Parametric and nonparametric linkage analysis: a unified multipoint approach.
paper
Cited
Public
Unavailable
- Authors
- Kruglyak, L; Daly, M J; Reeve-Daly, M P; Lander, E S
- Year
- 1996
- Journal
- American journal of human genetics
- PMID
- 8651312
- PMCID
- PMC1915045
In complex disease studies, it is crucial to perform multipoint linkage analysis with many markers and to use robust nonparametric methods that take account of all pedigree information. Currently available methods fall short in both regards. In this paper, we describe how to extract complete multipoint inheritance information from general pedigrees of moderate size. This information is captured in the multipoint inheritance distribution, which provides a framework for a unified approach to both parametric and nonparametric methods of linkage analysis. Specifically, the approach includes the following: (1) Rapid exact computation of multipoint LOD scores involving dozens of highly polymorphic markers, even in the presence of loops and missing data. (2) Non-parametric linkage (NPL) analysis, a powerful new approach to pedigree analysis. We show that NPL is robust to uncertainty about mode of inheritance, is much more powerful than commonly used nonparametric methods, and loses little power relative to parametric linkage analysis. NPL thus appears to be the method of choice for pedigree studies of complex traits. (3) Information-content mapping, which measures the fraction of the total inheritance information extracted by the available marker data and points out the regions in which typing additional markers is most useful. (4) Maximum-likelihood reconstruction of many-marker haplotypes, even in pedigrees with missing data. We have implemented NPL analysis, LOD-score computation, information-content mapping, and haplotype reconstruction in a new computer package, GENEHUNTER. The package allows efficient multipoint analysis of pedigree data to be performed rapidly in a single user-friendly environment.
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| Homozygosity mapping with SNP arrays confirms 3p21 as a recessive locus for gray platelet syndrome and narrows the interval significantly. | Fabbro S et al. | β | 2011 | β |
| Identification of novel suggestive loci for high-grade myopia in Polish families. | Rydzanicz M et al. | β | 2011 | β |
| Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. | Liu W et al. | β | 2011 | β |
| Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set. | Yip WK et al. | β | 2011 | β |
| Identity by descent estimation with dense genome-wide genotype data. | Han L et al. | β | 2011 | β |
| Immunogenetics of ageing. | Naumova E et al. | β | 2011 | β |
| Integration of SNP genotyping confidence scores in IBD inference. | Markus B et al. | β | 2011 | β |
| KELVIN: a software package for rigorous measurement of statistical evidence in human genetics. | Vieland VJ et al. | β | 2011 | β |
| Linkage analysis. | Barrett JH et al. | β | 2011 | β |
| Linkage analysis in the next-generation sequencing era. | Bailey-Wilson JE et al. | β | 2011 | β |
| Linkage and association on 8p21.2-p21.1 in schizophrenia. | Fallin MD et al. | β | 2011 | β |
| Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome). | Roberts A et al. | β | 2011 | β |
| Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. | KΓΆnig IR et al. | β | 2011 | β |
| No evidence for a role of CRISPLD2 in non-syndromic cleft lip with or without cleft palate in an Italian population. | Girardi A et al. | β | 2011 | β |
| Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism. | Stefan M et al. | β | 2011 | β |
| PSEUDOMARKER: a powerful program for joint linkage and/or linkage disequilibrium analysis on mixtures of singletons and related individuals. | Hiekkalinna T et al. | β | 2011 | β |
| Reducing the exome search space for mendelian diseases using genetic linkage analysis of exome genotypes. | Smith KR et al. | β | 2011 | β |
| SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations. | Matsson H et al. | β | 2011 | β |
| Statistical Analysis in Genetic Studies of Mental Illnesses. | Zhang H | β | 2011 | β |
| Study of the 12q13 region in nonsyndromic cleft lip with or without cleft palate. | Martinelli M et al. | β | 2011 | β |
| The identification of a novel locus for mandibular prognathism in the Han Chinese population. | Li Q et al. | β | 2011 | β |
| The interferon regulatory factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype. | Dawidowicz K et al. | β | 2011 | β |
| The Maximum-Likelihood-Binomial method revisited: a robust approach for model-free linkage analysis of quantitative traits in large sibships. | Cobat A et al. | β | 2011 | β |
| The structure of genetic linkage data: from LIPED to 1M SNPs. | Thompson E | β | 2011 | β |
| Unifying ideas for non-parametric linkage analysis. | Day-Williams AG et al. | β | 2011 | β |
| Validity and power of association testing in family-based sampling designs: evidence for and against the common wisdom. | Knight S et al. | β | 2011 | β |
| Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. | FlΓΌck CE et al. | β | 2011 | β |
| Accounting for disease model uncertainty in mapping heterogeneous traits--a Bayesian model averaging approach. | Biswas S et al. | β | 2010 | β |
| A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1. | Marques-Pinheiro A et al. | β | 2010 | β |
| A likelihood-based trait-model-free approach for linkage detection of binary trait. | Basu S et al. | β | 2010 | β |
| Allele-sharing statistics using information on family history. | Callegaro A et al. | β | 2010 | β |
| A locus for an auditory processing deficit and language impairment in an extended pedigree maps to 12p13.31-q14.3. | Addis L et al. | β | 2010 | β |
| A locus for juvenile myoclonic epilepsy maps to 2q33-q36. | Ratnapriya R et al. | β | 2010 | β |
| Analysis of genetic inheritance in a family quartet by whole-genome sequencing. | Roach JC et al. | β | 2010 | β |
| A new susceptibility locus for bipolar affective disorder in PAR1 on Xp22.3/Yp11.3. | Flaquer A et al. | β | 2010 | β |
| A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians. | Liu W et al. | β | 2010 | β |
| Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case-control study of schizophrenia (ICCSS). | Thiselton DL et al. | β | 2010 | β |
| Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort. | Krischek B et al. | β | 2010 | β |
| A visual migraine aura locus maps to 9q21-q22. | Tikka-Kleemola P et al. | β | 2010 | β |
| Bayesian linkage analysis of categorical traits for arbitrary pedigree designs. | Brisbin A et al. | β | 2010 | β |
| Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. | Otto EA et al. | β | 2010 | β |
| Clinical characterization and genetic analysis of a possible novel type of dominant Charcot-Marie-Tooth disease. | Lee YC et al. | β | 2010 | β |
| Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer. | Neklason DW et al. | β | 2010 | β |
| Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. | Hashikata H et al. | β | 2010 | β |
| Designs for linkage analysis and association studies of complex diseases. | Cui Y et al. | β | 2010 | β |
| Distribution of model-based multipoint heterogeneity lod scores. | Xing C et al. | β | 2010 | β |
| Dominant spinal muscular atrophy with lower extremity predominance: linkage to 14q32. | Harms MB et al. | β | 2010 | β |
| Efficient genome ancestry inference in complex pedigrees with inbreeding. | Liu EY et al. | β | 2010 | β |
| Efficient identification of identical-by-descent status in pedigrees with many untyped individuals. | Li X et al. | β | 2010 | β |
| Estimating genome-wide IBD sharing from SNP data via an efficient hidden Markov model of LD with application to gene mapping. | Bercovici S et al. | β | 2010 | β |
| European collaborative study of early-onset bipolar disorder: Evidence for genetic heterogeneity on 2q14 according to age at onset. | Mathieu F et al. | β | 2010 | β |
| Fragmented coronoid process in the dog: a heritable disease. | Temwichitr J et al. | β | 2010 | β |
| Genetics of complex disorders. | Kere J | β | 2010 | β |
| Genome scan for locus involved in mandibular prognathism in pedigrees from China. | Li Q et al. | β | 2010 | β |
| Haplotype association analyses in resources of mixed structure using Monte Carlo testing. | Abo R et al. | β | 2010 | β |
| Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China. | Shi XW et al. | β | 2010 | β |
| High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. | Boyden SE et al. | β | 2010 | β |
| Identification of candidate genes for dyslexia susceptibility on chromosome 18. | Scerri TS et al. | β | 2010 | β |
| Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population. | Palo OM et al. | β | 2010 | β |
| Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. | Cirak S et al. | β | 2010 | β |
| MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. | Li Y et al. | β | 2010 | β |
| Mapping of a new locus for congenital anomalies of the kidney and urinary tract on chromosome 8q24. | Ashraf S et al. | β | 2010 | β |
| MQScore_SNP software for multipoint parametric linkage analysis of quantitative traits in large pedigrees. | Axenovich TI et al. | β | 2010 | β |
| Mutations in C16orf57 and normal-length telomeres unify a subset of patients with dyskeratosis congenita, poikiloderma with neutropenia and Rothmund-Thomson syndrome. | Walne AJ et al. | β | 2010 | β |
| Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss. | Li Y et al. | β | 2010 | β |
| Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. | LandourΓ© G et al. | β | 2010 | β |
| Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. | Gurnett CA et al. | β | 2010 | β |
| Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. | Lin MW et al. | β | 2010 | β |
| Novel loci interacting epistatically with bone morphogenetic protein receptor 2 cause familial pulmonary arterial hypertension. | Rodriguez-Murillo L et al. | β | 2010 | β |
| Overview of linkage analysis in complex traits. | Bush WS et al. | β | 2010 | β |
| Pleiotropic effects of the 11p13 locus on developmental verbal dyspraxia and EEG centrotemporal sharp waves. | Pal DK et al. | β | 2010 | β |
| Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans. | Au AC et al. | β | 2010 | β |
| Rapid haplotype inference for nuclear families. | Williams AL et al. | β | 2010 | β |
| Recurrent and private MYO15A mutations are associated with deafness in the Turkish population. | Cengiz FB et al. | β | 2010 | β |
| Robust age at onset linkage analysis in nuclear families. | Callegaro A et al. | β | 2010 | β |
| Statistical analysis strategies for association studies involving rare variants. | Bansal V et al. | β | 2010 | β |
| Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling. | Li Y et al. | β | 2010 | β |
| Variance-components methods for linkage and association analysis of ordinal traits in general pedigrees. | Diao G et al. | β | 2010 | β |
| Whole-genome scan identifies quantitative trait loci for chronic pastern dermatitis in German draft horses. | Mittmann EH et al. | β | 2010 | β |
| A founder TMIE mutation is a frequent cause of hearing loss in southeastern Anatolia. | Sirmaci A et al. | β | 2009 | β |
| A genome screen of 35 bipolar affective disorder pedigrees provides significant evidence for a susceptibility locus on chromosome 15q25-26. | McAuley EZ et al. | β | 2009 | β |
| A genome-wide scan for the Sasang constitution in a Korean family suggests significant linkage at chromosomes 8q11.22-23 and 11q22.1-3. | Won HH et al. | β | 2009 | β |
| A kinship-based modification of the armitage trend test to address hidden population structure and small differential genotyping errors. | Rakovski CS et al. | β | 2009 | β |
| A locus for autosomal dominant reflex epilepsy precipitated by hot water maps at chromosome 10q21.3-q22.3. | Ratnapriya R et al. | β | 2009 | β |
