Complete multipoint sib-pair analysis of qualitative and quantitative traits.
paper
Cited
Public
Unavailable
- Authors
- Kruglyak, L; Lander, E S
- Year
- 1995
- Journal
- American journal of human genetics
- PMID
- 7668271
- PMCID
- PMC1801561
Sib-pair analysis is an increasingly important tool for genetic dissection of complex traits. Current methods for sib-pair analysis are primarily based on studying individual genetic markers one at a time and thus fail to use the full inheritance information provided by multipoint linkage analysis. In this paper, we describe how to extract the complete multipoint inheritance information for each sib pair. We then describe methods that use this information to map loci affecting traits, thereby providing a unified approach to both qualitative and quantitative traits. Specifically, complete multipoint approaches are presented for (1) exclusion mapping of qualitative traits; (2) maximum-likelihood mapping of qualitative traits; (3) information-content mapping, showing the extent to which all inheritance information has been extracted at each location in the genome; and (4) quantitative-trait mapping, by two parametric methods and one nonparametric method. In addition, we explore the effects of marker density, marker polymorphism, and availability of parents on the information content of a study. We have implemented the analysis methods in a new computer package, MAPMAKER/SIBS. With this computer package, complete multipoint analysis with dozens of markers in hundreds of sib pairs can be carried out in minutes.
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| Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis. | Akesson E et al. | — | 2003 | → |
| Sibling recurrence risk ratio analysis of the metabolic syndrome and its components over time. | Chen WJ et al. | — | 2003 | → |
| Significant linkage of Parkinson disease to chromosome 2q36-37. | Pankratz N et al. | — | 2003 | → |
| Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci. | Shaw SH et al. | — | 2003 | → |
| The SLC6A14 gene shows evidence of association with obesity. | Suviolahti E et al. | — | 2003 | → |
| A genome screen for linkage in Australian sibling-pairs with multiple sclerosis. | Ban M et al. | — | 2002 | → |
| A genomewide linkage screen for relative hand skill in sibling pairs. | Francks C et al. | — | 2002 | → |
| A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. | Fisher SE et al. | — | 2002 | → |
| A genomewide scan identifies two novel loci involved in specific language impairment. | SLI Consortium | — | 2002 | → |
| A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27. | Auranen M et al. | — | 2002 | → |
| A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. | Akesson E et al. | — | 2002 | → |
| A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size. | Wang K et al. | — | 2002 | → |
| Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. | Van Eerdewegh P et al. | — | 2002 | → |
| Asthma and atopy - a total genome scan for susceptibility genes. | Haagerup A et al. | — | 2002 | → |
| Asthma and IL-4 receptor alpha gene variants. | Wjst M et al. | — | 2002 | → |
| Beta-2 adrenergic receptor gene variations and coping styles in twins. | Busjahn A et al. | — | 2002 | → |
| Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. | Han Z et al. | — | 2002 | → |
| Developmental dyslexia: genetic dissection of a complex cognitive trait. | Fisher SE et al. | — | 2002 | → |
| Differential genetic etiology of reading component processes as a function of IQ. | Knopik VS et al. | — | 2002 | → |
| Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. | Alarcón M et al. | — | 2002 | → |
| Full genome screen for Alzheimer disease: stage II analysis. | Myers A et al. | — | 2002 | → |
| Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism. | Smalley SL et al. | — | 2002 | → |
| Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients. | Marchal-Victorion S et al. | — | 2002 | → |
| Genetics of multiple sclerosis: linkage and association studies. | Giordano M et al. | — | 2002 | → |
| Genetics of osteoporosis. | Peacock M et al. | — | 2002 | → |
| Genetics of type 1 diabetes mellitus. | Pociot F et al. | — | 2002 | → |
| Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations. | Pankratz N et al. | — | 2002 | → |
| Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2. | Harrap SB et al. | — | 2002 | → |
| Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome. | Zhang H et al. | — | 2002 | → |
| Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes. | Straub RE et al. | — | 2002 | → |
| Impact of parental relationships in maximum lod score affected sib-pair method. | Leutenegger AL et al. | — | 2002 | → |
| Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. | Fisher SE et al. | — | 2002 | → |
| Limitations of stratifying sib-pair data in common disease linkage studies: an example using chromosome 10p14-10q11 in type 1 diabetes. | Johnson GC et al. | — | 2002 | → |
| Linkage and association studies of IL1B and IL1RN gene polymorphisms in preeclampsia. | Lachmeijer AM et al. | — | 2002 | → |
| Linkage for platelet monoamine oxidase (MAO) activity: results from a replication sample. | Saccone NL et al. | — | 2002 | → |
| Linkage heterogeneity of end-stage renal disease on human chromosome 10. | Freedman BI et al. | — | 2002 | → |
| Linkage stratification and mutation analysis at the Parkin locus identifies mutation positive Parkinson's disease families. | Nichols WC et al. | — | 2002 | → |
| Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. | Abecasis GR et al. | — | 2002 | → |
| Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study. | Feitosa MF et al. | — | 2002 | → |
| Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder. | Willcutt EG et al. | — | 2002 | → |
| Recent advances in the genetics of schizophrenia. | Waterwort DM et al. | — | 2002 | → |
| Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7. | Badner JA et al. | — | 2002 | → |
| Regression models for allele sharing: analysis of accumulating data in affected sib pair studies. | Bull SB et al. | — | 2002 | → |
| Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible. | Wang K et al. | — | 2002 | → |
| Search for intracranial aneurysm susceptibility gene(s) using Finnish families. | Olson JM et al. | — | 2002 | → |
| Segregation at three loci explains familial and population risk in Hirschsprung disease. | Gabriel SB et al. | — | 2002 | → |
| Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. | Busjahn A et al. | — | 2002 | → |
| Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13. | Carn G et al. | — | 2002 | → |
| Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. | Dick DM et al. | — | 2002 | → |
| The International Endogene Study: a collection of families for genetic research in endometriosis. | Treloar S et al. | — | 2002 | → |
| The Siblings With Ischemic Stroke Study (SWISS) protocol. | Meschia JF et al. | — | 2002 | → |
| The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. | Bennett P et al. | — | 2002 | → |
| Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom. | MacKay K et al. | — | 2002 | → |
| Adaptations of linkage and association methods for the study of asthma, a complex trait. | Bosken CH et al. | — | 2001 | → |
| Affected sibling pair linkage analysis of qualitative and quantitative traits for schizophrenia on chromosome 22 in a Chinese population. | Cai G et al. | — | 2001 | → |
| A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22. | Liu J et al. | — | 2001 | → |
| A genome screen for multiple sclerosis in Sardinian multiplex families. | Coraddu F et al. | — | 2001 | → |
| A genomewide linkage study of age at onset in schizophrenia. | Cardno AG et al. | — | 2001 | → |
| A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. | Nerup J et al. | — | 2001 | → |
| A genomewide screen for autism susceptibility loci. | Liu J et al. | — | 2001 | → |
| A genome-wide search for genes that relate to a low level of response to alcohol. | Schuckit MA et al. | — | 2001 | → |
| Allergic rhinitis--a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27. | Haagerup A et al. | — | 2001 | → |
| A major susceptibility locus for leprosy in India maps to chromosome 10p13. | Siddiqui MR et al. | — | 2001 | → |
| Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families. | Sullivan PF et al. | — | 2001 | → |
| An autosome-wide search for loci underlying wheezing age of onset in German asthmatic children identifies a new region of interest on 6q24-q25. | Alcaïs A et al. | — | 2001 | → |
| Applications of neural networks for gene finding. | Sherriff A et al. | — | 2001 | → |
| Approaches to gene mapping in complex disorders and their application in child psychiatry and psychology. | Asherson PJ et al. | — | 2001 | → |
| A weighted test using both extreme discordant and concordant sib pairs for detecting linkage. | Li Z et al. | — | 2001 | → |
| Candidate gene case-control association studies: advantages and potential pitfalls. | Daly AK et al. | — | 2001 | → |
| Candidate gene regions and genetic heterogeneity in gluten sensitivity. | Holopainen P et al. | — | 2001 | → |
| Comparison of sib pair-based approaches for identifying quantitative trait loci underlying asthma in the Busselton families. | Shugart YY et al. | — | 2001 | → |
| Covariates in linkage analysis using sibling and cousin pairs. | Saccone NL et al. | — | 2001 | → |
| Defining the genetic contribution of type 2 diabetes mellitus. | van Tilburg J et al. | — | 2001 | → |
| Diagnosis as a covariate in sib-pair linkage analysis. | Rice JP | — | 2001 | → |
| Evidence for a susceptibility locus on chromosome 6q influencing phonological coding dyslexia. | Petryshen TL et al. | — | 2001 | → |
| Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome. | Vermeire S et al. | — | 2001 | → |
| Exclusion mapping of major crystallization inhibitors in idiopathic calcium urolithiasis. | Cailhier JF et al. | — | 2001 | → |
| Factor analysis of asthma and atopy traits shows 2 major components, one of which is linked to markers on chromosome 5q. | Holberg CJ et al. | — | 2001 | → |
| Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. | Pankow JS et al. | — | 2001 | → |
| Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. | Immervoll T et al. | — | 2001 | → |
| Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. | Hampe J et al. | — | 2001 | → |
| Full-genome scans with autistic disorder: a review. | Gutknecht L | — | 2001 | → |
| Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes. | Brown MA et al. | — | 2001 | → |
| Genetic determinism in the relationship between human CD4+ and CD8+ T lymphocyte populations? | Ahmadi KR et al. | — | 2001 | → |
| Genetic linkage methods for quantitative traits. | Amos CI et al. | — | 2001 | → |
| Genome partitioning and whole-genome analysis. | Schork NJ | — | 2001 | → |
| Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. | Allayee H et al. | — | 2001 | → |
| Genome scan for quantitative trait loci linked to high-density lipoprotein cholesterol: The NHLBI Family Heart Study. | Peacock JM et al. | — | 2001 | → |
| Genome screen for quantitative trait loci underlying normal variation in femoral structure. | Koller DL et al. | — | 2001 | → |
| Genomics and atherosclerosis. | Sakaki Y | — | 2001 | → |
| Genomic scan for exercise blood pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. | Rankinen T et al. | — | 2001 | → |
| Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE. | Chagnon YC et al. | — | 2001 | → |
| Hair on a gene string: recent advances in understanding the molecular genetics of hair loss. | Irvine AD et al. | — | 2001 | → |
| Homogeneity of asthma genome scan results. | Babron MC et al. | — | 2001 | → |
| Impact of overlapping recruitment on linkage analysis of complex disorders: simulation studies. | Davis S et al. | — | 2001 | → |
| Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura. | Terwindt GM et al. | — | 2001 | → |
| Likelihood-ratio affected sib-pair tests applied to multiply affected sibships: issues of power and type I error rate. | Holmans P | — | 2001 | → |
| Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method. | Garner C et al. | — | 2001 | → |
| Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. | Morahan G et al. | — | 2001 | → |
| Major strengths and weaknesses of model-free methods. | Goldgar DE | — | 2001 | → |
| Methods for linkage analysis of quantitative trait loci in humans. | Feingold E | — | 2001 | → |
| Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4. | Goddard KA et al. | — | 2001 | → |
| Multipoint development of the weighted pairwise correlation (WPC) linkage method for pedigrees of arbitrary size and application to the analysis of breast cancer and alcoholism familial data. | Zinn-Justin A et al. | — | 2001 | → |
| No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. | Dupont S et al. | — | 2001 | → |
| No linkage and association of atopy to chromosome 16 including the interleukin-4 receptor gene. | Haagerup A et al. | — | 2001 | → |
| Nonparametric linkage regression. I: Combined Caucasian CSGA and German genome scans for asthma. | Langefeld CD et al. | — | 2001 | → |
| On the detection of linkage in multiple data sets: a comparison of various statistical approaches. | Van Eerdewegh P et al. | — | 2001 | → |
| Optimum study designs. | Gu C et al. | — | 2001 | → |
| Overview of linkage analysis in complex traits. | Pericak-Vance MA | — | 2001 | → |
| Overview of model-free methods for linkage analysis. | Elston RC et al. | — | 2001 | → |
| Pathogenesis of diabetes: our current understanding. | Pietropaolo M et al. | — | 2001 | → |
| Power and robustness of a score test for linkage analysis of quantitative traits using identity by descent data on sib pairs. | Goldstein DR et al. | — | 2001 | → |
| Power of multipoint identity-by-descent methods to detect linkage using variance component models. | Ekstrøm CT | — | 2001 | → |
| Sustained and selective attention as measures of genetic liability to schizophrenia. | Jones LA et al. | — | 2001 | → |
| The genetic architecture of quantitative traits. | Mackay TF | — | 2001 | → |
| The genetics of obsessive-compulsive disorder. | Pato MT et al. | — | 2001 | → |
| The genetics of Tourette syndrome. | Pauls DL | — | 2001 | → |
| The Ising model in physics and statistical genetics. | Majewski J et al. | — | 2001 | → |
| The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis. | Dai KZ et al. | — | 2001 | → |
| The tissue transglutaminase gene is not a primary factor predisposing to celiac disease. | van Belzen MJ et al. | — | 2001 | → |
| Transformation of sib-pair values for the Haseman-Elston method. | Wang D et al. | — | 2001 | → |
| Use of variable marker density, principal components, and neural networks in the dissection of disease etiology. | Pankratz N et al. | — | 2001 | → |
| Variance component methods for detecting complex trait loci. | Blangero J et al. | — | 2001 | → |
| Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: confirmation of qualitative analyses. | Petryshen TL et al. | — | 2000 | → |
| A cholesterol-lowering gene maps to chromosome 13q. | Knoblauch H et al. | — | 2000 | → |
| A genome screen of maximum number of drinks as an alcoholism phenotype. | Saccone NL et al. | — | 2000 | → |
| A genome screen of multiplex sibships with prostate cancer. | Suarez BK et al. | — | 2000 | → |
| All LODs are not created equal. | Nyholt DR | — | 2000 | → |
| A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data. | Douglas JA et al. | — | 2000 | → |
| A sibling-pair based approach for mapping genetic loci that influence quantitative measures of reading disability. | Francks C et al. | — | 2000 | → |
| Association study of the chromosomal region containing the FCER2 gene suggests it has a regulatory role in atopic disorders. | Laitinen T et al. | — | 2000 | → |
| A two-stage variable-stringency semiparametric method for mapping quantitative-trait loci with the use of genomewide-scan data on sib pairs. | Ghosh S et al. | — | 2000 | → |
| A unified sampling approach for multipoint analysis of qualitative and quantitative traits in sib pairs. | Liang KY et al. | — | 2000 | → |
| beta-2 adrenergic receptor gene variations, blood pressure, and heart size in normal twins. | Busjahn A et al. | — | 2000 | → |
| Candidate locus for a nuclear modifier gene for maternally inherited deafness. | Bykhovskaya Y et al. | — | 2000 | → |
| Clustering methods applied to allele sharing data. | Neuman RJ et al. | — | 2000 | → |
| Composite statistics for QTL mapping with moderately discordant sibling pairs. | Forrest WF et al. | — | 2000 | → |
| Correcting for ascertainment bias of relative-risk estimates obtained using affected-sib-pair linkage data. | Cordell HJ et al. | — | 2000 | → |
| Cytokines in genetic susceptibility to multiple sclerosis: a candidate gene approach. French Multiple Sclerosis Genetics Group. | Reboul J et al. | — | 2000 | → |
| Equivalence of single- and multilocus markers: power to detect linkage with composite markers derived from biallelic loci. | Wilson AF et al. | — | 2000 | → |
