The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods.
paper
Cited
Public
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- Authors
- Boerwinkle, E; Chakraborty, R; Sing, C F
- Year
- 1986
- Journal
- Annals of human genetics
- PMID
- 3435047
- DOI
- 10.1111/j.1469-1809.1986.tb01037.x
Improved laboratory methods allow one to investigate the contribution of measured allelic variability at a locus physiologically involved in determining the expression of a quantitative trait. We present statistical methods that incorporate measured genotype information into the analysis of a quantitative phenotype that allows one simultaneously to detect and estimate the effects of a measured single locus and residual polygenic effects. Likelihoods are presented for the joint distribution of the quantitative phenotype and a measured genotype that are appropriate when the data are collected as a sample of unrelated individuals or as a sample of nuclear families. Application of this method to the analysis of serum cholesterol levels and the concentration of the group specific component (Gc) are presented. The analysis of the contribution of the common Gc polymorphism to the determination of quantitative variability in Gc using samples of related and unrelated individuals presents, for the first time, the simultaneous estimation of the frequencies and the effects of the genotypes at a measured locus, and the contribution of residual unmeasured polygenes to phenotypic variability.
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| The effect of variation in the apolipoprotein B gene on plasmid lipid and apolipoprotein B levels. I. A likelihood-based approach to cladistic analysis. | Hallman DM et al. | β | 1994 | β |
| A DNA polymorphism for lecithin:cholesterol acyltransferase (LCAT) is associated with high density lipoprotein cholesterol concentrations in baboons. | Kammerer CM et al. | β | 1993 | β |
| Genetic contributions to quantitative lipoprotein traits associated with coronary artery disease: analysis of a large pedigree from the Bogalusa Heart Study. | Heiba IM et al. | β | 1993 | β |
| Genetics of atherosclerosis: Some strategies for studies of apolipoprotein E. | Moll PP | β | 1993 | β |
| Assessing the effects of candidate genes on quantitative traits in primate populations. | Blangero J et al. | β | 1992 | β |
| Detection of genetic heterogeneity for complex quantitative phenotypes. | Schork NJ | β | 1992 | β |
| Estimation of the frequency of isoform-genotype discrepancies at the apolipoprotein E locus in heterozygotes for the isoforms. | Mailly F et al. | β | 1992 | β |
| Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. | Tiret L et al. | β | 1992 | β |
| Family study of alpha 1-antitrypsin deficiency: effects of cigarette smoking, measured genotype, and their interaction on pulmonary function and biochemical traits. | Silverman EK et al. | β | 1992 | β |
| Fitting mixture distributions to phenylthiocarbamide (PTC) sensitivity. | Jones PN et al. | β | 1991 | β |
| Multivariate segregation analysis using the mixed model. | Blangero J et al. | β | 1991 | β |
| Quantitative trait loci and psychopharmacology. | Plomin R et al. | β | 1991 | β |
| Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application to traits related to hypertension. | Wilson AF et al. | β | 1991 | β |
| The role of inheritance in behavior. | Plomin R | β | 1990 | β |
| An analysis of genotype effects and their interactions by using the apolipoprotein E polymorphism and longitudinal data. | Gueguen R et al. | β | 1989 | β |
| Estimation of genetic model parameters: variables correlated with a quantitative phenotype exhibiting major locus inheritance. | Hasstedt SJ et al. | β | 1989 | β |
| Genetic determination of plasma apolipoprotein AI in a population-based sample. | Moll PP et al. | β | 1989 | β |
| Genetics of the quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation. | Boerwinkle E et al. | β | 1989 | β |
| Genetic studies of human apolipoproteins. VIII. Role of the apolipoprotein H polymorphism in relation to serum lipoprotein concentrations. | Sepehrnia B et al. | β | 1989 | β |
| Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of lipoproteins in Nigerian blacks. | Sepehrnia B et al. | β | 1989 | β |
| Apolipoprotein E polymorphism and atherosclerosis. | Davignon J et al. | β | 1988 | β |
| Genetics of essential hypertension. From the unimodal-bimodal controversy to molecular technology. | Camussi A et al. | β | 1988 | β |
| Genetic variation in the apolipoproteins C-II and C-III. | Ferrell RE et al. | β | 1988 | β |
| Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. | Boerwinkle E et al. | β | 1988 | β |
| Biochemical heterozygosity and phenotypic variability of polygenic traits. | Chakraborty R | β | 1987 | β |
| Innovations in the statistical analysis of twin studies. | Hopper JL et al. | β | 1987 | β |
| Testing the association between polymorphic markers and quantitative traits in pedigrees. | George VT et al. | β | 1987 | β |
| The use of measured genotype information in the analysis of quantitative phenotypes in man. III. Simultaneous estimation of the frequencies and effects of the apolipoprotein E polymorphism and residual polygenetic effects on cholesterol, betalipoprotein and triglyceride levels. | Boerwinkle E et al. | β | 1987 | β |
| The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals. | Boerwinkle E et al. | β | 1987 | β |
| Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population. | Boerwinkle E et al. | β | 1986 | β |
| Bias of the contribution of single-locus effects to the variance of a quantitative trait. | Boerwinkle E et al. | β | 1986 | β |