| A multiple splitting approach to linkage analysis in large pedigrees identifies a linkage to asthma on chromosome 12. | Bellenguez C et al. | β | 2009 | β |
| [A new gene locus for an autosomal-dominant non-syndromic hearing impairment (DFNA 33) is situated on chromosome 13q34-qter]. | BΓΆnsch D et al. | β | 2009 | β |
| A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2-q12.3. | Chatterjee A et al. | β | 2009 | β |
| A novel locus for adolescent idiopathic scoliosis on chromosome 12p. | Raggio CL et al. | β | 2009 | β |
| A novel SIX3 mutation segregates with holoprosencephaly in a large family. | Solomon BD et al. | β | 2009 | β |
| A novel VPS13B mutation in two brothers with Cohen syndrome, cutis verticis gyrata and sensorineural deafness. | MΓ©garbanΓ© A et al. | β | 2009 | β |
| Application of homozygosity haplotype analysis to genetic mapping with high-density SNP genotype data. | Jiang H et al. | β | 2009 | β |
| A QTL on 12q influencing an inflammation marker and obesity in white women: the NHLBI Family Heart Study. | Wu J et al. | β | 2009 | β |
| Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. | Hodges LM et al. | β | 2009 | β |
| Association between genotypes and phenotypes in coeliac disease. | GudjΓ³nsdΓ³ttir AH et al. | β | 2009 | β |
| Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. | Kainu K et al. | β | 2009 | β |
| A susceptibility locus for papillary thyroid carcinoma on chromosome 8q24. | He H et al. | β | 2009 | β |
| Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. | Villano MJ et al. | β | 2009 | β |
| A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes. | Epstein MP et al. | β | 2009 | β |
| Bayesian latent trait modeling of migraine symptom data. | Chen CC et al. | β | 2009 | β |
| CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait. | TΓΌrkmen S et al. | β | 2009 | β |
| Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4). | Strug LJ et al. | β | 2009 | β |
| Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. | Laurin N et al. | β | 2009 | β |
| Collagen type III alpha I is a gastro-oesophageal reflux disease susceptibility gene and a male risk factor for hiatus hernia. | Asling B et al. | β | 2009 | β |
| Conditional tests for localizing trait genes. | Di Y et al. | β | 2009 | β |
| Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage. | Stanford JL et al. | β | 2009 | β |
| Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2. | Dathe K et al. | β | 2009 | β |
| Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease. | Wang K et al. | β | 2009 | β |
| Familial autosomal dominant reflex epilepsy triggered by hot water maps to 4q24-q28. | Ratnapriya R et al. | β | 2009 | β |
| Familial dyskinesia and facial myokymia (FDFM): Follow-up of a large family and linkage to chromosome 3p21-3q21. | Raskind WH et al. | β | 2009 | β |
| Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study. | Shi G et al. | β | 2009 | β |
| Genetic epidemiology of complex phenotypes. | Peddle L et al. | β | 2009 | β |
| Genetic linkage localizes an adolescent idiopathic scoliosis and pectus excavatum gene to chromosome 18 q. | Gurnett CA et al. | β | 2009 | β |
| Genetic mapping of the belt pattern in Brown Swiss cattle to BTA3. | DrΓΆgemΓΌller C et al. | β | 2009 | β |
| Genetic markers for idiopathic scoliosis in arab population: a pilot study. | Al-Omran AS et al. | β | 2009 | β |
| Genome scan in sibling pairs with juvenile-onset mood disorders: Evidence for linkage to 13q and Xq. | Wigg K et al. | β | 2009 | β |
| Genome screen in familial intracranial aneurysm. | Foroud T et al. | β | 2009 | β |
| Genome-wide scan of African-American and white families for linkage to myopia. | Ciner E et al. | β | 2009 | β |
| Genotype imputation. | Li Y et al. | β | 2009 | β |
| Genotype-phenotype relationship of F7 R353Q polymorphism and plasma factor VII coagulant activity in Asian Indian families predisposed to coronary artery disease. | Shanker J et al. | β | 2009 | β |
| Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy. | Cho K et al. | β | 2009 | β |
| Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. | Alders M et al. | β | 2009 | β |
| Haplotyping methods for pedigrees. | Gao G et al. | β | 2009 | β |
| HomozygosityMapper--an interactive approach to homozygosity mapping. | Seelow D et al. | β | 2009 | β |
| Hypomorphic mutations in meckelin (MKS3/TMEM67) cause nephronophthisis with liver fibrosis (NPHP11). | Otto EA et al. | β | 2009 | β |
| Identification of a new quantitative trait locus on equine chromosome 18 responsible for osteochondrosis in Hanoverian warmblood horses. | Lampe V et al. | β | 2009 | β |
| Investigation of parent-of-origin effect in comitant strabismus using MOD score analysis. | Shaaban S et al. | β | 2009 | β |
| Linkage analysis of candidate genes in families with vesicoureteral reflux. | Kelly H et al. | β | 2009 | β |
| Linkage analysis with dense SNP maps in isolated populations. | Bellenguez C et al. | β | 2009 | β |
| Linkage and association study of FcgammaR polymorphisms in celiac disease. | Sareneva I et al. | β | 2009 | β |
| Linkage and heritability analysis of migraine symptom groupings: a comparison of three different clustering methods on twin data. | Chen CC et al. | β | 2009 | β |
| Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations. | Bruce HA et al. | β | 2009 | β |
| Maternal fumonisin exposure as a risk factor for neural tube defects. | Gelineau-van Waes J et al. | β | 2009 | β |
| Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results. | Dorfman R et al. | β | 2009 | β |
| Molecular genetics of human myopia: an update. | Young TL | β | 2009 | β |
| Most parsimonious haplotype allele sharing determination. | Cai Z et al. | β | 2009 | β |
| Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. | Wu XL et al. | β | 2009 | β |
| Mutations in PYCR1 cause cutis laxa with progeroid features. | Reversade B et al. | β | 2009 | β |
| Novel EXT1 and EXT2 mutations in hereditary multiple exostoses families of Indian origin. | Vanita V et al. | β | 2009 | β |
| Novel mutation in the gamma-S crystallin gene causing autosomal dominant cataract. | Vanita V et al. | β | 2009 | β |
| PedStr software for cutting large pedigrees for haplotyping, IBD computation and multipoint linkage analysis. | Kirichenko AV et al. | β | 2009 | β |
| Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. | Beetz N et al. | β | 2009 | β |
| Refinement of a quantitative gene locus on equine chromosome 16 responsible for osteochondrosis in Hanoverian warmblood horses. | Lampe V et al. | β | 2009 | β |
| Score test for age at onset genetic linkage analysis in selected sibling pairs. | Callegaro A et al. | β | 2009 | β |
| Speeding up HMM algorithms for genetic linkage analysis via chain reductions of the state space. | Geiger D et al. | β | 2009 | β |
| Statistical genetic approaches for mapping ophthalmic trait and disease genes. | Sinsheimer J | β | 2009 | β |
| Suggestive linkage at 9p22 in bipolar disorder weighted by alcohol abuse. | Saunders EF et al. | β | 2009 | β |
| Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study. | Teixeira VH et al. | β | 2009 | β |
| The scurs inheritance: new insights from the French Charolais breed. | Capitan A et al. | β | 2009 | β |
| TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort. | ThiΓ©baut R et al. | β | 2009 | β |
| Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. | Thomas NJ et al. | β | 2009 | β |
| Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study. | Houwing-Duistermaat JJ et al. | β | 2009 | β |
| Whole-genome scan for guttural pouch tympany in Arabian and German warmblood horses. | Zeitz A et al. | β | 2009 | β |
| A Generalized Caprine-like Hypoplasia Syndrome is localized within a 6-cM interval on bovine chromosome 13 in the MontbΓ©liarde breed. | Duchesne A et al. | β | 2008 | β |
| A general method for linkage disequilibrium correction for multipoint linkage and association. | Kurbasic A et al. | β | 2008 | β |
| A genome search for primary vesicoureteral reflux shows further evidence for genetic heterogeneity. | Conte ML et al. | β | 2008 | β |
| A genome-wide scan suggests a susceptibility locus on 5p 13 for nasopharyngeal carcinoma. | Hu LF et al. | β | 2008 | β |
| A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q. | Pinto JM et al. | β | 2008 | β |
| A genome-wide screen for hyposmia susceptibility Loci. | Pinto JM et al. | β | 2008 | β |
| A genomic imprinting test for ordinal traits in pedigree data. | Feng R et al. | β | 2008 | β |
| A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative. | Dickson MR et al. | β | 2008 | β |
| A missense mutation in ALDH18A1, encoding Delta1-pyrroline-5-carboxylate synthase (P5CS), causes an autosomal recessive neurocutaneous syndrome. | Bicknell LS et al. | β | 2008 | β |
| An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene. | Ramoz N et al. | β | 2008 | β |
| An approach for cutting large and complex pedigrees for linkage analysis. | Liu F et al. | β | 2008 | β |
| A new candidate locus for bilateral perisylvian polymicrogyria mapped on chromosome Xq27. | Santos NF et al. | β | 2008 | β |
| [A new locus for an autosomal dominant, non-syndromic hearing impairment (DFNA57) located on chromosome 19p13.2 and overlapping with DFNB15]. | BΓΆnsch D et al. | β | 2008 | β |
| An idiopathic epilepsy syndrome linked to 3q13.3-q21 and missense mutations in the extracellular calcium sensing receptor gene. | Kapoor A et al. | β | 2008 | β |
| A novel locus for dilated cardiomyopathy maps to canine chromosome 8. | Werner P et al. | β | 2008 | β |
| A parallel genetic algorithm to discover patterns in genetic markers that indicate predisposition to multifactorial disease. | Rausch T et al. | β | 2008 | β |
| A score test for linkage analysis of ordinal traits based on IBD sharing. | Feng R et al. | β | 2008 | β |
| A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy. | D'Alfonso S et al. | β | 2008 | β |
| Association of LY9 in UK and Canadian SLE families. | Cunninghame Graham DS et al. | β | 2008 | β |
| Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families. | Adamovic S et al. | β | 2008 | β |
| A survey on haplotyping algorithms for tightly linked markers. | Li J et al. | β | 2008 | β |
| Asymmetric lower-limb malformations in individuals with homeobox PITX1 gene mutation. | Gurnett CA et al. | β | 2008 | β |
| A unified discussion on the concept of score functions used in the context of nonparametric linkage analysis. | Angquist L | β | 2008 | β |
| Autosomal dominant moyamoya disease maps to chromosome 17q25.3. | Mineharu Y et al. | β | 2008 | β |
| Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass. | Zhao J et al. | β | 2008 | β |
| Breaking loops in large complex pedigrees. | Axenovich TI et al. | β | 2008 | β |
| Calculation of IBD probabilities with dense SNP or sequence data. | Keith JM et al. | β | 2008 | β |
| CANDID: a flexible method for prioritizing candidate genes for complex human traits. | Hutz JE et al. | β | 2008 | β |
| Characteristics of a spina bifida population including North American Caucasian and Hispanic individuals. | Au KS et al. | β | 2008 | β |
| Clinical and genetic correlates of soluble P-selectin in the community. | Lee DS et al. | β | 2008 | β |
| Clinical and genetic investigation of atrial septal defect with atrioventricular conduction defect in a large consanguineous Tunisian family. | Nouira S et al. | β | 2008 | β |
| Computation of the posterior probability of linkage using 'high effect' genetic model priors. | Logue MW et al. | β | 2008 | β |
| Consistently replicating locus linked to migraine on 10q22-q23. | Anttila V et al. | β | 2008 | β |
| Design considerations in a sib-pair study of linkage for susceptibility loci in cancer. | Kerber RA et al. | β | 2008 | β |
