Construction of multilocus genetic linkage maps in humans.
- Authors
- Lander, E S; Green, P
- Year
- 1987
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 3470801
- DOI
- 10.1073/pnas.84.8.2363
- PMCID
- PMC304651
Human genetic linkage maps are most accurately constructed by using information from many loci simultaneously. Traditional methods for such multilocus linkage analysis are computationally prohibitive in general, even with supercomputers. The problem has acquired practical importance because of the current international collaboration aimed at constructing a complete human linkage map of DNA markers through the study of three-generation pedigrees. We describe here several alternative algorithms for constructing human linkage maps given a specified gene order. One method allows maximum-likelihood multilocus linkage maps for dozens of DNA markers in such three-generation pedigrees to be constructed in minutes.
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| Development of an integrated genetic map of a sugarcane (Saccharum spp.) commercial cross, based on a maximum-likelihood approach for estimation of linkage and linkage phases. | Garcia AA et al. | β | 2006 | β |
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| A general framework for statistical linkage analysis in multivalent tetraploids. | Wu R et al. | β | 2005 | β |
| A genome-wide linkage analysis of alcoholism on microsatellite and single-nucleotide polymorphism data, using alcohol dependence phenotypes and electroencephalogram measures. | Zhang C et al. | β | 2005 | β |
| A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study. | Samani NJ et al. | β | 2005 | β |
| Allegro version 2. | Gudbjartsson DF et al. | β | 2005 | β |
| A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3. | Aslam M et al. | β | 2005 | β |
| A novel Markov chain monte carlo approach for constructing accurate meiotic maps. | George AW | β | 2005 | β |
| A paternally imprinted QTL for mature body mass on mouse chromosome 8. | Rance KA et al. | β | 2005 | β |
| A powerful and robust method for mapping quantitative trait loci in general pedigrees. | Diao G et al. | β | 2005 | β |
| Applications of whole-genome high-density SNP genotyping. | Craig DW et al. | β | 2005 | β |
| A second-generation genetic linkage map of tilapia (Oreochromis spp.). | Lee BY et al. | β | 2005 | β |
| A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans. | Lehman DM et al. | β | 2005 | β |
| Association testing in a linked region using large pedigrees. | Cantor RM et al. | β | 2005 | β |
| Association testing with Mendel. | Lange K et al. | β | 2005 | β |
| Bias of allele-sharing linkage statistics in the presence of intermarker linkage disequilibrium. | Goode EL et al. | β | 2005 | β |
| Calculation of multipoint likelihoods using flanking marker data: a simulation study. | George AW et al. | β | 2005 | β |
| Combining the meiosis Gibbs sampler with the random walk approach for linkage and association studies with a general complex pedigree and multimarker loci. | Lee SH et al. | β | 2005 | β |
| Comparative linkage analysis and visualization of high-density oligonucleotide SNP array data. | Leykin I et al. | β | 2005 | β |
| Comparison of single-nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3. | Wilcox MA et al. | β | 2005 | β |
| Construction of linkage maps in full-sib families of diploid outbreeding species by minimizing the number of recombinations in hidden inheritance vectors. | Jansen J | β | 2005 | β |
| Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14. | Edenberg HJ et al. | β | 2005 | β |
| Evidence for a novel glaucoma locus at chromosome 3p21-22. | Baird PN et al. | β | 2005 | β |
| Genetic markers data in survival studies of twins: the results of a simulation study. | Begun AZ et al. | β | 2005 | β |
| Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. | Camp NJ et al. | β | 2005 | β |
| Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study. | Hunt KJ et al. | β | 2005 | β |
| Genomewide screen for pulmonary function in 200 families ascertained for asthma. | Postma DS et al. | β | 2005 | β |
| Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers. | Abecasis GR et al. | β | 2005 | β |
| HAPLORE: a program for haplotype reconstruction in general pedigrees without recombination. | Zhang K et al. | β | 2005 | β |
| Hidden Markov Models, grammars, and biology: a tutorial. | Mukherjee S et al. | β | 2005 | β |
| High-resolution mapping and mutation analysis separate the rust resistance genes Sr31, Lr26 and Yr9 on the short arm of rye chromosome 1. | Mago R et al. | β | 2005 | β |
| Investigation of genomic organization in switchgrass (Panicum virgatum L.) using DNA markers. | Missaoui AM et al. | β | 2005 | β |
| Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese families. | Liu CM et al. | β | 2005 | β |
| Linkage map of birch, Betula pendula Roth, based on microsatellites and amplified fragment length polymorphisms. | Pekkinen M et al. | β | 2005 | β |
| Linkage mapping reveals sex-dimorphic map distances in a passerine bird. | Hansson B et al. | β | 2005 | β |
| MAP-O-MAT: internet-based linkage mapping. | Kong X et al. | β | 2005 | β |
| Mapping of a novel autosomal recessive nonsyndromic deafness locus (DFNB46) to chromosome 18p11.32-p11.31. | Mir A et al. | β | 2005 | β |
| Mapping quantitative trait loci in humans: achievements and limitations. | Majumder PP et al. | β | 2005 | β |
| Mapping quantitative trait loci using naturally occurring genetic variance among commercial inbred lines of maize (Zea mays L.). | Zhang YM et al. | β | 2005 | β |
| Maximum likelihood haplotyping for general pedigrees. | Fishelson M et al. | β | 2005 | β |
| MCMC multilocus lod scores: application of a new approach. | George AW et al. | β | 2005 | β |
| Parametric approach to genomic imprinting analysis with applications to Angelman's syndrome. | Shete S et al. | β | 2005 | β |
| Prediction of protein interdomain linker regions by a hidden Markov model. | Bae K et al. | β | 2005 | β |
| Prospects for admixture mapping of complex traits. | McKeigue PM | β | 2005 | β |
| Sex-linked recombination variation and distribution of disease-related genes. | Chelala C et al. | β | 2005 | β |
| Software for quantitative trait analysis. | Almasy L et al. | β | 2005 | β |
| Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22. | Lambert D et al. | β | 2005 | β |
| Statistical tools for linkage analysis and genetic association studies. | Forabosco P et al. | β | 2005 | β |