| Evaluation of the calcium-sensing receptor gene in idiopathic hypercalciuria and calcium nephrolithiasis. | Petrucci M et al. | — | 2000 | → |
| Evidence for a new Graves disease susceptibility locus at chromosome 18q21. | Vaidya B et al. | — | 2000 | → |
| Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. | Pratt SC et al. | — | 2000 | → |
| Exclusion of linkage of Crohn's disease to previously reported regions on chromosomes 12, 7, and 3 in the Belgian population indicates genetic heterogeneity. | Vermeire S et al. | — | 2000 | → |
| Failure to establish linkage on the X chromosome in 301 families with schizophrenia or schizoaffective disorder. | DeLisi LE et al. | — | 2000 | → |
| Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. | Friddle C et al. | — | 2000 | → |
| Genetic aspects of obsessive-compulsive disorder. | Wolff M et al. | — | 2000 | → |
| Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture. | Deng HW et al. | — | 2000 | → |
| Genetic studies of autism: from the 1970s into the millennium. | Rutter M | — | 2000 | → |
| Genetic susceptibility to tuberculosis in Africans: a genome-wide scan. | Bellamy R et al. | — | 2000 | → |
| Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. | van der Kallen CJ et al. | — | 2000 | → |
| Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis. | Koller DL et al. | — | 2000 | → |
| Genome-wide linkage analysis of systolic and diastolic blood pressure: the Québec Family Study. | Rice T et al. | — | 2000 | → |
| Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24. | Ohman M et al. | — | 2000 | → |
| Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings. | Perola M et al. | — | 2000 | → |
| Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. | Vionnet N et al. | — | 2000 | → |
| Haseman and Elston revisited. | Elston RC et al. | — | 2000 | → |
| Human Na+/H+ exchanger genes : identification of polymorphisms by radiation hybrid mapping and analysis of linkage in end-stage renal disease. | Yu H et al. | — | 2000 | → |
| Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder. | DeLisi LE et al. | — | 2000 | → |
| Linkage analysis in the presence of errors I: complex-valued recombination fractions and complex phenotypes. | Göring HH et al. | — | 2000 | → |
| Linkage and associated studies of schizophrenia. | Riley BP et al. | — | 2000 | → |
| Model-free sib-pair linkage analysis: combining full-sib and half-sib pairs. | Schaid DJ et al. | — | 2000 | → |
| Multilocus linkage tests based on affected relative pairs. | Cordell HJ et al. | — | 2000 | → |
| Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region. | Fife MS et al. | — | 2000 | → |
| Multipoint linkage analysis of the pseudoautosomal regions, using affected sibling pairs. | Dupuis J et al. | — | 2000 | → |
| No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians. | Frayling TM et al. | — | 2000 | → |
| Possible locus on chromosome 18q influencing postural systolic blood pressure changes. | Pankow JS et al. | — | 2000 | → |
| Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. | Sham PC et al. | — | 2000 | → |
| Pseudoautosomal linkage in chronic lymphocytic leukaemia. | Houlston RS et al. | — | 2000 | → |
| Psychiatric genetics: back to the future. | Owen MJ et al. | — | 2000 | → |
| Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus. The NHLBI Family Heart Study. | Coon H et al. | — | 2000 | → |
| Search for schizophrenia susceptibility genes. | Pulver AE | — | 2000 | → |
| Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus. | Takacs I et al. | — | 2000 | → |
| Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. | Yokouchi Y et al. | — | 2000 | → |
| Some properties of a variance components model for fine-mapping quantitative trait loci. | Cardon LR et al. | — | 2000 | → |
| Study of two ectopeptidases in the susceptibility to celiac disease: two newly identified polymorphisms of dipeptidylpeptidase IV. | Clot F et al. | — | 2000 | → |
| Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. | Pajukanta P et al. | — | 2000 | → |
| Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values. | Sham PC et al. | — | 2000 | → |
| A comparison of some allele-sharing based linkage analysis methods for detecting complex trait loci. | Liu Y et al. | — | 1999 | → |
| A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome. The Tourette Syndrome Association International Consortium for Genetics. | — | — | 1999 | → |
| Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12. | Yang H et al. | — | 1999 | → |
| A general conditional-logistic model for affected-relative-pair linkage studies. | Olson JM | — | 1999 | → |
| A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11. | Aouizerat BE et al. | — | 1999 | → |
| A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. | Hampe J et al. | — | 1999 | → |
| A genome-wide search for linkage to asthma. German Asthma Genetics Group. | Wjst M et al. | — | 1999 | → |
| A genome-wide search identifies potential new susceptibility loci for Crohn's disease. | Ma Y et al. | — | 1999 | → |
| A genome-wide search strategy for identifying quantitative trait loci involved in reading and spelling disability (developmental dyslexia). | Fisher SE et al. | — | 1999 | → |
| A joint test of linkage and gene x environment interaction, with affected sib pairs. | Gauderman WJ et al. | — | 1999 | → |
| Alpha-2 macroglobulin gene and Alzheimer disease. | Rudrasingham V et al. | — | 1999 | → |
| A method for meta-analysis of genome searches: application to simulated data. | Wise LH et al. | — | 1999 | → |
| Analysis of affected sib pairs, with covariates--with and without constraints. | Greenwood CM et al. | — | 1999 | → |
| An extreme-sib-pair genome scan for genes regulating blood pressure. | Xu X et al. | — | 1999 | → |
