QTL) with extremal and random samples. | Zhang K et al. | β | 2005 | β |
| Association analysis of estrogen receptor alpha gene polymorphisms with cross-sectional geometry of the femoral neck in Caucasian nuclear families. | Xiong DH et al. | β | 2005 | β |
| Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings. | Nash MW et al. | β | 2005 | β |
| Association and haplotype analyses of the COL1A2 and ER-alpha gene polymorphisms with bone size and height in Chinese. | Lei SF et al. | β | 2005 | β |
| Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese. | Lei SF et al. | β | 2005 | β |
| Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD. | Park L et al. | β | 2005 | β |
| Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. | Baker M et al. | β | 2005 | β |
| Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease. | Noureddine MA et al. | β | 2005 | β |
| Association mapping: methodologies, strategies, and issues. | Havill LM et al. | β | 2005 | β |
| Association of ANKH gene polymorphisms with radiographic hand bone size and geometry in a Chuvasha population. | Malkin I et al. | β | 2005 | β |
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| Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population. | Suk EK et al. | β | 2005 | β |
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| Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians. | Red Eagle AR et al. | β | 2005 | β |
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| PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. | James ES et al. | β | 2005 | β |
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| PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. | Wigginton JE et al. | β | 2005 | β |
| Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women. | Ichikawa S et al. | β | 2005 | β |
| Quantitative trait loci for human muscle strength: linkage analysis of myostatin pathway genes. | Huygens W et al. | β | 2005 | β |
| Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. | Mill J et al. | β | 2005 | β |
| Serotonin transporter intron 2 polymorphism associated with rigid-compulsive behaviors in Dutch individuals with pervasive developmental disorder. | Mulder EJ et al. | β | 2005 | β |
| SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. | Butcher LM et al. | β | 2005 | β |
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| Support for involvement of neuregulin 1 in schizophrenia pathophysiology. | Petryshen TL et al. | β | 2005 | β |
| Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone mass. | Long JR et al. | β | 2005 | β |
| The -1997 G/T polymorphism in the COLIA1 upstream regulatory region is associated with hip bone mineral density (BMD) in Chinese nuclear families. | Zhang YY et al. | β | 2005 | β |
| The (CA)n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families. | Xu H et al. | β | 2005 | β |
| The effect of missing data on linkage disequilibrium mapping and haplotype association analysis in the GAW14 simulated datasets. | McCaskie PA et al. | β | 2005 | β |
| The (GT)n polymorphism and haplotype of the COL1A2 gene, but not the (AAAG)n polymorphism of the PTHR1 gene, are associated with bone mineral density in Chinese. | Lei SF et al. | β | 2005 | β |
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| The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification. | Havill LM et al. | β | 2005 | β |
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| The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. | Willis-Owen SA et al. | β | 2005 | β |
| The ubiquilin 1 gene and Alzheimer's disease. | Slifer MA et al. | β | 2005 | β |
| The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. | Willis-Owen SA et al. | β | 2005 | β |
| The VDR, COL1A1, PTH, and PTHR1 gene polymorphisms are not associated with bone size and height in Chinese nuclear families. | Lei SF et al. | β | 2005 | β |
| TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso. | Flori L et al. | β | 2005 | β |
| Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. | Zhang Z et al. | β | 2005 | β |
| Two-level Haseman-Elston regression for general pedigree data analysis. | Wang T et al. | β | 2005 | β |
| Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. | Batra J et al. | β | 2005 | β |
| Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. | Ohmura K et al. | β | 2005 | β |
| Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. | Goodarzi MO et al. | β | 2005 | β |
| Vitamin D receptor gene polymorphisms are linked to and associated with adult height. | Xiong DH et al. | β | 2005 | β |
| A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. | Francks C et al. | β | 2004 | β |
| An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. | Noguchi E et al. | β | 2004 | β |
| APOE haplotypes influence bone mineral density in Caucasian males but not females. | Long JR et al. | β | 2004 | β |
| Apolipoprotein E controls the risk and age at onset of Parkinson disease. | Li YJ et al. | β | 2004 | β |
| Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis. | Li YJ et al. | β | 2004 | β |
| Association between COL1A1 gene polymorphisms and bone size in Caucasians. | Long JR et al. | β | 2004 | β |
| Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion. | Wojciechowska W et al. | β | 2004 | β |
| A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins. | Hammond CJ et al. | β | 2004 | β |
| A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents. | Gordon D et al. | β | 2004 | β |
| Attention-Deficit Hyperactivity Disorder in the post-genomic era. | Asherson P et al. | β | 2004 | β |
| BF, HP, DQB and DRB are associated with haemolytic complement activity, acute phase protein reaction and antibody response in the pig. | Wimmers K et al. | β | 2004 | β |
| Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. | Hebebrand J et al. | β | 2004 | β |
| Blood pressure in relation to three candidate genes in a Chinese population. | Wang JG et al. | β | 2004 | β |
| Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. | Cordell HJ et al. | β | 2004 | β |
| Case-sibling gene-association studies for diseases with variable age at onset. | Kraft P et al. | β | 2004 | β |
| Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD. | Taerk E et al. | β | 2004 | β |
| Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study. | Fanous AH et al. | β | 2004 | β |
| Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families. | Bouzigon E et al. | β | 2004 | β |
| Combined association and linkage analysis applied to the APOE locus. | Beekman M et al. | β | 2004 | β |
| Comparing linkage disequilibrium-based methods for fine mapping quantitative trait loci. | Grapes L et al. | β | 2004 | β |
| Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels. | BossΓ© Y et al. | β | 2004 | β |
| Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. | Nicodemus KK et al. | β | 2004 | β |
| Determinants and upper-limit heritabilities of skeletal muscle mass and strength. | Huygens W et al. | β | 2004 | β |
| DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer. | Rybicki BA et al. | β | 2004 | β |
| Effects of dopamine receptor D4 variation on alcohol and tobacco use and on novelty seeking: multivariate linkage and association analysis. | Luciano M et al. | β | 2004 | β |
| Exploring positional candidate genes: linkage conditional on measured genotype. | Almasy L et al. | β | 2004 | β |
| Family-based associations between the angiotensin- converting enzyme insertion/deletion polymorphism and multiple cardiovascular risk factors in Chinese. | Wang JG et al. | β | 2004 | β |
| Family-based association studies between 5-HT5A receptor gene and schizophrenia. | Dubertret C et al. | β | 2004 | β |
| Genetic analysis of genome-wide variation in human gene expression. | Morley M et al. | β | 2004 | β |
| Genetic epidemiological approaches in the study of risk factors for cardiovascular disease. | Iliadou A et al. | β | 2004 | β |
| GENETIC FACTORS IN EXTERNAL APICAL ROOT RESORPTION AND ORTHODONTIC TREATMENT. | Hartsfield JK et al. | β | 2004 | β |
| Genetic influence on inflammation variables in the elderly. | de Maat MP et al. | β | 2004 | β |
| Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion. | Stolarz K et al. | β | 2004 | β |
| Genome-wide linkage analysis of chromogranin B expression in the CEPH pedigrees: implications for exocytotic sympathochromaffin secretion in humans. | Greenwood TA et al. | β | 2004 | β |
| Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study. | BossΓ© Y et al. | β | 2004 | β |
| Influence of LRP5 polymorphisms on normal variation in BMD. | Koay MA et al. | β | 2004 | β |
| Left ventricular mass in relation to genetic variation in angiotensin II receptors, renin system genes, and sodium excretion. | Kuznetsova T et al. | β | 2004 | β |
| Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. | Lakka TA et al. | β | 2004 | β |
| Linkage/association study of a locus modulating total serum IgE on chromosome 14q13-24 in families with asthma. | Mansur AH et al. | β | 2004 | β |
| Linkage of myostatin pathway genes with knee strength in humans. | Huygens W et al. | β | 2004 | β |
| Lipoprotein lipase gene is in linkage with blood pressure phenotypes in Chinese pedigrees. | Yang W et al. | β | 2004 | β |
| Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. | Goodarzi MO et al. | β | 2004 | β |
| Method for using complete and incomplete trios to identify genes related to a quantitative trait. | Kistner EO et al. | β | 2004 | β |
| Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity. | Bouchard L et al. | β | 2004 | β |
| PBAT: tools for family-based association studies. | Lange C et al. | β | 2004 | β |
| Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. | Addington AM et al. | β | 2004 | β |
| Positional cloning by linkage disequilibrium. | Maniatis N et al. | β | 2004 | β |
| Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen. | Timmann C et al. | β | 2004 | β |
| Quantifying the relationship between gene expressions and trait values in general pedigrees. | Lu Y et al. | β | 2004 | β |
| Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses. | Deffenbacher KE et al. | β | 2004 | β |
| Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake. | Kuznetsova T et al. | β | 2004 | β |
