A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population.
paper
Cited
Public
- Authors
- Li, Ming D; Ma, Jennie Z; Cheng, Rong; Dupont, Randolph T; Williams, Nancy J; Crews, Karen M; Payne, Thomas J; Elston, Robert C; Framingham Heart Study
- Year
- 2003
- Journal
- BMC genetics
- PMID
- 14975171
- DOI
- 10.1186/1471-2156-4-S1-S103
- PMCID
- PMC1866441
BACKGROUND: Although many years of genetic epidemiological studies have demonstrated that genetics plays a significant role in determining smoking behavior, little information is available on genomic loci or genes affecting nicotine dependence. Several susceptibility chromosomal regions for nicotine dependence have been reported, but few have received independent confirmation. To identify susceptibility loci for nicotine dependence, 313 extended pedigrees selected from the Framingham Heart Study population were analyzed by both the GENEHUNTER and S.A.G.E. programs. RESULTS: After performing linkage analyses on the 313 extended Framingham Heart Study families, the EM Haseman-Elston method implemented in GENEHUNTER provided evidence for significant linkage of smoking rate to chromosome 11 and suggestive linkage to chromosomes 9, 14, and 17. Multipoint sib-pair regression analysis using the SIBPAL program of S.A.G.E. on 1389 sib pairs that were split from the 313 extended families identified suggestive linkage of smoking rate to chromosomes 4, 7, and 17. Of these identified positive regions for nicotine dependence, loci on chromosomes 7, 11, and 17 were identified by both GENEHUNTER and S.A.G.E. programs. CONCLUSION: Our genome-wide scan results on the Framingham Heart Study data provide evidence for significant linkage of smoking rate to chromosome 11 and suggestive linkage to chromosomes 4, 7, 9, 14, and 17. These findings suggest that some of these regions may harbor susceptibility loci for nicotine dependence, and warrant further investigation in this and other populations.
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1–16 of 16
| Name | Type |
|---|---|
| CategorizedSmokingRate local | phenotype |
| Christchurch cohort local | cohort |
| Christchurch sample of New Zealand local | cohort |
| chromosome 1 local | gene |
| chromosome 11 local | gene |
| Chromosome 11 local | gene |
| chromosome 12 local | gene |
| chromosome 14 local | gene |
| Chromosome 14 local | gene |
| chromosome 15 local | gene |
| Chromosome 15 local | gene |
| chromosome 17 local | gene |
| Chromosome 17 local | gene |
| chromosome 20 local | gene |
| Chromosome 20 local | gene |
| chromosome 21 local | gene |
| chromosome 4 local | gene |
| Chromosome 4 local | gene |
| Chromosome 5 local | anatomy |
| Chromosome 5q local | anatomy |
| chromosome 6 local | gene |
| chromosome 7 local | gene |
| Chromosome 7 local | gene |
| chromosome 9 local | gene |
| Chromosome 9 local | gene |
| cigarette brand local | drug |
| cigarettes | phenotype |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| families | cohort |
| Framingham Heart Study | cohort |
| Framingham Heart Study families local | cohort |
| Framingham Heart Study offspring cohort local | cohort |
| Framingham Heart Study original cohort local | cohort |
| GAW13 analyses local | cohort |
| LogTransformedSmokingRate local | phenotype |
| Long-term smoker local | phenotype |
| Maximum number of cigarettes smoked per day local | phenotype |
| nicotine | drug |
| nicotine concentration local | phenotype |
| nicotine dependence | phenotype |
| non-smoking group local | cohort |
| Nuclear families local | cohort |
| offspring | cohort |
| Richmond cohort local | cohort |
| Richmond sample of Virginia local | cohort |
| second-hand smoke | drug |
| smoking | phenotype |
| smoking behavior | phenotype |
| smoking initiation | phenotype |
| smoking persistence | phenotype |
| smoking rate local | phenotype |
| Smoking rate local | phenotype |
| SmokingRate local | phenotype |
| study cohort | cohort |
| Twin cohort | cohort |
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