Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
paper
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- Authors
- Zeggini, Eleftheria; Weedon, Michael N; Lindgren, Cecilia M; Frayling, Timothy M; Elliott, Katherine S; Lango, Hana; Timpson, Nicholas J; Perry, John R B; Rayner, Nigel W; Freathy, Rachel M; Barrett, Jeffrey C; Shields, Beverley; Morris, Andrew P; Ellard, Sian; Groves, Christopher J; Harries, Lorna W; Marchini, Jonathan L; Owen, Katharine R; Knight, Beatrice; Cardon, Lon R; Walker, Mark; Hitman, Graham A; Morris, Andrew D; Doney, Alex S F; Wellcome Trust Case Control Consortium (WTCCC); McCarthy, Mark I; Hattersley, Andrew T
- Year
- 2007
- Journal
- Science (New York, N.Y.)
- PMID
- 17463249
- DOI
- 10.1126/science.1142364
- PMCID
- PMC3772310
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent data from other international consortia. We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8. Our findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect. The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes.
Overview of CDKAL1 signal regionA Plot of −log(p values) for T2D (Cochran-Armitage test for trend) against chromosome position in Mb. Blue diamonds represent primary scan results and pink triangles denote meta-analysis results across all UK samples.B Genomic location of genes showing intron and exon structure (NCBI Build 35). Pink triangles show position of replication SNPs relative to gene structure.C MULTIZ (24) vertebrate alignment of 17 species showing evolutionary conservation.D GoldSurfer2 (25) plot of linkage disequilibrium (r2) for SNPs genotyped in WTCCC scan (passing T2D-specific quality control) in WTCCC T2D cases.E Recombination rate given as cM/MB. Red boxes represent recombination hotspots (26).F GoldSurfer2 plot of linkage disequilibrium (r2) for all HapMap SNPs across the region (HapMap CEU data).
Overview of chr9 signal regionPanel layout as per Figure 1
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| Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors. | Witka BZ et al. | — | 2019 | → |
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| A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes. | Piao X et al. | — | 2018 | → |
| A genetic variant in CDKN2A/B gene is associated with the increased risk of breast cancer. | ShahidSales S et al. | — | 2018 | → |
| Analysis of the 9p21.3 sequence associated with coronary artery disease reveals a tendency for duplication in a CAD patient. | Kouprina N et al. | — | 2018 | → |
| Association Between SLC30A8 rs13266634 Polymorphism and Risk of T2DM and IGR in Chinese Population: A Systematic Review and Meta-Analysis. | Dong F et al. | — | 2018 | → |
| Association of CDKAL1 nucleotide variants with the risk of non-syndromic cleft lip with or without cleft palate. | Gaczkowska A et al. | — | 2018 | → |
| Association of CDKN2A/CDKN2B with inflammatory bowel disease in Koreans. | Lee HS et al. | — | 2018 | → |
| Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women. | Nfor ON et al. | — | 2018 | → |
| Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women. | Justice JN et al. | — | 2018 | → |
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| Design of Arab Diabetes Gene-Centric Array (ADGCA) in population with an epidemic of Type 2 Diabetes: A population specific SNP evaluation. | Al-Rubeaan K et al. | — | 2018 | → |
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| Evaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants. | Fukue K et al. | — | 2018 | → |
| Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population. | O'Beirne SL et al. | — | 2018 | → |
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| FTO, GCKR, CDKAL1 and CDKN2A/B gene polymorphisms and the risk of gestational diabetes mellitus: a meta-analysis. | Guo F et al. | — | 2018 | → |
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| Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8. | Merriman C et al. | — | 2018 | → |
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| IAPP/amylin and β-cell failure: implication of the risk factors of type 2 diabetes. | Kanatsuka A et al. | — | 2018 | → |
| <i>CDKN2A/B</i> T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets. | Kong Y et al. | — | 2018 | → |
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| Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population. | Plengvidhya N et al. | — | 2018 | → |
| Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors. | Liu KC et al. | — | 2018 | → |
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| Mediating Effect of Diabetes Mellitus on the Association Between Chromosome 9p21.3 Locus and Myocardial Infarction Risk: A Case-Control Study in Shanghai, China. | Wu Z et al. | — | 2018 | → |
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| Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects. | Li YY et al. | — | 2018 | → |
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| Variants of CDKAL1 rs7754840 (G/C) and CDKN2A/2B rs10811661 (C/T) with gestational diabetes: insignificant association. | Noury AE et al. | — | 2018 | → |
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| A Loss-of-Function Splice Acceptor Variant in <i>IGF2</i> Is Protective for Type 2 Diabetes. | Mercader JM et al. | — | 2017 | → |
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| Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study. | Sikhayeva N et al. | — | 2017 | → |
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| Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development. | Rosta K et al. | — | 2017 | → |
| A Statistical Framework for Pathway and Gene Identification from Integrative Analysis. | Li Q et al. | — | 2017 | → |
| CDK5 Regulatory Subunit-Associated Protein 1-like 1 Negatively Regulates Adipocyte Differentiation through Activation of Wnt Signaling Pathway. | Take K et al. | — | 2017 | → |
| Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue. | Palmer CJ et al. | — | 2017 | → |
| Cellular senescence: Implications for metabolic disease. | Schafer MJ et al. | — | 2017 | → |
| Common and rare exonic MUC5B variants associated with type 2 diabetes in Han Chinese. | Chen G et al. | — | 2017 | → |
| Computational analyses of type 2 diabetes-associated loci identified by genome-wide association studies. | Cheng M et al. | — | 2017 | → |
| Concise Review: Challenges in Regenerating the Diabetic Heart: A Comprehensive Review. | Satthenapalli VR et al. | — | 2017 | → |
| Dwarfism and Altered Craniofacial Development in Rabbits Is Caused by a 12.1 kb Deletion at the HMGA2 Locus. | Carneiro M et al. | — | 2017 | → |
| Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel. | Wong WP et al. | — | 2017 | → |
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| FTO Genotype and Type 2 Diabetes Mellitus: Spatial Analysis and Meta-Analysis of 62 Case-Control Studies from Different Regions. | Yang Y et al. | — | 2017 | → |
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| Genetic Variations as Modifying Factors to Dietary Zinc Requirements-A Systematic Review. | Day KJ et al. | — | 2017 | → |
| Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus. | Saucedo R et al. | — | 2017 | → |
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| Implications of impaired zinc homeostasis in diabetic cardiomyopathy and nephropathy. | Giacconi R et al. | — | 2017 | → |