| EM-random forest and new measures of variable importance for multi-locus quantitative trait linkage analysis. | Lee SS et al. | β | 2008 | β |
| Evidence for a novel x-linked modifier locus for leber hereditary optic neuropathy. | Shankar SP et al. | β | 2008 | β |
| Evidence for linkage of a new region (11p14) to eczema and allergic diseases. | Guilloud-Bataille M et al. | β | 2008 | β |
| Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci? | Lohmann-Hedrich K et al. | β | 2008 | β |
| Exact trait-model-free tests for linkage detection in pedigrees. | Basu S et al. | β | 2008 | β |
| Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data. | Kim Y et al. | β | 2008 | β |
| Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. | Ehlers CL et al. | β | 2008 | β |
| Familial pure paroxysmal kinesigenic dyskinesia in Han population from the Chinese mainland: a new subtype? | Zhou J et al. | β | 2008 | β |
| Female-specific association of C-C chemokine receptor 5 gene polymorphisms with LΓΆfgren's syndrome. | Fischer A et al. | β | 2008 | β |
| Fine mapping of a locus for nonsyndromic mental retardation on chromosome 19p13. | Nolan DK et al. | β | 2008 | β |
| Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. | Johanneson B et al. | β | 2008 | β |
| Follow-up analysis of 180 Chinese Han families: identification of a novel locus for psoriasis at 2p22.3-11.2. | Sun LD et al. | β | 2008 | β |
| Further evidence for a susceptibility locus contributing to reading disability on chromosome 15q15-q21. | Schumacher J et al. | β | 2008 | β |
| Genes to diseases (G2D) computational method to identify asthma candidate genes. | Tremblay K et al. | β | 2008 | β |
| Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. | BilusiΔ M et al. | β | 2008 | β |
| Genetic and genomic discovery using family studies. | Borecki IB et al. | β | 2008 | β |
| Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment. | Falcaro M et al. | β | 2008 | β |
| Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network. | Iossifov I et al. | β | 2008 | β |
| Genetic loci linked to type 1 diabetes and multiple sclerosis families in Sardinia. | Pitzalis M et al. | β | 2008 | β |
| Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. | Shanker J et al. | β | 2008 | β |
| Genome scan of M. tuberculosis infection and disease in Ugandans. | Stein CM et al. | β | 2008 | β |
| Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. | Foroud T et al. | β | 2008 | β |
| Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. | Uda M et al. | β | 2008 | β |
| Genome-wide linkage analysis and mutation analysis of hereditary congenital blepharoptosis in a Japanese family. | Nakashima M et al. | β | 2008 | β |
| Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12. | Romanos M et al. | β | 2008 | β |
| Genomewide linkage in a large Dutch family with intracranial aneurysms: replication of 2 loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32. | Ruigrok YM et al. | β | 2008 | β |
| Genome-wide linkage scan in Dutch hereditary non-BRCA1/2 breast cancer families identifies 9q21-22 as a putative breast cancer susceptibility locus. | Oldenburg RA et al. | β | 2008 | β |
| Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. | GayΓ‘n J et al. | β | 2008 | β |
| Genomewide linkage survey of nicotine dependence phenotypes. | Sullivan PF et al. | β | 2008 | β |
| Genome-wide scan in 124 Indonesian sib-pair families with schizophrenia reveals genome-wide significant linkage to a locus on chromosome 3p26-21. | Irmansyah et al. | β | 2008 | β |
| Haplotype-association analysis. | Liu N et al. | β | 2008 | β |
| Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population. | Engert JC et al. | β | 2008 | β |
| Identification of a major locus for Paget's disease on chromosome 10p13 in families of British descent. | Lucas GJ et al. | β | 2008 | β |
| Identification of novel mutations in X-linked retinitis pigmentosa families and implications for diagnostic testing. | Neidhardt J et al. | β | 2008 | β |
| Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. | Daley D et al. | β | 2008 | β |
| Identity-by-descent estimation and mapping of qualitative traits in large, complex pedigrees. | Abney M | β | 2008 | β |
| Inferential testing for linkage with GENEHUNTER-MODSCORE: the impact of the pedigree structure on the null distribution of multipoint MOD scores. | Mattheisen M et al. | β | 2008 | β |
| Influence of genotyping error in linkage mapping for complex traits--an analytic study. | Lebrec JJ et al. | β | 2008 | β |
| Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. | Huber A et al. | β | 2008 | β |
| Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. | Dudbridge F | β | 2008 | β |
| Linkage analysis of high myopia susceptibility locus in 26 families. | Paget S et al. | β | 2008 | β |
| 'Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease. | Ban Y et al. | β | 2008 | β |
| Linkage and association: basic concepts. | Borecki IB et al. | β | 2008 | β |
| Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia. | Chowdari KV et al. | β | 2008 | β |
| Linkage of bilateral convergent strabismus with exophthalmus (BCSE) to BTA5 and BTA18 in German Brown cattle. | MΓΆmke S et al. | β | 2008 | β |
| LINKGEN: a new algorithm to process data in genetic linkage studies. | Secolin R et al. | β | 2008 | β |
| Locus homogeneity between syndactyly type 1A and craniosynostosis Philadelphia type? | Jain M et al. | β | 2008 | β |
| LOT: a tool for linkage analysis of ordinal traits for pedigree data. | Zhang M et al. | β | 2008 | β |
| Mapping quantitative trait Loci for left-sided displacement of the abomasum in German Holstein dairy cows. | MΓΆmke S et al. | β | 2008 | β |
| Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis. | Presson AP et al. | β | 2008 | β |
| Meta-analysis methods. | Trikalinos TA et al. | β | 2008 | β |
| Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium. | Guan W et al. | β | 2008 | β |
| Mixed effects models for quantitative trait loci mapping with inbred strains. | Bauman LE et al. | β | 2008 | β |
| Molecular diagnostics in autosomal dominant polycystic kidney disease: utility and limitations. | Zhao X et al. | β | 2008 | β |
| Multipoint approximations of identity-by-descent probabilities for accurate linkage analysis of distantly related individuals. | Albers CA et al. | β | 2008 | β |
| Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. | Kuhl A et al. | β | 2008 | β |
| Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association. | Koskinen LL et al. | β | 2008 | β |
| Neuropathy target esterase gene mutations cause motor neuron disease. | Rainier S et al. | β | 2008 | β |
| Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. | Cunninghame Graham DS et al. | β | 2008 | β |
| Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. | Engelmark MT et al. | β | 2008 | β |
| Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls. | Gorman CL et al. | β | 2008 | β |
| Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16. | Wassink TH et al. | β | 2008 | β |
| Primary ciliary dyskinesia associated with normal axoneme ultrastructure is caused by DNAH11 mutations. | Schwabe GC et al. | β | 2008 | β |
| QTL for the heritable inverted teat defect in pigs. | Jonas E et al. | β | 2008 | β |
| QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study. | Kraja AT et al. | β | 2008 | β |
| Reconstructing the genealogy of a BRCA1 founder mutation by phylogenetic analysis. | Marroni F et al. | β | 2008 | β |
| Searching for epistasis and linkage heterogeneity by correlations of pedigree-specific linkage scores. | Schaid DJ et al. | β | 2008 | β |
| Strategies for conditional two-locus nonparametric linkage analysis. | Angquist L et al. | β | 2008 | β |
| Study of Toll-like receptor gene loci in sarcoidosis. | SchΓΌrmann M et al. | β | 2008 | β |
| The power of two-locus affected sib-pair linkage analysis to detect interacting disease loci. | HallgrΓmsdΓ³ttir IB et al. | β | 2008 | β |
| Thyroglobulin polymorphisms in Tunisian patients with autoimmune thyroid diseases (AITD). | Belguith-Maalej S et al. | β | 2008 | β |
| TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. | Savage SA et al. | β | 2008 | β |
| tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. | Budde BS et al. | β | 2008 | β |
| Variation in WNT7A is unlikely to be a cause of familial congenital talipes equinovarus. | Liu G et al. | β | 2008 | β |
| Viruses associated with human cancer. | McLaughlin-Drubin ME et al. | β | 2008 | β |
| A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. | Schulz F et al. | β | 2007 | β |
| Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29. | Schosser A et al. | β | 2007 | β |
| A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? | Chow E et al. | β | 2007 | β |
| A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12. | Onouchi Y et al. | β | 2007 | β |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | β | 2007 | β |
| A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland. | Qiao Q et al. | β | 2007 | β |
| A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. | Liu F et al. | β | 2007 | β |
| A hierarchical model for estimating significance levels of non-parametric linkage statistics for large pedigrees. | Brock GN et al. | β | 2007 | β |
| A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. | Sellick GS et al. | β | 2007 | β |
| Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients. | Rubio JP et al. | β | 2007 | β |
| A new locus for autosomal recessive non-syndromic mental retardation maps to 1p21.1-p13.3. | Uyguner O et al. | β | 2007 | β |
| A new method for haplotype inference including full-sib information. | Ding XD et al. | β | 2007 | β |
| An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus. | DeLuca GC et al. | β | 2007 | β |
| A novel genetic locus for juvenile myoclonic epilepsy at chromosome 5q12-q14. | Kapoor A et al. | β | 2007 | β |
| A novel LEMD3 mutation common to patients with osteopoikilosis with and without melorheostosis. | Couto AR et al. | β | 2007 | β |
| A novel locus for syndromic chronic idiopathic intestinal pseudo-obstruction maps to chromosome 8q23-q24. | Deglincerti A et al. | β | 2007 | β |
| A novel X-linked recessive form of Mendelian susceptibility to mycobaterial disease. | Bustamante J et al. | β | 2007 | β |
| A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer. | Middeldorp A et al. | β | 2007 | β |
| Association analyses of NCR3 polymorphisms with P. falciparum mild malaria. | Delahaye NF et al. | β | 2007 | β |
| Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus. | Wu H et al. | β | 2007 | β |
| Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation. | Cunninghame Graham DS et al. | β | 2007 | β |
| Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. | Dickel DE et al. | β | 2007 | β |
| Autosomal dominant nonsyndromic cleft lip and palate: significant evidence of linkage at 18q21.1. | Beiraghi S et al. | β | 2007 | β |
| Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16. | Jones I et al. | β | 2007 | β |
| CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. | Gao X et al. | β | 2007 | β |
| Combination of linkage and association studies for brain arteriovenous malformation. | Inoue S et al. | β | 2007 | β |
| Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics. | Camp NJ et al. | β | 2007 | β |
| Comprehensive multi-stage linkage analyses identify a locus for adult height on chromosome 3p in a healthy Caucasian population. | Ellis JA et al. | β | 2007 | β |
| Confirmation of psoriasis susceptibility loci on chromosome 6p21 and 20p13 in French families. | Lesueur F et al. | β | 2007 | β |
| CRISPLD2: a novel NSCLP candidate gene. | Chiquet BT et al. | β | 2007 | β |
| Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1. | Crisponi L et al. | β | 2007 | β |
| Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis method. | Forabosco P et al. | β | 2007 | β |
| Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis. | Tomer Y et al. | β | 2007 | β |
| Effect of linkage disequilibrium between markers in linkage and association analyses. | Dupuis J et al. | β | 2007 | β |
| Evidence for a novel psoriasis susceptibility locus at 9q33-9q34 in Chinese Hans. | Sun LD et al. | β | 2007 | β |
| Evidence for two schizophrenia susceptibility genes on chromosome 22q13. | Condra JA et al. | β | 2007 | β |
| Evidence for two susceptibility loci on chromosomes 22q12 and 6p21-p22 in Chinese generalized vitiligo families. | Liang Y et al. | β | 2007 | β |
| Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations. | Martin LJ et al. | β | 2007 | β |
| Evidence of genetic effects on blood lead concentration. | Whitfield JB et al. | β | 2007 | β |
| Evidence of linkage to chromosome 1 for early age of onset of rheumatoid arthritis and HLA marker DRB1 genotype in NARAC data. | Xu W et al. | β | 2007 | β |
| Explorative two-locus linkage analysis suggests a multiplicative interaction between the 7q32 and 16p13 myoclonic seizures-related photosensitivity loci. | Pinto D et al. | β | 2007 | β |
| Exploring causality via identification of SNPs or haplotypes responsible for a linkage signal. | Biernacka JM et al. | β | 2007 | β |
| Follow-up analysis of PSORS9 in 151 Chinese families confirmed the linkage to 4q31-32 and refined the evidence to the families of early-onset psoriasis. | Yan KL et al. | β | 2007 | β |
| Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort. | Perry RT et al. | β | 2007 | β |
| Forward-time simulations of human populations with complex diseases. | Peng B et al. | β | 2007 | β |
| Gene by environment interactions. | Culverhouse RC et al. | β | 2007 | β |
| Gene mapping in asthma-related traits. | Laitinen T | β | 2007 | β |
| Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. | Walne AJ et al. | β | 2007 | β |
| Genetic heterogeneity of megaloblastic anaemia type 1 in Tunisian patients. | Bouchlaka C et al. | β | 2007 | β |
| Genetic studies of stuttering in a founder population. | Wittke-Thompson JK et al. | β | 2007 | β |
| Gene x Environment interactions in speech sound disorder predict language and preliteracy outcomes. | McGrath LM et al. | β | 2007 | β |
| Genome-wide linkage analysis of malaria infection intensity and mild disease. | Timmann C et al. | β | 2007 | β |
| Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study. | Bella JN et al. | β | 2007 | β |
| Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC). | Baffoe-Bonnie AB et al. | β | 2007 | β |
| Genomewide linkage scan for split-hand/foot malformation with long-bone deficiency in a large Arab family identifies two novel susceptibility loci on chromosomes 1q42.2-q43 and 6q14.1. | Naveed M et al. | β | 2007 | β |
| Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36. | Paterson AD et al. | β | 2007 | β |
| Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q. | Osterholm AM et al. | β | 2007 | β |
| Genome-wide scan of bipolar disorder and investigation of population stratification effects on linkage: support for susceptibility loci at 4q21, 7q36, 9p21, 12q24, 14q24, and 16p13. | Cassidy F et al. | β | 2007 | β |
| Genome-wide scan of bipolar II disorder. | Nwulia EA et al. | β | 2007 | β |
| Genome-wide scan supports the existence of a susceptibility locus for schizophrenia and bipolar disorder on chromosome 15q26. | Vazza G et al. | β | 2007 | β |
| Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses. | Dierks C et al. | β | 2007 | β |
| Genome-wide search for microsatellite markers associated with radiologic alterations in the navicular bone of Hanoverian warmblood horses. | Diesterbeck US et al. | β | 2007 | β |
| Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer. | Pierce BL et al. | β | 2007 | β |
| Genomic screen for substance dependence and body mass index in southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| Haplotype inference in general pedigrees using the cluster variation method. | Albers CA et al. | β | 2007 | β |
| Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome. | Thomas NJ et al. | β | 2007 | β |
| Incorporating covariates in mapping heterogeneous traits: a hierarchical model using empirical Bayes estimation. | Biswas S et al. | β | 2007 | β |
| Incorporating prior biological information in linkage studies increases power and limits multiple testing. | Lantieri F et al. | β | 2007 | β |
| Interpretation of simultaneous linkage and family-based association tests in genome screens. | Chung RH et al. | β | 2007 | β |
| Interrelationship and familiality of dyslexia related quantitative measures. | Schulte-KΓΆrne G et al. | β | 2007 | β |
| IRAK-M is involved in the pathogenesis of early-onset persistent asthma. | Balaci L et al. | β | 2007 | β |
| Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibships. | Hsu YH et al. | β | 2007 | β |
| Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience. | Ghosh S et al. | β | 2007 | β |
| Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE. | Dietter J et al. | β | 2007 | β |
| Linkage and association analysis of CACNG3 in childhood absence epilepsy. | Everett KV et al. | β | 2007 | β |
| Linkage and mutational analysis of CLCN2 in childhood absence epilepsy. | Everett K et al. | β | 2007 | β |
| Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. | Schneider G et al. | β | 2007 | β |
| Linkage of Graves' disease to the human leucocyte antigen region in the Chinese-Han population in Taiwan. | Chen PL et al. | β | 2007 | β |
| Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families. | Jang YL et al. | β | 2007 | β |
| Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux. | van Eerde AM et al. | β | 2007 | β |
| Linkage to CFA29 detected in a genome-wide linkage screen of a canine pedigree segregating Sry-negative XX sex reversal. | Pujar S et al. | β | 2007 | β |
| Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. | Xing C et al. | β | 2007 | β |
| Localization of white spotting locus in Boxer dogs on CFA20 by genome-wide linkage analysis with 1500 SNPs. | Leegwater PA et al. | β | 2007 | β |
| Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. | Goldberg YP et al. | β | 2007 | β |
| MCMC-based linkage analysis for complex traits on general pedigrees: multipoint analysis with a two-locus model and a polygenic component. | Sung YJ et al. | β | 2007 | β |
| Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm. | Mineharu Y et al. | β | 2007 | β |
| Modeling linkage disequilibrium in exact linkage computations: a comparison of first-order Markov approaches and the clustered-markers approach. | Albers CA et al. | β | 2007 | β |
| Multiple sclerosis susceptibility and the X chromosome. | Herrera BM et al. | β | 2007 | β |
| Multivariate linkage analysis of specific language impairment (SLI). | Monaco AP | β | 2007 | β |
| No evidence of linkage between 7q33-36 locus (OTSC2) and otosclerosis in seven British Caucasian pedigrees. | Alzoubi FQ et al. | β | 2007 | β |
| Non-B27 MHC associations of ankylosing spondylitis. | Sims AM et al. | β | 2007 | β |
| On the choice of linkage statistics. | Margaritte-Jeannin P et al. | β | 2007 | β |
| Optimal peeling order for pedigrees with incomplete genotypic information. | Belonogova NM et al. | β | 2007 | β |
| Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. | Otonkoski T et al. | β | 2007 | β |
| Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. | Shirts BH et al. | β | 2007 | β |
| PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton. | VilariΓ±o-GΓΌell C et al. | β | 2007 | β |
| Recessive congenital total cataract with microcornea and heterozygote carrier signs caused by a novel missense CRYAA mutation (R54C). | Khan AO et al. | β | 2007 | β |
| Regression-based multivariate linkage analysis with an application to blood pressure and body mass index. | Wang T et al. | β | 2007 | β |
| Sample size needed to detect gene-gene interactions using linkage analysis. | Wang S et al. | β | 2007 | β |
| Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. | Nikolova G et al. | β | 2007 | β |
| Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy. | Fanous AH et al. | β | 2007 | β |
| Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene. | Avramopoulos D et al. | β | 2007 | β |
| Suggestive genetic linkage to chromosome 11p11.2-q12.2 in hereditary prostate cancer families with primary kidney cancer. | Johanneson B et al. | β | 2007 | β |
| Testing association in the presence of linkage--a powerful score for binary traits. | Jonasdottir G et al. | β | 2007 | β |
| Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations. | Brown AM et al. | β | 2007 | β |
| The advantages of dense marker sets for linkage analysis with very large families. | Thomson R et al. | β | 2007 | β |
| The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. | Delous M et al. | β | 2007 | β |
| The elusive goal of pedigree weights. | Sengul H et al. | β | 2007 | β |
| The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus. | Hellquist A et al. | β | 2007 | β |
| The star-allele nomenclature: retooling for translational genomics. | Robarge JD et al. | β | 2007 | β |
| The use of grid computing to drive data-intensive genetic research. | Andrade J et al. | β | 2007 | β |
| Truncating mutation of the DFNB59 gene causes cochlear hearing impairment and central vestibular dysfunction. | Ebermann I et al. | β | 2007 | β |
| Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis. | SΓΆderhΓ€ll C et al. | β | 2007 | β |
| VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies. | Xie J et al. | β | 2007 | β |
| Y chromosome lineage- and village-specific genes on chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan. | Miller EN et al. | β | 2007 | β |
| 24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes. | Fava C et al. | β | 2006 | β |
| Accommodating chromosome inversions in linkage analysis. | Chen GK et al. | β | 2006 | β |
| Accurate haplotype inference for multiple linked single-nucleotide polymorphisms using sibship data. | Liu PY et al. | β | 2006 | β |
| A cholinergic receptor gene (CHRM2) affects event-related oscillations. | Jones KA et al. | β | 2006 | β |
| A comparison of methods for intermediate fine mapping. | Papachristou C et al. | β | 2006 | β |
| A comparison of several methods for haplotype frequency estimation and haplotype reconstruction for tightly linked markers from general pedigrees. | Zhang K et al. | β | 2006 | β |
| Advances in statistical human genetics over the last 25 years. | Elston RC et al. | β | 2006 | β |
| A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. | Jeanneteau F et al. | β | 2006 | β |
| A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba. | Marcheco-Teruel B et al. | β | 2006 | β |
| A genome wide linkage search for breast cancer susceptibility genes. | Smith P et al. | β | 2006 | β |
| A genome-wide screen for nicotine dependence susceptibility loci. | Swan GE et al. | β | 2006 | β |
| A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27. | Plancoulaine S et al. | β | 2006 | β |
| Analysis of chromosome 5q31-32 and psoriasis: confirmation of a susceptibility locus but no association with SNPs within SLC22A4 and SLC22A5. | Friberg C et al. | β | 2006 | β |
| Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16q. | SchΓ€ffer AA et al. | β | 2006 | β |
| An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults. | Baghdadi JE et al. | β | 2006 | β |
| An evaluation of the replicate pool method: quick estimation of genome-wide linkage peak p-values. | Wigginton JE et al. | β | 2006 | β |
| A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3. | Verlaan DJ et al. | β | 2006 | β |
| A new type of leukoencephalopathy with metaphyseal chondrodysplasia maps to Xq25-q27. | Neubauer BA et al. | β | 2006 | β |