| Statistical Viewer: a tool to upload and integrate linkage and association data as plots displayed within the Ensembl genome browser. | Stenger JE et al. | β | 2005 | β |
| The Autism Genome Project: goals and strategies. | Hu-Lince D et al. | β | 2005 | β |
| The role of pedigree information in combined linkage disequilibrium and linkage mapping of quantitative trait loci in a general complex pedigree. | Lee SH et al. | β | 2005 | β |
| A 3347-locus genetic recombination map of sequence-tagged sites reveals features of genome organization, transmission and evolution of cotton (Gossypium). | Rong J et al. | β | 2004 | β |
| A combined linkage-physical map of the human genome. | Kong X et al. | β | 2004 | β |
| A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5. | Hsiung GY et al. | β | 2004 | β |
| A gene locus responsible for the familial hair shaft abnormality pili annulati maps to chromosome 12q24.32-24.33. | Giehl KA et al. | β | 2004 | β |
| A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma. | Blumenthal MN et al. | β | 2004 | β |
| A genomewide search using an original pairwise sampling approach for large genealogies identifies a new locus for total and low-density lipoprotein cholesterol in two genetically differentiated isolates of Sardinia. | Falchi M et al. | β | 2004 | β |
| A highly informative SNP linkage panel for human genetic studies. | Murray SS et al. | β | 2004 | β |
| A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family. | Ma CX et al. | β | 2004 | β |
| A microsatellite genetic linkage map for Xiphophorus. | Walter RB et al. | β | 2004 | β |
| A multilocus likelihood approach to joint modeling of linkage, parental diplotype and gene order in a full-sib family. | Lu Q et al. | β | 2004 | β |
| A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins. | Rainwater DL et al. | β | 2004 | β |
| Ascertainment-adjusted maximum likelihood estimation for the additive genetic gamma frailty model. | Sun W et al. | β | 2004 | β |
| Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11. | Arcos-Burgos M et al. | β | 2004 | β |
| Biography of Phil Green. | Brownlee C | β | 2004 | β |
| Characterization and mapping of canine microsatellites isolated from BAC clones harbouring DNA sequences homologous to seven human genes. | Klukowska J et al. | β | 2004 | β |
| Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci. | Schaid DJ et al. | β | 2004 | β |
| Conditional probability methods for haplotyping in pedigrees. | Gao G et al. | β | 2004 | β |
| Efficient two-trait-locus linkage analysis through program optimization and parallelization: application to hypercholesterolemia. | Dietter J et al. | β | 2004 | β |
| Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians. | Jamieson SE et al. | β | 2004 | β |
| Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. | Grisart B et al. | β | 2004 | β |
| Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping. | Stylianou IM et al. | β | 2004 | β |
| Genomewide linkage scan for myopia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 22q12. | Stambolian D et al. | β | 2004 | β |
| Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. | Zubenko GS et al. | β | 2004 | β |
| Global genetic analysis. | Elahi E et al. | β | 2004 | β |
| Inherent bias toward the null hypothesis in conventional multipoint nonparametric linkage analysis. | Schork NJ et al. | β | 2004 | β |
| Joining genetic linkage maps using a joint likelihood function. | Hu XS et al. | β | 2004 | β |
| Joint oligogenic segregation and linkage analysis using bayesian Markov chain Monte Carlo methods. | Wijsman EM et al. | β | 2004 | β |
| Linkage analysis of a complex disease through use of admixed populations. | Zhu X et al. | β | 2004 | β |
| Linkage analysis using single nucleotide polymorphisms. | Browning BL et al. | β | 2004 | β |
| Linkage mapping of ovine cysteine and histidine-rich protein gene (CYHR1) to chromosome 9. | Calvo JH et al. | β | 2004 | β |
| Linkage of the locus for canine dewclaw to chromosome 16. | Park K et al. | β | 2004 | β |
| Mapping quantitative trait loci affecting dairy conformation to chromosome 27 in two Holstein grandsire families. | Van Tassell CP et al. | β | 2004 | β |
| Maximum-likelihood estimation of haplotype frequencies in nuclear families. | Becker T et al. | β | 2004 | β |
| Methods for high-density admixture mapping of disease genes. | Patterson N et al. | β | 2004 | β |
| Molecular characterization of the tumor microenvironment in breast cancer. | Allinen M et al. | β | 2004 | β |
| Multipoint linkage analysis of quantitative traits on sex-chromosomes. | EkstrΓΈm CT | β | 2004 | β |
| Optimizing exact genetic linkage computations. | Fishelson M et al. | β | 2004 | β |
| Ovine alpha-amylase genes: isolation, linkage mapping and association analysis with milk traits. | Calvo JH et al. | β | 2004 | β |
| Physical and linkage mapping of mammary-derived expressed sequence tags in cattle. | Connor EE et al. | β | 2004 | β |
| QTLs for pre- and postweaning body weight and body composition in selected mice. | Brockmann GA et al. | β | 2004 | β |
| Quantitative analysis of nucleic acids--the last few years of progress. | Ding C et al. | β | 2004 | β |
| Score test for detecting linkage to complex traits in selected samples. | Lebrec J et al. | β | 2004 | β |
| Seven bacterial artificial chromosome-derived canine microsatellite-linking physical and genetic maps. | Klukowska J et al. | β | 2004 | β |
| Structural organization, mapping, characterization and evolutionary relationships of CDKN2 gene family members in Xiphophorus fishes. | Kazianis S et al. | β | 2004 | β |
| The Bayesian revolution in genetics. | Beaumont MA et al. | β | 2004 | β |
| Theoretical basis for genetic linkage analysis in autotetraploid species. | Luo ZW et al. | β | 2004 | β |
| The pedigree trimming problem. | Lange K et al. | β | 2004 | β |
| Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania. | Faraone SV et al. | β | 2004 | β |
| Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3. | Lemire M et al. | β | 2004 | β |
| A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. | Matise TC et al. | β | 2003 | β |
| A graph-theoretic approach to comparing and integrating genetic, physical and sequence-based maps. | Yap IV et al. | β | 2003 | β |
| Analysis of the 5' region of the canine PAX3 gene and exclusion as a candidate for Dalmatian deafness. | Brenig B et al. | β | 2003 | β |
