Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
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- Authors
- Willer, Cristen J; Sanna, Serena; Jackson, Anne U; Scuteri, Angelo; Bonnycastle, Lori L; Clarke, Robert; Heath, Simon C; Timpson, Nicholas J; Najjar, Samer S; Stringham, Heather M; Strait, James; Duren, William L; Maschio, Andrea; Busonero, Fabio; Mulas, Antonella; Albai, Giuseppe; Swift, Amy J; Morken, Mario A; Narisu, Narisu; Bennett, Derrick; Parish, Sarah; Shen, Haiqing; Galan, Pilar; Meneton, Pierre; Hercberg, Serge; Zelenika, Diana; Chen, Wei-Min; Li, Yun; Scott, Laura J; Scheet, Paul A; Sundvall, Jouko; Watanabe, Richard M; Nagaraja, Ramaiah; Ebrahim, Shah; Lawlor, Debbie A; Ben-Shlomo, Yoav; Davey-Smith, George; Shuldiner, Alan R; Collins, Rory; Bergman, Richard N; Uda, Manuela; Tuomilehto, Jaakko; Cao, Antonio; Collins, Francis S; Lakatta, Edward; Lathrop, G Mark; Boehnke, Michael; Schlessinger, David; Mohlke, Karen L; Abecasis, Gonçalo R
- Year
- 2008
- Journal
- Nature genetics
- PMID
- 18193043
- DOI
- 10.1038/ng.76
- PMCID
- PMC5206900
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. We subsequently examined promising signals in 11,569 additional individuals. Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides and LDL cholesterol). Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls.
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| Largest GWAS of PTSD (N=20β070) yields genetic overlap with schizophrenia and sex differences in heritability. | Duncan LE et al. | β | 2018 | β |
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| ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels. | Li Q et al. | β | 2012 | β |
| Chapter 11: Genome-wide association studies. | Bush WS et al. | β | 2012 | β |
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| Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis. | Hager J et al. | β | 2012 | β |
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| Identification of genes affecting apolipoprotein B secretion following siRNA-mediated gene knockdown in primary human hepatocytes. | Shen X et al. | β | 2012 | β |
| Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia. | Ma L et al. | β | 2012 | β |
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| Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. | Zhang R | β | 2012 | β |
| LPL gene variants affect apoC-III response to combination therapy of statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia. | Brautbar A et al. | β | 2012 | β |
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| Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease. | Besler C et al. | β | 2012 | β |
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| Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. | Musunuru K et al. | β | 2012 | β |
| Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. | Tran DT et al. | β | 2012 | β |
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| Relation of lipid gene scores to longitudinal trends in lipid levels and incidence of abnormal lipid levels among individuals of European ancestry: the Atherosclerosis Risk in Communities (ARIC) study. | Lutsey PL et al. | β | 2012 | β |
| Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. | Dumitrescu L et al. | β | 2012 | β |
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| Significant correlation between a set of genetic polymorphisms and a functional brain network revealed by feature selection and sparse Partial Least Squares. | Le Floch E et al. | β | 2012 | β |
| Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study. | Povel CM et al. | β | 2012 | β |
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| The 719Arg variant of KIF6 and cardiovascular outcomes in statin-treated, stable coronary patients of the treating to new targets and incremental decrease in end points through aggressive lipid-lowering prospective studies. | Arsenault BJ et al. | β | 2012 | β |
| The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach. | Nordestgaard BG et al. | β | 2012 | β |
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| The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes. | Fava C et al. | β | 2012 | β |
| The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism. | Jiang XC et al. | β | 2012 | β |
| The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. | Vrieze SI et al. | β | 2012 | β |
| The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis. | LΓ³pez-MejΓas R et al. | β | 2012 | β |
| The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases. | Prudente S et al. | β | 2012 | β |
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| Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. | Santoro N et al. | β | 2012 | β |
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| Cardiovascular diseases and genome-wide association studies. | Ndiaye NC et al. | β | 2011 | β |