| An integrated system for genetic analysis. | Fiddy S et al. | β | 2006 | β |
| An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians. | Bugeja MJ et al. | β | 2006 | β |
| An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. | Bugeja MJ et al. | β | 2006 | β |
| A novel framework for sib pair linkage analysis. | Poznik GD et al. | β | 2006 | β |
| A novel KCNQ4 one-base deletion in a large pedigree with hearing loss: implication for the genotype-phenotype correlation. | Kamada F et al. | β | 2006 | β |
| A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family. | Vanita V et al. | β | 2006 | β |
| A novel primary immunodeficiency with specific natural-killer cell deficiency maps to the centromeric region of chromosome 8. | Eidenschenk C et al. | β | 2006 | β |
| A population-based latent variable approach for association mapping of quantitative trait loci. | Wang T et al. | β | 2006 | β |
| A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. | Morley KI et al. | β | 2006 | β |
| A quantitative linkage score for an association study following a linkage analysis. | Wang T et al. | β | 2006 | β |
| A second locus for Aicardi-Goutieres syndrome at chromosome 13q14-21. | Ali M et al. | β | 2006 | β |
| Aspects of genetic susceptibility to human infectious diseases. | Hill AV | β | 2006 | β |
| Assessment of collagen genes involved in fragmented medial coronoid process development in Labrador Retrievers as determined by affected sibling-pair analysis. | Salg KG et al. | β | 2006 | β |
| A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci. | Fyer AJ et al. | β | 2006 | β |
| A tree-based model for allele-sharing-based linkage analysis in human complex diseases. | Xu W et al. | β | 2006 | β |
| A two-stage linkage analysis of Chinese schizophrenia pedigrees in 10 target chromosomes. | Zheng Y et al. | β | 2006 | β |
| A two-step procedure for constructing confidence intervals of trait loci with application to a rheumatoid arthritis dataset. | Papachristou C et al. | β | 2006 | β |
| Autosomal dominant early-onset cortical myoclonus, photic-induced myoclonus, and epilepsy in a large pedigree. | Gardella E et al. | β | 2006 | β |
| Characterization of a susceptibility locus for SLE, SLEB5, on chromosome 4p14-13. | Johansson CM et al. | β | 2006 | β |
| Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. | Frodsham AJ et al. | β | 2006 | β |
| Cognitive traits link to human chromosomal regions. | Buyske S et al. | β | 2006 | β |
| Comparison of methods incorporating quantitative covariates into affected sib pair linkage analysis. | Tsai HJ et al. | β | 2006 | β |
| Confirmation of the adult-onset primary open angle glaucoma locus GLC1B at 2cen-q13 in an Australian family. | Charlesworth JC et al. | β | 2006 | β |
| Constructing the parental linkage phase and the genetic map over distances <1 cM using pooled haploid DNA. | Gasbarra D et al. | β | 2006 | β |
| Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores. | Xing C et al. | β | 2006 | β |
| Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. | Li M et al. | β | 2006 | β |
| ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis. | Hodgson U et al. | β | 2006 | β |
| Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease. | Zheng W et al. | β | 2006 | β |
| Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. | Talkowski ME et al. | β | 2006 | β |
| Evaluation of CACNA1H in European patients with childhood absence epilepsy. | Chioza B et al. | β | 2006 | β |
| Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study. | Cunninghame Graham DS et al. | β | 2006 | β |
| Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. | Kenealy SJ et al. | β | 2006 | β |
| Familial isolated hyperparathyroidism is linked to a 1.7 Mb region on chromosome 2p13.3-14. | Warner JV et al. | β | 2006 | β |
| Family-based association study of TPH1 and TPH2 polymorphisms in autism. | Ramoz N et al. | β | 2006 | β |
| Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS. | Floros J et al. | β | 2006 | β |
| Finding cardiovascular disease genes in the dog. | Parker HG et al. | β | 2006 | β |
| Fine-mapping chromosome 20 in 230 systemic lupus erythematosus sib pair and multiplex families: evidence for genetic epistasis with chromosome 16q12. | Gaffney PM et al. | β | 2006 | β |
| FLOSS: flexible ordered subset analysis for linkage mapping of complex traits. | Browning BL | β | 2006 | β |
| Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's disease. | Bassett SS et al. | β | 2006 | β |
| Further evidence of the clinical and genetic heterogeneity of recessive transgressive PPK in the Mediterranean region. | Charfeddine C et al. | β | 2006 | β |
| Gene-dropping vs. empirical variance estimation for allele-sharing linkage statistics. | Jung J et al. | β | 2006 | β |
| Genetic analysis and functional evaluation of the C/T(-318) and A/G(-1661) polymorphisms of the CTLA-4 gene in patients affected with Graves' disease. | Chistiakov DA et al. | β | 2006 | β |
| Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci. | Bisceglia L et al. | β | 2006 | β |
| Genetic linkage and association analysis in type 1 von Willebrand disease: results from the Canadian type 1 VWD study. | James PD et al. | β | 2006 | β |
| Genetic linkage of human height is confirmed to 9q22 and Xq24. | Liu YZ et al. | β | 2006 | β |
| Genetic linkage study for bipolar disorders on chromosomes 17 and 18 in families with a high expression of mental illness from the Balearic Islands. | TomΓ s C et al. | β | 2006 | β |
| Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. | Hellmig S et al. | β | 2006 | β |
| Genome scan on Swedish Alzheimer's disease families. | SillΓ©n A et al. | β | 2006 | β |
| Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia. | Vawter MP et al. | β | 2006 | β |
| Genome-wide linkage analysis of inguinal hernia in pigs using affected sib pairs. | Grindflek E et al. | β | 2006 | β |
| Genome-wide linkage analysis of population variation in high-density lipoprotein cholesterol. | Harrap SB et al. | β | 2006 | β |
| Genome-wide linkage scan for loci influencing plasma triglycerides. | Middelberg RP et al. | β | 2006 | β |
| Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. | Cheng R et al. | β | 2006 | β |
| Genomewide linkage screen for Waldenstrom macroglobulinemia susceptibility loci in high-risk families. | McMaster ML et al. | β | 2006 | β |
| Genome-wide meta-analysis for rheumatoid arthritis. | Etzel CJ et al. | β | 2006 | β |
| Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. | Etain B et al. | β | 2006 | β |
| Genome-wide scan for premature hypertension supports linkage to chromosome 2 in a large Kyrgyz family. | Kalmyrzaev B et al. | β | 2006 | β |
| Genome-wide scan for white matter hyperintensity: the Framingham Heart Study. | DeStefano AL et al. | β | 2006 | β |
| Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis. | Xiong DH et al. | β | 2006 | β |
| Genome-wide scan identifies a susceptibility locus for familial primary cutaneous amyloidosis on chromosome 5p13.1-q11.2. | Lee DD et al. | β | 2006 | β |
| Genome-wide tagging SNPs with entropy-based Monte Carlo method. | Liu Z et al. | β | 2006 | β |
| Genomic screen for loci associated with tobacco usage in Mission Indians. | Ehlers CL et al. | β | 2006 | β |
| Haplotype-based quantitative trait mapping using a clustering algorithm. | Li J et al. | β | 2006 | β |
| Haplotype reconstruction and estimation of haplotype frequencies from nuclear families with only one parent available. | Ding X et al. | β | 2006 | β |
| Heritability and genetic loci of fatty liver in familial combined hyperlipidemia. | Brouwers MC et al. | β | 2006 | β |
| High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia. | Ng D et al. | β | 2006 | β |
| High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33. | Amos CI et al. | β | 2006 | β |
| Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations. | Yan Q et al. | β | 2006 | β |
| Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. | Greenwood TA et al. | β | 2006 | β |
| Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle. | Duchesne A et al. | β | 2006 | β |
| Identification of genetic loci for basal cell nevus syndrome and inflammatory bowel disease in a single large pedigree. | Panhuysen CI et al. | β | 2006 | β |
| Identification of susceptibility loci for cervical carcinoma by genome scan of affected sib-pairs. | Engelmark MT et al. | β | 2006 | β |
| Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3. | Karlsen AE et al. | β | 2006 | β |
| Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene. | GuzmΓ‘n B et al. | β | 2006 | β |
| Improvement of mapping accuracy by unifying linkage and association analysis. | Lou XY et al. | β | 2006 | β |
| Improving the power of association tests for quantitative traits in family studies. | Diao G et al. | β | 2006 | β |
| Increase in linkage information by stratification of pedigree data into gold-standard and standard diagnoses: application to the NIMH Alzheimer Disease Genetics Initiative Dataset. | Gordon D et al. | β | 2006 | β |
| Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome. | RehnstrΓΆm K et al. | β | 2006 | β |
| In silico method for inferring genotypes in pedigrees. | Burdick JT et al. | β | 2006 | β |
| Interleukin-10 -1082 promoter polymorphism is associated with schizophrenia in a Han Chinese sib-pair study. | He G et al. | β | 2006 | β |
| Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm? | Krischek B et al. | β | 2006 | β |
| Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism. | Ramoz N et al. | β | 2006 | β |
| Linkage analyses of chromosomal region 18p11-q12 in dyslexia. | Schumacher J et al. | β | 2006 | β |
| Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate. | Pichler I et al. | β | 2006 | β |
| Linkage analysis localises a Kartagener syndrome gene to a 3.5 cM region on chromosome 15q24-25. | Geremek M et al. | β | 2006 | β |
| Linkage analysis of rheumatoid arthritis in US and UK families reveals interactions between HLA-DRB1 and loci on chromosomes 6q and 16p. | John S et al. | β | 2006 | β |
| Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population. | Kim JW et al. | β | 2006 | β |
| Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. | Games Collaborative Group et al. | β | 2006 | β |
| Linkage of autosomal-dominant common variable immunodeficiency to chromosome 4q. | Finck A et al. | β | 2006 | β |
| Locus-specific heritability estimation via the bootstrap in linkage scans for quantitative trait loci. | Wu LY et al. | β | 2006 | β |
| Microsatellites versus Single-Nucleotide Polymorphisms in confidence interval estimation of disease loci. | Papachristou C et al. | β | 2006 | β |
| Modeling the effect of inbreeding among founders in linkage analysis. | HΓΆssjer O | β | 2006 | β |
| Molecular characterization and exclusion of porcine GUSB as a candidate gene for congenital hernia inguinalis/scrotalis. | Beck J et al. | β | 2006 | β |
| MORM syndrome (mental retardation, truncal obesity, retinal dystrophy and micropenis), a new autosomal recessive disorder, links to 9q34. | Hampshire DJ et al. | β | 2006 | β |
| Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-GoutiΓ¨res syndrome and mimic congenital viral brain infection. | Crow YJ et al. | β | 2006 | β |
| Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss. | Kalay E et al. | β | 2006 | β |
| Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. | Konrad M et al. | β | 2006 | β |
| Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. | Kuokkanen M et al. | β | 2006 | β |
| New Alzheimer's disease locus on chromosome 8. | Giedraitis V et al. | β | 2006 | β |
| Nonparametric linkage analysis using person-specific covariates. | Whittemore AS et al. | β | 2006 | β |
| Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples. | Talkowski ME et al. | β | 2006 | β |