| Applications of continuous time hidden Markov models to the study of misclassified disease outcomes. | Bureau A et al. | β | 2003 | β |
| Association scan of the novel psoriasis susceptibility region on chromosome 19: evidence for both susceptible and protective loci. | Hensen P et al. | β | 2003 | β |
| A systematic genomewide linkage study in 353 sib pairs with schizophrenia. | Williams NM et al. | β | 2003 | β |
| A tobit variance-component method for linkage analysis of censored trait data. | Epstein MP et al. | β | 2003 | β |
| Constructing large-scale genetic maps using an evolutionary strategy algorithm. | Mester D et al. | β | 2003 | β |
| Constructing linkage maps in autotetraploid species using simulated annealing. | Hackett CA et al. | β | 2003 | β |
| Contribution of a new set of canine microsatellites to the knowledge of the canine genetic map. | Parra D et al. | β | 2003 | β |
| Convergent evolution of perenniality in rice and sorghum. | Hu FY et al. | β | 2003 | β |
| Effects of genotyping errors, missing values and segregation distortion in molecular marker data on the construction of linkage maps. | Hackett CA et al. | β | 2003 | β |
| Efficient multipoint mapping: making use of dominant repulsion-phase markers. | Mester DI et al. | β | 2003 | β |
| Finding starting points for Markov chain Monte Carlo analysis of genetic data from large and complex pedigrees. | Luo Y et al. | β | 2003 | β |
| Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. | Ertekin-Taner N et al. | β | 2003 | β |
| Genetic linkage and association studies in bipolar affective disorder: a time for optimism. | Schulze TG et al. | β | 2003 | β |
| Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X. | Zandi PP et al. | β | 2003 | β |
| Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21. | Willour VL et al. | β | 2003 | β |
| Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection. | Thye T et al. | β | 2003 | β |
| Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. | Zubenko GS et al. | β | 2003 | β |
| Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. | McInnis MG et al. | β | 2003 | β |
| Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12. | McInnis MG et al. | β | 2003 | β |
| Linkage analysis with sequential imputation. | Skrivanek Z et al. | β | 2003 | β |
| Linkage mapping of beta 2 EEG waves via non-parametric regression. | Ghosh S et al. | β | 2003 | β |
| Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series. | Shaw SH et al. | β | 2003 | β |
| Localization of a novel autosomal recessive non-syndromic hearing impairment locus (DFNB38) to 6q26-q27 in a consanguineous kindred from Pakistan. | Ansar M et al. | β | 2003 | β |
| Mapping of the bovine spinal muscular atrophy locus to Chromosome 24. | Medugorac I et al. | β | 2003 | β |
| Monte Carlo simulations on marker grouping and ordering. | Wu J et al. | β | 2003 | β |
| On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis. | GΓΆring HH et al. | β | 2003 | β |
| On the complexity of fundamental computational problems in pedigree analysis. | Piccolboni A et al. | β | 2003 | β |
| Pedigree data analysis with crossover interference. | Browning S | β | 2003 | β |
| Predisposition locus for major depression at chromosome 12q22-12q23.2. | Abkevich V et al. | β | 2003 | β |
| Preliminary linkage map of the turkey (Meleagris gallopavo) based on microsatellite markers. | Burt DW et al. | β | 2003 | β |
| Sequence variations in CREB1 cosegregate with depressive disorders in women. | Zubenko GS et al. | β | 2003 | β |
| A bivalent polyploid model for linkage analysis in outcrossing tetraploids. | Wu R et al. | β | 2002 | β |
| Age at onset in two common neurodegenerative diseases is genetically controlled. | Li YJ et al. | β | 2002 | β |
| A genome scan for loci influencing anti-atherogenic serum bilirubin levels. | Kronenberg F et al. | β | 2002 | β |
| A major predisposition locus for severe obesity, at 4p15-p14. | Stone S et al. | β | 2002 | β |
| An additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families. | Li H | β | 2002 | β |
| Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. | Scott BT et al. | β | 2002 | β |
| Crossover interference in the mouse. | Broman KW et al. | β | 2002 | β |
| Detection and integration of genotyping errors in statistical genetics. | Sobel E et al. | β | 2002 | β |
| Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28. | Howard TD et al. | β | 2002 | β |
| Fine mapping of the IBD1 locus did not identify Crohn disease-associated NOD2 variants: implications for complex disease genetics. | van Heel DA et al. | β | 2002 | β |
| Genetic fieldwork for hereditary prostate cancer studies. | Plaetke R et al. | β | 2002 | β |
| Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. | Zubenko GS et al. | β | 2002 | β |
| Genetic mapping of ovine growth differentiation factor 9 (GDF9) to sheep chromosome 5. | Sadighi M et al. | β | 2002 | β |
| Linkage mapping of microsatellites associated with the glycosylation dependent cell adhesion molecule (GLYCAM1) and thyroid hormone receptor alpha chain (THRA) genes to ovine chromosomes 3 and 11. | Maddox JF | β | 2002 | β |
| Map error reduction: using genetic and sequence-based physical maps to order closely linked markers. | DeWan AT et al. | β | 2002 | β |
| Mapping and analysis of quantitative trait loci in experimental populations. | Doerge RW | β | 2002 | β |
| Mapping of quantitative trait loci for body weight at three, six, and nine weeks of age in a broiler layer cross. | Sewalem A et al. | β | 2002 | β |
| Mapping quantitative trait loci and identification of genes that control fatness in poultry. | Burt DW et al. | β | 2002 | β |
| Merlin: faster linkage analysis with improved genotyping error detection. | Cook EH | β | 2002 | β |
| Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. | Abecasis GR et al. | β | 2002 | β |
| Non-ahr gene susceptibility Loci for porphyria and liver injury induced by the interaction of 'dioxin' with iron overload in mice. | Robinson SW et al. | β | 2002 | β |
| On reducing the statespace of hidden Markov models for the identity by descent process. | Browning S et al. | β | 2002 | β |
| PCR multiplexed microsatellite panels to expedite canine genetic disease linkage analysis. | Eggleston ML et al. | β | 2002 | β |
| Powerful regression-based quantitative-trait linkage analysis of general pedigrees. | Sham PC et al. | β | 2002 | β |
| Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites. | Abney M et al. | β | 2002 | β |
| Regression models for allele sharing: analysis of accumulating data in affected sib pair studies. | Bull SB et al. | β | 2002 | β |