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| Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes. | van Herpt TTW et al. | — | 2017 | → |
| K<sub>ATP</sub> Channel Mutations and Neonatal Diabetes. | Shimomura K et al. | — | 2017 | → |
| LncRNAs: key players and novel insights into diabetes mellitus. | He X et al. | — | 2017 | → |
| Long Noncoding RNAs as Diagnostic and Therapeutic Targets in Type 2 Diabetes and Related Complications. | Leti F et al. | — | 2017 | → |
| Long noncoding RNA variations in cardiometabolic diseases. | Dechamethakun S et al. | — | 2017 | → |
| Major review: Molecular genetics of primary open-angle glaucoma. | Liu Y et al. | — | 2017 | → |
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| No association detected between seven common variants in the CDKAL1 gene and gestational glycemic traits. | Ju H et al. | — | 2017 | → |
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| Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. | da Silva Xavier G et al. | — | 2017 | → |
| Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey. | Curtis EM et al. | — | 2017 | → |
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| RNA sequencing of db/db mice liver identifies lncRNA H19 as a key regulator of gluconeogenesis and hepatic glucose output. | Goyal N et al. | — | 2017 | → |
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| The Pathophysiology of Hyperglycemia in Older Adults: Clinical Considerations. | Lee PG et al. | — | 2017 | → |
| The rs7903146 Variant in the <i>TCF7L2</i> Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity. | Cropano C et al. | — | 2017 | → |
| Transdisciplinary approaches enhance the production of translational knowledge. | Ciesielski TH et al. | — | 2017 | → |
| Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms. | Votsi C et al. | — | 2017 | → |
| Utilization of genetic data can improve the prediction of type 2 diabetes incidence in a Swedish cohort. | Zarkoob H et al. | — | 2017 | → |
| A Clustered Multiclass Likelihood-Ratio Ensemble Method for Family-Based Association Analysis Accounting for Phenotypic Heterogeneity. | Wen Y et al. | — | 2016 | → |
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| Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case-Control Study and Meta-Analysis. | Rao P et al. | — | 2016 | → |
| Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes. | van der Kroef S et al. | — | 2016 | → |
| Association of CDKAL1, CDKN2A/B & HHEX gene polymorphisms with type 2 diabetes mellitus in the population of Hyderabad, India. | Kommoju UJ et al. | — | 2016 | → |
| Association of SLC30A8 gene polymorphism with type 2 diabetes, evidence from 46 studies: a meta-analysis. | Fan M et al. | — | 2016 | → |
| A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. | Oram RA et al. | — | 2016 | → |
| Body mass index: Has epidemiology started to break down causal contributions to health and disease? | Corbin LJ et al. | — | 2016 | → |
| CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates. | Zhong S et al. | — | 2016 | → |
| Common variant within the FTO gene, rs9939609, obesity and type 2 diabetes in population of Karachi, Pakistan. | Fawwad A et al. | — | 2016 | → |
| Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores. | Lee CH et al. | — | 2016 | → |
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| Exploiting Linkage Disequilibrium for Ultrahigh-Dimensional Genome-Wide Data with an Integrated Statistical Approach. | Carlsen M et al. | — | 2016 | → |
| FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population. | Duicu C et al. | — | 2016 | → |
| Gene Polymorphism Association with Type 2 Diabetes and Related Gene-Gene and Gene-Environment Interactions in a Uyghur Population. | Xiao S et al. | — | 2016 | → |
| Genes associated with diabetes: potential for novel therapeutic targets? | Hara K et al. | — | 2016 | → |
| Genetic and clinical variables identify predictors for chronic kidney disease in type 2 diabetes. | Jiang G et al. | — | 2016 | → |
| Genetic markers of type 2 diabetes: Progress in genome-wide association studies and clinical application for risk prediction. | Wang X et al. | — | 2016 | → |
| Genetic variants associated with lean and obese type 2 diabetes in a Han Chinese population: A case-control study. | Kong X et al. | — | 2016 | → |
| Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European American women. | Cheng TY et al. | — | 2016 | → |
| Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. | Imamura M et al. | — | 2016 | → |
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| IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories. | Preitner N et al. | — | 2016 | → |
| Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population. | Li J et al. | — | 2016 | → |
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| Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion. | Collins SC et al. | — | 2016 | → |
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| Lack of Association between <i>SLC30A8</i> Variants and Type 2 Diabetes in Mexican American Families. | Kulkarni H et al. | — | 2016 | → |
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| Predictive utility of a genetic risk score of common variants associated with type 2 diabetes in a black South African population. | Chikowore T et al. | — | 2016 | → |
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| Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies. | Matsuba R et al. | — | 2016 | → |
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| Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion. | Ali S et al. | — | 2016 | → |
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| Whole-genome re-sequencing for the identification of high contribution susceptibility gene variants in patients with type 2 diabetes. | Sun X et al. | — | 2016 | → |
| Zinc Transport Gets Its Zing Back: Double-Knockout of ZnT7 and ZnT8 Reveals the Importance of Zinc Transporters to Insulin Secretion. | Nunemaker CS et al. | — | 2016 | → |
| Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis. | Cheng L et al. | — | 2015 | → |
| Association of gene variants with susceptibility to type 2 diabetes among Omanis. | Al-Sinani S et al. | — | 2015 | → |
| Association of rs7754840 G/C polymorphisms in CDKAL1 with type 2 diabetes: a meta-analysis of 70141 subjects. | Tuerxunyiming M et al. | — | 2015 | → |
| Association of Type 2 Diabetes Mellitus related SNP genotypes with altered serum adipokine levels and metabolic syndrome phenotypes. | Al-Daghri NM et al. | — | 2015 | → |
| Association study of polymorphisms in miRNAs with T2DM in Chinese population. | Li Y et al. | — | 2015 | → |
| Association study of the miRNA-binding site polymorphisms of CDKN2A/B genes with gestational diabetes mellitus susceptibility. | Wang X et al. | — | 2015 | → |
| ATP-dependent potassium channels and type 2 diabetes mellitus. | Bonfanti DH et al. | — | 2015 | → |
| Beyond the Protein-Coding Sequence: Noncoding RNAs in the Pathogenesis of Type 2 Diabetes. | DiStefano JK | — | 2015 | → |
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| Candidate gene analysis supports a role for polymorphisms at TCF7L2 as risk factors for type 2 diabetes in Sudan. | Ibrahim AT et al. | — | 2015 | → |