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| Commentary: the year in endocrine genetics for basic scientists. | Crowley WF | β | 2011 | β |
| Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans. | Roder C et al. | β | 2011 | β |
| Common Variants in 6 Lipid-Related Genes Discovered by High-Resolution DNA Melting Analysis and Their Association with Plasma Lipids. | Carlquist JF et al. | β | 2011 | β |
| Coronary artery disease: an example case study. | Barrett JH | β | 2011 | β |
| Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease. | Gonzalez M et al. | β | 2011 | β |
| Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. | Edmondson AC et al. | β | 2011 | β |
| Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs. | Uddin MJ et al. | β | 2011 | β |
| Disease gene interaction pathways: a potential framework for how disease genes associate by disease-risk modules. | Chen L et al. | β | 2011 | β |
| Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels. | Francone OL et al. | β | 2011 | β |
| Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men. | StanΔΓ‘kovΓ‘ A et al. | β | 2011 | β |
| Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population. | Liu Y et al. | β | 2011 | β |
| Effects of lecithin: cholesterol acyltransferase genotypes, enzyme levels, and activity on high-density lipoprotein levels. | Agirbasli D et al. | β | 2011 | β |
| Effects of SNPs at newly identified lipids loci on blood lipid levels and risk of coronary heart disease in Chinese Han population: a case control study. | Zhuang K et al. | β | 2011 | β |
| Emerging genomic applications in coronary artery disease. | Damani SB et al. | β | 2011 | β |
| Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. | Gerken TA et al. | β | 2011 | β |
| Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study. | Peter I et al. | β | 2011 | β |
| Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk. | Simmons CR et al. | β | 2011 | β |
| Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles. | Haas BE et al. | β | 2011 | β |
| Evolutionary evidence of the effect of rare variants on disease etiology. | Gorlov IP et al. | β | 2011 | β |
| Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese. | Jiang F et al. | β | 2011 | β |
| Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. | Sanna S et al. | β | 2011 | β |
| Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children. | Horvatovich K et al. | β | 2011 | β |
| Functional validation of new pathways in lipoprotein metabolism identified by human genetics. | Bauer RC et al. | β | 2011 | β |
| Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity. | Schleinitz D et al. | β | 2011 | β |
| Genetic architecture of circulating lipid levels. | Demirkan A et al. | β | 2011 | β |
| Genetic determinants of coronary heart disease: new discoveries and insights from genome-wide association studies. | Patel RS et al. | β | 2011 | β |
| Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. | Dumitrescu L et al. | β | 2011 | β |
| Genetic determinants of plasma triglycerides. | Johansen CT et al. | β | 2011 | β |
| Genetic factors associated with age-related macular degeneration. | Leveziel N et al. | β | 2011 | β |
| Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. | Park MH et al. | β | 2011 | β |
| Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. | Lemaitre RN et al. | β | 2011 | β |
| Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids. | Walker CG et al. | β | 2011 | β |
| Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. | Zhou L et al. | β | 2011 | β |
| Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. | Middelberg RP et al. | β | 2011 | β |
| Genetic variants in transient receptor potential cation channel, subfamily M 1 (TRPM1) and their risk of albuminuria-related traits in Mexican Americans. | Thameem F et al. | β | 2011 | β |
| Genetic variation in ABCA1 and risk of cardiovascular disease. | Frikke-Schmidt R | β | 2011 | β |
| Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. | Speliotes EK et al. | β | 2011 | β |
| Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. | Tantisira KG et al. | β | 2011 | β |
| Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. | Wang F et al. | β | 2011 | β |
| Genome-wide association studies and systems biology: together at last. | Ala-Korpela M et al. | β | 2011 | β |
| Genome-wide association study identifies common variants associated with circulating vitamin E levels. | Major JM et al. | β | 2011 | β |
| Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. | Lettre G et al. | β | 2011 | β |
| Genome-wide association study of recurrent early-onset major depressive disorder. | Shi J et al. | β | 2011 | β |
| Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. | Duncan EL et al. | β | 2011 | β |
| Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. | Adkins DE et al. | β | 2011 | β |
| Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease. | Ellis KL et al. | β | 2011 | β |
| Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record. | Ding K et al. | β | 2011 | β |
| Glucokinase regulatory protein (GCKR) gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women. | Cao F et al. | β | 2011 | β |
| Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks. | HodoΔlugil U et al. | β | 2011 | β |
| High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome. | Wilke RA | β | 2011 | β |
| High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia. | Nakayama K et al. | β | 2011 | β |
| Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques. | Kassim SH et al. | β | 2011 | β |
| Implications of discoveries from genome-wide association studies in current cardiovascular practice. | Jeemon P et al. | β | 2011 | β |
| Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population. | Kenny EE et al. | β | 2011 | β |
| Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. | Turner SD et al. | β | 2011 | β |
| LAMP-2 gene expression in peripheral leukocytes is increased in patients with coronary artery disease. | Wu G et al. | β | 2011 | β |
| Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. | Kim YJ et al. | β | 2011 | β |
| Lipase maturation factor 1 is required for endothelial lipase activity. | Ben-Zeev O et al. | β | 2011 | β |
| Lipoprotein lipase gene polymorphisms and risks of childhood obesity in Chinese preschool children. | Wang LN et al. | β | 2011 | β |
| Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS. | Wood AC et al. | β | 2011 | β |
| Location, location, location: new insights into O-GalNAc protein glycosylation. | Gill DJ et al. | β | 2011 | β |
| Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking. | Terracciano A et al. | β | 2011 | β |
| Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis. | Umeno J et al. | β | 2011 | β |
| Methods for testing association between uncertain genotypes and quantitative traits. | Kutalik Z et al. | β | 2011 | β |
| Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. | O'Dushlaine C et al. | β | 2011 | β |
| Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor. | Wu YM et al. | β | 2011 | β |
| New insights into how adenovirus might lead to obesity: An oxidative stress theory. | Waye MM | β | 2011 | β |
| No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study. | Hopewell JC et al. | β | 2011 | β |
| Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. | Oexle K et al. | β | 2011 | β |
| Protein interaction-based genome-wide analysis of incident coronary heart disease. | Jensen MK et al. | β | 2011 | β |
| Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. | Rossin EJ et al. | β | 2011 | β |
| Quality control procedures for genome-wide association studies. | Turner S et al. | β | 2011 | β |
| Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. | Trompet S et al. | β | 2011 | β |
| Replication of putative susceptibility loci from genome-wide association studies associated with coronary atherosclerosis in Chinese Han population. | Xie F et al. | β | 2011 | β |
| Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels in the Mulao and Han populations. | Yan TT et al. | β | 2011 | β |
| Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism. | DubΓ© JB et al. | β | 2011 | β |
| Sorting out sortilin. | Tall AR et al. | β | 2011 | β |
| Susceptibility genes for coronary heart disease and myocardial infarction. | Kibos A et al. | β | 2011 | β |
| The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol. | Leduc MS et al. | β | 2011 | β |
| The relative importance of common and rare genetic variants in the development of hypertriglyceridemia. | Evans D et al. | β | 2011 | β |
| The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease. | Kolovou G et al. | β | 2011 | β |
| Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. | Zhang Y et al. | β | 2011 | β |
| TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. | Varbo A et al. | β | 2011 | β |
| Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke. | JΓ‘romi L et al. | β | 2011 | β |
| Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. | Pollin TI et al. | β | 2011 | β |
| Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. | Chapman MJ et al. | β | 2011 | β |
| Triglycerides and heart disease: still a hypothesis? | Goldberg IJ et al. | β | 2011 | β |
| Utility of genetic determinants of lipids and cardiovascular events in assessing risk. | Holmes MV et al. | β | 2011 | β |
| Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia. | Brautbar A et al. | β | 2011 | β |
| A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain. | Feng Q et al. | β | 2010 | β |
| Adaptive genetic variation and heart disease risk. | Parnell LD et al. | β | 2010 | β |
| A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1. | Marques-Pinheiro A et al. | β | 2010 | β |
| A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations. | Keller L et al. | β | 2010 | β |