| A paradigm for finding genes for a complex human trait: polycystic ovary syndrome and follistatin. | Odunsi K et al. | — | 1999 | → |
| Application of probabilistic neural network analysis to a disease with complex inheritance: the GAW11 simulated data. | Naimark DM et al. | — | 1999 | → |
| A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia. | Fisher SE et al. | — | 1999 | → |
| A random model approach to mapping quantitative trait loci for complex binary traits in outbred populations. | Yi N et al. | — | 1999 | → |
| A semiquantitative whole genome screen analysis of alcohol dependence. | John S et al. | — | 1999 | → |
| A simulation study of the effects of assignment of prior identity-by-descent probabilities to unselected sib pairs, in covariance-structure modeling of a quantitative-trait locus. | Dolan CV et al. | — | 1999 | → |
| Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension. | Lin RC et al. | — | 1999 | → |
| Asymptotic power of likelihood-ratio tests for detecting quantitative trait loci using the COGA data. | Williams JT et al. | — | 1999 | → |
| A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. | Williams NM et al. | — | 1999 | → |
| Combined linkage and association sib-pair analysis for quantitative traits. | Fulker DW et al. | — | 1999 | → |
| Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis. | Cox A et al. | — | 1999 | → |
| Comparison of evidence supporting a chromosome 6 alcoholism gene. | Cantor RM et al. | — | 1999 | → |
| Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples. | Williams JT et al. | — | 1999 | → |
| Contribution of the MHC region to the familial risk of coeliac disease. | Bevan S et al. | — | 1999 | → |
| Covariates in linkage analysis. | Rice JP et al. | — | 1999 | → |
| Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13. | Zielenski J et al. | — | 1999 | → |
| DNA pooling and dense marker maps: a systematic search for genes for cognitive ability. | Hill L et al. | — | 1999 | → |
| Down-weighting of multiple affected sib pairs leads to biased likelihood-ratio tests, under the assumption of no linkage. | Greenwood CM et al. | — | 1999 | → |
| Effects of genotype x sex interaction on linkage analysis of visual event-related evoked potentials. | Towne B et al. | — | 1999 | → |
| Evaluation of markers on human chromosome 10, including the homologue of the rodent Rf-1 gene, for linkage to ESRD in black patients. | Yu H et al. | — | 1999 | → |
| Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension. | Kainulainen K et al. | — | 1999 | → |
| Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. | Baima J et al. | — | 1999 | → |
| Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian anglo-caucasians. | Wang WY et al. | — | 1999 | → |
| Exploring linkage for alcoholism using affection status and quantitative event related potential phenotypes. | Lunetta KL et al. | — | 1999 | → |
| Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis. | Feakes R et al. | — | 1999 | → |
| Further evidence for a susceptibility locus on chromosome 20q13.11 in families with dominant transmission of Graves disease. | Pearce SH et al. | — | 1999 | → |
| Gene mapping by linkage and association analysis. | March RE | — | 1999 | → |
| Genetic analysis of a complex disease in the presence of an environmental risk factor. | Eichenbaum-Voline S et al. | — | 1999 | → |
| Genetic dissection of a complex trait. | Lin JH et al. | — | 1999 | → |
| Genetic linkage analysis of simulated complex disease data. | Alarcón M et al. | — | 1999 | → |
| Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure. | Wong ZY et al. | — | 1999 | → |
| Genetic mapping of complex traits. | Olson JM et al. | — | 1999 | → |
| Genetic model-free linkage analysis using the maximum-likelihood-binomial method for categorical traits. | Alcaïs A et al. | — | 1999 | → |
| Genome scan for human obesity and linkage to markers in 20q13. | Lee JH et al. | — | 1999 | → |
| Genome screen for platelet monoamine oxidase (MAO) activity. | Saccone NL et al. | — | 1999 | → |
| Impact of family structure on the power of linkage tests using sib-pair methods. | Goddard KA et al. | — | 1999 | → |
| Improving the power for disease locus detection in affected-sib-pair studies by using two-locus analysis and multiple regression methods. | Cordell HJ et al. | — | 1999 | → |
| Incorporating larger families in identity-by-descent based linkage analysis. | Loesgen S et al. | — | 1999 | → |
| Indication of linkage of serum IgE levels to the interleukin-4 gene and exclusion of the contribution of the (-590 C to T) interleukin-4 promoter polymorphism to IgE variation. | Dizier MH et al. | — | 1999 | → |
| Issues in genomic screening: critical values, sample sizes, and the ability to detect linkage. | Rogus JJ et al. | — | 1999 | → |
| Linkage analysis of candidate genes and gene-gene interactions in chinese hypertensive sib pairs. | Niu T et al. | — | 1999 | → |
| Linkage analysis of endothelial nitric oxide synthase gene with human blood pressure. | Takami S et al. | — | 1999 | → |
| Linkage and association study of the CTLA-4 region in coeliac disease for Italian and Tunisian populations. | Clot F et al. | — | 1999 | → |
| Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins. | Busjahn A et al. | — | 1999 | → |
| Linkage of inflammatory bowel disease to human chromosome 6p. | Hampe J et al. | — | 1999 | → |
| Mapping genotype to phenotype for linkage analysis. | Saccone NL et al. | — | 1999 | → |
| Mapping of a blood pressure quantitative trait locus to chromosome 15q in a Chinese population. | Xu X et al. | — | 1999 | → |
| Mapping quantitative trait loci for complex binary traits in outbred populations. | Yi N et al. | — | 1999 | → |