| CDKAL1 gene variants affect the anti-TNF response among Psoriasis patients. | Coto-Segura P et al. | — | 2015 | → |
| CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population. | Binh TQ et al. | — | 2015 | → |
| Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2. | Xia Q et al. | — | 2015 | → |
| Comparative Genome of GK and Wistar Rats Reveals Genetic Basis of Type 2 Diabetes. | Liu T et al. | — | 2015 | → |
| Contribution of CDKAL1 rs7756992 and IGF2BP2 rs4402960 polymorphisms in type 2 diabetes, diabetic complications, obesity risk and hypertension in the Tunisian population. | Lasram K et al. | — | 2015 | → |
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| Correlation between polymorphism of FTO gene and type 2 diabetes mellitus in Uygur people from northwest China. | Xiao S et al. | — | 2015 | → |
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| Effects of IGF2BP2, KCNQ1 and GCKR polymorphisms on clinical outcome in metastatic gastric cancer treated with EOF regimen. | Liu X et al. | — | 2015 | → |
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| Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. | Gaulton KJ et al. | — | 2015 | → |
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| Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis. | Hromatka BS et al. | — | 2015 | → |
| Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. | Jansen H et al. | — | 2015 | → |
| Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women. | Chan KH et al. | — | 2015 | → |
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| HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study. | Xu WL et al. | — | 2015 | → |
| High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction. | McClay JL et al. | — | 2015 | → |
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| Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage. | Casellas A et al. | — | 2015 | → |
| Interaction of Wnt pathway related variants with type 2 diabetes in a Chinese Han population. | Zhou JB et al. | — | 2015 | → |
| Joint effect of CENTD2 and KCNQ1 polymorphisms on the risk of type 2 diabetes mellitus among Chinese Han population. | Qian Y et al. | — | 2015 | → |
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| Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk. | Walker CG et al. | — | 2015 | → |
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| Polymorphism on Chromosome 9p21.3 Is Associated with Severity and Early-Onset CAD in Type 2 Diabetic Tunisian Population. | Abid K et al. | — | 2015 | → |
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| Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. | Usher CL et al. | — | 2015 | → |
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| The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes. | Kong X et al. | — | 2015 | → |
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| The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion. | Solomou A et al. | — | 2015 | → |
| Type 2 diabetes as a protein misfolding disease. | Mukherjee A et al. | — | 2015 | → |
| Type 2 diabetes-related variants influence the risk of developing multiple myeloma: results from the IMMEnSE consortium. | Ríos R et al. | — | 2015 | → |
| Zip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells. | Hardy AB et al. | — | 2015 | → |
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| A comparison of type 2 diabetes risk allele load between African Americans and European Americans. | Keaton JM et al. | — | 2014 | → |
| Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. | Jeff JM et al. | — | 2014 | → |
| A gene variant in the transcription factor 7-like 2 (TCF7L2) is associated with an increased risk of gestational diabetes mellitus. | Pagán A et al. | — | 2014 | → |
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| Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study. | Carty CL et al. | — | 2014 | → |
| Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. | Maianti JP et al. | — | 2014 | → |
| Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women. | Frasco MA et al. | — | 2014 | → |
| A polymorphism in the melanocortin 4 receptor gene (MC4R:c.92C>T) is associated with diabetes mellitus in overweight domestic shorthaired cats. | Forcada Y et al. | — | 2014 | → |
| A robust method for genome-wide association meta-analysis with the application to circulating insulin-like growth factor I concentrations. | Wang T et al. | — | 2014 | → |
| Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population. | Al-Daghri NM et al. | — | 2014 | → |
| Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry. | Morris BJ et al. | — | 2014 | → |
| Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis. | Benrahma H et al. | — | 2014 | → |
| Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population. | Al-Daghri NM et al. | — | 2014 | → |
| Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis. | Huang Y et al. | — | 2014 | → |
| Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest. | DeMenna J et al. | — | 2014 | → |
| Association of IRS1, CAPN10, and PPARG gene polymorphisms with type 2 diabetes mellitus in the high-risk population of Hyderabad, India. | Kommoju UJ et al. | — | 2014 | → |
| Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis. | Xi B et al. | — | 2014 | → |
| Candidate disease gene prediction using Gentrepid: application to a genome-wide association study on coronary artery disease. | Ballouz S et al. | — | 2014 | → |
| CDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people. | Klimentidis YC et al. | — | 2014 | → |
| Cdkn2a/p16Ink4a regulates fasting-induced hepatic gluconeogenesis through the PKA-CREB-PGC1α pathway. | Bantubungi K et al. | — | 2014 | → |
| Cellular senescence mediated by p16INK4A-coupled miRNA pathways. | Overhoff MG et al. | — | 2014 | → |
| Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus. | Bukhari SA et al. | — | 2014 | → |
| Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study. | Salem SD et al. | — | 2014 | → |
| Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes. | Giannini C et al. | — | 2014 | → |
| Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese. | Zhao Q et al. | — | 2014 | → |
| Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait. | Torres JM et al. | — | 2014 | → |
| Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease. | Dauriz M et al. | — | 2014 | → |
| Current understanding of ZIP and ZnT zinc transporters in human health and diseases. | Kambe T et al. | — | 2014 | → |
| Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. | Lee Y et al. | — | 2014 | → |
| DataSHIELD: taking the analysis to the data, not the data to the analysis. | Gaye A et al. | — | 2014 | → |
| Disease risk factors identified through shared genetic architecture and electronic medical records. | Li L et al. | — | 2014 | → |
| Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. | Ciesielski TH et al. | — | 2014 | → |
| Drosophila 3' UTRs are more complex than protein-coding sequences. | Algama M et al. | — | 2014 | → |
| Evaluation of common type 2 diabetes risk variants in a South Asian population of Sri Lankan descent. | Hassanali N et al. | — | 2014 | → |
| Exploring the genetic basis of stroke. Spanish stroke genetics consortium. | Giralt-Steinhauer E et al. | — | 2014 | → |
| Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese. | Ma RC et al. | — | 2014 | → |