| A genome-wide association study of the metabolic syndrome in Indian Asian men. | Zabaneh D et al. | β | 2010 | β |
| Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK. | Fogarty MP et al. | β | 2010 | β |
| Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk. | Reynolds CA et al. | β | 2010 | β |
| A new statistic to evaluate imputation reliability. | Lin P et al. | β | 2010 | β |
| An immune response network associated with blood lipid levels. | Inouye M et al. | β | 2010 | β |
| APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men. | Ken-Dror G et al. | β | 2010 | β |
| Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar. | Smith AJ et al. | β | 2010 | β |
| Are high-density lipoprotein genes and their products targets for therapy? | Motazacker MM et al. | β | 2010 | β |
| A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese. | Jiang CQ et al. | β | 2010 | β |
| A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. | Nakayama K et al. | β | 2010 | β |
| Association analysis of 33 lipoprotein candidate genes in multi-generational families of African ancestry. | Miljkovic I et al. | β | 2010 | β |
| Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study. | Kashani Farid MA et al. | β | 2010 | β |
| Association of repeatedly measured intermediate risk factors for complex diseases with high dimensional SNP data. | Waaijenborg S et al. | β | 2010 | β |
| Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. | Bi M et al. | β | 2010 | β |
| Association of the apolipoprotein A5 gene -1131 T>C polymorphism with fasting blood lipids: a meta-analysis in 37859 subjects. | Zhao T et al. | β | 2010 | β |
| Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese. | Hiura Y et al. | β | 2010 | β |
| Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study. | Tang W et al. | β | 2010 | β |
| Asthma-susceptibility variants identified using probands in case-control and family-based analyses. | Himes BE et al. | β | 2010 | β |
| ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci. | Turner SD et al. | β | 2010 | β |
| A triglyceride-raising APOA5 genetic variant is negatively associated with obesity and BMI in the Chinese population. | Wu CK et al. | β | 2010 | β |
| Biological, clinical and population relevance of 95 loci for blood lipids. | Teslovich TM et al. | β | 2010 | β |
| Clinical Implications of Lipid Genetics for Cardiovascular Disease. | Strong A et al. | β | 2010 | β |
| Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. | Mangravite LM et al. | β | 2010 | β |
| Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. | Peloso GM et al. | β | 2010 | β |
| Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. | Jablonski KA et al. | β | 2010 | β |
| Computational prediction of O-linked glycosylation sites that preferentially map on intrinsically disordered regions of extracellular proteins. | Nishikawa I et al. | β | 2010 | β |
| Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population. | Vasseur F et al. | β | 2010 | β |
| Control of adipose tissue inflammation through TRB1. | Ostertag A et al. | β | 2010 | β |
| Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds. | Humphries SE et al. | β | 2010 | β |
| Dyslipidemia in HIV-infected individuals: from pharmacogenetics to pharmacogenomics. | Tarr PE et al. | β | 2010 | β |
| Early identification of cardiovascular risk using genomics and proteomics. | Kullo IJ et al. | β | 2010 | β |
| Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population. | Guella I et al. | β | 2010 | β |
| Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice. | Li RH et al. | β | 2010 | β |
| Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. | Johansen CT et al. | β | 2010 | β |
| Fenofibrate and metabolic syndrome. | Kraja AT et al. | β | 2010 | β |
| Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. | Keebler ME et al. | β | 2010 | β |
| From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. | Musunuru K et al. | β | 2010 | β |
| GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? | MohΓ‘s M et al. | β | 2010 | β |
| Genetic causes of high and low serum HDL-cholesterol. | Weissglas-Volkov D et al. | β | 2010 | β |
| Genetic causes of myocardial infarction: new insights from genome-wide association studies. | Erdmann J et al. | β | 2010 | β |
| Genetic determinants of major blood lipids in Pakistanis compared with Europeans. | Saleheen D et al. | β | 2010 | β |
| Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. | Okser S et al. | β | 2010 | β |
| Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey. | Chang MH et al. | β | 2010 | β |
| Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians. | Bhanushali AA et al. | β | 2010 | β |
| Genetic variants influencing circulating lipid levels and risk of coronary artery disease. | Waterworth DM et al. | β | 2010 | β |
| Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. | Chen W et al. | β | 2010 | β |
| Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility. | Vergeer M et al. | β | 2010 | β |
| Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos. | Voruganti VS et al. | β | 2010 | β |
| Genome3D: a viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional genome. | Asbury TM et al. | β | 2010 | β |
| Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data. | Ma L et al. | β | 2010 | β |
| Genome-wide association of lipid-lowering response to statins in combined study populations. | Barber MJ et al. | β | 2010 | β |
| Genome-wide association scan of trait depression. | Terracciano A et al. | β | 2010 | β |
| Genome-wide association studies identify new targets in cardiovascular disease. | Calkin AC et al. | β | 2010 | β |
| Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. | Suchindran S et al. | β | 2010 | β |
| Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene. | Kapur K et al. | β | 2010 | β |
| Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. | Panagiotou OA et al. | β | 2010 | β |
| Genomic approaches to coronary artery disease. | Padmanabhan S et al. | β | 2010 | β |
| Genomics: Variations in blood lipids. | Shuldiner AR et al. | β | 2010 | β |
| High prevalence of diabetes and pre-diabetes in adults with Williams syndrome. | Pober BR et al. | β | 2010 | β |
| Identification and characterization of novel loss of function mutations in ATP-binding cassette transporter A1 in patients with low plasma high-density lipoprotein cholesterol. | Candini C et al. | β | 2010 | β |
| Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. | Brown RJ et al. | β | 2010 | β |
| Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT. | Vergeer M et al. | β | 2010 | β |
| Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study. | Juonala M et al. | β | 2010 | β |
| Linkage and association analyses identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families. | Wijsman EM et al. | β | 2010 | β |
| Localization of genes for V+LDL plasma cholesterol levels on two diets in the opossum Monodelphis domestica. | Kammerer CM et al. | β | 2010 | β |
| Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. | Smith EN et al. | β | 2010 | β |
| MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. | Li Y et al. | β | 2010 | β |
| METAL: fast and efficient meta-analysis of genomewide association scans. | Willer CJ et al. | β | 2010 | β |
| Minor allele C of chromosome 1p32 single nucleotide polymorphism rs11206510 confers risk of ischemic stroke in the Chinese Han population. | Xu C et al. | β | 2010 | β |
| Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. | Hersh CP et al. | β | 2010 | β |
| No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. | Marques-Vidal P et al. | β | 2010 | β |
| O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids. | Schjoldager KT et al. | β | 2010 | β |
| Patterns of linkage disequilibrium in different populations: implications and opportunities for lipid-associated loci identified from genome-wide association studies. | Teo YY et al. | β | 2010 | β |
| Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? | RuaΓ±o G et al. | β | 2010 | β |
| Regulation of hepatic ApoC3 expression by PGC-1Ξ² mediates hypolipidemic effect of nicotinic acid. | Hernandez C et al. | β | 2010 | β |
| Role of endothelial lipase in atherosclerosis. | Huang J et al. | β | 2010 | β |
| Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels. | Zhang Y et al. | β | 2010 | β |
| Sibship analysis of associations between SNP haplotypes and a continuous trait with application to mammographic density. | Stone J et al. | β | 2010 | β |
| Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. | Kjolby M et al. | β | 2010 | β |
| Strategies for identifying the genetic basis of dyslipidemia: genome-wide association studies vs. the resequencing of extremes. | Khor CC et al. | β | 2010 | β |
| Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis. | Pendergrass SA et al. | β | 2010 | β |
| The genetics of Alzheimer disease: back to the future. | Bertram L et al. | β | 2010 | β |
| The genetics of obesity and the metabolic syndrome. | Monda KL et al. | β | 2010 | β |
| The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis? | Vergeer M et al. | β | 2010 | β |
| The KIF6 collapse. | Topol EJ et al. | β | 2010 | β |
| Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned. | Maasz A et al. | β | 2010 | β |
| Translating genomic analyses into improved management of coronary artery disease. | Johansen CT et al. | β | 2010 | β |
| Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. | Burkhardt R et al. | β | 2010 | β |
| Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke. | PolgΓ‘r N et al. | β | 2010 | β |
| Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes. | Su Z et al. | β | 2010 | β |
| WWOX gene is associated with HDL cholesterol and triglyceride levels. | SΓ‘ez ME et al. | β | 2010 | β |