| Online system for faster multipoint linkage analysis via parallel execution on thousands of personal computers. | Silberstein M et al. | β | 2006 | β |
| Overview of genetic-epidemiological studies in ethnically and demographically diverse isolates of Dagestan, Northern Caucasus, Russia. | Bulayeva KB | β | 2006 | β |
| PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. | Allen-Brady K et al. | β | 2006 | β |
| Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics. | Schaid DJ et al. | β | 2006 | β |
| Primary palmar hyperhidrosis locus maps to 14q11.2-q13. | Higashimoto I et al. | β | 2006 | β |
| Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness. | Stanford JL et al. | β | 2006 | β |
| Quantifying genomic imprinting in the presence of linkage. | Vincent Q et al. | β | 2006 | β |
| Quantifying the amount of missing information in genetic association studies. | Nicolae DL | β | 2006 | β |
| Quantitative trait linkage analysis using Gaussian copulas. | Li M et al. | β | 2006 | β |
| Quantitative trait loci controlling refractoriness to Plasmodium falciparum in natural Anopheles gambiae mosquitoes from a malaria-endemic region in western Kenya. | Menge DM et al. | β | 2006 | β |
| Quantitative trait loci define genes and pathways underlying genetic variation in longevity. | Shmookler Reis RJ et al. | β | 2006 | β |
| Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder. | Chen GK et al. | β | 2006 | β |
| Quantitative-trait-locus mapping in the presence of locus heterogeneity. | Wang K et al. | β | 2006 | β |
| Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders. | Hasselbacher K et al. | β | 2006 | β |
| Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. | Blackman SM et al. | β | 2006 | β |
| Relative risks and effective number of meioses: a unified approach for general genetic models and phenotypes. | Kurbasic A et al. | β | 2006 | β |
| Response to paper by Molloy et al.: linkage on 21q and 7q in autism subset with regression. | Parr JR et al. | β | 2006 | β |
| Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorder. | Service S et al. | β | 2006 | β |
| Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families. | Ylisaukko-oja T et al. | β | 2006 | β |
| Sex and age specific effects of chromosomal regions linked to body mass index in the Framingham Study. | Atwood LD et al. | β | 2006 | β |
| Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia. | Tang J et al. | β | 2006 | β |
| SNP array-based homozygosity mapping reveals MCPH1 deletion in family with autosomal recessive mental retardation and mild microcephaly. | Garshasbi M et al. | β | 2006 | β |
| Solution for underflow problem in linkage and segregation analysis. | Axenovich TI et al. | β | 2006 | β |
| Stratification based on language-related endophenotypes in autism: attempt to replicate reported linkage. | Spence SJ et al. | β | 2006 | β |
| Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes. | Meulenbelt I et al. | β | 2006 | β |
| Testing groups of genomic locations for enrichment in disease loci using linkage scan data: a method for hypothesis testing. | Avramopoulos D et al. | β | 2006 | β |
| The cluster variation method for efficient linkage analysis on extended pedigrees. | Albers CA et al. | β | 2006 | β |
| The impact of data quality on the identification of complex disease genes: experience from the Family Blood Pressure Program. | Chang YP et al. | β | 2006 | β |
| Thermometers: something for statistical geneticists to think about. | Vieland VJ | β | 2006 | β |
| The role of vascular endothelial growth factor (VEGF) in inflammatory bowel disease. | Ferrante M et al. | β | 2006 | β |
| The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. | Sharma M et al. | β | 2006 | β |
| The value of molecular haplotypes in a family-based linkage study. | Gillanders EM et al. | β | 2006 | β |
| Trait components provide tools to dissect the genetic susceptibility of migraine. | Anttila V et al. | β | 2006 | β |
| Unified method for Bayesian calculation of genetic risk. | Kuno SI et al. | β | 2006 | β |
| Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known. | Fingerlin TE et al. | β | 2006 | β |
| Variance calculations for identity-by-descent estimation. | McQueen MB et al. | β | 2006 | β |
| Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. | Tosh K et al. | β | 2006 | β |
| Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility. | Weiss LA et al. | β | 2006 | β |
| Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. | Tosh K et al. | β | 2006 | β |
| A 4-bp deletion in the Birt-Hogg-DubΓ© gene (FLCN) causes dominantly inherited spontaneous pneumothorax. | Painter JN et al. | β | 2005 | β |
| A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. | Xu J et al. | β | 2005 | β |
| A comparison between microsatellite and single-nucleotide polymorphism markers with respect to two measures of information content. | Thalamuthu A et al. | β | 2005 | β |
| A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms. | Chiu YF et al. | β | 2005 | β |
| A confidence set inference procedure for gene mapping using markers with incomplete polymorphism. | Papachristou C et al. | β | 2005 | β |
| A genome screen of families at high risk for Hodgkin lymphoma: evidence for a susceptibility gene on chromosome 4. | Goldin LR et al. | β | 2005 | β |
| A genomewide linkage analysis for prostate cancer susceptibility genes in families from Germany. | Maier C et al. | β | 2005 | β |
| A genome-wide linkage analysis of alcoholism on microsatellite and single-nucleotide polymorphism data, using alcohol dependence phenotypes and electroencephalogram measures. | Zhang C et al. | β | 2005 | β |
| A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study. | Samani NJ et al. | β | 2005 | β |
| A genome-wide scan for carotid artery intima-media thickness: the Mexican-American Coronary Artery Disease family study. | Wang D et al. | β | 2005 | β |
| A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. | Posthuma D et al. | β | 2005 | β |
| A genome-wide scan for quantitative trait loci linked to obesity phenotypes among West Africans. | Chen G et al. | β | 2005 | β |
| A genome-wide scanning and fine mapping study of COGA data. | Yang HC et al. | β | 2005 | β |
| A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder. | Ewald H et al. | β | 2005 | β |
| A Greek family with a follicular variant of familial papillary thyroid carcinoma: TCO, MNG1, fPTC/PRN, and NMTC1 excluded as susceptibility loci. | Tsilchorozidou T et al. | β | 2005 | β |
| A high-density screen for linkage in multiple sclerosis. | Sawcer S et al. | β | 2005 | β |
| A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. | Sellick GS et al. | β | 2005 | β |
| A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. | Miretti MM et al. | β | 2005 | β |
| A likelihood approach for quantitative-trait-locus mapping with selected pedigrees. | Wang K | β | 2005 | β |
| A linkage study between the GABAA beta2 and GABAA gamma2 subunit genes and major psychoses. | AmbrΓ³sio AM et al. | β | 2005 | β |
| A locus for Bowen-Conradi syndrome maps to chromosome region 12p13.3. | Lamont RE et al. | β | 2005 | β |
| A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26. | Puranam RS et al. | β | 2005 | β |
| ALOHOMORA: a tool for linkage analysis using 10K SNP array data. | RΓΌschendorf F et al. | β | 2005 | β |
| Amish brittle hair syndrome gene maps to 7p14.1. | Seboun E et al. | β | 2005 | β |
| Analysis of alcohol dependence phenotype in the COGA families using covariates to detect linkage. | Reck BH et al. | β | 2005 | β |
| Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects. | Lamb JA et al. | β | 2005 | β |
| Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region. | Shink E et al. | β | 2005 | β |
| An analysis of identical single-nucleotide polymorphisms genotyped by two different platforms. | Suarez BK et al. | β | 2005 | β |
| An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study. | Chiu YF et al. | β | 2005 | β |
| An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese. | Zhao JY et al. | β | 2005 | β |
| A new Bayesian approach incorporating covariate information for heterogeneity and its comparison with HLOD. | Biswas S et al. | β | 2005 | β |
| A new congenital form of X-linked autophagic vacuolar myopathy. | Yan C et al. | β | 2005 | β |
| A new dominant distal myopathy affecting posterior leg and anterior upper limb muscles. | Williams DR et al. | β | 2005 | β |
| A note on linkage analysis with affected sib triplets. | Knapp M | β | 2005 | β |
| A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection. | de Villartay JP et al. | β | 2005 | β |
| A novel linkage to generalized vitiligo on 4q13-q21 identified in a genomewide linkage analysis of Chinese families. | Chen JJ et al. | β | 2005 | β |
| A novel locus of ectodermal dysplasia maps to chromosome 10q24.32-q25.1. | Rafiq MA et al. | β | 2005 | β |
| A novel Markov chain monte carlo approach for constructing accurate meiotic maps. | George AW | β | 2005 | β |
| An updated meta-analysis approach for genetic linkage. | Etzel CJ et al. | β | 2005 | β |
| A powerful and robust method for mapping quantitative trait loci in general pedigrees. | Diao G et al. | β | 2005 | β |
| Applications of whole-genome high-density SNP genotyping. | Craig DW et al. | β | 2005 | β |
| Assessment of 115 candidate genes for diabetic nephropathy by transmission/disequilibrium test. | Ewens KG et al. | β | 2005 | β |
| Association analysis of estrogen receptor alpha gene polymorphisms with cross-sectional geometry of the femoral neck in Caucasian nuclear families. | Xiong DH et al. | β | 2005 | β |
| Association and linkage analysis of RGS4 polymorphisms with schizophrenia and bipolar disorder in Brazil. | Cordeiro Q et al. | β | 2005 | β |
| Association mapping: methodologies, strategies, and issues. | Havill LM et al. | β | 2005 | β |
| Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD. | Vermeire S et al. | β | 2005 | β |
| Association testing with Mendel. | Lange K et al. | β | 2005 | β |
| A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases. | Liu PY et al. | β | 2005 | β |
| AUTOGSCAN: powerful tools for automated genome-wide linkage and linkage disequilibrium analysis. | Hiekkalinna T et al. | β | 2005 | β |
| A variance component analysis on recombination rate in the COGA pedigrees. | Wang L et al. | β | 2005 | β |
| Bias of allele-sharing linkage statistics in the presence of intermarker linkage disequilibrium. | Goode EL et al. | β | 2005 | β |
| Boosting alternating decision trees modeling of disease trait information. | Liu KY et al. | β | 2005 | β |
| Calculation of multipoint likelihoods using flanking marker data: a simulation study. | George AW et al. | β | 2005 | β |
| Challenges of examining complex genetic disorders like GERD. | Orenstein SR et al. | β | 2005 | β |
| Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. | McQueen MB et al. | β | 2005 | β |
| Comparative linkage analysis and visualization of high-density oligonucleotide SNP array data. | Leykin I et al. | β | 2005 | β |
| Comparing strategies for association mapping in samples with related individuals. | Bourgain C | β | 2005 | β |
| Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis. | Xing C et al. | β | 2005 | β |
| Comparison of single-nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3. | Wilcox MA et al. | β | 2005 | β |
| Comparison of single-nucleotide polymorphisms and microsatellites in inference of population structure. | Liu N et al. | β | 2005 | β |
| Comparisons of methods for linkage analysis and haplotype reconstruction using extended pedigree data. | Lin S et al. | β | 2005 | β |
| Complex phenotypes and complex genetics: an introduction to genetic studies of complex traits. | Belmont JW et al. | β | 2005 | β |