| Frequency of fat mass and obesity-associated gene rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene rs1801282 polymorphisms among Trinidadian neonates of different ethnicities and their relationship to anthropometry at birth. | Cuthbert CE et al. | — | 2014 | → |
| FTO and obesity: mechanisms of association. | Zhao X et al. | — | 2014 | → |
| Gene dose effect between a fat mass and obesity-associated polymorphism and body mass index was observed in Korean women with polycystic ovary syndrome but not in control women. | Kim JJ et al. | — | 2014 | → |
| Genetic and epigenetic risk factors for diabetic kidney disease. | McKnight AJ et al. | — | 2014 | → |
| Genetic architecture of type 2 diabetes. | Hara K et al. | — | 2014 | → |
| Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population. | Yang J et al. | — | 2014 | → |
| Genetic comorbidities in Parkinson's disease. | Nalls MA et al. | — | 2014 | → |
| Genetic & epigenetic approach to human obesity. | Rao KR et al. | — | 2014 | → |
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| Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. | Basile KJ et al. | — | 2014 | → |
| Genetic Testing and Type 2 Diabetes Risk Awareness. | de Groot M et al. | — | 2014 | → |
| Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population. | Liu S et al. | — | 2014 | → |
| Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan. | Jiang YD et al. | — | 2014 | → |
| Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. | Olsson AH et al. | — | 2014 | → |
| Genome-wide association study identifies two novel Loci with sex-specific effects for type 2 diabetes mellitus and glycemic traits in a korean population. | Go MJ et al. | — | 2014 | → |
| Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3. | Stergiakouli E et al. | — | 2014 | → |
| Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human. | Zhou B et al. | — | 2014 | → |
| Identifying causal variants at loci with multiple signals of association. | Hormozdiari F et al. | — | 2014 | → |
| Inhibition of secreted frizzled-related protein 5 improves glucose metabolism. | Rulifson IC et al. | — | 2014 | → |
| Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits. | Marullo L et al. | — | 2014 | → |
| Interactions between zinc transporter-8 gene (SLC30A8) and plasma zinc concentrations for impaired glucose regulation and type 2 diabetes. | Shan Z et al. | — | 2014 | → |
| Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study. | Chen Z et al. | — | 2014 | → |
| Lack of genetic susceptibility of KCNJ11 E23K polymorphism with risk of type 2 diabetes in an Iranian population. | Keshavarz P et al. | — | 2014 | → |
| Legal aspects of biobanking as key issues for personalized medicine and translational exploitation. | Minssen T et al. | — | 2014 | → |
| Maternal genotype and gestational diabetes. | Stuebe AM et al. | — | 2014 | → |
| Meta-analysis of sequencing studies with heterogeneous genetic associations. | Tang ZZ et al. | — | 2014 | → |
| Modify or die?--RNA modification defects in metazoans. | Sarin LP et al. | — | 2014 | → |
| Moving into a new era of periodontal genetic studies: relevance of large case-control samples using severe phenotypes for genome-wide association studies. | Vaithilingam RD et al. | — | 2014 | → |
| Nutrigenetics: bridging two worlds to understand type 2 diabetes. | Harrington JM et al. | — | 2014 | → |
| Nutrigenomics: the role of nutrients in gene expression. | Dang TS et al. | — | 2014 | → |
| Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population. | Kong X et al. | — | 2014 | → |
| Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults. | Basile KJ et al. | — | 2014 | → |
| Pleiotropic genes for metabolic syndrome and inflammation. | Kraja AT et al. | — | 2014 | → |
| Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction. | Szpakowicz A et al. | — | 2014 | → |
| Polymorphisms of cell cycle control genes influence the development of sporadic medullary thyroid carcinoma. | Barbieri RB et al. | — | 2014 | → |
| Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study. | Phani NM et al. | — | 2014 | → |
| Recent advances in the molecular genetics of type 2 diabetes mellitus. | Brunetti A et al. | — | 2014 | → |
| Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. | Wu Y et al. | — | 2014 | → |
| SLC30A8 nonsynonymous variant is associated with recovery following exercise and skeletal muscle size and strength. | Sprouse C et al. | — | 2014 | → |
| System-based approaches to decode the molecular links in Parkinson's disease and diabetes. | Santiago JA et al. | — | 2014 | → |
| T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. | Ghassibe-Sabbagh M et al. | — | 2014 | → |
| Targeting the pancreatic β-cell to treat diabetes. | Vetere A et al. | — | 2014 | → |
| TBC1D1 reduces palmitate oxidation by inhibiting β-HAD activity in skeletal muscle. | Maher AC et al. | — | 2014 | → |
| TCF7L2 is a master regulator of insulin production and processing. | Zhou Y et al. | — | 2014 | → |
| The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings. | Abdullah N et al. | — | 2014 | → |
| The effect of IGF2BP2 gene polymorphisms on pioglitazone response in Chinese type 2 diabetes patients. | Zhang LF et al. | — | 2014 | → |
| The regulation of pre- and post-maturational plasticity of mammalian islet cell mass. | Mezza T et al. | — | 2014 | → |
| The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice. | Byun HR et al. | — | 2014 | → |
| Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients. | Buraczynska M et al. | — | 2014 | → |
| Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data. | Johnson ME et al. | — | 2014 | → |
| Using volcano plots and regularized-chi statistics in genetic association studies. | Li W et al. | — | 2014 | → |
| Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus. | Al-Sinani S et al. | — | 2014 | → |
| Validation of type 2 diabetes risk variants identified by genome-wide association studies in Han Chinese population: a replication study and meta-analysis. | Chang YC et al. | — | 2014 | → |
| Zinc-finger BED domain-containing 3 (Zbed3) is a novel secreted protein associated with insulin resistance in humans. | Jia Y et al. | — | 2014 | → |
| Zinc transporter 8 (ZnT8) and β cell function. | Davidson HW et al. | — | 2014 | → |
| ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis. | Al-Rubeaan K et al. | — | 2013 | → |
| Adaptive clustering and adaptive weighting methods to detect disease associated rare variants. | Sha Q et al. | — | 2013 | → |
| AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study. | Chu H et al. | — | 2013 | → |
| A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye. | Zheng Y et al. | — | 2013 | → |
| A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. | Pendse J et al. | — | 2013 | → |
| Advances in genetic studies of substance abuse in China. | Sun Y et al. | — | 2013 | → |
| A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. | Li H et al. | — | 2013 | → |
| A genome-wide search for type 2 diabetes susceptibility genes in an extended Arab family. | Al Safar HS et al. | — | 2013 | → |
| A multiclass likelihood ratio approach for genetic risk prediction allowing for phenotypic heterogeneity. | Wen Y et al. | — | 2013 | → |
| Animal models of GWAS-identified type 2 diabetes genes. | da Silva Xavier G et al. | — | 2013 | → |