| Maximum-Likelihood-Binomial method for genetic model-free linkage analysis of quantitative traits in sibships. | Alcaïs A et al. | — | 1999 | → |
| Meta-analysis of genetic linkage to quantitative trait loci with study-specific covariates: a mixed-effects model. | Gu C et al. | — | 1999 | → |
| Multipoint genetic mapping of quantitative trait loci with dominant markers in outbred populations. | Gessler DD et al. | — | 1999 | → |
| Nonparametric linkage and family-based association studies of a simulated complex disorder. | Koller DL et al. | — | 1999 | → |
| On a randomization procedure in linkage analysis. | Zhao H et al. | — | 1999 | → |
| PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. | Tsao BP et al. | — | 1999 | → |
| Peroxisome proliferator-activated receptor gamma gene locus is related to body mass index and lipid values in healthy nonobese subjects. | Knoblauch H et al. | — | 1999 | → |
| Possible linkage of alcoholism, monoamine oxidase activity and P300 amplitude to markers on chromosome 12q24. | Juo SH et al. | — | 1999 | → |
| Psychiatric genetics: progress, problems, and potential. | Owen MJ et al. | — | 1999 | → |
| Quantitative trait linkage mapping in anthropology. | Rogers J et al. | — | 1999 | → |
| Quantitative-trait locus for specific language and reading deficits on chromosome 6p. | Gayán J et al. | — | 1999 | → |
| Quantitative trait transmission disequilibrium test: allowance for missing parents. | Schaid DJ et al. | — | 1999 | → |
| Relationship estimation by Markov-process models in a sib-pair linkage study. | Olson JM | — | 1999 | → |
| Replication of linkage studies of complex traits: an examination of variation in location estimates. | Roberts SB et al. | — | 1999 | → |
| Search for susceptibility genes, gene x gene interactions, and gene x environment interactions utilizing nonparametric linkage analysis. | Ehm MG et al. | — | 1999 | → |
| Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus. | Takacs I et al. | — | 1999 | → |
| Strategies for detecting susceptibility genes in a complex disease. | Babron MC et al. | — | 1999 | → |
| Suggestive linkage of the parathyroid receptor type 1 to osteoporosis. | Duncan EL et al. | — | 1999 | → |
| The Emerging Importance of Genetics in Epidemiologic Research III. Bioinformatics and statistical genetic methods. | Ellsworth DL et al. | — | 1999 | → |
| The impact of marker allele frequency misspecification in variance components quantitative trait locus analysis using sibship data. | Borecki IB et al. | — | 1999 | → |
| The importance of watching our weights: how the choice of weights for non-independent sib pairs can dramatically alter results. | Van Eerdewegh P et al. | — | 1999 | → |
| Validation of linkage by sampling based on environmental exposures. | Greenwood CM et al. | — | 1999 | → |
| A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. | Hager J et al. | — | 1998 | → |
| A linkage and cross-sectional study of hypertension and obesity using a poly (A) Alu-repeat polymorphism at the glucagon receptor gene locus (17q25). | Rutherford S et al. | — | 1998 | → |
| Allele identical by descent sharing at any point of a chromosome of a sib pair. | Drigalenko E | — | 1998 | → |
| A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients. | Cucca F et al. | — | 1998 | → |
| American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12. | Brant SR et al. | — | 1998 | → |
| An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. | Pratley RE et al. | — | 1998 | → |
| An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. | Hanson RL et al. | — | 1998 | → |
| Angiotensinogen gene and hypertension in Chinese. | Niu T et al. | — | 1998 | → |
| Anxiety proneness linked to epistatic loci in genome scan of human personality traits. | Cloninger CR et al. | — | 1998 | → |
| A rank-based nonparametric method for mapping quantitative trait loci in outbred half-sib pedigrees: application to milk production in a granddaughter design. | Coppieters W et al. | — | 1998 | → |
| Combining different line crosses for mapping quantitative trait loci using the identical by descent-based variance component method. | Xie C et al. | — | 1998 | → |
| Efficient, robust, and unified method for mapping complex traits (I): two-point linkage analysis. | Zhao LP et al. | — | 1998 | → |
| Evaluation of the angiotensinogen locus in human essential hypertension: a European study. | Brand E et al. | — | 1998 | → |
| Evidence for complex nuclear inheritance in a pedigree with nonsyndromic deafness due to a homoplasmic mitochondrial mutation. | Bykhovskaya Y et al. | — | 1998 | → |
| Evidence for linkage to psychosis and cerebral asymmetry (relative hand skill) on the X chromosome. | Laval SH et al. | — | 1998 | → |
| Evidence of linkage of the inflammatory bowel disease susceptibility locus on chromosome 16 (IBD1) to ulcerative colitis. | Mirza MM et al. | — | 1998 | → |
| Faster multipoint linkage analysis using Fourier transforms. | Kruglyak L et al. | — | 1998 | → |
| Finding specific genes that cause autism: a combination of approaches will be needed to maximize power. | Folstein SE et al. | — | 1998 | → |
| Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13. | Nakagawa Y et al. | — | 1998 | → |
| Genetic analysis of male pattern baldness and the 5alpha-reductase genes. | Ellis JA et al. | — | 1998 | → |
| Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil. | Blackwell JM | — | 1998 | → |
| Genome search in celiac disease. | Greco L et al. | — | 1998 | → |
| Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease. | Yu H et al. | — | 1998 | → |
| Inflation of sibling recurrence-risk ratio, due to ascertainment bias and/or overreporting. | Guo SW | — | 1998 | → |