| Corroboration of a familial chordoma locus on chromosome 7q and evidence of genetic heterogeneity using single nucleotide polymorphisms (SNPs). | Yang X' et al. | β | 2005 | β |
| Cytokine gene polymorphisms and genetic association with coeliac disease in the Finnish population. | Woolley N et al. | β | 2005 | β |
| Description of the International Consortium For Prostate Cancer Genetics, and failure to replicate linkage of hereditary prostate cancer to 20q13. | Schaid DJ et al. | β | 2005 | β |
| Detecting gene-gene interaction in linkage analysis. | Li C | β | 2005 | β |
| Detection of susceptibility loci by genome-wide linkage analysis. | Babron MC et al. | β | 2005 | β |
| EMX2-independent familial schizencephaly: clinical and genetic analyses. | Tietjen I et al. | β | 2005 | β |
| Eosinophil infiltration in three patients with generalized atrophic benign epidermolysis bullosa from a Japanese family: molecular genetic and immunohistochemical studies. | Nomura M et al. | β | 2005 | β |
| Escobar variant with pursed mouth, creased tongue, ophthalmologic features, and scoliosis in 6 children from Oman. | Rajab A et al. | β | 2005 | β |
| Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene. | Wassink TH et al. | β | 2005 | β |
| Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer. | Chang BL et al. | β | 2005 | β |
| Evidence for a novel glaucoma locus at chromosome 3p21-22. | Baird PN et al. | β | 2005 | β |
| Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31. | Malik S et al. | β | 2005 | β |
| Evidence for linkage on 21q and 7q in a subset of autism characterized by developmental regression. | Molloy CA et al. | β | 2005 | β |
| Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1. | Huertas-Vazquez A et al. | β | 2005 | β |
| Family-based association between Alzheimer's disease and variants in UBQLN1. | Bertram L et al. | β | 2005 | β |
| Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes. | Bergholdt R et al. | β | 2005 | β |
| Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12. | Riise Stensland HM et al. | β | 2005 | β |
| Focal palmoplantar and gingival keratosis: a distinct palmoplantar ectodermal dysplasia with epidermolytic alterations but lack of mutations in known keratins. | Kolde G et al. | β | 2005 | β |
| GENEHUNTER versus SimWalk2 in the context of an extended kindred and a qualitative trait locus. | Romero-Hidalgo S et al. | β | 2005 | β |
| Gene locus ambiguity in posterior urethral valves/prune-belly syndrome. | Weber S et al. | β | 2005 | β |
| Genetic analysis of 31 Swedish type 1 von Willebrand disease families reveals incomplete linkage to the von Willebrand factor gene and a high frequency of a certain disease haplotype. | Lanke E et al. | β | 2005 | β |
| Genetic analysis of anal atresia in pigs: evidence for segregation at two main loci. | Cassini P et al. | β | 2005 | β |
| Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. | Golden B et al. | β | 2005 | β |
| Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy. | Tauer U et al. | β | 2005 | β |
| Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members. | Xing C et al. | β | 2005 | β |
| Genetic linkage studies. | Dawn Teare M et al. | β | 2005 | β |
| Genetic markers data in survival studies of twins: the results of a simulation study. | Begun AZ et al. | β | 2005 | β |
| Genetic polymorphisms and mechanisms of neurotoxicity: overview. | Tiffany-Castiglioni E et al. | β | 2005 | β |
| Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct Loci. | Karason A et al. | β | 2005 | β |
| Genetic variants of ApoE account for variability of plasma low-density lipoprotein and apolipoprotein B levels in FHBL. | Yue P et al. | β | 2005 | β |
| Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease. | Burns JC et al. | β | 2005 | β |
| Genome scan linkage analysis comparing microsatellites and single-nucleotide polymorphisms markers for two measures of alcoholism in chromosomes 1, 4, and 7. | Chen G et al. | β | 2005 | β |
| Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q. | Dupuis J et al. | β | 2005 | β |
| Genome screen in the French EGEA study: detection of linked regions shared or not shared by allergic rhinitis and asthma. | Dizier MH et al. | β | 2005 | β |
| Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. | Arinami T et al. | β | 2005 | β |
| Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. | Yang Q et al. | β | 2005 | β |
| Genome-wide linkage analysis to age at natural menopause in a community-based sample: the Framingham Heart Study. | Murabito JM et al. | β | 2005 | β |
| Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26. | Treloar SA et al. | β | 2005 | β |
| Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24. | Schumacher J et al. | β | 2005 | β |
| Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population. | Venken T et al. | β | 2005 | β |
| Genomewide scan for anal atresia in swine identifies linkage and association with a chromosome region on Sus scrofa chromosome 1. | Wiedemann S et al. | β | 2005 | β |
| Genome-wide scan for linkage to obesity-associated hypertension in French Canadians. | Pausova Z et al. | β | 2005 | β |
| Genome-wide scan for myopia in the Old Order Amish. | Stambolian D et al. | β | 2005 | β |
| Genome-wide scan of homogeneous subtypes of NIMH genetics initiative schizophrenia families. | Takahashi S et al. | β | 2005 | β |
| Genome-wide screen for prostate cancer susceptibility genes in men with clinically significant disease. | Chang BL et al. | β | 2005 | β |
| Genomewide significant linkage to migrainous headache on chromosome 5q21. | Nyholt DR et al. | β | 2005 | β |
| Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers. | Abecasis GR et al. | β | 2005 | β |
| Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. | Armanios M et al. | β | 2005 | β |
| HaploPainter: a tool for drawing pedigrees with complex haplotypes. | Thiele H et al. | β | 2005 | β |
| Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes. | Holmkvist J et al. | β | 2005 | β |
| Haplotype sharing analysis using mantel statistics. | Beckmann L et al. | β | 2005 | β |
| Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism. | Philippi A et al. | β | 2005 | β |
| Haplotype structure of TNFRSF5-TNFSF5 (CD40-CD40L) and association analysis in systemic lupus erythematosus. | Chadha S et al. | β | 2005 | β |
| Hearing loss associated with enlarged vestibular aqueduct and Mondini dysplasia is caused by splice-site mutation in the PDS gene. | Yang JJ et al. | β | 2005 | β |
| Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study. | Mitchell GF et al. | β | 2005 | β |
| Heterogeneity: GAW Group 15. | Vieland VJ | β | 2005 | β |
| Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. | Boycott KM et al. | β | 2005 | β |
| How useful is the fine-scale mapping of complex trait linkage peaks? Evaluating the impact of additional microsatellite genotyping on the posterior probability of linkage. | Wiltshire S et al. | β | 2005 | β |
| Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1. | Grasberger H et al. | β | 2005 | β |
| Identification of polymorphisms explaining a linkage signal: application to the GAW14 simulated data. | Chen MH et al. | β | 2005 | β |
| Impact of the diagnosis definition on linkage detection. | Dizier MH et al. | β | 2005 | β |
| Inclusion of unaffected sibs increases power in model-free linkage analysis of a behavioral trait. | Plancoulaine S et al. | β | 2005 | β |
| Information and effective number of meioses in linkage analysis. | HΓΆssjer O | β | 2005 | β |
| Interaction between obesity-susceptibility loci in chromosome regions 2p25-p24 and 13q13-q21. | Dong C et al. | β | 2005 | β |
| Interval estimation of disease loci: development and applications of new linkage methods. | Papachristou C et al. | β | 2005 | β |
| Lack of support for the presence of an osteoarthritis susceptibility locus on chromosome 6p. | Meenagh GK et al. | β | 2005 | β |
| Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3. | Jenne DE et al. | β | 2005 | β |
| Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data. | Zhong X et al. | β | 2005 | β |
| Linkage analysis of alcohol dependence using MOD scores. | Strauch K et al. | β | 2005 | β |
| Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates. | Bacanu SA et al. | β | 2005 | β |
| Linkage analysis of chromosome 1 with essential hypertension and blood pressure quantitative traits in Chinese families. | Ge D et al. | β | 2005 | β |
| Linkage analysis of complex diseases using microsatellites and single-nucleotide polymorphisms: application to alcoholism. | Nsengimana J et al. | β | 2005 | β |
| Linkage analysis of the GAW14 simulated dataset with microsatellite and single-nucleotide polymorphism markers in large pedigrees. | Yang XR et al. | β | 2005 | β |
| Linkage analysis reveals two independent loci for ocular disorders in a local Japanese Black cattle population. | Ihara N et al. | β | 2005 | β |
| Linkage and association analyses of microsatellites and single-nucleotide polymorphisms in nuclear families. | Lin J et al. | β | 2005 | β |
| Linkage and association analysis in pedigrees from different populations. | Beyene J et al. | β | 2005 | β |
| Linkage and candidate gene analysis of 14q22-24 in bipolar disorder: support for GCHI as a novel susceptibility gene. | Kealey C et al. | β | 2005 | β |
| Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese families. | Liu CM et al. | β | 2005 | β |
| Linkage mapping methods applied to the COGA data set: presentation Group 4 of Genetic Analysis Workshop 14. | Daw EW et al. | β | 2005 | β |
| Linkage of speech sound disorder to reading disability loci. | Smith SD et al. | β | 2005 | β |
| Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. | Ng MY et al. | β | 2005 | β |
| Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study. | Chen P et al. | β | 2005 | β |
| Low expression VEGF haplotype increases the risk for tetralogy of Fallot: a family based association study. | Lambrechts D et al. | β | 2005 | β |
| Mapping and exclusion mapping of genomic imprinting effects in mouse F2 families. | Mantey C et al. | β | 2005 | β |
| Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis. | Wang D et al. | β | 2005 | β |
| Mapping genes of complex psychiatric diseases in Daghestan genetic isolates. | Bulayeva KB et al. | β | 2005 | β |
| Mapping of familial thoracic aortic aneurysm/dissection with patent ductus arteriosus to 16p12.2-p13.13. | Khau Van Kien P et al. | β | 2005 | β |
| Mapping quantitative trait loci in humans: achievements and limitations. | Majumder PP et al. | β | 2005 | β |
| Maximum likelihood haplotyping for general pedigrees. | Fishelson M et al. | β | 2005 | β |
| MCMC multilocus lod scores: application of a new approach. | George AW et al. | β | 2005 | β |
| Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians. | Red Eagle AR et al. | β | 2005 | β |
| Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures. | Dunn G et al. | β | 2005 | β |
| Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps. | Hinrichs AL et al. | β | 2005 | β |
| Mutation analysis of the MCHR1 gene in human obesity. | Wermter AK et al. | β | 2005 | β |
| Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. | Kelsell DP et al. | β | 2005 | β |
| Mutations in NOTCH1 cause aortic valve disease. | Garg V et al. | β | 2005 | β |
| Mx scripts library: structural equation modeling scripts for twin and family data. | Posthuma D et al. | β | 2005 | β |
| Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. | Go RC et al. | β | 2005 | β |
| New locus for autosomal dominant mitral valve prolapse on chromosome 13: clinical insights from genetic studies. | Nesta F et al. | β | 2005 | β |
| No convincing evidence of linkage for restless legs syndrome on chromosome 9p. | Ray A et al. | β | 2005 | β |