| Apolipoprotein E2 accentuates postprandial inflammation and diet-induced obesity to promote hyperinsulinemia in mice. | Kuhel DG et al. | — | 2013 | → |
| A population-based association study of 2q32.3 and 8q21.3 loci with schizophrenia in Han Chinese. | Guan F et al. | — | 2013 | → |
| Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes. | Rivera NV et al. | — | 2013 | → |
| Association between 9p21.3 genomic markers and coronary artery disease in East Asians: a meta-analysis involving 9,813 cases and 10,710 controls. | Guo J et al. | — | 2013 | → |
| Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis. | Li H et al. | — | 2013 | → |
| Association of ANRIL polymorphism (rs1333049:C>G) with myocardial infarction and its pharmacogenomic role in hypercholesterolemia. | Ahmed W et al. | — | 2013 | → |
| Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a Han Chinese population. | Kong X et al. | — | 2013 | → |
| Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis. | Cheng S et al. | — | 2013 | → |
| Association of TCF7L2 gene polymorphisms with T2DM in the population of Hyderabad, India. | Uma Jyothi K et al. | — | 2013 | → |
| Association of variants in PPARγ², IGF2BP2, and KCNQ1 with a susceptibility to gestational diabetes mellitus in a Korean population. | Chon SJ et al. | — | 2013 | → |
| Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population. | Chen G et al. | — | 2013 | → |
| A variant in FTO shows association with melanoma risk not due to BMI. | Iles MM et al. | — | 2013 | → |
| Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases. | Wallace DC | — | 2013 | → |
| Bridging the gap between genetic associations and molecular mechanisms for type 2 diabetes. | Ng HJ et al. | — | 2013 | → |
| Chromosome 9p21 rs10757278 polymorphism is associated with the risk of metabolic syndrome. | Bayoglu B et al. | — | 2013 | → |
| Correlations between psoriasis and inflammatory bowel diseases. | Skroza N et al. | — | 2013 | → |
| Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets. | Ho MM et al. | — | 2013 | → |
| Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease. | Bullock JM et al. | — | 2013 | → |
| Ethical and practical challenges to studying patients who opt out of large-scale biorepository research. | Rosenbloom ST et al. | — | 2013 | → |
| Familial atrial fibrillation predicts increased risk of mortality: a study in Danish twins. | Christophersen IE et al. | — | 2013 | → |
| Generation of high quality chromatin immunoprecipitation DNA template for high-throughput sequencing (ChIP-seq). | Deliard S et al. | — | 2013 | → |
| Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. | Lam VK et al. | — | 2013 | → |
| Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association. | Ganesh SK et al. | — | 2013 | → |
| Genetics of type 2 diabetes and potential clinical implications. | Kwak SH et al. | — | 2013 | → |
| Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese. | Qian Y et al. | — | 2013 | → |
| Genome wide association studies for diabetes: perspective on results and challenges. | Torres JM et al. | — | 2013 | → |
| Genome-wide association study identifies possible genetic risk factors for colorectal adenomas. | Edwards TL et al. | — | 2013 | → |
| Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. | Chen DT et al. | — | 2013 | → |
| HMGA2 expression in white adipose tissue linking cellular senescence with diabetes. | Markowski DN et al. | — | 2013 | → |
| HuR maintains a replicative life span by repressing the ARF tumor suppressor. | Kawagishi H et al. | — | 2013 | → |
| Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight. | Park MH et al. | — | 2013 | → |
| Identification of an intermediate methyl carrier in the radical S-adenosylmethionine methylthiotransferases RimO and MiaB. | Landgraf BJ et al. | — | 2013 | → |
| Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. | Dayeh TA et al. | — | 2013 | → |
| Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes. | Karnes JH et al. | — | 2013 | → |
| Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging. | González-Navarro H et al. | — | 2013 | → |
| Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. | Schenkein HA et al. | — | 2013 | → |
| Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. | Schenkein HA et al. | — | 2013 | → |
| Insights into the genetic basis of type 2 diabetes. | Kato N | — | 2013 | → |
| Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study. | de Miguel-Yanes JM et al. | — | 2013 | → |
| Linkage of type 2 diabetes on chromosome 9p24 in Mexican Americans: additional evidence from the Veterans Administration Genetic Epidemiology Study (VAGES). | Farook VS et al. | — | 2013 | → |
| Long-term sustained autoimmune response to beta cell specific zinc transporter (ZnT8, W, R, Q) in young adult patients with preserved beta cell function at diagnosis of diabetes. | Ingemansson S et al. | — | 2013 | → |
| Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes. | Liu J et al. | — | 2013 | → |
| Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans. | Elliott HR et al. | — | 2013 | → |
| Multiple neurofibromas as the presenting feature of familial atypical multiple malignant melanoma (FAMMM) syndrome. | Vanneste R et al. | — | 2013 | → |
| Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. | Goldsworthy M et al. | — | 2013 | → |
| New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. | Horikoshi M et al. | — | 2013 | → |
| No detectable association of IGF2BP2 and SLC30A8 genes with type 2 diabetes in the population of Hyderabad, India. | Kommoju UJ et al. | — | 2013 | → |
| Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL. | Kim DS et al. | — | 2013 | → |
| Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. | Pendergrass SA et al. | — | 2013 | → |
| Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes. | Saxena R et al. | — | 2013 | → |
| Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction. | Szpakowicz A et al. | — | 2013 | → |
| Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits. | Yaghootkar H et al. | — | 2013 | → |
| Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups. | Ali S et al. | — | 2013 | → |
| Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population. | Sakai K et al. | — | 2013 | → |
| Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population. | Fukuda H et al. | — | 2013 | → |
| Senescent cells and their secretory phenotype as targets for cancer therapy. | Velarde MC et al. | — | 2013 | → |
| Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. | Randall JC et al. | — | 2013 | → |
| Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. | Goodarzi MO et al. | — | 2013 | → |
| Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. | Patel CJ et al. | — | 2013 | → |
| The current state of play on the molecular genetics of depression. | Cohen-Woods S et al. | — | 2013 | → |
| The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. | Tamaki M et al. | — | 2013 | → |
| The genetics of human obesity. | Xia Q et al. | — | 2013 | → |
| The genetics of type 2 diabetes and its clinical relevance. | Pal A et al. | — | 2013 | → |
| The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. | Bochenek G et al. | — | 2013 | → |
| The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study. | InterAct Consortium et al. | — | 2013 | → |
| The new perspectives on genetic studies of type 2 diabetes and thyroid diseases. | Xu M et al. | — | 2013 | → |