| Simultaneous maximum likelihood estimation of linkage and linkage phases in outcrossing species. | Wu R et al. | β | 2002 | β |
| The impact of genotyping error on haplotype reconstruction and frequency estimation. | Kirk KM et al. | β | 2002 | β |
| The map problem: a comparison of genetic and sequence-based physical maps. | DeWan AT et al. | β | 2002 | β |
| A candidate prostate cancer susceptibility gene at chromosome 17p. | Tavtigian SV et al. | β | 2001 | β |
| A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. | Nerup J et al. | β | 2001 | β |
| A linkage analysis of sex determination in Bombus terrestris (L.) (Hymenoptera: Apidae). | Gadau J et al. | β | 2001 | β |
| Allele-sharing among affected relatives: non-parametric methods for identifying genes. | Shih MC et al. | β | 2001 | β |
| A multivalent pairing model of linkage analysis in autotetraploids. | Wu SS et al. | β | 2001 | β |
| An enhanced linkage map of the sheep genome comprising more than 1000 loci. | Maddox JF et al. | β | 2001 | β |
| A new nonparametric linkage statistic for mapping both qualitative and quantitative trait loci. | Camp NJ et al. | β | 2001 | β |
| A robust multipoint linkage statistic (tlod) for mapping complex trait loci. | Abkevich V et al. | β | 2001 | β |
| Association analysis in a variance components framework. | Abecasis GR et al. | β | 2001 | β |
| A statistical framework for quantitative trait mapping. | Sen S et al. | β | 2001 | β |
| Bayesian oligogenic analysis of quantitative and qualitative traits in general pedigrees. | Uimari P et al. | β | 2001 | β |
| Characterization of a minimal screening set of 172 microsatellite markers for genome-wide screens of the canine genome. | Richman M et al. | β | 2001 | β |
| Computational issues in mapping variation affecting susceptibility to complex disorders: the chicken and the egg. | Cox NJ | β | 2001 | β |
| Construction of a genetic linkage map in tetraploid species using molecular markers. | Luo ZW et al. | β | 2001 | β |
| Construction of reference genetic maps. | Buetow KH | β | 2001 | β |
| Description of three data sets: Collaborative Study on the Genetics of Asthma (CSGA), the German Affected-Sib-Pair Study, and the Hutterites of South Dakota. | Meyers DA et al. | β | 2001 | β |
| Detection of human genetic linkage: foundations. | Thompson E | β | 2001 | β |
| Efficient multipoint linkage analysis through reduction of inheritance space. | Markianos K et al. | β | 2001 | β |
| Evidence for a susceptibility locus on chromosome 6q influencing phonological coding dyslexia. | Petryshen TL et al. | β | 2001 | β |
| Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians. | Hanson RL et al. | β | 2001 | β |
| Genetic analysis of quantitative traits in highly ascertained samples: total serum IgE in families with asthma. | Bethony J et al. | β | 2001 | β |
| Genetic linkage methods for quantitative traits. | Amos CI et al. | β | 2001 | β |
| Genetic refinement and physical mapping of a chromosome 16q candidate region for inflammatory bowel disease. | Zouali H et al. | β | 2001 | β |
| Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. | Xu J et al. | β | 2001 | β |
| Genome-wide search for loci controlling serum IGF binding protein levels of mice. | Brockmann GA et al. | β | 2001 | β |
| Identification, by homozygosity mapping, of a novel locus for autosomal recessive congenital ichthyosis on chromosome 17p, and evidence for further genetic heterogeneity. | KrebsovΓ‘ A et al. | β | 2001 | β |
| Interval mapping of quantitative trait loci in autotetraploid species. | Hackett CA et al. | β | 2001 | β |
| Joint linkage and linkage disequilibrium mapping in natural populations. | Wu R et al. | β | 2001 | β |
| Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method. | Garner C et al. | β | 2001 | β |
| Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23. | Xu J et al. | β | 2001 | β |
| Linkage studies suggest a possible locus for developmental dyslexia on chromosome 1p. | Grigorenko EL et al. | β | 2001 | β |
| Locating genes by linkage and association. | Ewens WJ et al. | β | 2001 | β |
| Locus ordering based on crossover information in family haplotypes: application of a "minimum break" algorithm. | Falk CT | β | 2001 | β |
| Lod scores for gene mapping in the presence of marker map uncertainty. | Stringham HM et al. | β | 2001 | β |
| Mapping the matrix metalloproteinase 9 (MMP9) gene and the BL1071 microsatellite to ovine chromosome 13 (OAR13). | Maddox JF | β | 2001 | β |
| Multipoint development of the weighted pairwise correlation (WPC) linkage method for pedigrees of arbitrary size and application to the analysis of breast cancer and alcoholism familial data. | Zinn-Justin A et al. | β | 2001 | β |
| Novel COL1A1 mutation (G559C) [correction of G599C] associated with mild osteogenesis imperfecta and dentinogenesis imperfecta. | Pallos D et al. | β | 2001 | β |
| Power of multipoint identity-by-descent methods to detect linkage using variance component models. | EkstrΓΈm CT | β | 2001 | β |
| Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3). | Dechairo B et al. | β | 2001 | β |
| The effect of genotype and pedigree error on linkage analysis: analysis of three asthma genome scans. | Cherny SS et al. | β | 2001 | β |
| The impact of genotyping error on family-based analysis of quantitative traits. | Abecasis GR et al. | β | 2001 | β |
| A century of biometrical genetics. | Elston RC et al. | β | 2000 | β |
| A genome screen of maximum number of drinks as an alcoholism phenotype. | Saccone NL et al. | β | 2000 | β |
| Allegro, a new computer program for multipoint linkage analysis. | Gudbjartsson DF et al. | β | 2000 | β |
| All LODs are not created equal. | Nyholt DR | β | 2000 | β |
| A method for fine mapping quantitative trait loci in outbred animal stocks. | Mott R et al. | β | 2000 | β |
| Assignment of the gene for a new hereditary nail disorder, isolated congenital nail dysplasia, to chromosome 17p13. | KrebsovΓ‘ A et al. | β | 2000 | β |
| A unique form of mental retardation with a distinctive phenotype maps to Xq26-q27. | Shashi V et al. | β | 2000 | β |
| Bayesian fine-scale mapping of disease loci, by hidden Markov models. | Morris AP et al. | β | 2000 | β |
| Characterization of human crossover interference. | Broman KW et al. | β | 2000 | β |
| Development and characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms and other markers. | Forche A et al. | β | 2000 | β |
| Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23. | Kort EN et al. | β | 2000 | β |
| Follistatin (FST), growth hormone receptor (GHR) and prolactin receptor (PRLR) genes map to the same region of sheep chromosome 16. | Jenkins ZA et al. | β | 2000 | β |
| Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. | Friddle C et al. | β | 2000 | β |
| Genetic analyses of chromosome 12 loci in Crohn's disease. | Lesage S et al. | β | 2000 | β |
| Genetic localization to chromosome 1p32 of the third locus for familial hypercholesterolemia in a Utah kindred. | Hunt SC et al. | β | 2000 | β |
| Genomewide search for type 2 diabetes susceptibility genes in four American populations. | Ehm MG et al. | β | 2000 | β |
| Linkage analysis in the presence of errors I: complex-valued recombination fractions and complex phenotypes. | GΓΆring HH et al. | β | 2000 | β |
| Linkage analysis in the presence of errors III: marker loci and their map as nuisance parameters. | GΓΆring HH et al. | β | 2000 | β |
| Linkage analysis in the presence of errors II: marker-locus genotyping errors modeled with hypercomplex recombination fractions. | GΓΆring HH et al. | β | 2000 | β |
| Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation. | Hart TC et al. | β | 2000 | β |
| Major genes regulating total serum immunoglobulin E levels in families with asthma. | Xu J et al. | β | 2000 | β |
| Mixed model analysis of quantitative trait loci. | Xu S et al. | β | 2000 | β |
| Multipoint admixture mapping. | McKeigue PM | β | 2000 | β |
| Multipoint mapping of viability and segregation distorting loci using molecular markers. | Vogl C et al. | β | 2000 | β |
| Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization. | Strauch K et al. | β | 2000 | β |
| Patterns of meiotic recombination on the long arm of human chromosome 21. | Lynn A et al. | β | 2000 | β |
| Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. | Brockmann GA et al. | β | 2000 | β |
| Statistical approaches to gene mapping. | Ott J et al. | β | 2000 | β |
| Statistical tests for detection of misspecified relationships by use of genome-screen data. | McPeek MS et al. | β | 2000 | β |
| The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. | Ghosh S et al. | β | 2000 | β |
| Zero-recombinant haplotyping: applications to fine mapping using SNPs. | O'Connell JR | β | 2000 | β |
| A Bayesian Markov chain Monte Carlo approach to map disease genes in simulated GAW11 data. | Uimari P et al. | β | 1999 | β |
| A genetic linkage map of microsatellites in the domestic cat (Felis catus). | Menotti-Raymond M et al. | β | 1999 | β |
| A more powerful method to evaluate p-values in GENEHUNTER. | Zhao H et al. | β | 1999 | β |
| Analysis of affected sib pairs, with covariates--with and without constraints. | Greenwood CM et al. | β | 1999 | β |
| Bayesian mapping of multiple quantitative trait loci from incomplete outbred offspring data. | SillanpÀÀ MJ et al. | β | 1999 | β |
| Computing probabilities of homozygosity by descent. | SchΓ€ffer AA | β | 1999 | β |
| Construction of a linkage map of the medaka (Oryzias latipes) and mapping of the Da mutant locus defective in dorsoventral patterning. | Ohtsuka M et al. | β | 1999 | β |
| Description of the Genetic Analysis Workshop 11 Collaborative Study on the Genetics of Alcoholism. | Begleiter H et al. | β | 1999 | β |
| Development of molecular genetics. | Tahvanainen E | β | 1999 | β |
| Dominant optic atrophy. Refining the clinical diagnostic criteria in light of genetic linkage studies. | Johnston RL et al. | β | 1999 | β |
| Fine-mapping of quantitative trait loci by identity by descent in outbred populations: application to milk production in dairy cattle. | Riquet J et al. | β | 1999 | β |
| Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. | Bailey ME et al. | β | 1999 | β |
| Genetic studies of autistic disorder and chromosome 7. | Ashley-Koch A et al. | β | 1999 | β |
| Genome screen for platelet monoamine oxidase (MAO) activity. | Saccone NL et al. | β | 1999 | β |
| Haplotype analysis in the Collaborative Study on the Genetics of Alcoholism data: double recombinants. | Petronis A et al. | β | 1999 | β |
| Isolation and mapping of the first ruminant multidrug resistance genes. | Longley M et al. | β | 1999 | β |
| Linkage and association study of the CTLA-4 region in coeliac disease for Italian and Tunisian populations. | Clot F et al. | β | 1999 | β |
| Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees. | Kendler KS et al. | β | 1999 | β |
| Multipoint genetic mapping of quantitative trait loci with dominant markers in outbred populations. | Gessler DD et al. | β | 1999 | β |
| Multipoint linkage disequilibrium mapping with particular reference to the African-American population. | Zheng C et al. | β | 1999 | β |
| On a randomization procedure in linkage analysis. | Zhao H et al. | β | 1999 | β |
| Progress toward positional cloning of ovine neuronal ceroid lipofuscinosis, a model of the human late-infantile variant CLN6. | Broom MF et al. | β | 1999 | β |
| Retinitis pigmentosa and progressive sensorineural hearing loss caused by a C12258A mutation in the mitochondrial MTTS2 gene. | Mansergh FC et al. | β | 1999 | β |
| Seven new linkage groups assigned to the DogMap reference families. | Ryder EJ et al. | β | 1999 | β |
| Sex-based linkage analysis of alcoholism. | Paterson AD et al. | β | 1999 | β |
| Statistical aspects of genetic mapping in autopolyploids. | Ripol MI et al. | β | 1999 | β |
| TKY101: a highly polymorphic equine dinucleotide repeat locus. | Mashima S et al. | β | 1999 | β |
| Transmission ratio distortion in females on chromosome 10p11-p15. | Paterson AD et al. | β | 1999 | β |
| Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. | Ghosh S et al. | β | 1999 | β |
| A detailed physical and transcriptional map of the region of chromosome 20 that is deleted in myeloproliferative disorders and refinement of the common deleted region. | Bench AJ et al. | β | 1998 | β |
| A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. | Ghosh S et al. | β | 1998 | β |
| Allele identical by descent sharing at any point of a chromosome of a sib pair. | Drigalenko E | β | 1998 | β |
| An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. | Pratley RE et al. | β | 1998 | β |
| An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. | Hanson RL et al. | β | 1998 | β |
| A second locus for familial high myopia maps to chromosome 12q. | Young TL et al. | β | 1998 | β |
| A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9. | Leal SM et al. | β | 1998 | β |
| Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. | Norman RA et al. | β | 1998 | β |
| Comprehensive human genetic maps: individual and sex-specific variation in recombination. | Broman KW et al. | β | 1998 | β |
| Estimation of distances and map construction using radiation hybrids. | Newell W et al. | β | 1998 | β |
| Evidence for a novel gene for familial febrile convulsions, FEB2, linked to chromosome 19p in an extended family from the Midwest. | Johnson EW et al. | β | 1998 | β |
| Evidence for a prostate cancer susceptibility locus on the X chromosome. | Xu J et al. | β | 1998 | β |
| Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. | Long JC et al. | β | 1998 | β |
| Evidence that a locus for familial high myopia maps to chromosome 18p. | Young TL et al. | β | 1998 | β |
| Faster multipoint linkage analysis using Fourier transforms. | Kruglyak L et al. | β | 1998 | β |
| Further investigation on the regression method of mapping quantitative trait loci. | Xu S | β | 1998 | β |
| Genetic analysis of meiotic recombination in humans by use of sperm typing: reduced recombination within a heterozygous paracentric inversion of chromosome 9q32-q34.3. | Brown GM et al. | β | 1998 | β |
| Genetic linkage of hereditary gingival fibromatosis to chromosome 2p21. | Hart TC et al. | β | 1998 | β |
| Identification of genetic markers associated with Gilles de la Tourette syndrome in an Afrikaner population. | Simonic I et al. | β | 1998 | β |
| Lack of evidence for genetic heterogeneity in Best vitelliform macular dystrophy. | Mansergh F et al. | β | 1998 | β |
| Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores. | Wilkinson J et al. | β | 1998 | β |
| Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor suppressor. | Kazianis S et al. | β | 1998 | β |
| Localization of the gene for familial partial lipodystrophy (Dunnigan variety) to chromosome 1q21-22. | Peters JM et al. | β | 1998 | β |
| Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture. | McKeigue PM | β | 1998 | β |
| Multipoint quantitative-trait linkage analysis in general pedigrees. | Almasy L et al. | β | 1998 | β |
| Ovine neuronal ceroid lipofuscinosis: a large animal model syntenic with the human neuronal ceroid lipofuscinosis variant CLN6. | Broom MF et al. | β | 1998 | β |
| Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth. | Brockmann GA et al. | β | 1998 | β |
| Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data. | Abel L et al. | β | 1998 | β |
| Sib mating designs for mapping quantitative trait loci. | Xie C et al. | β | 1998 | β |
| Statistical recovering of incomplete genotypic information of DNA molecular markers. | Jiang C et al. | β | 1998 | β |
| Sublocalization of the Papillon-Lefevre syndrome locus on 11q14-q21. | Hart TC et al. | β | 1998 | β |
| 1996 William Allan Award Address. Algorithms and inferences: the challenge of multifactorial diseases. | Elston RC | β | 1997 | β |
| Affected-sib-pair analyses of bipolar disorder using data on chromosome 18. | Haghighi F et al. | β | 1997 | β |
| Affected sibpair linkage tests for multiple linked susceptibility genes. | Farrall M | β | 1997 | β |
| A genome wide search for susceptibility loci in three European malignant hyperthermia pedigrees. | Robinson RL et al. | β | 1997 | β |
| A linkage map of chromosome 6 based on 2 large kindreds segregating bipolar affective disorder. | Gerhard DS et al. | β | 1997 | β |
| A linkage map of the canine genome. | Mellersh CS et al. | β | 1997 | β |
| An algorithm for haplotype analysis. | Lin S et al. | β | 1997 | β |
| Building human genome maps with radiation hybrids. | Slonim D et al. | β | 1997 | β |
| Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2, 11, 13, 14, and X. | Stine OC et al. | β | 1997 | β |
| Linkage mapping of wool keratin and keratin-associated protein genes in sheep. | McLaren RJ et al. | β | 1997 | β |
| Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping. | Nichols WC et al. | β | 1997 | β |
| Linkage studies in dominant optic atrophy, Kjer type: possible evidence for heterogeneity. | Seller MJ et al. | β | 1997 | β |
| Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. | Heath SC | β | 1997 | β |
| Specifying the introgressed regions from H. argophyllus in cultivated sunflower (Helianthus annuus L.) to mark Phomopsis resistance genes. | Besnard G et al. | β | 1997 | β |
| A comprehensive genetic map of the human genome based on 5,264 microsatellites. | Dib C et al. | β | 1996 | β |
| A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish. | LaBuda MC et al. | β | 1996 | β |
| A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA). | Reich T | β | 1996 | β |
| A linkage map of porcine chromosome 7 composed of 19 short tandem repeat polymorphisms. | Wilkie PJ et al. | β | 1996 | β |
| A locus for bipolar affective disorder on chromosome 4p. | Blackwood DH et al. | β | 1996 | β |
| An integrated genetic map of Chromosome 6. | Cooke IE et al. | β | 1996 | β |
| Characterization and linkage mapping of ten sheep microsatellite markers derived from a sheep x hamster cell hybrid. | Lumsden JM et al. | β | 1996 | β |
| Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. | Rubattu S et al. | β | 1996 | β |
| Development of a bovine X chromosome linkage group and painting probes to assess cattle, sheep, and goat X chromosome segment homologies. | Ponce de Leon FA et al. | β | 1996 | β |
| Error detection for genetic data, using likelihood methods. | Ehm MG et al. | β | 1996 | β |
| Establishment of molecular markers and linkage groups in two F2 populations of Upland cotton. | Shappley ZW et al. | β | 1996 | β |
| Genetic mapping in Xiphophorus hybrid fish: assignment of 43 AP-PCR/RAPD and isozyme markers to multipoint linkage groups. | Kazianis S et al. | β | 1996 | β |
| Genetic mapping of a pulmonary adenoma resistance (Par1) in mouse. | Manenti G et al. | β | 1996 | β |
| Genetic mapping of the laminin gamma 2 gene on sheep chromosome 12. | Jenkins ZA et al. | β | 1996 | β |
| Genome scanning for linkage: an overview. | Whittemore AS | β | 1996 | β |
| Identification and genetic mapping of random amplified polymorphic DNA (RAPD) markers to the sheep genome. | Cushwa WT et al. | β | 1996 | β |
| Molecular mapping of the Arabidopsis locus RPP11 which conditions isolate-specific hypersensitive resistance against downy mildew in ecotype RLD. | Joos HJ et al. | β | 1996 | β |
| Mosquito dopa decarboxylase cDNA characterization and blood-meal-induced ovarian expression. | Ferdig MT et al. | β | 1996 | β |