| Inheritance of susceptibility to multiple sclerosis. | Sawcer S et al. | — | 1998 | → |
| Issues and strategies in the genetic analysis of alcoholism and related addictive behaviors. | Schork NJ et al. | — | 1998 | → |
| Iteratively reweighted least squares mapping of quantitative trait loci. | Xu S | — | 1998 | → |
| Linkage analysis, kinship, and the short-term evolution of chromosomes. | Schork NJ et al. | — | 1998 | → |
| Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators. | Eeles RA et al. | — | 1998 | → |
| Linkage of a QTL contributing to normal variation in bone mineral density to chromosome 11q12-13. | Koller DL et al. | — | 1998 | → |
| Linkage of circulating eosinophils to markers on chromosome 5q. | Martinez FD et al. | — | 1998 | → |
| Linkage thresholds for two-stage genome scans. | Kruglyak L et al. | — | 1998 | → |
| Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. | Rihet P et al. | — | 1998 | → |
| Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture. | McKeigue PM | — | 1998 | → |
| Mapping quantitative trait loci for ordered categorical traits in four-way crosses. | Rao S et al. | — | 1998 | → |
| Mapping quantitative trait loci using multiple families of line crosses. | Xu S | — | 1998 | → |
| Multipoint quantitative-trait linkage analysis in general pedigrees. | Almasy L et al. | — | 1998 | → |
| No evidence for significant linkage between bipolar affective disorder and chromosome 18 pericentromeric markers in a large series of multiplex extended pedigrees. | Knowles JA et al. | — | 1998 | → |
| Optimal ascertainment strategies to detect linkage to common disease alleles. | Badner JA et al. | — | 1998 | → |
| Overview of strategies for complex genetic diseases. | Clerget-Darpoux F | — | 1998 | → |
| Progress on the genetics of schizophrenia. | Bassett AS | — | 1998 | → |
| Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. | Begleiter H et al. | — | 1998 | → |
| Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data. | Abel L et al. | — | 1998 | → |
| Scanning the genome for essential hypertension loci. | Morris BJ et al. | — | 1998 | → |
| Sib mating designs for mapping quantitative trait loci. | Xie C et al. | — | 1998 | → |
| Susceptibility to multiple sclerosis and the immunoglobulin heavy chain gene cluster. | Feakes R et al. | — | 1998 | → |
| Understanding developmental psychopathology: how useful are evolutionary accounts? | Leckman JF et al. | — | 1998 | → |
| Using family history information to distinguish true and false positive model-free linkage results. | Olson JM et al. | — | 1998 | → |
| [A brief history of twin study methods]. | Lorenzi F | — | 1997 | → |
| Accurate inference of relationships in sib-pair linkage studies. | Boehnke M et al. | — | 1997 | → |
| Affected-sib-pair analyses of bipolar disorder using data on chromosome 18. | Haghighi F et al. | — | 1997 | → |
| Affected sibpair linkage tests for multiple linked susceptibility genes. | Farrall M | — | 1997 | → |
| Affected sib-pair tests for linkage: type I errors with dependent sib-pairs. | Meunier F et al. | — | 1997 | → |
| A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. | Guerra R et al. | — | 1997 | → |
| A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits. | Vogler GP et al. | — | 1997 | → |
| Analysis of a complex oligogenic disease. | O'Connell JR et al. | — | 1997 | → |
| A variance component approach to dichotomous trait linkage analysis using a threshold model. | Duggirala R et al. | — | 1997 | → |
| Behavioral genetics '97: ASHG statement. Recent developments in human behavioral genetics: past accomplishments and future directions. | Sherman SL et al. | — | 1997 | → |
| Caution in the interpretation of MLS. | Eichenbaum-Voline S et al. | — | 1997 | → |
| Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect. | Lehto M et al. | — | 1997 | → |
| Comparison of evidence for linkage from different analytic methods. | Bull SB et al. | — | 1997 | → |
| Comparison of model-free linkage mapping strategies for the study of a complex trait. | Amos CI et al. | — | 1997 | → |
| Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation. | Davis S et al. | — | 1997 | → |
| Comparison of parametric and nonparametric methods to map oligogenes by linkage. | Liò P et al. | — | 1997 | → |
| Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes. | Iyengar S et al. | — | 1997 | → |
| Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci. | Rogus JJ et al. | — | 1997 | → |
| Effects of genotype-by-sex interaction on quantitative trait linkage analysis. | Towne B et al. | — | 1997 | → |
| Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis. | Holmans P et al. | — | 1997 | → |
| Empirical affected-sib-pair statistics: two simulation strategies. | Dina C et al. | — | 1997 | → |
| Empirical genomewide significance levels established by whole genome simulations. | Sawcer S et al. | — | 1997 | → |
| Factors influencing the identification of major genes in a complex disease genome scan. | Yang H et al. | — | 1997 | → |
| False positive rates in a genomic screen for complex quantitative traits. | Scott WK et al. | — | 1997 | → |
| Further evidence suggesting the presence of a locus, on human chromosome 5q31-q33, influencing the intensity of infection with Schistosoma mansoni. | Müller-Myhsok B et al. | — | 1997 | → |
| Genetic analysis of bipolar disorder: summary of GAW10. | Rice J | — | 1997 | → |
| Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions. | Wijsman EM et al. | — | 1997 | → |
| Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. | Laitinen T et al. | — | 1997 | → |
| Genetic linkage analysis of growth factor loci and end-stage renal disease in African Americans. | Freedman BI et al. | — | 1997 | → |