| The relationship between five widely-evaluated variants in CDKN2A/B and CDKAL1 genes and the risk of type 2 diabetes: a meta-analysis. | Peng F et al. | — | 2013 | → |
| The role of aging upon β cell turnover. | Kushner JA | — | 2013 | → |
| The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. | Steneberg P et al. | — | 2013 | → |
| Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population. | Kuo JZ et al. | — | 2013 | → |
| Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. | Ng MC et al. | — | 2013 | → |
| Use of net reclassification improvement (NRI) method confirms the utility of combined genetic risk score to predict type 2 diabetes. | Tam CH et al. | — | 2013 | → |
| Zinc, pancreatic islet cell function and diabetes: new insights into an old story. | Chimienti F | — | 2013 | → |
| 11q13 is a susceptibility locus for hormone receptor positive breast cancer. | Lambrechts D et al. | — | 2012 | → |
| Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. | da Silva Xavier G et al. | — | 2012 | → |
| African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts. | Cheng CY et al. | — | 2012 | → |
| A genome-wide association search for type 2 diabetes genes in African Americans. | Palmer ND et al. | — | 2012 | → |
| A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. | Osman W et al. | — | 2012 | → |
| A genome-wide association study of gestational diabetes mellitus in Korean women. | Kwak SH et al. | — | 2012 | → |
| A likelihood ratio-based Mann-Whitney approach finds novel replicable joint gene action for type 2 diabetes. | Lu Q et al. | — | 2012 | → |
| Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. | Campbell DD et al. | — | 2012 | → |
| Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus. | Kurzawski M et al. | — | 2012 | → |
| ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. | Chen XD et al. | — | 2012 | → |
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| Applying semantic web technologies for phenome-wide scan using an electronic health record linked Biobank. | Pathak J et al. | — | 2012 | → |
| A review of familial, genetic, and congenital aspects of primary varicose vein disease. | Anwar MA et al. | — | 2012 | → |
| A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. | Imamura M et al. | — | 2012 | → |
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| Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs. | Gupta V et al. | — | 2012 | → |
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| Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes. | Kim JJ et al. | — | 2012 | → |
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| RCM: a novel association approach to search for coronary artery disease genetic related metabolites based on SNPs and metabolic network. | Li X et al. | — | 2012 | → |
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| Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency. | Kose H et al. | — | 2012 | → |
| Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. | Langberg KA et al. | — | 2012 | → |
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| A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. | Cui B et al. | — | 2011 | → |
| Alternative methods to a TaqMan assay to detect a tri-allelic single nucleotide polymorphism rs757210 in the HNF1β gene. | Swen JJ et al. | — | 2011 | → |
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| A powerful hybrid approach to select top single-nucleotide polymorphisms for genome-wide association study. | Wang J et al. | — | 2011 | → |
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| Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. | Ke X et al. | — | 2011 | → |
| Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population. | Qu L et al. | — | 2011 | → |
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| Association of genetic variations in TCF7L2, SLC30A8, HHEX, LOC387761, and EXT2 with Type 2 diabetes mellitus in Tunisia. | Kifagi C et al. | — | 2011 | → |
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| Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes. | Wei FY et al. | — | 2011 | → |
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| Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79). | Ramya K et al. | — | 2011 | → |
| Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes. | Ketterer C et al. | — | 2011 | → |
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| Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations. | Rees SD et al. | — | 2011 | → |
| Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia. | Karns R et al. | — | 2011 | → |
| Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. | Palmer ND et al. | — | 2011 | → |
| Short telomeres compromise β-cell signaling and survival. | Guo N et al. | — | 2011 | → |
| SLC30A8 polymorphism and type 2 diabetes risk: evidence from 27 study groups. | Jing YL et al. | — | 2011 | → |
| SNP-based pathway enrichment analysis for genome-wide association studies. | Weng L et al. | — | 2011 | → |
| Stability selection for genome-wide association. | Alexander DH et al. | — | 2011 | → |
| Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans. | Myles S et al. | — | 2011 | → |
| The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel. | Chistiakov DA et al. | — | 2011 | → |
| The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. | Royds JA et al. | — | 2011 | → |
| The chromosome 9p21 region and myocardial infarction in a European population. | Koch W et al. | — | 2011 | → |
| The false-positive to false-negative ratio in epidemiologic studies. | Ioannidis JP et al. | — | 2011 | → |
| The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study. | Cheung CY et al. | — | 2011 | → |
| The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. | Pound LD et al. | — | 2011 | → |
| The porcine TBC1D1 gene: mapping, SNP identification, and association study with meat, carcass and production traits in Italian heavy pigs. | Fontanesi L et al. | — | 2011 | → |
| The same chromosome 9p21.3 locus is associated with type 2 diabetes and coronary artery disease in a Chinese Han population. | Cheng X et al. | — | 2011 | → |
| The search for genetic risk factors of type 2 diabetes mellitus. | Park KS | — | 2011 | → |
| Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. | Kanoni S et al. | — | 2011 | → |
| Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients. | Buraczynska M et al. | — | 2011 | → |
| Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. | Sim X et al. | — | 2011 | → |
| Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo. | Olsson AH et al. | — | 2011 | → |
| Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. | Chen J et al. | — | 2011 | → |
| Type 2 diabetes and obesity: genomics and the clinic. | Travers ME et al. | — | 2011 | → |
| Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies. | Cheng I et al. | — | 2011 | → |
| Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects. | Sharma NK et al. | — | 2011 | → |
| UCP2 -866G/A and Ala55Val, and UCP3 -55C/T polymorphisms in association with type 2 diabetes susceptibility: a meta-analysis study. | Xu K et al. | — | 2011 | → |
| Use of mouse models in studying type 2 diabetes mellitus. | Lee AW et al. | — | 2011 | → |
| Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. | de Miguel-Yanes JM et al. | — | 2011 | → |