| Parametric approach to genomic imprinting analysis with applications to Angelman's syndrome. | Shete S et al. | β | 2005 | β |
| Performance comparison of two-point linkage methods using microsatellite markers flanking known disease locations. | Logue MW et al. | β | 2005 | β |
| Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. | Meschia JF et al. | β | 2005 | β |
| Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs. | Rampersaud E et al. | β | 2005 | β |
| Promotor genotype of the platelet-derived growth factor receptor-alpha gene shows population stratification but not association with spina bifida meningomyelocele. | Au KS et al. | β | 2005 | β |
| QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study. | Newton-Cheh C et al. | β | 2005 | β |
| Quantitative genome scan and Ordered-Subsets Analysis of autism endophenotypes support language QTLs. | AlarcΓ³n M et al. | β | 2005 | β |
| Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study. | Kraja AT et al. | β | 2005 | β |
| Recursive partitioning models for linkage in COGA data. | Xu W et al. | β | 2005 | β |
| Reduction of selection bias in genomewide studies by resampling. | Sun L et al. | β | 2005 | β |
| Replication of autism linkage: fine-mapping peak at 17q21. | Cantor RM et al. | β | 2005 | β |
| Robust estimation of critical values for genome scans to detect linkage. | Bacanu SA | β | 2005 | β |
| Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13. | Ferreira MA et al. | β | 2005 | β |
| Robust multipoint identical-by-descent mapping for affected relative pairs. | Schaid DJ et al. | β | 2005 | β |
| Robust trend tests for genetic association in case-control studies using family data. | Tian X et al. | β | 2005 | β |
| Sarcoidosis is associated with a truncating splice site mutation in BTNL2. | Valentonyte R et al. | β | 2005 | β |
| Schistosomal hepatic fibrosis and the interferon gamma receptor: a linkage analysis using single-nucleotide polymorphic markers. | Blanton RE et al. | β | 2005 | β |
| Score statistic to test for genetic correlation for proband-family design. | el Galta R et al. | β | 2005 | β |
| Selecting cases from nuclear families for case-control association analysis. | Moore RM et al. | β | 2005 | β |
| Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families. | Cornes BK et al. | β | 2005 | β |
| SimPed: a simulation program to generate haplotype and genotype data for pedigree structures. | Leal SM et al. | β | 2005 | β |
| Simultaneous localization of two linked disease susceptibility genes. | Biernacka JM et al. | β | 2005 | β |
| SNPLINK: multipoint linkage analysis of densely distributed SNP data incorporating automated linkage disequilibrium removal. | Webb EL et al. | β | 2005 | β |
| Software for quantitative trait analysis. | Almasy L et al. | β | 2005 | β |
| Spinocerebellar ataxia type 26 maps to chromosome 19p13.3 adjacent to SCA6. | Yu GY et al. | β | 2005 | β |
| Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22. | Lambert D et al. | β | 2005 | β |
| Strategies in analysis of the genetic component of multifactorial diseases; biostatistical aspects. | Barnetche T et al. | β | 2005 | β |
| Study of folate receptor genes in nonsyndromic familial and sporadic cleft lip with or without cleft palate cases. | Scapoli L et al. | β | 2005 | β |
| Suggestive linkage of familial primary cutaneous amyloidosis to a locus on chromosome 1q23. | Lin MW et al. | β | 2005 | β |
| Support for previously identified alcoholism susceptibility Loci in a cohort selected for smoking behavior. | Wilhelmsen KC et al. | β | 2005 | β |
| Tests for the presence of two linked disease susceptibility genes. | Biernacka JM et al. | β | 2005 | β |
| The case for selection at CCR5-Delta32. | Sabeti PC et al. | β | 2005 | β |
| The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction. | Pierik M et al. | β | 2005 | β |
| The keeshond defect in cardiac conotruncal development is oligogenic. | Werner P et al. | β | 2005 | β |
| The most common mutation in FKRP causing limb girdle muscular dystrophy type 2I (LGMD2I) may have occurred only once and is present in Hutterites and other populations. | Frosk P et al. | β | 2005 | β |
| The power to detect genetic linkage for quantitative traits in the Utah CEPH pedigrees. | Malhotra A et al. | β | 2005 | β |
| The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. | Chistiakov DA et al. | β | 2005 | β |
| Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. | Kraja AT et al. | β | 2005 | β |
| Two new putative susceptibility loci for ADNFLE. | Combi R et al. | β | 2005 | β |
| Type II collagen gene variants and inherited osteonecrosis of the femoral head. | Liu YF et al. | β | 2005 | β |
| Uroplakin III is not a major candidate gene for primary vesicoureteral reflux. | Kelly H et al. | β | 2005 | β |
| Variation in CASP10 gene is associated with idiopathic talipes equinovarus. | Heck AL et al. | β | 2005 | β |
| Variation in IRF6 contributes to nonsyndromic cleft lip and palate. | Blanton SH et al. | β | 2005 | β |
| Vitamin D receptor gene polymorphisms are linked to and associated with adult height. | Xiong DH et al. | β | 2005 | β |
| Whole-genome screening for susceptibility genes in multicase families with BehΓ§et's disease. | Karasneh J et al. | β | 2005 | β |
| A genome-wide scan for juvenile rheumatoid arthritis in affected sibpair families provides evidence of linkage. | Thompson SD et al. | β | 2004 | β |
| A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands. | Faraone SV et al. | β | 2004 | β |
| Allelic loss on chromosomes 2q21 and 19p 13.2 in oxyphilic thyroid tumors. | Stankov K et al. | β | 2004 | β |
| A new phenotype of recessively inherited foveal hypoplasia and anterior segment dysgenesis maps to a locus on chromosome 16q23.2-24.2. | Pal B et al. | β | 2004 | β |
| Ascertainment-adjusted maximum likelihood estimation for the additive genetic gamma frailty model. | Sun W et al. | β | 2004 | β |
| Assessing genomewide statistical significance in linkage studies. | Lin DY et al. | β | 2004 | β |
| Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples. | Prasad S et al. | β | 2004 | β |
| Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11. | Arcos-Burgos M et al. | β | 2004 | β |
| "Bias toward the null" means reduced power. | Sieberts SK et al. | β | 2004 | β |
| Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia. | Ibay G et al. | β | 2004 | β |
| Chronic and recurrent otitis media: a genome scan for susceptibility loci. | Daly KA et al. | β | 2004 | β |
| Combined genome-wide scan for prostate cancer susceptibility genes. | Gillanders EM et al. | β | 2004 | β |
| Common variants at the PCOL2 and Sp1 binding sites of the COL1A1 gene and their interactive effect influence bone mineral density in Caucasians. | Liu PY et al. | β | 2004 | β |
| Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci. | Schaid DJ et al. | β | 2004 | β |
| Complexities in psychiatric genetics. | Sanders AR et al. | β | 2004 | β |
| Conventional multipoint nonparametric linkage analysis is not necessarily inherently biased. | Visscher PM et al. | β | 2004 | β |
| Co-segregation of the PROS1 locus and protein S deficiency in families having no detectable mutations in PROS1. | Lanke E et al. | β | 2004 | β |
| Dense genome-wide linkage analysis of rheumatoid arthritis, including covariates. | Osorio Y FortΓ©a J et al. | β | 2004 | β |
| Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p. | Brintnell W et al. | β | 2004 | β |
| Evidence for a type 1 diabetes susceptibility locus (IDDM10) on chromosome 10p11-q11 in a Russian population. | Chistiakov DA et al. | β | 2004 | β |
| Examination of AVPR1a as an autism susceptibility gene. | Wassink TH et al. | β | 2004 | β |
| Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics. | Lee JH et al. | β | 2004 | β |
| Genetic analysis of primary microcephaly in Indian families: novel ASPM mutations. | Kumar A et al. | β | 2004 | β |
| Genetic control of autoantibody expression in autoimmune myasthenia gravis: role of the self-antigen and of HLA-linked loci. | Giraud M et al. | β | 2004 | β |
| Genetic susceptibility loci for essential hypertension and blood pressure on chromosome 17 in 147 Chinese pedigrees. | Gu F et al. | β | 2004 | β |
| Genomewide linkage searches for Mendelian disease loci can be efficiently conducted using high-density SNP genotyping arrays. | Sellick GS et al. | β | 2004 | β |
| Genome-wide scan for Japanese familial intracranial aneurysms: linkage to several chromosomal regions. | Yamada S et al. | β | 2004 | β |
| Genome-wide studies of psoriasis susceptibility loci: a review. | Sagoo GS et al. | β | 2004 | β |
| Genomic screen for loci associated with alcohol dependence in Mission Indians. | Ehlers CL et al. | β | 2004 | β |
| Heterogeneity of hereditary persistence of alpha-fetoprotein. | Yeh SH et al. | β | 2004 | β |
| HLA class II haplotypes in Mexican systemic lupus erythematosus patients. | Cortes LM et al. | β | 2004 | β |
| Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. | Huang Q et al. | β | 2004 | β |
| Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region. | Paschou P et al. | β | 2004 | β |
| Linkage analysis between BCL3 and nearby genes on 19q13.2 and non-syndromic cleft lip with or without cleft palate in multigenerational Japanese families. | Fujita H et al. | β | 2004 | β |
| Linkage analysis of ordinal traits for pedigree data. | Feng R et al. | β | 2004 | β |
| Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. | Bilusic M et al. | β | 2004 | β |
| Missense mutations of ACTA1 cause dominant congenital myopathy with cores. | Kaindl AM et al. | β | 2004 | β |
| Multicenter linkage study of schizophrenia loci on chromosome 22q. | Mowry BJ et al. | β | 2004 | β |
| No bias in linkage analysis. | Abecasis G et al. | β | 2004 | β |
| No "bias" toward the null hypothesis in most conventional multipoint nonparametric linkage analyses. | Mukhopadhyay I et al. | β | 2004 | β |
| No evidence of the involvement of the Fas -670 promoter polymorphism in cervical cancer in situ. | Engelmark MT et al. | β | 2004 | β |
| No genetic linkage or molecular evidence for involvement of the PCSK9, ARH or CYP7A1 genes in the Familial Hypercholesterolemia phenotype in a sample of Danish families without pathogenic mutations in the LDL receptor and apoB genes. | Damgaard D et al. | β | 2004 | β |
| Novel troponin T mutation in familial dilated cardiomyopathy with gender-dependant severity. | Stefanelli CB et al. | β | 2004 | β |
| Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3. | Bykhovskaya Y et al. | β | 2004 | β |
| Power of variance component linkage analysis-II. Discrete traits. | Williams JT et al. | β | 2004 | β |
| Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees. | Cantor RM et al. | β | 2004 | β |
| Score test for detecting linkage to complex traits in selected samples. | Lebrec J et al. | β | 2004 | β |
| Sequence-based linkage analysis. | Furman I et al. | β | 2004 | β |
| Significant association between nonsyndromic oral clefts and arylhydrocarbon receptor nuclear translocator (ARNT). | Kayano S et al. | β | 2004 | β |
| Statistical tests for admixture mapping with case-control and cases-only data. | Montana G et al. | β | 2004 | β |
| TCR beta polymorphisms and multiple sclerosis. | Dyment DA et al. | β | 2004 | β |
| TEAM: a tool for the integration of expression, and linkage and association maps. | Franke L et al. | β | 2004 | β |
| Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families. | Zhao LJ et al. | β | 2004 | β |
| The genetics of hypogammaglobulinemia. | Grimbacher B et al. | β | 2004 | β |
| The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. | Timms AE et al. | β | 2004 | β |
| The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology. | Freimer N et al. | β | 2004 | β |
| Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3. | Lemire M et al. | β | 2004 | β |