| Renal function in relation to three candidate genes in a Chinese population. | Wang JG et al. | β | 2004 | β |
| Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. | Sen S et al. | β | 2004 | β |
| Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. | Vollmert C et al. | β | 2004 | β |
| Suggestive evidence of association of C-159T functional polymorphism of the CD14 gene with atopic asthma in northern and northwestern Indian populations. | Sharma M et al. | β | 2004 | β |
| Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families. | Zhao LJ et al. | β | 2004 | β |
| Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families. | Liu YJ et al. | β | 2004 | β |
| Variants of the serotonin transporter gene (SLC6A4) significantly contribute to hyperserotonemia in autism. | Coutinho AM et al. | β | 2004 | β |
| Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. | Wexler NS et al. | β | 2004 | β |
| A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. | Sen S et al. | β | 2003 | β |
| A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. | Stallings MC et al. | β | 2003 | β |
| Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. | Kammerer S et al. | β | 2003 | β |
| APOE and TGF-beta1 genes are associated with obesity phenotypes. | Long JR et al. | β | 2003 | β |
| A tobit variance-component method for linkage analysis of censored trait data. | Epstein MP et al. | β | 2003 | β |
| Atopy, respiratory function and HLA-DR in Aboriginal Australians. | Moffatt MF et al. | β | 2003 | β |
| Blood pressure phenotypes in relation to the beta-adducin C1797T polymorphism in the European Project on Genes in Hypertension (EPOGH). | Tikhonoff V et al. | β | 2003 | β |
| Candidate gene association analysis for a quantitative trait, using parent-offspring trios. | Gauderman WJ | β | 2003 | β |
| Combined high resolution linkage and association mapping of quantitative trait loci. | Fan R et al. | β | 2003 | β |
| Estimation and testing of parent-of-origin effects for quantitative traits. | Whittaker JC et al. | β | 2003 | β |
| Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. | Qin YJ et al. | β | 2003 | β |
| Evidence for a major quantitative trait locus on chromosome 17q21 affecting low-density lipoprotein peak particle diameter. | BossΓ© Y et al. | β | 2003 | β |
| Evolutionary-based association analysis using haplotype data. | Seltman H et al. | β | 2003 | β |
| Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. | Gasperoni TL et al. | β | 2003 | β |
| Genetic predisposition to external apical root resorption. | Al-Qawasmi RA et al. | β | 2003 | β |
| Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker. | Al-Qawasmi RA et al. | β | 2003 | β |
| Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection. | Thye T et al. | β | 2003 | β |
| High-resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship data. | Fan R et al. | β | 2003 | β |
| Human genetics of common mycobacterial infections. | Remus N et al. | β | 2003 | β |
| Insertion/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population. | Noguchi E et al. | β | 2003 | β |
| Interleukin 10 polymorphisms in ankylosing spondylitis. | Goedecke V et al. | β | 2003 | β |
| LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta. | Traherne JA et al. | β | 2003 | β |
| Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31-q33. | Flori L et al. | β | 2003 | β |
| Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations. | Huang QY et al. | β | 2003 | β |
| Linkage and linkage disequilibrium mapping of genes influencing human obesity in chromosome region 7q22.1-7q35. | Li WD et al. | β | 2003 | β |
| Measured haplotype analysis of the aldosterone synthase gene and heart size. | Mayosi BM et al. | β | 2003 | β |
| Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity. | Stefan N et al. | β | 2003 | β |
| No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. | Nabi R et al. | β | 2003 | β |
| No association between the EN2 gene and autistic disorder. | Zhong H et al. | β | 2003 | β |
| Novel association suggests multiple independent QTLs within chromosome 5q21-33 region control variation in total humans IgE levels. | Ahmadi KR et al. | β | 2003 | β |
| On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals. | Zhang S et al. | β | 2003 | β |
| Parathyroid hormone gene with bone phenotypes in Chinese. | Zhou XG et al. | β | 2003 | β |
| Pedigree disequilibrium tests for multilocus haplotypes. | Dudbridge F | β | 2003 | β |
| Positional cloning of a novel gene influencing asthma from chromosome 2q14. | Allen M et al. | β | 2003 | β |
| Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. | Zhang Y et al. | β | 2003 | β |
| Psychopathology in the postgenomic era. | Plomin R et al. | β | 2003 | β |
| Removing phenotypic distribution assumptions from tests of linkage disequilibrium for quantitative traits. | AlcaΓ―s A et al. | β | 2003 | β |
| Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition. | Comings DE et al. | β | 2003 | β |
| Tests of linkage and association of the COL1A2 gene with bone phenotypes' variation in Chinese nuclear families. | Deng FY et al. | β | 2003 | β |