| Visual integration of results from a large DNA biobank (BioVU) using synthesis-view. | Pendergrass S et al. | — | 2011 | → |
| World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease: part 2. | Bloomgarden ZT | — | 2011 | → |
| Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function. | El Muayed M et al. | — | 2010 | → |
| A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population. | Li X et al. | — | 2010 | → |
| A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. | Tsai FJ et al. | — | 2010 | → |
| A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. | Yamauchi T et al. | — | 2010 | → |
| A genome-wide association study of optic disc parameters. | Ramdas WD et al. | — | 2010 | → |
| Aging induces a distinct gene expression program in mouse islets. | Rankin MM et al. | — | 2010 | → |
| Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci. | Ye ZQ et al. | — | 2010 | → |
| Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. | Lewis JP et al. | — | 2010 | → |
| An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. | Patel CJ et al. | — | 2010 | → |
| A new statistic to evaluate imputation reliability. | Lin P et al. | — | 2010 | → |
| An interactive effect of batch size and composition contributes to discordant results in GWAS with the CHIAMO genotyping algorithm. | Chierici M et al. | — | 2010 | → |
| Antidiabetic effects of IGFBP2, a leptin-regulated gene. | Hedbacker K et al. | — | 2010 | → |
| A powerful approach to sub-phenotype analysis in population-based genetic association studies. | Morris AP et al. | — | 2010 | → |
| Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples. | Hong H et al. | — | 2010 | → |
| Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients. | Huang Q et al. | — | 2010 | → |
| Association between a literature-based genetic risk score and cardiovascular events in women. | Paynter NP et al. | — | 2010 | → |
| Association between type 2 diabetes loci and measures of fatness. | Pecioska S et al. | — | 2010 | → |
| Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorphism with elevated hemoglobin A₁(c) levels and the prevalence of metabolic syndrome in Japanese men: interaction with dietary energy intake. | Miyaki K et al. | — | 2010 | → |
| [Association of FTO gene polymorphisms and morbid obesity in the population of Extremadura (Spain)]. | Rodríguez-López R et al. | — | 2010 | → |
| Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. | Tönjes A et al. | — | 2010 | → |
| Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. | Musunuru K et al. | — | 2010 | → |
| Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis. | Gong M et al. | — | 2010 | → |
| Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. | Danoy P et al. | — | 2010 | → |
| Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. | Lin Y et al. | — | 2010 | → |
| Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. | Wijesekara N et al. | — | 2010 | → |
| Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City. | Cruz M et al. | — | 2010 | → |
| Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults? | Grant SF et al. | — | 2010 | → |
| Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. | Nair AK et al. | — | 2010 | → |
| CDKAL1 and type 2 diabetes: a global meta-analysis. | Dehwah MA et al. | — | 2010 | → |
| Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy. | Leak TS et al. | — | 2010 | → |
| Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. | Cunnington MS et al. | — | 2010 | → |
| Colloquium paper: bioenergetics, the origins of complexity, and the ascent of man. | Wallace DC | — | 2010 | → |
| Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. | Xu M et al. | — | 2010 | → |
| Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism. | Ruchat SM et al. | — | 2010 | → |
| Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population. | Gori F et al. | — | 2010 | → |
| Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. | Segrè AV et al. | — | 2010 | → |
| Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. | Zhang G et al. | — | 2010 | → |
| Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups. | Waters KM et al. | — | 2010 | → |
| Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort. | Pechlivanis S et al. | — | 2010 | → |
| Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. | Georgia S et al. | — | 2010 | → |
| DataSHIELD: resolving a conflict in contemporary bioscience--performing a pooled analysis of individual-level data without sharing the data. | Wolfson M et al. | — | 2010 | → |
| Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. | Ohara-Imaizumi M et al. | — | 2010 | → |
| Detecting rare variants for complex traits using family and unrelated data. | Zhu X et al. | — | 2010 | → |
| Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo. | Zhao J et al. | — | 2010 | → |
| Effects of ascertainment bias and marker number on estimations of barley diversity from high-throughput SNP genotype data. | Moragues M et al. | — | 2010 | → |
| Epigenetic regulation of p16Ink4a and Arf by JDP2 in cellular senescence. | Nakade K et al. | — | 2010 | → |
| Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health. | Popov N et al. | — | 2010 | → |
| Evaluating diabetes and hypertension disease causality using mouse phenotypes. | Yu H et al. | — | 2010 | → |
| Evaluating variations of genotype calling: a potential source of spurious associations in genome-wide association studies. | Hong H et al. | — | 2010 | → |
| Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. | Elliott KS et al. | — | 2010 | → |
| Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study. | Lehtovirta M et al. | — | 2010 | → |
| Evolutionary adaptations to dietary changes. | Luca F et al. | — | 2010 | → |
| Expansion of beta-cell mass in response to pregnancy. | Rieck S et al. | — | 2010 | → |
| Experimental approaches to the study of epigenomic dysregulation in ageing. | Thompson RF et al. | — | 2010 | → |
| Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. | Burd CE et al. | — | 2010 | → |
| Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. | Solberg Woods LC et al. | — | 2010 | → |
| FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. | Davis DB et al. | — | 2010 | → |
| From genetic association to molecular mechanism. | van de Bunt M et al. | — | 2010 | → |
| Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish. | Muller YL et al. | — | 2010 | → |
| Gene and pathway-based second-wave analysis of genome-wide association studies. | Peng G et al. | — | 2010 | → |
| Genetic influences on the association between fetal growth and susceptibility to type 2 diabetes. | Shields BM et al. | — | 2010 | → |
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| Genetics of type 2 diabetes. | Smushkin G et al. | — | 2010 | → |
| Genetic variants affecting incretin sensitivity and incretin secretion. | Müssig K et al. | — | 2010 | → |
| Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. | Qi L et al. | — | 2010 | → |
| Genetic variants in MTNR1B affecting insulin secretion. | Müssig K et al. | — | 2010 | → |
| Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2 are not associated with polycystic ovary syndrome in Chinese women. | Liu X et al. | — | 2010 | → |
| Genetic variation at the FTO locus influences RBL2 gene expression. | Jowett JB et al. | — | 2010 | → |
| Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data. | Yoshimi A et al. | — | 2010 | → |
| Genome-wide association study identifies five new breast cancer susceptibility loci. | Turnbull C et al. | — | 2010 | → |
| Genome-wide association study of coronary artery disease. | Ogawa N et al. | — | 2010 | → |
| Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. | Panagiotou OA et al. | — | 2010 | → |
| Genomic approaches to coronary artery disease. | Padmanabhan S et al. | — | 2010 | → |
| Genomics, type 2 diabetes, and obesity. | McCarthy MI | — | 2010 | → |
| Genotype imputation for genome-wide association studies. | Marchini J et al. | — | 2010 | → |
| Gestational diabetes mellitus screening based on the gene chip technique. | Liang Z et al. | — | 2010 | → |
| High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass. | Golson ML et al. | — | 2010 | → |
| Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging. | Huang YC et al. | — | 2010 | → |
| Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross. | Derry JM et al. | — | 2010 | → |
| Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. | Okamoto K et al. | — | 2010 | → |
| Identification of new genetic risk variants for type 2 diabetes. | Shu XO et al. | — | 2010 | → |
| Identifying candidate causal variants via trans-population fine-mapping. | Teo YY et al. | — | 2010 | → |
| IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes. | Rodriguez S et al. | — | 2010 | → |
| IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population. | Huang Q et al. | — | 2010 | → |
| Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. | Chauhan G et al. | — | 2010 | → |
| Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. | Han X et al. | — | 2010 | → |
| Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study. | Ruchat SM et al. | — | 2010 | → |
| Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. | Bell CG et al. | — | 2010 | → |
| Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes. | Qi L et al. | — | 2010 | → |
| Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. | Wen J et al. | — | 2010 | → |
| KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population. | Chen Z et al. | — | 2010 | → |
| Kinase mutations in human disease: interpreting genotype-phenotype relationships. | Lahiry P et al. | — | 2010 | → |
| Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. | Boraska V et al. | — | 2010 | → |
| Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. | Ragvin A et al. | — | 2010 | → |
| Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. | Liu Y et al. | — | 2010 | → |
| Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. | Cauchi S et al. | — | 2010 | → |
| Meta-analysis of genome-wide association studies: no efficiency gain in using individual participant data. | Lin DY et al. | — | 2010 | → |
| Multiethnic genetic association studies improve power for locus discovery. | Pulit SL et al. | — | 2010 | → |
| No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits. | Szopa M et al. | — | 2010 | → |
| Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits. | De Silva NM et al. | — | 2010 | → |
| Nutrigenomics: where are we with genetic and epigenetic markers for disposition and susceptibility? | Kussmann M et al. | — | 2010 | → |
| Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. | Morgan AR et al. | — | 2010 | → |
| Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group. | Zhuang JJ et al. | — | 2010 | → |
| Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. | Huang L et al. | — | 2010 | → |
| Pharmacogenetics of Anti-Diabetes Drugs. | Distefano JK et al. | — | 2010 | → |
| Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome. | Xu P et al. | — | 2010 | → |
| Presymptomatic risk assessment for chronic non-communicable diseases. | Padhukasahasram B et al. | — | 2010 | → |
| Progress in the genetics of common obesity and type 2 diabetes. | Vimaleswaran KS et al. | — | 2010 | → |
| Quantification of population structure using correlated SNPs by shrinkage principal components. | Zou F et al. | — | 2010 | → |
| Recent advances in the genetics and genomics of asthma and related traits. | Sleiman PM et al. | — | 2010 | → |
| Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. | Siontis KC et al. | — | 2010 | → |
| Replication of recently described type 2 diabetes gene variants in a South Indian population. | Chidambaram M et al. | — | 2010 | → |
| Resequencing of pooled DNA for detecting disease associations with rare variants. | Wang T et al. | — | 2010 | → |
| Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. | Bressler J et al. | — | 2010 | → |
| Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. | Ritchie MD et al. | — | 2010 | → |
| Role of zinc in human islet amyloid polypeptide aggregation. | Brender JR et al. | — | 2010 | → |
| Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. | Gonzalez R et al. | — | 2010 | → |
| Simultaneous and selective inference: Current successes and future challenges. | Benjamini Y | — | 2010 | → |
| SNP selection in genome-wide and candidate gene studies via penalized logistic regression. | Ayers KL et al. | — | 2010 | → |
| Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. | Sattar N et al. | — | 2010 | → |
| The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors. | Guo G et al. | — | 2010 | → |
| The epidemiology of diabetes in Korea: from the economics to genetics. | Cho NH | — | 2010 | → |
| The genetics of autism: key issues, recent findings, and clinical implications. | El-Fishawy P et al. | — | 2010 | → |
| The genetics of insulin resistance: Where's Waldo? | Watanabe RM | — | 2010 | → |
| The genetics of obesity and the metabolic syndrome. | Monda KL et al. | — | 2010 | → |
| The genetics of type 2 diabetes: what have we learned from GWAS? | Billings LK et al. | — | 2010 | → |
| The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI. | Webster RJ et al. | — | 2010 | → |
| The pursuit of genome-wide association studies: where are we now? | Ku CS et al. | — | 2010 | → |
| The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm. | Deka R et al. | — | 2010 | → |
| The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus. | Gupta D et al. | — | 2010 | → |
| The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion. | Lebrun P et al. | — | 2010 | → |
| Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W. | Weijers RN | — | 2010 | → |
| Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. | Voight BF et al. | — | 2010 | → |
| Two-stage testing strategies for genome-wide association studies in family-based designs. | Murphy A et al. | — | 2010 | → |
| Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. | Andersson EA et al. | — | 2010 | → |
| Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors. | Kirkpatrick CL et al. | — | 2010 | → |
| Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. | Talmud PJ et al. | — | 2010 | → |
| Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese. | Zhou DZ et al. | — | 2010 | → |
| Wnt signaling in pancreatic islets. | Liu Z et al. | — | 2010 | → |
| Mitochondrial DNA variants in the pathogenesis of type 2 diabetes - relevance of asian population studies. | Wang PW et al. | — | 2009 | → |
| Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus. | Parikh H et al. | — | 2009 | → |
| The effect of multiple genetic variants in predicting the risk of type 2 diabetes. | Lu Q et al. | — | 2009 | → |