| Multivariate multipoint linkage analysis of quantitative trait loci. | Eaves LJ et al. | β | 1996 | β |
| Parallel computing of physical maps--a comparative study in SIMD and MIMD parallelism. | Bhandarkar SM et al. | β | 1996 | β |
| Parametric and nonparametric linkage analysis: a unified multipoint approach. | Kruglyak L et al. | β | 1996 | β |
| Programs, databases, and expert systems for human geneticists--a survey. | Fischer C et al. | β | 1996 | β |
| Software for genetic linkage analysis: an update. | Bryant SP | β | 1996 | β |
| Susceptible chiasmate configurations of chromosome 21 predispose to non-disjunction in both maternal meiosis I and meiosis II. | Lamb NE et al. | β | 1996 | β |
| The human complement C8G gene, a member of the lipocalin gene family: polymorphisms and mapping to chromosome 9q34.3. | Dewald G et al. | β | 1996 | β |
| The linkage map of sheep Chromosome 6 compared with orthologous regions in other species. | Lord EA et al. | β | 1996 | β |
| A chromosome-based method to infer IBD scores for missing and ambiguous markers. | Gu C et al. | β | 1995 | β |
| Adrenocorticotropin receptor/melanocortin receptor-2 maps within a reported susceptibility region for bipolar illness on chromosome 18. | Detera-Wadleigh SD et al. | β | 1995 | β |
| A familial Alzheimer's disease locus on chromosome 1. | Levy-Lahad E et al. | β | 1995 | β |
| A high-resolution genetic linkage map of the pericentromeric region of the human X chromosome. | Weeks DE et al. | β | 1995 | β |
| A maximum likelihood algorithm for genome mapping of cytogenetic loci from meiotic configuration data. | Reyes-ValdΓ©s MH et al. | β | 1995 | β |
| An anchored molecular map of mouse chromosome 6 with an analysis of interference. | Davies PO et al. | β | 1995 | β |
| An integrated map of chromosome 9. | Collins A et al. | β | 1995 | β |
| An STS-based map of the human genome. | Hudson TJ et al. | β | 1995 | β |
| Autosomal dominant zonular cataract with sutural opacities localized to chromosome 17q11-12. | Padma T et al. | β | 1995 | β |
| cDNA cloning of the rat APC gene and assignment to chromosome 18. | Toyota M et al. | β | 1995 | β |
| Characterization of a dinucleotide repeat in the 92 kDa type IV collagenase gene (CLG4B), localization of CLG4B to chromosome 20 and the role of CLG4B in aortic aneurysmal disease. | St Jean PL et al. | β | 1995 | β |
| Complete multipoint sib-pair analysis of qualitative and quantitative traits. | Kruglyak L et al. | β | 1995 | β |
| Computer programs for multilocus haplotyping of general pedigrees. | Weeks DE et al. | β | 1995 | β |
| Computing conditional recombination probabilities given marker information. | Miller MB | β | 1995 | β |
| Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. | Stine OC et al. | β | 1995 | β |
| Fine genetic mapping of a gene for autosomal recessive retinitis pigmentosa on chromosome 6p21. | Shugart YY et al. | β | 1995 | β |
| Genetic mapping of the LMP2 proteasome subunit gene to the BoLA class IIb region. | Shalhevet D et al. | β | 1995 | β |
| HLA disease associations: models for the study of complex human genetic disorders. | Thomson G | β | 1995 | β |
| Integration of gene maps: updating chromosome 1. | Forabosco P et al. | β | 1995 | β |
| Linkage studies on chromosome 22 in familial schizophrenia. | Vallada HP et al. | β | 1995 | β |
| Mapping eight new polymorphisms in 11q13 in the vicinity of multiple endocrine neoplasia type 1: identification of a new distal recombinant. | Smith CM et al. | β | 1995 | β |
| Mapping of body weight loci on mouse chromosome X. | Dragani TA et al. | β | 1995 | β |
| Maximum-likelihood models for mapping genetic markers showing segregation distortion. 1. Backcross populations. | Lorieux M et al. | β | 1995 | β |
| Microsatellite-based fine mapping of the Van der Woude syndrome locus to an interval of 4.1 cM between D1S245 and D1S414. | Sander A et al. | β | 1995 | β |
| Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. | Kruglyak L et al. | β | 1995 | β |
| Recombination and maternal age-dependent nondisjunction: molecular studies of trisomy 16. | Hassold T et al. | β | 1995 | β |
| Refined localization of the cerebral cavernous malformation gene (CCM1) to a 4-cM interval of chromosome 7q contained in a well-defined YAC contig. | Johnson EW et al. | β | 1995 | β |
| Robust multipoint linkage analysis: an extension of the Haseman-Elston method. | Olson JM | β | 1995 | β |
| Sib-based detection of QTLs. | Suarez BK et al. | β | 1995 | β |
| Systematic search for major genes in schizophrenia: methodological issues and results from chromosome 12. | Dawson E et al. | β | 1995 | β |
| The CEPH consortium linkage map of human chromosome 16. | Kozman HM et al. | β | 1995 | β |
| The gonadotrophin-releasing hormone receptor maps to sheep chromosome 6 outside of the region of the FecB locus. | Montgomery GW et al. | β | 1995 | β |
| The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. | O'Connell JR et al. | β | 1995 | β |
| Towards fully automated genotyping: use of an X linked recessive spastic paraplegia family to test alternative analysis methods. | Kobayashi H et al. | β | 1995 | β |
| A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC). | Murray JC et al. | β | 1994 | β |
| A fast random cost algorithm for physical mapping. | Wang Y et al. | β | 1994 | β |
| A gene for episodic ataxia/myokymia maps to chromosome 12p13. | Litt M et al. | β | 1994 | β |
| A genetic map of nine loci on bovine chromosome 2. | Beever JE et al. | β | 1994 | β |
| Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. | Matise TC et al. | β | 1994 | β |
| Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. | Berrettini WH et al. | β | 1994 | β |
| Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. | Reed PW et al. | β | 1994 | β |
| Clinical and linkage study of a large family with simple ectopia lentis linked to FBN1. | Edwards MJ et al. | β | 1994 | β |
| Combining two-point genetic linkage analyses using mapping functions. | Schaid DJ et al. | β | 1994 | β |
| Computing the genetic map. | Lathrop GM | β | 1994 | β |
| Empirical threshold values for quantitative trait mapping. | Churchill GA et al. | β | 1994 | β |
| Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. | Tomfohrde J et al. | β | 1994 | β |
| Genetic dissection of complex traits. | Lander ES et al. | β | 1994 | β |
| Genetic mapping of 14 short tandem repeat polymorphisms on human chromosome 22. | Vallada HP et al. | β | 1994 | β |