| Genetics of manic depressive illness. | MacKinnon DF et al. | — | 1997 | → |
| Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. | Norman RA et al. | — | 1997 | → |
| Heterogeneity of marker allele frequencies hinders interpretation of linkage analysis: illustration on chromosome 18 markers. | Margaritte-Jeannin P et al. | — | 1997 | → |
| Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder. | Greenwood CM et al. | — | 1997 | → |
| Linkage study of chromosome 6p in sib-pairs with schizophrenia. | Daniels JK et al. | — | 1997 | → |
| Multipoint analysis of quantitative traits. | Marlow AJ et al. | — | 1997 | → |
| Mutational analysis of BRCA1 gene in ovarian and breast-ovarian cancer families in Japan. | Takano M et al. | — | 1997 | → |
| Optimal strategies for mapping complex diseases in the presence of multiple loci. | Goldgar DE et al. | — | 1997 | → |
| Pathogenesis of Tourette's syndrome. | Leckman JF et al. | — | 1997 | → |
| Preliminary data on a genome search in NIDDM siblings: the NIDDM1 locus on chromosome 2 is not linked to NIDDM in the Sardinian population. Study Group for the Genetics of Diabetes in Sardinia. | Ciccarese M et al. | — | 1997 | → |
| Probabilistic diagnosis in linkage analysis of bipolar disorder: putting weights on the fringe. | Van Eerdewegh P et al. | — | 1997 | → |
| Proceedings of the Genetic Analysis Workshop 10 (GAW10). Watsonville, California, USA. October 26-29, 1996. | — | — | 1997 | → |
| Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. | Hasstedt SJ et al. | — | 1997 | → |
| Relationship of a novel polymorphic marker near the human obese (OB) gene to fat mass in healthy women. | Lapsys NM et al. | — | 1997 | → |
| Selected methodological issues in meiotic mapping of obesity genes in humans: issues of power and efficiency. | Allison DB et al. | — | 1997 | → |
| Sequential sib-pair and association studies to detect genes in quantitative traits. | Savage A et al. | — | 1997 | → |
| Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees. | Williams JT et al. | — | 1997 | → |
| Strategies for mapping heterogeneous recessive traits by allele-sharing methods. | Feingold E et al. | — | 1997 | → |
| Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. | Cao Q et al. | — | 1997 | → |
| Summary of human linkage and association studies. | Pérusse L et al. | — | 1997 | → |
| The effect of selective sampling on mapping quantitative trait loci. | Camp NJ et al. | — | 1997 | → |
| The genetic analysis of multiple sclerosis. | Sawcer S et al. | — | 1997 | → |
| The genetics of Tourette syndrome. | Alsobrook JP et al. | — | 1997 | → |
| The method of sib-pair linkage analysis in context of case-control design. | Yang Q et al. | — | 1997 | → |
| The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs. | Shugart YY et al. | — | 1997 | → |
| The phenotypic difference discards sib-pair QTL linkage information. | Wright FA | — | 1997 | → |
| The role of meta-analysis in linkage studies of complex traits. | Rice JP | — | 1997 | → |
| The use of a genetic map of biallelic markers in linkage studies. | Kruglyak L | — | 1997 | → |
| The utility of deviant sib pairs in the detection of linkage. | Rochberg DR et al. | — | 1997 | → |
| Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8. | — | — | 1996 | → |
| A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. | Sawcer S et al. | — | 1996 | → |
| A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. | Ginns EI et al. | — | 1996 | → |
| An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland. | Zhong F et al. | — | 1996 | → |
| An improved multipoint sib-pair analysis of quantitative traits. | Fulker DW et al. | — | 1996 | → |
| Assessing genetic linkage and association with robust components of variance approaches. | Amos CI et al. | — | 1996 | → |
| Complex traits on the map. | Ott J | — | 1996 | → |
| Computation of the full likelihood function for estimating variance at a quantitative trait locus. | Xu S | — | 1996 | → |
| Genetic analysis of autoimmune disease. | Vyse TJ et al. | — | 1996 | → |
| Logarithm of odds (lods) for linkage in complex inheritance. | Morton NE | — | 1996 | → |
| Mapping of a susceptibility locus for Crohn's disease on chromosome 16. | Hugot JP et al. | — | 1996 | → |
| Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus. | Morahan G et al. | — | 1996 | → |
| Mixture distributions in human genetics research. | Schork NJ et al. | — | 1996 | → |
| Multivariate multipoint linkage analysis of quantitative trait loci. | Eaves LJ et al. | — | 1996 | → |
| Parametric and nonparametric linkage analysis: a unified multipoint approach. | Kruglyak L et al. | — | 1996 | → |
| Quantitative trait loci analysis for five milk production traits on chromosome six in the Dutch Holstein-Friesian population. | Spelman RJ et al. | — | 1996 | → |
| The geneticist's approach to complex disease. | Ghosh S et al. | — | 1996 | → |
| Trials of the beta model for complex inheritance. | Collins A et al. | — | 1996 | → |
| Two-stage global search designs for linkage analysis using pairs of affected relatives. | Elston RC et al. | — | 1996 | → |
| Using multivariate genetic modeling to detect pleiotropic quantitative trait loci. | Boomsma DI | — | 1996 | → |
| Using the expectation or the distribution of the identity by descent for mapping quantitative trait loci under the random model. | Gessler DD et al. | — | 1996 | → |
| Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | Lander E et al. | — | 1995 | → |
| How do you compute a lod score? | Ott J | — | 1995 | → |
| Linkage between sexual orientation and chromosome Xq28 in males but not in females. | Hu S et al. | — | 1995 | → |
| Polygenic disease: methods for mapping complex disease traits. | Weeks DE et al. | — | 1995 | → |