To identify other putatively causal variants in our associated regions, we searched for non-synonymous coding SNPs in strong LD (r2>0.7) with the most strongly associated SNPs at each locus using data from the HapMap (Build 21) and 1000 Genomes Project (April and August 2009 releases). In this search, one lead SNP (rs6784615, at the NISCH-STAB1 locus) was correlated with non-synonymous changes in two nearby genes, DNAH1 (Val441Leu, Arg1285Trp and Arg3809Cys) and GLYCTK (Leu170Val). Fine-mapping and functional studies will be required to determine whether the DNAH1 or GLYCTK SNPs or the LY86 CNV are causal for the WHR-associations at these loci.