| The metabotropic glutamate receptor 8 gene at 7q31: partial duplication and possible association with autism. | Serajee FJ et al. | β | 2003 | β |
| The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease. | Oliveira SA et al. | β | 2003 | β |
| Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study. | Rankinen T et al. | β | 2003 | β |
| Using the noninformative families in family-based association tests: a powerful new testing strategy. | Lange C et al. | β | 2003 | β |
| 5' flanking variants of resistin are associated with obesity. | Engert JC et al. | β | 2002 | β |
| A Bayesian approach to the transmission/disequilibrium test for binary traits. | George V et al. | β | 2002 | β |
| A genome-wide scan for obesity in African-Americans. | Zhu X et al. | β | 2002 | β |
| Association studies of QTL for multi-allele markers by mixed models. | Fan R et al. | β | 2002 | β |
| Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. | Han Z et al. | β | 2002 | β |
| Currently identified genes affecting insulin resistance are not associated with birth weight in the Pima population. | Lindsay RS et al. | β | 2002 | β |
| Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. | Giess R et al. | β | 2002 | β |
| Evidence for linkage and association with reading disability on 6p21.3-22. | Kaplan DE et al. | β | 2002 | β |
| Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. | Francks C et al. | β | 2002 | β |
| FOXP2 is not a major susceptibility gene for autism or specific language impairment. | Newbury DF et al. | β | 2002 | β |
| Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. | Schulze TG et al. | β | 2002 | β |
| Genetic variation in the 22q11 locus and susceptibility to schizophrenia. | Liu H et al. | β | 2002 | β |
| Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. | Cassell PG et al. | β | 2002 | β |
| High resolution mapping of quantitative trait loci by linkage disequilibrium analysis. | Fan R et al. | β | 2002 | β |
| Including measured genotypes in statistical models to study the interplay of multiple factors affecting complex traits. | van den Oord EJ et al. | β | 2002 | β |
| Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. | CeledΓ³n JC et al. | β | 2002 | β |
| Models and tests of linkage and association studies of quantitative trait locus for multi-allele marker Loci. | Fan R et al. | β | 2002 | β |
| New insights into the role of thyroid hormone in the CNS: the microglial track. | Mallat M et al. | β | 2002 | β |
| Positive association to IgE levels and a physical map of the 13q14 atopy locus. | Anderson GG et al. | β | 2002 | β |
| Power and design considerations for a general class of family-based association tests: quantitative traits. | Lange C et al. | β | 2002 | β |
| Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites. | Abney M et al. | β | 2002 | β |
| Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations. | Hall MA et al. | β | 2002 | β |
| Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13. | Carn G et al. | β | 2002 | β |
| Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. | Deng HW et al. | β | 2002 | β |
| Unified sampling approach for multipoint linkage disequilibrium mapping of qualitative and quantitative traits. | Hsu FC et al. | β | 2002 | β |
| Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels. | Orho-Melander M et al. | β | 2002 | β |
| Association analysis in a variance components framework. | Abecasis GR et al. | β | 2001 | β |
| Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels. | Noguchi E et al. | β | 2001 | β |
| Association mapping: where we've been, where we're going. | Nielsen DM et al. | β | 2001 | β |
| Association study designs for complex diseases. | Cardon LR et al. | β | 2001 | β |
| Combined linkage and association analysis in pedigrees. | Siegmund KD et al. | β | 2001 | β |
| Comparison of the QTDT analysis for IgE in the CSGA data set. | Page GP et al. | β | 2001 | β |
| Effect of polygenes on Xiong's transmission disequilibrium test of a QTL in nuclear families with multiple children. | Deng HW et al. | β | 2001 | β |
| Estimating effects of latent and measured genotypes in multilevel models. | van den Oord EJ | β | 2001 | β |
| Genetics of human obesity. | Boutin P et al. | β | 2001 | β |
| Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits. | Walley AJ et al. | β | 2001 | β |
| Molecular genetics of essential hypertension: recent results and emerging strategies. | Timberlake DS et al. | β | 2001 | β |
| Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees. | Sobel E et al. | β | 2001 | β |
| Pedigree selection and tests of linkage in a Hutterite asthma pedigree. | Greenwood CM et al. | β | 2001 | β |
| Quantitative similarity-based association tests using population samples. | Zhang S et al. | β | 2001 | β |
| Reading disability and chromosome 6p21.3: evaluation of MOG as a candidate gene. | Smith SD et al. | β | 2001 | β |
| Serotonin transporter promoter polymorphism genotype is associated with behavioral disinhibition and negative affect in children of alcoholics. | Twitchell GR et al. | β | 2001 | β |
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