| Genetic mapping of the FACC gene and linkage analysis in Fanconi anaemia families. | Gibson RA et al. | β | 1994 | β |
| Initial report of a genome search for the affective disorder predisposition gene in the old order Amish pedigrees: chromosomes 1 and 11. | Gerhard DS et al. | β | 1994 | β |
| Sequential imputation for multilocus linkage analysis. | Irwin M et al. | β | 1994 | β |
| Sheep linkage mapping: nineteen linkage groups derived from the analysis of paternal half-sib families. | Crawford AM et al. | β | 1994 | β |
| The 1993-94 GΓ©nΓ©thon human genetic linkage map. | Gyapay G et al. | β | 1994 | β |
| The gene for achondroplasia maps to the telomeric region of chromosome 4p. | Velinov M et al. | β | 1994 | β |
| A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10. | Angrist M et al. | β | 1993 | β |
| Analysis of four microsatellite markers on the long arm of chromosome 9 by meiotic recombination in flow-sorted single sperm. | Furlong RA et al. | β | 1993 | β |
| Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene. | Richards FM et al. | β | 1993 | β |
| DOLINK--a computer program to facilitate management of genetic data and analyses. | Cook CC et al. | β | 1993 | β |
| Flanking markers define the X-linked hypophosphatemic rickets gene locus. | Econs MJ et al. | β | 1993 | β |
| Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. | Easton DF et al. | β | 1993 | β |
| Linkage mapping of dopa-responsive dystonia (DRD) to chromosome 14q. | Nygaard TG et al. | β | 1993 | β |
| Map of seven polymorphic markers on rat chromosome 14: linkage conservation with human chromosome 4. | Remmers EF et al. | β | 1993 | β |
| Metropolis sampling in pedigree analysis. | Sobel E et al. | β | 1993 | β |
| Molecular and statistical approaches to the detection and correction of errors in genotype databases. | Brzustowicz LM et al. | β | 1993 | β |
| Polymorphic microsatellites and Wilson disease (WD). | Stewart EA et al. | β | 1993 | β |
| Pooled-sampling makes high-resolution mapping practical with DNA markers. | Churchill GA et al. | β | 1993 | β |
| Seed-protein variation in maritime pine (Pinus pinaster Ait.) revealed by two-dimensional electrophoresis: genetic determinism and construction of a linkage map. | Gerber S et al. | β | 1993 | β |
| Two novel microsatellite markers for prenatal prediction of spinal muscular atrophy (SMA). | Morrison KE et al. | β | 1993 | β |
| A genetic map of citrus based on the segregation of isozymes and RFLPs in an intergeneric cross. | Jarrell DC et al. | β | 1992 | β |
| A linkage map of 10 loci flanking the Marfan syndrome locus on 15q: results of an International Consortium study. | Sarfarazi M et al. | β | 1992 | β |
| High-resolution genetic map around the spinal muscular atrophy (SMA) locus on chromosome 5. | Morrison KE et al. | β | 1992 | β |
| Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. | Stuber CW et al. | β | 1992 | β |
| Linkage maps in pea. | Ellis TH et al. | β | 1992 | β |
| Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: a strategy for cloning the putative tumor suppressor gene. | Latif F et al. | β | 1992 | β |
| Preliminary ordering of multiple linked loci using pairwise linkage data. | Falk CT | β | 1992 | β |
| A linkage map based on information from four F2 populations of maize (Zea mays L.). | Beavis WD et al. | β | 1991 | β |
| A random walk method for computing genetic location scores. | Lange K et al. | β | 1991 | β |
| Counting algorithms for linkage: correction to Morton and Collins. | Lander ES et al. | β | 1991 | β |
| Efficient methods for computing linkage likelihoods of recessive diseases in inbred pedigrees. | Kong A | β | 1991 | β |
| Error filtration, interference, and the human linkage map. | Shields DC et al. | β | 1991 | β |
| Extended map for the phaseolin linkage group ofPhaseolus vulgaris L. | Vallejos CE et al. | β | 1991 | β |
| High-density genetic and physical mapping of DNA markers near the X-linked Alport syndrome locus: definition and use of flanking polymorphic markers. | Barker DF et al. | β | 1991 | β |
| Linkage analysis of neurofibromatosis type 1. Study of a homogeneous North Italian population with five DNA markers of chromosome 17. | Clementi M et al. | β | 1991 | β |
| Marfan syndrome is closely linked to a marker on chromosome 15q1.5----q2.1. | Tsipouras P et al. | β | 1991 | β |
| Meiotic mapping of murine chromosome 17: the string of loci around l(17)-2Pas. | King TR et al. | β | 1991 | β |
| Analysis of human enamel genes: insights into genetic disorders of enamel. | Lau EC et al. | β | 1990 | β |
| Counting algorithms for linkage. | Morton NE et al. | β | 1990 | β |
| Genetic linkage map of 46 DNA markers on human chromosome 16. | Keith TP et al. | β | 1990 | β |
| Localization by restriction fragment length polymorphism mapping in potato of a major dominant gene conferring resistance to the potato cyst nematode Globodera rostochiensis. | Barone A et al. | β | 1990 | β |
| A 12 megabase restriction map at the cystic fibrosis locus. | Fulton TR et al. | β | 1989 | β |
| Efficient computation of lod scores: genotype elimination, genotype redefinition, and hybrid maximum likelihood algorithms. | Lange K et al. | β | 1989 | β |
| Identification and characterization of 23 RFLP loci by screening random cosmid genomic clones. | Bowden DW et al. | β | 1989 | β |
| Maximum likelihood estimation of linkage between a marker gene and a quantitative locus. | Luo ZW et al. | β | 1989 | β |
| A major simplification in the preliminary ordering of linked loci. | Wilson SR | β | 1988 | β |
| Computers in molecular biology: current applications and emerging trends. | DeLisi C | β | 1988 | β |
| DNA diagnostics--molecular techniques and automation. | Landegren U et al. | β | 1988 | β |
| Efficient computations in multilocus linkage analysis. | Lathrop GM et al. | β | 1988 | β |
| Empirical power of three preliminary methods for ordering loci. | Kammerer CM et al. | β | 1988 | β |
| Genetic analysis of the fungus, Bremia lactucae, using restriction fragment length polymorphisms. | Hulbert SH et al. | β | 1988 | β |
| Identification of more than 500 RFLPs by screening random genomic clones. | Schumm JW et al. | β | 1988 | β |
| Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. | Chang C et al. | β | 1988 | β |
| Genetic linkage map of human chromosome 7 with 63 DNA markers. | Barker D et al. | β | 1987 | β |
| Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. | Lander ES et al. | β | 1987 | β |