Chunk #17 — RESULTS — Evaluation of effect of the WHR associations on expression in relevant tissues

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

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Expression-QTL (eQTL) data can implicate regional transcripts that mediate trait-associations, and we therefore examined the 14 WHR-associated loci using eQTL data from human subcutaneous adipose tissue (SAT)29 (two separate sample sets, N=610 and N=603), omental fat30 (N=740), liver30 (N=518), blood29 (N=745), and lymphocytes31 (N=830) (Online methods, Supplementary Note).